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16858-02-9,MFCD00036918
Catalog No.:AA001Y2O

16858-02-9 | Tpen

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1mg
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$7.00   $5.00
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10mg
97%
in stock  
$23.00   $16.00
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50mg
97%
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$36.00   $25.00
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250mg
95%
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$112.00   $78.00
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1g
>97.0%(T)
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001Y2O
Chemical Name:
Tpen
CAS Number:
16858-02-9
Molecular Formula:
C26H28N6
Molecular Weight:
424.5407
MDL Number:
MFCD00036918
SMILES:
c1ccc(nc1)CN(Cc1ccccn1)CCN(Cc1ccccn1)Cc1ccccn1
Properties
Properties
 
BP:
542.1°C at 760 mmHg  
Form:
Solid  
MP:
110-112 °C  
Refractive Index:
1.4570 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
419  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
11  
XLogP3:
2.1  

Literature

Title: Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca(v)3.2 in mice.

Journal: Toxicology 20180115

Title: Oxidative stress and endocytosis are involved in upregulation of interleukin-8 expression in airway cells exposed to PM2.5.

Journal: Environmental toxicology 20161201

Title: Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake.

Journal: Metallomics : integrated biometal science 20141101

Title: Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.

Journal: Toxicology and applied pharmacology 20140115

Title: Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells.

Journal: Investigative ophthalmology & visual science 20120809

Title: Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3.

Journal: The Journal of nutritional biochemistry 20120801

Title: Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway.

Journal: Biology of reproduction 20120701

Title: Zinc enhances adiponectin oligomerization to octadecamers but decreases the rate of disulfide bond formation.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120401

Title: Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine.

Journal: Inorganic chemistry 20120319

Title: Colorimetric and fluorescent signaling of Au3+ by desulfurization of thiocoumarin.

Journal: Inorganic chemistry 20120305

Title: Zinc balance is critical for NFI-C mediated regulation of odontoblast differentiation.

Journal: Journal of cellular biochemistry 20120301

Title: Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells.

Journal: Biochimica et biophysica acta 20120201

Title: Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo.

Journal: Journal of neurophysiology 20120201

Title: Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice.

Journal: Endocrinology 20120201

Title: Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways.

Journal: Nutritional neuroscience 20120101

Title: Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.

Journal: PloS one 20120101

Title: Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations.

Journal: PloS one 20120101

Title: Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure.

Journal: PloS one 20120101

Title: Hyperforin changes the zinc-storage capacities of brain cells.

Journal: Neuropharmacology 20111201

Title: Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia.

Journal: Glia 20111201

Title: Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain.

Journal: Brain research 20111018

Title: A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20110901

Title: Exposure to an environmental neurotoxicant hastens the onset of amyotrophic lateral sclerosis-like phenotype in human Cu2+/Zn2+ superoxide dismutase 1 G93A mice: glutamate-mediated excitotoxicity.

Journal: The Journal of pharmacology and experimental therapeutics 20110801

Title: Effects of divalent cations on slow unblock of native NMDA receptors in mouse neocortical pyramidal neurons.

Journal: The European journal of neuroscience 20110701

Title: NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.

Journal: Antioxidants & redox signaling 20110615

Title: Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore.

Journal: Neurobiology of disease 20110601

Title: A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium.

Journal: American journal of physiology. Lung cellular and molecular physiology 20110601

Title: LPS-induced decrease in intracellular labile zinc, [Zn]i, contributes to apoptosis in cultured sheep pulmonary artery endothelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20110401

Title: Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium.

Journal: Journal of neurochemistry 20110401

Title: Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway.

Journal: Biology of reproduction 20110301

Title: Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons.

Journal: Nutritional neuroscience 20110301

Title: Influence of zinc and zinc chelator on HT-29 colorectal cell line.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20110201

Title: Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice.

Journal: Toxicology letters 20110115

Title: MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy.

Journal: Oncogene 20110106

Title: MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.

Journal: PloS one 20110101

Title: HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung.

Journal: AIDS research and therapy 20110101

Title: Fetal bovine serum requirement for pyrrolidine dithiocarbamate-induced apoptotic cell death of MCF-7 breast tumor cells.

