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Title: Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload.
Journal: Bioorganic & medicinal chemistry 20121101
Title: Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters 20121015
Title: Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.
Journal: The Journal of biological chemistry 20121005
Title: O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
Journal: Bioorganic & medicinal chemistry 20121001
Title: Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.
Journal: European journal of medicinal chemistry 20120901
Title: Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins.
Journal: Brain research 20120827
Title: Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
Journal: Journal of medicinal chemistry 20120614
Title: Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease.
Journal: Neurobiology of disease 20120601
Title: Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells.
Journal: Journal of agricultural and food chemistry 20120530
Title: Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.
Journal: Journal of medicinal chemistry 20120510
Title: Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Journal: Bioorganic & medicinal chemistry 20120501
Title: Solid-state characterization of tacrine hydrochloride.
Journal: Journal of pharmaceutical and biomedical analysis 20120407
Title: Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia.
Journal: Neuroscience letters 20120323
Title: Affinity binding-guided fluorescent nanobiosensor for acetylcholinesterase inhibitors via distance modulation between the fluorophore and metallic nanoparticle.
Journal: Analytical chemistry 20120320
Title: Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats.
Journal: Journal of pharmaceutical and biomedical analysis 20120305
Title: Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain.
Journal: Journal of neurochemistry 20120301
Title: New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Journal: Journal of medicinal chemistry 20120209
Title: Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.
Journal: Neuropharmacology 20120201
Title: Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115
Title: Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.
Journal: Neuro-degenerative diseases 20120101
Title: Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.
Journal: PloS one 20120101
Title: 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution.
Journal: International journal of molecular sciences 20120101
Title: A single-center, randomized, open-label, dose-escalation study to evaluate the pharmacokinetics of tacrine analogue octahydrogenacridine succinate tablets in healthy Chinese subjects.
Journal: Biological & pharmaceutical bulletin 20120101
Title: An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs.
Journal: The Analyst 20111207
Title: Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B.
Journal: Neuropharmacology 20111201
Title: Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.
Journal: Neurochemistry international 20111201
Title: Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.
Journal: European journal of medicinal chemistry 20111201
Title: Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.
Journal: Current topics in medicinal chemistry 20111101
Title: Effective pharmacological management of Alzheimer's disease.
Journal: The American journal of managed care 20111101
Title: ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Journal: Behavioural brain research 20111010
Title: Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity.
Journal: Basic & clinical pharmacology & toxicology 20111001
Title: Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Journal: Fitoterapia 20111001
Title: Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
Journal: European journal of medicinal chemistry 20111001
Title: Reversible human serum albumin binding of lipocrine: a circular dichroism study.
Journal: Chirality 20111001
Title: Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Journal: Planta medica 20110901
Title: Reversible inhibition of esterase activity after separation and immobilization.
Journal: Applied biochemistry and biotechnology 20110901
Title: Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.
Journal: European journal of medicinal chemistry 20110801
Title: Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors.
Journal: Bioorganic chemistry 20110801
Title: New drugs for Alzheimer's disease in Japan.
Journal: Psychiatry and clinical neurosciences 20110801
Title: Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.
Journal: European journal of pharmacology 20110625
Title: HFE polymorphisms affect cellular glutamate regulation.
Journal: Neurobiology of aging 20110601
Title: Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity.
Journal: Basic & clinical pharmacology & toxicology 20110601
Title: Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
Journal: European journal of medicinal chemistry 20110601
Title: Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.
Journal: Bioorganic & medicinal chemistry 20110401
Title: Inhibition mechanism of rat α₃β₄ nicotinic acetylcholine receptor by the Alzheimer therapeutic tacrine.
Journal: Biochemistry 20110322
Title: Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds.
Journal: Organic & biomolecular chemistry 20110221
Title: Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats.
Journal: Behavioural pharmacology 20110201
Title: Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.
Journal: Bioorganic & medicinal chemistry 20110115
Title: Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants.
Journal: Analytical biochemistry 20110101
Title: Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Journal: Bioorganic & medicinal chemistry 20110101
Title: [Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds].
Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101
Title: In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain.
Journal: Neuro endocrinology letters 20110101
Title: Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice.
Journal: Journal of pharmacological sciences 20110101
Title: Sensitizing effect of tacrine on M-cholinergic receptors in gastric smooth muscle of rats.
