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Title: Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes inhibitors: The novel N,N'-bis-cyanomethylamine and alkoxymethylamine derivatives.
Journal: Journal of biochemical and molecular toxicology 20180401
Title: Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.
Journal: Chemical research in toxicology 20180219
Title: Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activities.
Journal: Journal of biochemical and molecular toxicology 20180201
Title: Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles.
Journal: Journal of biochemical and molecular toxicology 20180101
Title: Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes.
Journal: Journal of biochemical and molecular toxicology 20180101
Title: Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles.
Journal: Journal of biochemical and molecular toxicology 20170701
Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.
Journal: Archives of toxicology 20170301
Title: High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.
Journal: Archives of toxicology 20170101
Title: Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease.
Journal: Chemico-biological interactions 20160405
Title: N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice.
Journal: Chemico-biological interactions 20151205
Title: Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
Journal: Journal of applied toxicology : JAT 20150901
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors.
Journal: Chemico-biological interactions 20130325
Title: Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Journal: Journal of medicinal chemistry 20121108
Title: Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload.
Journal: Bioorganic & medicinal chemistry 20121101
Title: Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry 20121101
Title: Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters 20121015
Title: Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.
Journal: The Journal of biological chemistry 20121005
Title: O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
Journal: Bioorganic & medicinal chemistry 20121001
Title: Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.
Journal: European journal of medicinal chemistry 20120901
Title: Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins.
Journal: Brain research 20120827
Title: Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Journal: European journal of medicinal chemistry 20120801
Title: Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.
Journal: Bioorganic & medicinal chemistry letters 20120701
Title: Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
Journal: Journal of medicinal chemistry 20120614
Title: Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.
Journal: The Journal of pharmacology and experimental therapeutics 20120601
Title: Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease.
Journal: Neurobiology of disease 20120601
Title: Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Journal: European journal of medicinal chemistry 20120601
Title: Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells.
Journal: Journal of agricultural and food chemistry 20120530
Title: Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.
Journal: Journal of medicinal chemistry 20120510
Title: Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Journal: Bioorganic & medicinal chemistry 20120501
Title: Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.
Journal: Bioorganic & medicinal chemistry 20120415
Title: Solid-state characterization of tacrine hydrochloride.
Journal: Journal of pharmaceutical and biomedical analysis 20120407
Title: Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia.
Journal: Neuroscience letters 20120323
Title: Affinity binding-guided fluorescent nanobiosensor for acetylcholinesterase inhibitors via distance modulation between the fluorophore and metallic nanoparticle.
Journal: Analytical chemistry 20120320
Title: Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal: Bioorganic & medicinal chemistry letters 20120315
Title: Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats.
Journal: Journal of pharmaceutical and biomedical analysis 20120305
Title: Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain.
Journal: Journal of neurochemistry 20120301
Title: New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Journal: Journal of medicinal chemistry 20120209
Title: Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.
Journal: Neuropharmacology 20120201
Title: Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115
Title: Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.
Journal: Neuro-degenerative diseases 20120101
Title: Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.
Journal: PloS one 20120101
Title: Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.
Journal: International journal of molecular sciences 20120101
Title: Transdermal donepezil on the treatment of Alzheimer's disease.
Journal: Neuropsychiatric disease and treatment 20120101
Title: 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution.
Journal: International journal of molecular sciences 20120101
Title: A single-center, randomized, open-label, dose-escalation study to evaluate the pharmacokinetics of tacrine analogue octahydrogenacridine succinate tablets in healthy Chinese subjects.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Journal: Journal of medicinal chemistry 20111222
Title: An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs.
Journal: The Analyst 20111207
Title: Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B.
Journal: Neuropharmacology 20111201
Title: Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.
Journal: Neurochemistry international 20111201
Title: Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.
Journal: European journal of medicinal chemistry 20111201
Title: Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.
Journal: European journal of medicinal chemistry 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.