Journal: European journal of pharmacology 20101215

Title: Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20101201

Title: Complex role of zinc in methamphetamine toxicity in vitro.

Journal: Neuroscience 20101124

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Acidosis-induced zinc-dependent death of cultured cerebellar granule neurons.

Journal: Cellular and molecular neurobiology 20100801

Title: Full-term mouse development by abolishing Zn2+-dependent metaphase II arrest without Ca2+ release.

Journal: Development (Cambridge, England) 20100801

Title: The critical role of intracellular zinc in adenosine A(2) receptor activation induced cardioprotection against reperfusion injury.

Journal: Journal of molecular and cellular cardiology 20100701

Title: Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100701

Title: Levels of semenogelin in human spermatozoa decrease during capacitation: involvement of reactive oxygen species and zinc.

Journal: Human reproduction (Oxford, England) 20100701

Title: The thiol-modifying agent N-ethylmaleimide elevates the cytosolic concentration of free Zn(2+) but not of Ca(2+) in murine cortical neurons.

Journal: Cell calcium 20100701

Title: Cadmium inhibits acid secretion in stimulated frog gastric mucosa.

Journal: Toxicology and applied pharmacology 20100601

Title: [Progress in the study of HIV-1 Vif and related inhibitors].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100601

Title: Effects of zinc ex vivo and intracellular zinc chelator in vivo on taurine uptake in goldfish retina.

Journal: Amino acids 20100501

Title: Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3.

Journal: Journal of leukocyte biology 20100501

Title: Zinc signals promote IL-2-dependent proliferation of T cells.

Journal: European journal of immunology 20100501

Title: The zinc-dependent protease activity of the botulinum neurotoxins.

Journal: Toxins 20100501

Title: Nitric oxide synthase activation and oxidative stress, but not intracellular zinc dyshomeostasis, regulate ultraviolet B light-induced apoptosis.

Journal: Life sciences 20100313

Title: Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.

Journal: Bone 20100301

Title: Effects of postconditioning with N,N,N'N'-tetrakis-[2-pyridylmethyl]-ethylenediamine in isolated rat hearts.

Journal: Korean journal of anesthesiology 20100301

Title: Endogenous zinc mediates apoptotic programmed cell death in the developing brain.

Journal: Neurotoxicity research 20100201

Title: Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3beta signal pathway in cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20100201

Title: Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2.

Journal: Journal of fluorescence 20100101

Title: The Zur regulon of Corynebacterium glutamicum ATCC 13032.

Journal: BMC genomics 20100101

Title: Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators.

Journal: Virology journal 20100101

Title: Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neurons.

Journal: Journal of molecular signaling 20100101

Title: Light-induced photoreceptor and RPE degeneration involve zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light.

Journal: Molecular vision 20100101

Title: Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain.

Journal: PloS one 20100101

Title: Methylmercury elicits intracellular Zn2+ release in rat thymocytes: its relation to methylmercury-induced decrease in cellular thiol content.

Journal: Toxicology letters 20091215

Title: Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091201

Title: The selective quantification of iron by hexadentate fluorescent probes.

Journal: Bioorganic & medicinal chemistry 20091201

Title: Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach.

Journal: Molecular cancer therapeutics 20091101

Title: Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha.

Journal: Hepatology (Baltimore, Md.) 20091001

Title: Increase in intracellular Zn2+ concentration by thimerosal in rat thymocytes: intracellular Zn2+ release induced by oxidative stress.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090901

Title: Rising zinc: a significant cause of ischemic neuronal death in the CA1 region of rat hippocampus.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090801

Title: Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20090701

Title: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress.

Journal: Journal of thrombosis and haemostasis : JTH 20090601

Title: Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways.

Journal: The Biochemical journal 20090513

Title: Essential role of p53 in TPEN-induced neuronal apoptosis.

Journal: FEBS letters 20090506

Title: Theoretical study of cyclohexane hydroxylation by three possible isomers of [FeIV(O)(R-TPEN)] 2+: does the pentadentate ligand wrapping around the metal center differently lead to the different stability and reactivity?

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090501

Title: Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy.

Journal: Epilepsia 20090401

Title: Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione.