Journal: Folia medica 20110101
Title: Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state.
Journal: Journal of the American Chemical Society 20101229
Title: Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Journal: Molecules (Basel, Switzerland) 20101202
Title: Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands.
Journal: Analytical biochemistry 20101201
Title: Action potential bursts in central snail neurons elicited by procaine: roles of ionic currents.
Journal: The Chinese journal of physiology 20101031
Title: Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease.
Journal: Archiv der Pharmazie 20101001
Title: Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
Journal: Journal of natural products 20100924
Title: Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
Journal: Chemico-biological interactions 20100906
Title: Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities.
Journal: ChemMedChem 20100802
Title: Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
Journal: Journal of medicinal chemistry 20100708
Title: Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.
Journal: The Journal of biological chemistry 20100625
Title: Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.
Journal: Neurobiology of aging 20100601
Title: A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease.
Journal: Neurotoxicity research 20100501
Title: Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.
Journal: Journal of medicinal chemistry 20100311
Title: Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia.
Journal: European journal of pharmacology 20100310
Title: A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB.
Journal: Neuroscience letters 20100118
Title: Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells.
Journal: Archives of pharmacal research 20100101
Title: Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.
Journal: BMC neuroscience 20100101
Title: Tacrine derivatives and Alzheimer's disease.
Journal: Current medicinal chemistry 20100101
Title: Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine.
Journal: Arzneimittel-Forschung 20100101
Title: Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm.
Journal: Arzneimittel-Forschung 20100101
Title: Rapid determination of tacrine and other drug metabolites in microsomal incubate by newly developed targeting algorithm on UHPLC/TOFMS.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091215
Title: Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation.
Journal: Behavioural brain research 20091201
Title: Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
Journal: European journal of pharmacology 20091125
Title: Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Journal: Pharmacology, biochemistry, and behavior 20091101
Title: Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.
Journal: Toxicology and applied pharmacology 20091101
Title: Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration.
Journal: Pharmacology, biochemistry, and behavior 20091101
Title: Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Chromone glycosides and hepatoprotective constituents of Hypericum erectum.
Journal: Archives of pharmacal research 20091001
Title: The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain.
Journal: Biochimie 20090901
Title: The inhibitory avoidance test optimized for discovery of cognitive enhancers.
Journal: Behavior research methods 20090801
Title: Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons.
Journal: Neuropharmacology 20090701
Title: Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle.
Journal: Journal of the Association for Research in Otolaryngology : JARO 20090601
Title: Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Journal: Journal of medicinal chemistry 20090514
Title: Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.
Journal: ChemMedChem 20090501
Title: Kinetics of inhibition of acetylcholinesterase in the presence of acetonitrile.
Journal: The FEBS journal 20090401
Title: Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells.
Journal: Cell biology international 20090301
Title: Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation.
Journal: Biological & pharmaceutical bulletin 20090301
Title: Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions.
Journal: The Journal of membrane biology 20090301
Title: [Progress in the research on multi-target-directed drugs against Alzheimer's disease].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090301
Title: Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease.
Journal: Neurotoxicity research 20090201
Title: Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.
Journal: Biochemistry 20090127
Title: Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
Journal: Parkinsonism & related disorders 20090101
Title: Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101
Title: MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.
Journal: Current pharmaceutical design 20090101
Title: Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex.
Journal: Journal of Alzheimer's disease : JAD 20090101
Title: Comparison studies of tacrine and bis7-tacrine on the suppression of scopolamine-induced behavioral changes and inhibition of acetylcholinesterase in mice.
Journal: Pharmacology 20090101
Title: NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.
Journal: Journal of medicinal chemistry 20081225
Title: [Protection effects of acetylcholinesterase inhibitors on apoptosis].
Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20081201
Title: A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry.
Journal: Protein science : a publication of the Protein Society 20081001
Title: New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.
Journal: Neuro endocrinology letters 20081001
Title: An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
Journal: Journal of pharmaceutical and biomedical analysis 20080910
Title: An algorithm for thorough background subtraction from high-resolution LC/MS data: application for detection of glutathione-trapped reactive metabolites.
Journal: Journal of mass spectrometry : JMS 20080901
Title: Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080901
Title: Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b]quinoline.
Journal: Acta crystallographica. Section C, Crystal structure communications 20080901
Title: Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties.