Journal: Current topics in medicinal chemistry 20111101
Title: Effective pharmacological management of Alzheimer's disease.
Journal: The American journal of managed care 20111101
Title: ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Journal: Behavioural brain research 20111010
Title: Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity.
Journal: Basic & clinical pharmacology & toxicology 20111001
Title: Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Journal: Fitoterapia 20111001
Title: Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
Journal: European journal of medicinal chemistry 20111001
Title: Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry letters 20111001
Title: Reversible human serum albumin binding of lipocrine: a circular dichroism study.
Journal: Chirality 20111001
Title: Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Journal: Planta medica 20110901
Title: Reversible inhibition of esterase activity after separation and immobilization.
Journal: Applied biochemistry and biotechnology 20110901
Title: Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.
Journal: European journal of medicinal chemistry 20110901
Title: Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110801
Title: Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.
Journal: European journal of medicinal chemistry 20110801
Title: Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors.
Journal: Bioorganic chemistry 20110801
Title: New drugs for Alzheimer's disease in Japan.
Journal: Psychiatry and clinical neurosciences 20110801
Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal: Journal of medicinal chemistry 20110714
Title: Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights.
Journal: Bioorganic & medicinal chemistry letters 20110701
Title: Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.
Journal: European journal of pharmacology 20110625
Title: HFE polymorphisms affect cellular glutamate regulation.
Journal: Neurobiology of aging 20110601
Title: Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity.
Journal: Basic & clinical pharmacology & toxicology 20110601
Title: N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Journal: European journal of medicinal chemistry 20110601
Title: Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
Journal: European journal of medicinal chemistry 20110601
Title: Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
Journal: European journal of medicinal chemistry 20110601
Title: Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.
Journal: Journal of medicinal chemistry 20110428
Title: Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Inhibition mechanism of rat α₃β₄ nicotinic acetylcholine receptor by the Alzheimer therapeutic tacrine.
Journal: Biochemistry 20110322
Title: Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.
Journal: Bioorganic & medicinal chemistry 20110301
Title: Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds.
Journal: Organic & biomolecular chemistry 20110221
Title: Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats.
Journal: Behavioural pharmacology 20110201
Title: Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.
Journal: Bioorganic & medicinal chemistry 20110201
Title: Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.
Journal: Bioorganic & medicinal chemistry 20110115
Title: Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants.
Journal: Analytical biochemistry 20110101
Title: Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.
Journal: European journal of medicinal chemistry 20110101
Title: Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Journal: Bioorganic & medicinal chemistry 20110101
Title: Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
Journal: PloS one 20110101
Title: [Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds].
Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101
Title: Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain.
Journal: Neuro endocrinology letters 20110101
Title: Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice.
Journal: Journal of pharmacological sciences 20110101
Title: Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding.
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Title: Sensitizing effect of tacrine on M-cholinergic receptors in gastric smooth muscle of rats.
Journal: Folia medica 20110101
Title: Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state.
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Title: Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Journal: Molecules (Basel, Switzerland) 20101202
Title: Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands.
Journal: Analytical biochemistry 20101201
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.
Journal: European journal of medicinal chemistry 20101201
Title: Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
Journal: European journal of medicinal chemistry 20101201
Title: Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity.
Journal: Bioorganic & medicinal chemistry 20101115
Title: Action potential bursts in central snail neurons elicited by procaine: roles of ionic currents.
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Title: Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease.
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Title: Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
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Title: Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
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Title: Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
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Title: Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities.
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Title: Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
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Title: Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
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Title: Dual-acting drugs: an in vitro study of nonimidazole histamine H3 receptor antagonists combining anticholinesterase activity.
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Title: Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.
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Title: Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.
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Title: Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.
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Title: Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.
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Title: A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease.
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Title: Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Journal: European journal of medicinal chemistry 20100401
Title: Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
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Title: Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.
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Title: Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia.
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Title: Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.
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Title: 4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.