Journal: American journal of physiology. Cell physiology 20090401

Title: Intracellular Zn2+ increases contribute to the progression of excitotoxic Ca2+ increases in apical dendrites of CA1 pyramidal neurons.

Journal: Neuroscience 20090303

Title: Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells.

Journal: Toxicology and applied pharmacology 20090301

Title: Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090301

Title: Light stimulation evokes two different calcium responses in Müller glial cells of the guinea pig retina.

Journal: The European journal of neuroscience 20090301

Title: Detection of zinc translocation into apical dendrite of CA1 pyramidal neuron after electrical stimulation.

Journal: Journal of neuroscience methods 20090215

Title: Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis.

Journal: Biochimica et biophysica acta 20090201

Title: Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes.

Journal: Cell calcium 20090201

Title: Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.

Journal: European journal of immunology 20090201

Title: Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

Title: Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).

Journal: Molecular and cellular biochemistry 20090101

Title: Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells.

Journal: BMC neuroscience 20090101

Title: 'cAMP sponge': a buffer for cyclic adenosine 3', 5'-monophosphate.

Journal: PloS one 20090101

Title: Altered sarcoplasmic reticulum calcium transport in the presence of the heavy metal chelator TPEN.

Journal: Cell calcium 20090101

Title: Mechanisms of Zn2+ efflux in cultured cortical neurons.

Journal: Journal of neurochemistry 20081201

Title: Zinc-binding compounds induce cancer cell death via distinct modes of action.

Journal: Cancer letters 20081128

Title: Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis.

Journal: Cell death and differentiation 20081101

Title: Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms.

Journal: Brain research 20081027

Title: NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.

Journal: Cellular signalling 20081001

Title: Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling.

Journal: Journal of the American College of Nutrition 20081001

Title: Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor.

Journal: Journal of the American Chemical Society 20080924

Title: Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway.

Journal: The Prostate 20080915

Title: Isoquinoline-based TQEN family as TPEN-derived fluorescent zinc sensors.

Journal: Inorganic chemistry 20080818

Title: Zn2+ influx is critical for some forms of spreading depression in brain slices.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080806

Title: HIV-1-transgene expression in rats decreases alveolar macrophage zinc levels and phagocytosis.

Journal: American journal of respiratory cell and molecular biology 20080801

Title: The level of free intracellular zinc mediates programmed cell death/cell survival decisions in plant embryos.

Journal: Plant physiology 20080701

Title: Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone.

Journal: Circulation research 20080620

Title: The involvement of caspase-11 in TPEN-induced apoptosis.

Journal: FEBS letters 20080611

Title: Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.

Journal: Nutritional neuroscience 20080601

Title: Cooperation of metallothionein and zinc transporters for regulating zinc homeostasis in human intestinal Caco-2 cells.

Journal: Nutrition research (New York, N.Y.) 20080601

Title: HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein.

Journal: Virology 20080525

Title: Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes.

Journal: Journal of cellular biochemistry 20080501

Title: Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2, a zinc transporter protein.

Journal: Investigative ophthalmology & visual science 20080401

Title: Zinc binding ligands and cellular zinc trafficking: apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1.

Journal: Journal of inorganic biochemistry 20080301

Title: Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.

Journal: American journal of physiology. Cell physiology 20080301

Title: Antibacterial activity of pyrrolidine dithiocarbamate.

Journal: FEMS microbiology letters 20080301

Title: Prevention of calcification with TPEN in pericardial bio-prosthetic heart valve material.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20080201

Title: Expectation from science/prevention of calcification with TPEN in pericardial bio-prosthetic heart valve material.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20080201

Title: High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.

Journal: Cellular & molecular biology letters 20080101

Title: Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells.

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20080101

Title: Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5).

Journal: Biological chemistry 20071201

Title: Prevention of calcification with TPEN in pericardial bioprosthetic heart valve material.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20071201

Title: Extraction behavior and separation of lanthanides with a diglycol amic acid derivative and a nitrogen-donor ligand.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20071201

Title: Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands.

Journal: American journal of physiology. Cell physiology 20071101

Title: Zinc regulates the ability of Cdc25C to activate MPF/cdk1.

Journal: Journal of cellular physiology 20071001

Title: Cellular Zn2+ chelators cause 'dying-back' neurite degeneration associated with energy impairment.