Journal: Biochemical pharmacology 20080715
Title: Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia.
Journal: Neuroscience letters 20080711
Title: MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080701
Title: Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal: Journal of medicinal chemistry 20080626
Title: Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal: Journal of medicinal chemistry 20080612
Title: Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies.
Journal: Neuropharmacology 20080601
Title: Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584.
Journal: Behavioral neuroscience 20080601
Title: Effects of tamoxifen on L-glutamate transporters of astrocytes.
Journal: Journal of pharmacological sciences 20080601
Title: The cholinergic system in cyclophosphamide-induced Chagas dilated myocardiopathy in Trypanosoma-cruzi-infected rats: an electrocardiographic study.
Journal: Investigacion clinica 20080601
Title: Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.
Journal: Biochemical and biophysical research communications 20080516
Title: Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: In vitro hepatoprotective compounds from Suaeda glauca.
Journal: Archives of pharmacal research 20080501
Title: Diagnosis and treatment of dementia with Lewy bodies.
Journal: JAAPA : official journal of the American Academy of Physician Assistants 20080501
Title: AAFP and ACP release guideline on dementia treatment.
Journal: American family physician 20080415
Title: Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry.
Journal: Biomedical chromatography : BMC 20080401
Title: Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Journal: European journal of pharmacology 20080310
Title: Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations.
Journal: Annals of internal medicine 20080304
Title: Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians.
Journal: Annals of internal medicine 20080304
Title: Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.
Journal: Annals of internal medicine 20080304
Title: Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.
Journal: Biochemical and biophysical research communications 20080215
Title: Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases.
Journal: Bulletin of experimental biology and medicine 20080201
Title: The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.
Journal: Journal of pharmaceutical and biomedical analysis 20080107
Title: Effects of zonisamide on experimental tremors in rats.
Journal: Parkinsonism & related disorders 20080101
Title: Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats.
Journal: Psychopharmacology 20080101
Title: Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.
Journal: PloS one 20080101
Title: Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice.
Journal: The American journal of Chinese medicine 20080101
Title: Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
Journal: Journal of pharmacological and toxicological methods 20080101
Title: Modulation of hemorheological parameters by the erythrocyte redox thiol status.
Journal: Clinical hemorheology and microcirculation 20080101
Title: Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells.
Journal: Clinical hemorheology and microcirculation 20080101
Title: Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats.
Journal: Acta medica (Hradec Kralove) 20080101
Title: A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine.
Journal: International immunopharmacology 20071215
Title: Tacrine-induced liver damage: an analysis of 19 candidate genes.
Journal: Pharmacogenetics and genomics 20071201
Title: First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.
Journal: Journal of medicinal chemistry 20071115
Title: Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity.
Journal: Pharmacogenetics and genomics 20071101
Title: Thermodynamic analysis of binding between drugs and glycosaminoglycans by isothermal titration calorimetry and fluorescence spectroscopy.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071001
Title: Evaluation of centrally acting cholinesterase inhibitor exposures in adults.
Journal: The Annals of pharmacotherapy 20071001
Title: Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents.
Journal: Biochemical and biophysical research communications 20070921
Title: Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood.
Journal: Journal of pharmaceutical and biomedical analysis 20070903
Title: Alzheimer's disease: will advances made in the past turn the tide?
Journal: The Annals of pharmacotherapy 20070901
Title: Nose-to-brain delivery of tacrine.
Journal: The Journal of pharmacy and pharmacology 20070901
Title: The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.
Journal: Journal of pharmacological sciences 20070901
Title: East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Journal: Current Alzheimer research 20070901
Title: Treating autism pharmacologically: also tacrine might improve symptomatology in some cases.
Journal: Journal of child neurology 20070801
Title: WITHDRAWN: Tacrine for Alzheimer's disease.
Journal: The Cochrane database of systematic reviews 20070718
Title: Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
Journal: European journal of pharmacology 20070702
Title: Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.
Journal: Journal of proteome research 20070701
Title: Effect of histamine on muscimol-induced working memory deficits in radial maze performance.
Journal: Journal of pharmacological sciences 20070701
Title: Cytoprotective constituent of Hoveniae Lignum on both Hep G2 cells and rat primary hepatocytes.
Journal: Archives of pharmacal research 20070601
Title: Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.