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Title: Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis.
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Title: Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells.
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Title: Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.
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Title: Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine.
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Title: Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
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Title: Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm.
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Title: Thermodynamic analysis of binding between drugs and glycosaminoglycans by isothermal titration calorimetry and fluorescence spectroscopy.
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Title: Alzheimer's disease: will advances made in the past turn the tide?
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Title: The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.
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Title: Treating autism pharmacologically: also tacrine might improve symptomatology in some cases.
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Title: WITHDRAWN: Tacrine for Alzheimer's disease.
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Title: Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.
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Title: Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
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Title: Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands.
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Title: The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease.
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Title: Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers.
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Title: Screening of acetylcholinesterase inhibitors in natural extracts by CE with electrophoretically mediated microanalysis technique.
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Title: Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes.
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Title: Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network.
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Title: Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.
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Title: Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.
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Title: Long-term tetrahydroaminoacridine treatment and quantitative EEG in Alzheimer's disease.
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Title: Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
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Title: Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.
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Title: Fluorescent method for evaluation of cholinesterase inhibitors.
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Title: Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
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Title: Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.
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Title: Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles.
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Title: Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
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Title: Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.
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Title: Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
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Title: Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment.
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Title: Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
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Title: Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice.
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Title: Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
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Title: Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats.
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Title: Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
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Title: Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.
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Title: Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
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Title: Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
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Title: Memory-dependent novelty-related location preferences: sex-related attenuation of forgetting by D-glucose and tacrine.
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Title: CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival.
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Title: Current and emerging pharmacological treatment options for dementia.
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Title: Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease.
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Title: Alzheimer disease and its management: a review.
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Title: Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
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Title: Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.
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Title: Allosteric binding sites on muscarinic acetylcholine receptors.
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Title: Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells.
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Title: Intestinal single-pass in situ perfusion technique in rat: the influence of L-carnitine on absorption of 7-methoxytacrine.
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Title: Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
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Title: Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor.
Journal: Journal of medicinal chemistry 20051117
Title: Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells.
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Title: Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
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Title: Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task.
Journal: Fundamental & clinical pharmacology 20051001
Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
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Title: Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice.
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Title: SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.
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Title: Modification of motor cortical excitability by an acetylcholinesterase inhibitor.
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Title: Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.
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Title: In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.
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Title: Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
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Title: Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats.
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Title: Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production.
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Title: Role of molecular isoforms of acetylcholinesterase in learning and memory functions.
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Title: Actions of tacrine and galanthamine on histamine-N-methyltransferase.
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Title: Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
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Title: Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
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Title: Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport.
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Title: Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine.
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Title: Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
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Title: Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
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Title: Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.
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Title: Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism.
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Title: Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: effects of pimozide (Orap) in rats.
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Title: Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
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Title: The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane.
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Title: Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
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Title: (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
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Title: Dementia.
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Title: Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
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Title: Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine.
Journal: Neurobiology of aging 20041001
Title: A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic.
Journal: Indian journal of physiology and pharmacology 20041001
Title: A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells.
Journal: Life sciences 20040924
Title: Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters 20040920
Title: ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with 'calcium promotor' and neuroprotective properties.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions.
Journal: Experimental neurology 20040901
Title: Tetrahydroacridine inhibits voltage-dependent Na(+) current in guinea-pig ventricular myocytes.
Journal: Acta pharmacologica Sinica 20040901
Title: An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa.
Journal: Archives of pharmacal research 20040901
Title: Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells.
Journal: Archives of pharmacal research 20040901
Title: An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat.
Journal: Behavioural brain research 20040831
Title: Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons.
Journal: Experimental neurology 20040801
Title: Inhibition of murine cytochrome P4501A by tacrine: in vitro studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040801
Title: A latent normal distribution model for analysing ordinal responses with applications in meta-analysis.
Journal: Statistics in medicine 20040730
Title: Nanosecond dynamics of acetylcholinesterase near the active center gorge.