Journal: Journal of neuroscience research 20071001

Title: On the use of fluorescent probes to distinguish Ca2+ from Zn2+ in models of excitotoxicity.

Journal: Cell calcium 20070901

Title: Potentiation of acid-sensing ion channels by sulfhydryl compounds.

Journal: American journal of physiology. Cell physiology 20070601

Title: Contribution of calpain to cellular damage in human retinal pigment epithelial cells cultured with zinc chelator.

Journal: Current eye research 20070601

Title: Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815.

Journal: The Journal of biological chemistry 20070504

Title: Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.

Journal: Cancer science 20070501

Title: Zinc inhibits doxorubicin-activated calcineurin signal transduction pathway in H9c2 embryonic rat cardiac cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20070501

Title: Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability.

Journal: The Journal of biological chemistry 20070406

Title: Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators.

Journal: Toxicon : official journal of the International Society on Toxinology 20070401

Title: Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells.

Journal: European journal of pharmacology 20070214

Title: Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes.

Journal: Cell calcium 20070201

Title: T-helper type 1 cytokine release is enhanced by in vitro zinc supplementation due to increased natural killer cells.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20070201

Title: Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray.

Journal: International journal of cancer 20070115

Title: Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070101

Title: Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101

Title: The use of the zinc-fluorophore, Zinpyr-1, in the study of zinc homeostasis in Arabidopsis roots.

Journal: The New phytologist 20070101

Title: Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.

Journal: Molecular medicine (Cambridge, Mass.) 20070101

Title: Effect of TPEN on the calcium release of cultured C2C12 mouse myotubes.

Journal: Journal of muscle research and cell motility 20070101

Title: Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells.

Journal: Nutrition research and practice 20070101

Title: Zinc modulates cytokine-induced lung epithelial cell barrier permeability.

Journal: American journal of physiology. Lung cellular and molecular physiology 20061201

Title: Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.

Journal: The Journal of biological chemistry 20061110

Title: Reduced nonprotein thiols inhibit activation and function of MMP-9: implications for chemoprevention.

Journal: Free radical biology & medicine 20061015

Title: Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression.

Journal: Carcinogenesis 20061001

Title: Apo-metallothionein emerging as a major player in the cellular activities of metallothionein.

Journal: Experimental biology and medicine (Maywood, N.J.) 20061001

Title: Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes.

Journal: Experimental biology and medicine (Maywood, N.J.) 20061001

Title: Inhibition of cyclooxygenase-2 expression by zinc-chelator in retinal ischemia.

Journal: Vision research 20060901

Title: Endothelial response to stress from exogenous Zn2+ resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression.

Journal: American journal of physiology. Cell physiology 20060901

Title: Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.

Journal: Nature immunology 20060901

Title: Zinc is required for Fc epsilon RI-mediated mast cell activation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060715

Title: [Effect of zinc on mRNA expression of ZIP4 in Caco2 cells].

Journal: Wei sheng yan jiu = Journal of hygiene research 20060701

Title: Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060621

Title: The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.

Journal: Biochemical and biophysical research communications 20060519

Title: Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells.

Journal: Analytical biochemistry 20060515

Title: Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes.

Journal: The Journal of biological chemistry 20060407

Title: Selenium prevents diabetes-induced alterations in [Zn2+]i and metallothionein level of rat heart via restoration of cell redox cycle.

Journal: American journal of physiology. Heart and circulatory physiology 20060301

Title: Apoptosis may underlie the pathology of zinc-deficient skin.

Journal: Immunology and cell biology 20060201

Title: Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model.

Journal: Journal of pharmacological sciences 20060201

Title: Cytosolic labile zinc: a marker for apoptosis in the developing rat brain.

Journal: The European journal of neuroscience 20060101

Title: Apoptotic neuronal changes enhanced by zinc chelator--TPEN in organotypic rat hippocampal cultures exposed to anoxia.

Journal: Folia neuropathologica 20060101

Title: Effect of the zinc chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) on hippocampal mossy fiber calcium signals and on synaptic transmission.

Journal: Biological research 20060101

Title: Neuritic outgrowth from goldfish retinal explants, interaction of taurine and zinc.