Journal: Neurology 20070515
Title: Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.
Journal: Molecular pharmacology 20070501
Title: Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
Journal: Life sciences 20070501
Title: Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands.
Journal: Molecular pharmacology 20070301
Title: The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease.
Journal: Journal of the American Medical Directors Association 20070301
Title: Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers.
Journal: Neuropharmacology 20070201
Title: Screening of acetylcholinesterase inhibitors in natural extracts by CE with electrophoretically mediated microanalysis technique.
Journal: Electrophoresis 20070201
Title: Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes.
Journal: Toxicology letters 20070130
Title: Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network.
Journal: Clinical hemorheology and microcirculation 20070101
Title: Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.
Journal: Current medicinal chemistry 20070101
Title: Long-term tetrahydroaminoacridine treatment and quantitative EEG in Alzheimer's disease.
Journal: Journal of neural transmission. Supplementum 20070101
Title: Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
Journal: Journal of medicinal chemistry 20061228
Title: New multipotent tetracyclic tacrines with neuroprotective activity.
Journal: Bioorganic & medicinal chemistry 20061215
Title: Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.
Journal: Journal of medicinal chemistry 20061214
Title: Fluorescent method for evaluation of cholinesterase inhibitors.
Journal: Bulletin of experimental biology and medicine 20061201
Title: Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal: Journal of medicinal chemistry 20061116
Title: Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.
Journal: European journal of pharmacology 20061107
Title: Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles.
Journal: Canadian journal of physiology and pharmacology 20061101
Title: Rapid method for evaluation of cholinesterase inhibitors.
Journal: Bulletin of experimental biology and medicine 20061101
Title: Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Journal: Journal of the neurological sciences 20061025
Title: Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.
Journal: Journal of molecular graphics & modelling 20061001
Title: Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.
Journal: Journal of medicinal chemistry 20060907
Title: Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal: Journal of medicinal chemistry 20060907
Title: Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20060901
Title: Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
Journal: Journal of neurochemistry 20060901
Title: Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice.
Journal: Pharmacology, biochemistry, and behavior 20060901
Title: Inhibition of two different cholinesterases by tacrine.
Journal: Chemico-biological interactions 20060825
Title: [Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801
Title: Cover note article on the muscle relaxants suxamethonium and THA.
Journal: Anaesthesia and intensive care 20060801
Title: Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701
Title: Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats.
Journal: Pharmacology, biochemistry, and behavior 20060701
Title: Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal: Journal of medicinal chemistry 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine.
Journal: Neuroreport 20060403
Title: Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells.
Journal: Journal of neurophysiology 20060401
Title: New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer's disease.
Journal: Die Pharmazie 20060401
Title: Muscle relaxants--suxamethonium and THA.
Journal: Anaesthesia and intensive care 20060201
Title: Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Journal: Journal of medicinal chemistry 20060126
Title: Memory-dependent novelty-related location preferences: sex-related attenuation of forgetting by D-glucose and tacrine.
Journal: Behavioural brain research 20060106
Title: Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20060101
Title: Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060101
Title: CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival.
Journal: Dementia and geriatric cognitive disorders 20060101
Title: Long-term depression of neuron to glial signalling in rat cerebellar cortex.
Journal: The European journal of neuroscience 20060101
Title: Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition.
Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060101
Title: Current and emerging pharmacological treatment options for dementia.
Journal: Behavioural neurology 20060101
Title: Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease.
Journal: Alzheimer disease and associated disorders 20060101
Title: Pharmacological characterization of orally active cholinesterase inhibitory activity of Prunus persica L. Batsch in rats.
Journal: Journal of molecular neuroscience : MN 20060101
Title: Alzheimer disease and its management: a review.
Journal: American journal of therapeutics 20060101
Title: Effect of tacrine on cytosolic Ca2+ level and calmodulin in gastric muscle tissues of rat.
Journal: Folia medica 20060101
Title: Induced fit in mouse acetylcholinesterase upon binding a femtomolar inhibitor: a molecular dynamics study.
Journal: Journal of medicinal chemistry 20051229
Title: Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Journal: Bioorganic & medicinal chemistry 20051215
Title: Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.
Journal: Molecular pharmacology 20051201
Title: Allosteric binding sites on muscarinic acetylcholine receptors.