Journal: The Journal of biological chemistry 20040618
Title: Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons.
Journal: Neuroreport 20040607
Title: Dementia.
Journal: Clinical evidence 20040601
Title: Cholesterol and APOE genotype interact to influence Alzheimer disease progression.
Journal: Neurology 20040525
Title: Disclosure of a pro-apoptotic glyceraldehyde-3-phosphate dehydrogenase promoter: anti-dementia drugs depress its activation in apoptosis.
Journal: Life sciences 20040514
Title: Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients.
Journal: Journal of neurochemistry 20040301
Title: Influence of tacrine on dopamine-induced reactions of the gastric smooth muscle of rats.
Journal: Methods and findings in experimental and clinical pharmacology 20040301
Title: Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert.
Journal: Neuroscience letters 20040219
Title: Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Journal: European journal of pharmacology 20040213
Title: Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis.
Journal: Biochimica et biophysica acta 20040114
Title: Differences between clinical trials and postmarketing use.
Journal: British journal of clinical pharmacology 20040101
Title: Acetylcholinesterase inhibition in Alzheimer's Disease.
Journal: Current pharmaceutical design 20040101
Title: Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel.
Journal: Archives of pharmacal research 20040101
Title: Tetrahydroacridin-9-ones, 9-chlorotetrahydroacridines, 9-amino-tetrahydroacridines and 9-(pyrazol-1-yl)-tetrahydroacridines derived from chiral cyclanones.
Journal: European journal of medicinal chemistry 20040101
Title: [Drugs for the treatment of Alzheimer's disease].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040101
Title: Velnacrine for Alzheimer's disease.
Journal: The Cochrane database of systematic reviews 20040101
Title: Use of cognitive enhancement medication in persons with Alzheimer disease who have a family caregiver: results from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) project.
Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20040101
Title: [Study of the cholinesterase active site using a fluorescent probe].
Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20040101
Title: Comparison of desorption/ionization on silicon (DIOS) time-of-flight and liquid chromatography/tandem mass spectrometry for assaying enzyme-inhibition reactions.
Journal: Rapid communications in mass spectrometry : RCM 20040101
Title: The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies.
Journal: The Journal of neuropsychiatry and clinical neurosciences 20040101
Title: Spectrofluorimetric determination of velnacrine in human serum and urine.
Journal: Farmaco (Societa chimica italiana : 1989) 20031201
Title: Anticholinesterases in Alzheimer's disease: a modest effect on moderately severe disease.
Journal: Prescrire international 20031201
Title: [Synthesis of prodrugs of tacrine hydrochloride and evaluation of the stability and biodistribution in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20031201
Title: Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Journal: Journal of medicinal chemistry 20031009
Title: Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites.
Journal: The Journal of biological chemistry 20031003
Title: Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030901
Title: Recent developments in the synthesis of acetylcholinesterase inhibitors.
Journal: Mini reviews in medicinal chemistry 20030901
Title: Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver.
Journal: Hepatology (Baltimore, Md.) 20030901
Title: Benzodiazepine utilization patterns in Alzheimer's disease patients.
Journal: Pharmacoepidemiology and drug safety 20030901
Title: Reduction in distractibility with AF102B and THA in the macaque.
Journal: Pharmacology, biochemistry, and behavior 20030901
Title: Photoreversible inhibition of cholinesterases: catalytic serine-labeled caged butyrylcholinesterase.
Journal: Chembiochem : a European journal of chemical biology 20030804
Title: Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats.
Journal: Psychopharmacology 20030801
Title: Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus.
Journal: Journal of ethnopharmacology 20030801
Title: Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.
Journal: Bioorganic & medicinal chemistry letters 20030721
Title: Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Journal: Molecular pharmacology 20030701
Title: Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20030601
Title: The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030601
Title: Dementia.