Journal: Advances in experimental medicine and biology 20060101

Title: New example of a non-heme mononuclear iron(IV) oxo complex. Spectroscopic data and oxidation activity.

Journal: Inorganic chemistry 20051212

Title: Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger.

Journal: Molecular pharmacology 20051201

Title: Taurine and zinc modulate outgrowth from goldfish retinal explants.

Journal: Neurochemical research 20051201

Title: Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons.

Journal: Brain research 20051102

Title: Comparative sensitivity of rat cerebellar neurons to dysregulation of divalent cation homeostasis and cytotoxicity caused by methylmercury.

Journal: Toxicology and applied pharmacology 20051101

Title: Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis.

Journal: PLoS biology 20051001

Title: Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices.

Journal: Journal of the American Chemical Society 20050727

Title: Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase.

Journal: Molecular and cellular biochemistry 20050701

Title: ZINC-mediated gene expression offers protection against H2O2-induced cytotoxicity.

Journal: Toxicology and applied pharmacology 20050615

Title: N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine improves myocardial protection against ischemia by modulation of intracellular Ca2+ homeostasis.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

Journal: Biochemistry 20050510

Title: Simultaneous detection of [metal(II)-tpen]2+ as kinetically inert cationic complexes using pre-capillary derivatization electrophoresis: an application to biological samples.

Journal: The Analyst 20050501

Title: Search of chemical scaffolds for novel antituberculosis agents.

Journal: Journal of biomolecular screening 20050401

Title: Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050309

Title: Mechanisms of apoptosis in human retinal pigment epithelium induced by TNF-alpha in conditions of heavy metal ion deficiency.

Journal: Investigative ophthalmology & visual science 20050301

Title: Tetrakis(2-quinolinylmethyl)ethylenediamine (TQEN) as a new fluorescent sensor for zinc.

Journal: Dalton transactions (Cambridge, England : 2003) 20050207

Title: TPEN attenuates hepatic apoptotic ischemia/ reperfusion injury and remote early cardiac dysfunction.

Journal: Apoptosis : an international journal on programmed cell death 20050101

Title: Expression of apoptosis-related proteins in model of anoxia in vitro.

Journal: Folia neuropathologica 20050101

Title: Zinc has ambiguous effects on chromium (VI)-induced oxidative stress and apoptosis.

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20050101

Title: The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.

Journal: The Journal of biological chemistry 20041203

Title: Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041124

Title: Measurement of presynaptic zinc changes in hippocampal mossy fibers.

Journal: Brain research 20041105

Title: XAS characterization of end-on and side-on peroxoiron(III) complexes of the neutral pentadentate N-donor ligand N-methyl-N,N',N'-tris(2-pyridylmethyl)ethane-1,2-diamine.

Journal: Dalton transactions (Cambridge, England : 2003) 20041021

Title: Development of a zinc ion-selective luminescent lanthanide chemosensor for biological applications.

Journal: Journal of the American Chemical Society 20041006

Title: Fungal susceptibility to zinc deprivation.

Journal: The Journal of laboratory and clinical medicine 20041001

Title: Actions of zinc at mature Golgi cell to granule cell synapses in cerebellum of rats and mice.

Journal: Neuroscience letters 20040826

Title: Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.

Journal: Biochemical pharmacology 20040815

Title: Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.

Journal: The Journal of nutrition 20040701

Title: Hippocampal mossy fiber calcium transients are maintained during long-term potentiation and are inhibited by endogenous zinc.

Journal: Brain research 20040409

Title: Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.

Journal: American journal of respiratory cell and molecular biology 20040401

Title: Unliganded human mutant alpha 7 nicotinic receptors are modulated by Ca2+ and trace levels of Zn2+.

Journal: Neuropharmacology 20040401

Title: Evaluation, using targeted aequorins, of the roles of the endoplasmic reticulum and its (Ca2++Mg2+)ATP-ases in the activation of store-operated Ca2+ channels in liver cells.

Journal: Cell calcium 20040401

Title: Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels.

Journal: Neuron 20040205

Title: Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathway.

Journal: Journal of neurophysiology 20040201

Title: Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells.

Journal: Gastroenterology 20040101

Title: Depletion of endogenous zinc stores induces oxidative stress and cell death in human melanoma cells.