Journal: Molecular pharmacology 20051201
Title: Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Archives of pharmacal research 20051201
Title: Intestinal single-pass in situ perfusion technique in rat: the influence of L-carnitine on absorption of 7-methoxytacrine.
Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201
Title: Dementia.
Journal: Clinical evidence 20051201
Title: Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Journal: Journal of medicinal chemistry 20051117
Title: Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor.
Journal: Journal of medicinal chemistry 20051117
Title: Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells.
Journal: Biological & pharmaceutical bulletin 20051101
Title: Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
Journal: Journal of molecular biology 20051021
Title: Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task.
Journal: Fundamental & clinical pharmacology 20051001
Title: Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice.
Journal: Behavioural brain research 20050908
Title: Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo.
Journal: Basic & clinical pharmacology & toxicology 20050901
Title: SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.
Journal: Psychopharmacology 20050801
Title: Modification of motor cortical excitability by an acetylcholinesterase inhibitor.
Journal: Experimental brain research 20050701
Title: In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.
Journal: Journal of the American Chemical Society 20050511
Title: Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
Journal: The Journal of biological chemistry 20050506
Title: Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats.
Journal: Psychopharmacology 20050501
Title: Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production.
Journal: Annals of neurology 20050501
Title: Role of molecular isoforms of acetylcholinesterase in learning and memory functions.
Journal: Pharmacology, biochemistry, and behavior 20050501
Title: Actions of tacrine and galanthamine on histamine-N-methyltransferase.
Journal: Methods and findings in experimental and clinical pharmacology 20050401
Title: Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
Journal: Archives of pharmacal research 20050401
Title: Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301
Title: Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine.
Journal: European journal of medicinal chemistry 20050301
Title: Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
Journal: Journal of the American Academy of Nurse Practitioners 20050301
Title: Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
Journal: The American journal of geriatric pharmacotherapy 20050301
Title: Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism.
Journal: European journal of pharmacology 20050221
Title: Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243.
Journal: Behavioural brain research 20050130
Title: Rational approach to discover multipotent anti-Alzheimer drugs.
Journal: Journal of medicinal chemistry 20050127
Title: The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane.
Journal: British journal of pharmacology 20050101
Title: Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors.
Journal: Archiv der Pharmazie 20050101
Title: [Treatment of dementia].
Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050101
Title: [Mitochondria as the target for neuroprotectors].
Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20050101
Title: Non-anticholinesterase, non-cholinergic effect of tacrine on gastrointestinal smooth muscle tissues of rat.
Journal: Folia medica 20050101
Title: In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine).
Journal: Acta medica (Hradec Kralove) 20050101
Title: (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
Journal: Journal of Alzheimer's disease : JAD 20041201
Title: Dementia.
Journal: Clinical evidence 20041201
Title: Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
Journal: European journal of pharmacology 20041025
Title: Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine.
Journal: Neurobiology of aging 20041001
Title: A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic.
Journal: Indian journal of physiology and pharmacology 20041001
Title: A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells.
Journal: Life sciences 20040924
Title: Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters 20040920
Title: ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with 'calcium promotor' and neuroprotective properties.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions.
Journal: Experimental neurology 20040901
Title: Tetrahydroacridine inhibits voltage-dependent Na(+) current in guinea-pig ventricular myocytes.
Journal: Acta pharmacologica Sinica 20040901
Title: An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa.
Journal: Archives of pharmacal research 20040901
Title: Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells.
Journal: Archives of pharmacal research 20040901
Title: An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat.
Journal: Behavioural brain research 20040831
Title: Inhibition of murine cytochrome P4501A by tacrine: in vitro studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040801
Title: A latent normal distribution model for analysing ordinal responses with applications in meta-analysis.
Journal: Statistics in medicine 20040730
Title: Nanosecond dynamics of acetylcholinesterase near the active center gorge.
Journal: The Journal of biological chemistry 20040618
Title: Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons.
Journal: Neuroreport 20040607
Title: Dementia.
Journal: Clinical evidence 20040601
Title: Cholesterol and APOE genotype interact to influence Alzheimer disease progression.
Journal: Neurology 20040525
Title: Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients.
Journal: Journal of neurochemistry 20040301
Title: Influence of tacrine on dopamine-induced reactions of the gastric smooth muscle of rats.
Journal: Methods and findings in experimental and clinical pharmacology 20040301
Title: Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert.