Journal: Clinical evidence 20030601
Title: [Current therapy of patients with dementia].
Journal: MMW Fortschritte der Medizin 20030526
Title: Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.
Journal: Bioorganic & medicinal chemistry letters 20030519
Title: Manganese-based complexes of radical scavengers as neuroprotective agents.
Journal: Bioorganic & medicinal chemistry 20030515
Title: Pharmacology of delta2 glutamate receptors: effects of pentamidine and protons.
Journal: The Journal of pharmacology and experimental therapeutics 20030501
Title: Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Phytotherapy research : PTR 20030501
Title: Mitochondria as a target for neurotoxins and neuroprotective agents.
Journal: Annals of the New York Academy of Sciences 20030501
Title: Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.
Journal: Chemistry & biology 20030401
Title: Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.
Journal: Journal of medicinal chemistry 20030327
Title: Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal: Journal of medicinal chemistry 20030313
Title: Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.
Journal: International clinical psychopharmacology 20030301
Title: Acute effects of huperzine A and tacrine on rat liver.
Journal: Acta pharmacologica Sinica 20030301
Title: The evaluation of cognitive function in the dementias: methodological and regulatory considerations.
Journal: Dialogues in clinical neuroscience 20030301
Title: Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients.
Journal: Neuroscience letters 20030227
Title: Tacrine-scopolamine interactions on state-dependent retrieval.
Journal: Psychopharmacology 20030201
Title: Hormone replacement therapy in postmenopausal women with Alzheimer's disease: a randomized, prospective study.
Journal: Fertility and sterility 20030201
Title: Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030201
Title: Alzheimer's disease: emerging noncholinergic treatments.
Journal: Geriatrics 20030201
Title: Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor.
Journal: Psychopharmacology 20030101
Title: Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial.
Journal: Indian journal of physiology and pharmacology 20030101
Title: Inhibition of human cholinesterases by drugs used to treat Alzheimer disease.
Journal: Alzheimer disease and associated disorders 20030101
Title: Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain.
Journal: Acta biologica Hungarica 20030101
Title: Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze.
Journal: Life sciences 20021220
Title: Risk from lithium with acetylcholinesterase inhibitor.
Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20021201
Title: Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs.
Journal: Dialogues in clinical neuroscience 20021201
Title: Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Journal: European journal of pharmacology 20021129
Title: [Anti-dementia drugs for Alzheimer disease in present and future].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells.
Journal: Brain research. Molecular brain research 20021030
Title: In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase.
Journal: Brain research bulletin 20021015
Title: Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Journal: Neuroscience letters 20021004
Title: Dissolution and partitioning behavior of hydrophobic ion-paired compounds.
Journal: Pharmaceutical research 20021001
Title: [Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901
Title: Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Journal: Journal of medicinal chemistry 20020815
Title: Clinical use of cholinomimetic agents: a review.
Journal: The Journal of head trauma rehabilitation 20020801
Title: Binding and release of drugs into and from thermosensitive poly(N-vinyl caprolactam) nanoparticles.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701
Title: Medical treatment of Alzheimer's disease: past, present, and future.
Journal: Medicine and health, Rhode Island 20020701
Title: Nicotine and sensory memory in Alzheimer's disease: an event-related potential study.
Journal: Brain and cognition 20020701
Title: Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions.
Journal: European journal of pharmacology 20020628
Title: Novel tacrine derivatives that block neuronal calcium channels.
Journal: Bioorganic & medicinal chemistry 20020601
Title: Acute and chronic acetylcholinesterase inhibition regulates in vivo the localization and abundance of muscarinic receptors m2 and m4 at the cell surface and in the cytoplasm of striatal neurons.
Journal: Molecular and cellular neurosciences 20020601
Title: Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study.
Journal: Pharmacology, biochemistry, and behavior 20020501
Title: Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Planta medica 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Determination of tacrine metabolites in microsomal incubate by high performance liquid chromatography-nuclear magnetic resonance/mass spectrometry with a column trapping system.
Journal: Journal of pharmaceutical and biomedical analysis 20020401
Title: Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
Journal: The Journal of pharmacology and experimental therapeutics 20020401
Title: Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Journal: Acta pharmacologica Sinica 20020401
Title: 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Journal: Biochemistry 20020305
Title: Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Journal: Planta medica 20020301
Title: Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020301
Title: Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.
Journal: Journal of medicinal chemistry 20020227
Title: Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.
Journal: Biochemical and biophysical research communications 20020222
Title: Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment.
Journal: Neuropharmacology 20020201
Title: Effects of amphetamine on the plus-maze discriminative avoidance task in mice.
Journal: Psychopharmacology 20020201
Title: Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain.
Journal: Japanese journal of pharmacology 20020201
Title: [Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020201
Title: Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study.
Journal: Pharmacopsychiatry 20020101
Title: Effects of acute nicotine administration on cognitive event-related potentials in tacrine-treated and non-treated patients with Alzheimer's disease.
Journal: Neuropsychobiology 20020101
Title: Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine.
Journal: Current medical research and opinion 20020101
Title: Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.
Journal: Clinical pharmacokinetics 20020101
Title: Neuronal overexpression of 'readthrough' acetylcholinesterase is associated with antisense-suppressible behavioral impairments.
Journal: Molecular psychiatry 20020101
Title: Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat.
Journal: Neuropharmacology 20011201
Title: Galantamine: new preparation. The fourth cholinesterase inhibitor for Alzheimer's disease.
Journal: Prescrire international 20011201
Title: [Perspectives for drug treatment in Alzheimer's disease].
Journal: Annales de medecine interne 20011201
Title: Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
Journal: Journal of medicinal chemistry 20011108
Title: Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry 20011101
Title: Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Planta medica 20011101
Title: Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
Journal: Japanese journal of pharmacology 20011101
Title: A structure-based design approach to the development of novel, reversible AChE inhibitors.
Journal: Journal of medicinal chemistry 20010927
Title: Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
Journal: Mini reviews in medicinal chemistry 20010901
Title: Therapeutic approaches to age-associated neurocognitive disorders.
Journal: Dialogues in clinical neuroscience 20010901
Title: Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.
Journal: Journal of medicinal chemistry 20010816
Title: Meta-analysis of ordinal outcomes using individual patient data.
Journal: Statistics in medicine 20010815
Title: Medications for the treatment of Alzheimer's disease.
Journal: The Journal of the Oklahoma State Medical Association 20010801
Title: Maintaining functional and behavioral abilities in Alzheimer disease.
Journal: Alzheimer disease and associated disorders 20010801
Title: Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ.
Journal: Journal of neurophysiology 20010701
Title: Use of cholinesterase inhibitors for treatment of Alzheimer disease.
Journal: Cleveland Clinic journal of medicine 20010701
Title: Apoptosis: biphasic dose responses.
Journal: Critical reviews in toxicology 20010701
Title: Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.
Journal: Acta pharmacologica Sinica 20010701
Title: Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal: Mini reviews in medicinal chemistry 20010701
Title: [Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010701
Title: Does 'butyrylization' of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Journal: Biochemistry 20010626
Title: Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase.
Journal: Molecules and cells 20010430
Title: Action of tacrine on muscarinic receptors in rat intestinal smooth muscle.
Journal: Journal of autonomic pharmacology 20010401
Title: Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats.
Journal: European journal of pharmacology 20010301
Title: Ion-exchange fibers and drugs: an equilibrium study.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20010129
Title: Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients.
Journal: Dementia and geriatric cognitive disorders 20010101
Title: Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine.
Journal: Pharmacology 20010101
Title: Synthesis and in-vitro anticancer evaluation of bis-tacrine congeners.