Journal: Neuroscience letters 20040219
Title: Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Journal: European journal of pharmacology 20040213
Title: Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis.
Journal: Biochimica et biophysica acta 20040114
Title: Differences between clinical trials and postmarketing use.
Journal: British journal of clinical pharmacology 20040101
Title: Acetylcholinesterase inhibition in Alzheimer's Disease.
Journal: Current pharmaceutical design 20040101
Title: Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel.
Journal: Archives of pharmacal research 20040101
Title: Tetrahydroacridin-9-ones, 9-chlorotetrahydroacridines, 9-amino-tetrahydroacridines and 9-(pyrazol-1-yl)-tetrahydroacridines derived from chiral cyclanones.
Journal: European journal of medicinal chemistry 20040101
Title: [Drugs for the treatment of Alzheimer's disease].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040101
Title: Velnacrine for Alzheimer's disease.
Journal: The Cochrane database of systematic reviews 20040101
Title: Use of cognitive enhancement medication in persons with Alzheimer disease who have a family caregiver: results from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) project.
Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20040101
Title: [Study of the cholinesterase active site using a fluorescent probe].
Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20040101
Title: Comparison of desorption/ionization on silicon (DIOS) time-of-flight and liquid chromatography/tandem mass spectrometry for assaying enzyme-inhibition reactions.
Journal: Rapid communications in mass spectrometry : RCM 20040101
Title: The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies.
Journal: The Journal of neuropsychiatry and clinical neurosciences 20040101
Title: Spectrofluorimetric determination of velnacrine in human serum and urine.
Journal: Farmaco (Societa chimica italiana : 1989) 20031201
Title: Anticholinesterases in Alzheimer's disease: a modest effect on moderately severe disease.
Journal: Prescrire international 20031201
Title: [Synthesis of prodrugs of tacrine hydrochloride and evaluation of the stability and biodistribution in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20031201
Title: Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites.
Journal: The Journal of biological chemistry 20031003
Title: Recent developments in the synthesis of acetylcholinesterase inhibitors.
Journal: Mini reviews in medicinal chemistry 20030901
Title: Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver.
Journal: Hepatology (Baltimore, Md.) 20030901
Title: Benzodiazepine utilization patterns in Alzheimer's disease patients.
Journal: Pharmacoepidemiology and drug safety 20030901
Title: Reduction in distractibility with AF102B and THA in the macaque.
Journal: Pharmacology, biochemistry, and behavior 20030901
Title: Photoreversible inhibition of cholinesterases: catalytic serine-labeled caged butyrylcholinesterase.
Journal: Chembiochem : a European journal of chemical biology 20030804
Title: Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats.
Journal: Psychopharmacology 20030801
Title: Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus.
Journal: Journal of ethnopharmacology 20030801
Title: Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Journal: Molecular pharmacology 20030701
Title: Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20030601
Title: The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030601
Title: Dementia.
Journal: Clinical evidence 20030601
Title: [Current therapy of patients with dementia].
Journal: MMW Fortschritte der Medizin 20030526
Title: Manganese-based complexes of radical scavengers as neuroprotective agents.
Journal: Bioorganic & medicinal chemistry 20030515
Title: Pharmacology of delta2 glutamate receptors: effects of pentamidine and protons.
Journal: The Journal of pharmacology and experimental therapeutics 20030501
Title: Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Phytotherapy research : PTR 20030501
Title: Mitochondria as a target for neurotoxins and neuroprotective agents.
Journal: Annals of the New York Academy of Sciences 20030501
Title: Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.
Journal: Chemistry & biology 20030401
Title: Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.
Journal: International clinical psychopharmacology 20030301
Title: Acute effects of huperzine A and tacrine on rat liver.
Journal: Acta pharmacologica Sinica 20030301
Title: Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients.
Journal: Neuroscience letters 20030227
Title: Tacrine-scopolamine interactions on state-dependent retrieval.
Journal: Psychopharmacology 20030201
Title: Hormone replacement therapy in postmenopausal women with Alzheimer's disease: a randomized, prospective study.
Journal: Fertility and sterility 20030201
Title: Alzheimer's disease: emerging noncholinergic treatments.
Journal: Geriatrics 20030201
Title: Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor.
Journal: Psychopharmacology 20030101
Title: Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial.