Journal: The Journal of pharmacy and pharmacology 20010101
Title: Cholinesterase inhibitors for Alzheimer's disease.
Journal: Drugs 20010101
Title: [Ursodeoxycholic acid and prevention of tacrine-induced hepatotoxicity: a pilot study].
Journal: Therapie 20010101
Title: Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease.
Journal: Dementia and geriatric cognitive disorders 20010101
Title: Controlled release tacrine delivery system for the treatment of Alzheimer's disease.
Journal: Drug delivery 20010101
Title: Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101
Title: [Current strategies of pathogenetic therapy of Alzheimer's disease].
Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101
Title: Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
Journal: Neurologia i neurochirurgia polska 20010101
Title: Drugs used for cognitive symptoms of Alzheimer's disease.
Journal: Perspectives in psychiatric care 20010101
Title: Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds.
Journal: European journal of pharmacology 20000728
Title: Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy.
Journal: Neuroreport 20000427
Title: Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration.
Journal: JAMA 19981125
Title: [Convulsive crisis as a possible adverse reaction to the treatment with tacrine in Alzheimer's disease].
Journal: Medicina clinica 19980912
Title: Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Journal: European journal of pharmacology 19980522
Title: Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release.
Journal: European journal of pharmacology 19980508
Title: Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Journal: Pharmacology, biochemistry, and behavior 19980401
Title: Myoclonus induced by tacrine.
Journal: Journal of neurology, neurosurgery, and psychiatry 19980201
Title: Systemic administration of N omega-nitro-L-arginine methyl ester and indomethacin reduces the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by LiCl and tacrine in rat.
Journal: Experimental neurology 19980201
Title: Motor dysfunction produced by tacrine administration in rats.
Journal: Pharmacology, biochemistry, and behavior 19971201
Title: Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Journal: Methods and findings in experimental and clinical pharmacology 19970501
Title: Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects.
Journal: Pharmacology, biochemistry, and behavior 19970201
Title: Adverse interaction of tacrine and haloperidol.
Journal: The American journal of psychiatry 19961101
Title: [Flare-up of arterial hypertension during treatment with tacrine].
Journal: Presse medicale (Paris, France : 1983) 19961012
Title: Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells.
Journal: Neuroreport 19960902
Title: Delirium caused by tacrine and ibuprofen interaction.
Journal: The American journal of psychiatry 19960601
Title: Convulsive effects of tacrine.
Journal: Lancet (London, England) 19960511
Title: Systemic administration of lithium chloride and tacrine but not kainic acid augments citrulline content of rat brain.
Journal: European journal of pharmacology 19951227
Title: Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol.
Journal: Journal of clinical psychopharmacology 19950801
Title: Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats.
Journal: Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 19950301
Title: Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats.
Journal: European journal of pharmacology 19931130
Title: Tacrine inhibits ventricular fibrillation induced by ischaemia and reperfusion and widens QT interval in rat.
Journal: Cardiovascular research 19930301
Title: Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Journal: Journal of medicinal chemistry 19920320
Title: QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.
Journal: Journal of medicinal chemistry 19920207
Title: Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats.
Journal: Psychopharmacology 19920101
Title: A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice.
Journal: The Journal of pharmacology and experimental therapeutics 19901101
Title: Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes.
Journal: European journal of pharmacology 19891128
Title: Amino acridines action on Friend's retrovirus in relation to their molecular ionization.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 19890101
Title: Suxamethonium apnoea masked by tetrahydroaminacrine.
Journal: Anaesthesia 19780101
Title: Influence of tetrahydro-aminacrine on muscle pains after suxamethonium.
Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19750118
Title: Ketamine-induced postanesthetic delirium attenuated by tetrahydroaminoacridine.
Journal: Experimental neurology 19740701
Title: An appraisal of tacrine-extended suxamethonium.
Journal: British journal of anaesthesia 19700201