Journal: Indian journal of physiology and pharmacology 20030101
Title: Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain.
Journal: Acta biologica Hungarica 20030101
Title: Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze.
Journal: Life sciences 20021220
Title: Risk from lithium with acetylcholinesterase inhibitor.
Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20021201
Title: Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Journal: European journal of pharmacology 20021129
Title: [Anti-dementia drugs for Alzheimer disease in present and future].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells.
Journal: Brain research. Molecular brain research 20021030
Title: In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase.
Journal: Brain research bulletin 20021015
Title: Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Journal: Neuroscience letters 20021004
Title: Dissolution and partitioning behavior of hydrophobic ion-paired compounds.
Journal: Pharmaceutical research 20021001
Title: [Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901
Title: Clinical use of cholinomimetic agents: a review.
Journal: The Journal of head trauma rehabilitation 20020801
Title: Binding and release of drugs into and from thermosensitive poly(N-vinyl caprolactam) nanoparticles.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701
Title: Medical treatment of Alzheimer's disease: past, present, and future.
Journal: Medicine and health, Rhode Island 20020701
Title: Nicotine and sensory memory in Alzheimer's disease: an event-related potential study.
Journal: Brain and cognition 20020701
Title: Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions.
Journal: European journal of pharmacology 20020628
Title: Novel tacrine derivatives that block neuronal calcium channels.
Journal: Bioorganic & medicinal chemistry 20020601
Title: Acute and chronic acetylcholinesterase inhibition regulates in vivo the localization and abundance of muscarinic receptors m2 and m4 at the cell surface and in the cytoplasm of striatal neurons.
Journal: Molecular and cellular neurosciences 20020601
Title: Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study.
Journal: Pharmacology, biochemistry, and behavior 20020501
Title: Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Planta medica 20020501
Title: Determination of tacrine metabolites in microsomal incubate by high performance liquid chromatography-nuclear magnetic resonance/mass spectrometry with a column trapping system.
Journal: Journal of pharmaceutical and biomedical analysis 20020401
Title: Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
Journal: The Journal of pharmacology and experimental therapeutics 20020401
Title: Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Journal: Acta pharmacologica Sinica 20020401
Title: 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Journal: Biochemistry 20020305
Title: Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Journal: Planta medica 20020301
Title: Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020301
Title: Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.
Journal: Biochemical and biophysical research communications 20020222
Title: Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment.
Journal: Neuropharmacology 20020201
Title: Effects of amphetamine on the plus-maze discriminative avoidance task in mice.
Journal: Psychopharmacology 20020201
Title: Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain.
Journal: Japanese journal of pharmacology 20020201
Title: [Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020201
Title: Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study.
Journal: Pharmacopsychiatry 20020101
Title: Effects of acute nicotine administration on cognitive event-related potentials in tacrine-treated and non-treated patients with Alzheimer's disease.
Journal: Neuropsychobiology 20020101
Title: Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine.
Journal: Current medical research and opinion 20020101
Title: Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.
Journal: Clinical pharmacokinetics 20020101
Title: Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.
Journal: Journal of medicinal chemistry 20011220
Title: Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat.
Journal: Neuropharmacology 20011201
Title: Galantamine: new preparation. The fourth cholinesterase inhibitor for Alzheimer's disease.
Journal: Prescrire international 20011201
Title: [Perspectives for drug treatment in Alzheimer's disease].
Journal: Annales de medecine interne 20011201
Title: Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry 20011101
Title: Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Planta medica 20011101
Title: Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
Journal: Japanese journal of pharmacology 20011101
Title: A structure-based design approach to the development of novel, reversible AChE inhibitors.
Journal: Journal of medicinal chemistry 20010927
Title: Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
Journal: Mini reviews in medicinal chemistry 20010901
Title: Meta-analysis of ordinal outcomes using individual patient data.
Journal: Statistics in medicine 20010815
Title: Medications for the treatment of Alzheimer's disease.
Journal: The Journal of the Oklahoma State Medical Association 20010801
Title: Maintaining functional and behavioral abilities in Alzheimer disease.
Journal: Alzheimer disease and associated disorders 20010801
Title: Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ.
Journal: Journal of neurophysiology 20010701
Title: Use of cholinesterase inhibitors for treatment of Alzheimer disease.
Journal: Cleveland Clinic journal of medicine 20010701
Title: Apoptosis: biphasic dose responses.
Journal: Critical reviews in toxicology 20010701
Title: Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.
Journal: Acta pharmacologica Sinica 20010701
Title: Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal: Mini reviews in medicinal chemistry 20010701
Title: [Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010701
Title: Does 'butyrylization' of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Journal: Biochemistry 20010626
Title: Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase.
Journal: Molecules and cells 20010430
Title: Action of tacrine on muscarinic receptors in rat intestinal smooth muscle.
Journal: Journal of autonomic pharmacology 20010401
Title: Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats.
Journal: European journal of pharmacology 20010301
Title: Ion-exchange fibers and drugs: an equilibrium study.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20010129
Title: Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients.
Journal: Dementia and geriatric cognitive disorders 20010101
Title: Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine.
Journal: Pharmacology 20010101
Title: Synthesis and in-vitro anticancer evaluation of bis-tacrine congeners.
Journal: The Journal of pharmacy and pharmacology 20010101
Title: Cholinesterase inhibitors for Alzheimer's disease.
Journal: Drugs 20010101
Title: [Ursodeoxycholic acid and prevention of tacrine-induced hepatotoxicity: a pilot study].
Journal: Therapie 20010101
Title: Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease.
Journal: Dementia and geriatric cognitive disorders 20010101
Title: Controlled release tacrine delivery system for the treatment of Alzheimer's disease.
Journal: Drug delivery 20010101
Title: Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101
Title: [Current strategies of pathogenetic therapy of Alzheimer's disease].
Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101
Title: Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
Journal: Neurologia i neurochirurgia polska 20010101
Title: Drugs used for cognitive symptoms of Alzheimer's disease.
Journal: Perspectives in psychiatric care 20010101
Title: Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy.
Journal: Neuroreport 20000427
Title: Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration.
Journal: JAMA 19981125
Title: [Convulsive crisis as a possible adverse reaction to the treatment with tacrine in Alzheimer's disease].
Journal: Medicina clinica 19980912
Title: Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Journal: European journal of pharmacology 19980522
Title: Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release.
Journal: European journal of pharmacology 19980508
Title: Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Journal: Pharmacology, biochemistry, and behavior 19980401
Title: Myoclonus induced by tacrine.
Journal: Journal of neurology, neurosurgery, and psychiatry 19980201
Title: Systemic administration of N omega-nitro-L-arginine methyl ester and indomethacin reduces the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by LiCl and tacrine in rat.
Journal: Experimental neurology 19980201
Title: Motor dysfunction produced by tacrine administration in rats.
Journal: Pharmacology, biochemistry, and behavior 19971201
Title: Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Journal: Methods and findings in experimental and clinical pharmacology 19970501
Title: Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects.
Journal: Pharmacology, biochemistry, and behavior 19970201
Title: Adverse interaction of tacrine and haloperidol.
Journal: The American journal of psychiatry 19961101
Title: [Flare-up of arterial hypertension during treatment with tacrine].
Journal: Presse medicale (Paris, France : 1983) 19961012
Title: Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells.
Journal: Neuroreport 19960902
Title: Delirium caused by tacrine and ibuprofen interaction.
Journal: The American journal of psychiatry 19960601
Title: Convulsive effects of tacrine.
Journal: Lancet (London, England) 19960511
Title: Systemic administration of lithium chloride and tacrine but not kainic acid augments citrulline content of rat brain.
Journal: European journal of pharmacology 19951227
Title: Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol.
Journal: Journal of clinical psychopharmacology 19950801
Title: Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats.
Journal: Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 19950301
Title: Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats.
Journal: European journal of pharmacology 19931130
Title: Tacrine inhibits ventricular fibrillation induced by ischaemia and reperfusion and widens QT interval in rat.
Journal: Cardiovascular research 19930301
Title: Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats.
Journal: Psychopharmacology 19920101
Title: A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice.
Journal: The Journal of pharmacology and experimental therapeutics 19901101
Title: Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes.
Journal: European journal of pharmacology 19891128
Title: Suxamethonium apnoea masked by tetrahydroaminacrine.
Journal: Anaesthesia 19780101
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Title: Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62.
Title: The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Yi YM, et, al. Int J Ophthalmol. 2015 Oct 18; 8(5): 884-90.