Journal: Acta medica (Hradec Kralove) 20040101

Title: Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling.

Journal: Experimental cell research 20031210

Title: Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20031125

Title: A reassessment of the effects of luminal [Ca2+] on inositol 1,4,5-trisphosphate-induced Ca2+ release from internal stores.

Journal: The Journal of biological chemistry 20031010

Title: Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+.

Journal: The Journal of biological chemistry 20031003

Title: Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.

Journal: The Journal of nutrition 20031001

Title: Zinc chelators inhibit eotaxin, RANTES, and MCP-1 production in stimulated human airway epithelium and fibroblasts.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030901

Title: Hg2+ signaling in trout hepatoma (RTH-149) cells: involvement of Ca2+-induced Ca2+ release.

Journal: Cell calcium 20030901

Title: Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.

Journal: The Journal of nutrition 20030801

Title: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits ligand binding to certain G protein-coupled receptors.

Journal: European journal of pharmacology 20030801

Title: Zinc-induced changes in ionic currents of cardiomyocytes.

Journal: Biological trace element research 20030701

Title: A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20030610

Title: Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.

Journal: The Journal of biological chemistry 20030110

Title: N,N,N ',N '-Tetrakis(2-pyridylmethyl)ethylenediamine and its analogues as hypodentate ligands. Synthesis and characterization of the rhodium(III), ruthenium(II), and palladium(II) complexes.

Journal: Inorganic chemistry 20021202

Title: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.

Journal: European journal of biochemistry 20021201

Title: Zinc is involved in the expression of a nuclear-encoded alternative oxidase gene in the yeast Hansenula anomala.

Journal: Bioscience, biotechnology, and biochemistry 20021201

Title: Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria.

Journal: The Journal of biological chemistry 20021129

Title: Involvement of redox events in caspase activation in zinc-depleted airway epithelial cells.

Journal: Biochemical and biophysical research communications 20021004

Title: In situ chelation of Ca(2+) in intracellular stores induces capacitative Ca(2+) entry in bovine adrenal chromaffin cells.

Journal: Annals of the New York Academy of Sciences 20021001

Title: Role of Zn(2+) in oxidative stress caused by endotoxin challenge.

Journal: European journal of pharmacology 20020920

Title: A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion.

Journal: Journal of the American Chemical Society 20020911

Title: DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells.

Journal: American journal of physiology. Cell physiology 20020801

Title: Time course and magnitude of the calcium release induced by bright light in salamander rods.

Journal: The Journal of physiology 20020801

Title: Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity.

Journal: Mediators of inflammation 20020601

Title: Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem.

Journal: The Journal of physiology 20020501

Title: NMDA receptor-mediated currents in rat cerebellar granule and unipolar brush cells.

Journal: Journal of neurophysiology 20020401

Title: [Role of intracellular zinc in programmed cell death].

Journal: Pathologie-biologie 20020401

Title: pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons.

Journal: American journal of physiology. Cell physiology 20020201

Title: Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein.

Journal: American journal of physiology. Lung cellular and molecular physiology 20020201

Title: L-type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure.

Journal: Synapse (New York, N.Y.) 20020101

Title: Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons.

Journal: Brain research. Developmental brain research 20011231

Title: Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes.

Journal: Blood 20011215

Title: Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes.

Journal: Apoptosis : an international journal on programmed cell death 20011201

Title: Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis.

Journal: Journal of leukocyte biology 20011001

Title: Extreme zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR.

Journal: Journal of the American Chemical Society 20010905

Title: Characteristics of a store-operated calcium-permeable channel: sarcoendoplasmic reticulum calcium pump function controls channel gating.

Journal: The Journal of biological chemistry 20010810

Title: The role of zinc binding in the biological activity of botulinum toxin.

Journal: The Journal of biological chemistry 20010720

Title: Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors.

Journal: Biochemical pharmacology 20010701

Title: Role of zinc in pulmonary endothelial cell response to oxidative stress.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010701

Title: Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis.

Journal: Science (New York, N.Y.) 20010629

Title: Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity.

Journal: The Journal of biological chemistry 20010622

Title: Modulation of caspase-3 activity by zinc ions and by the cell redox state.

Journal: Experimental cell research 20010610

Title: p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515

Title: Receptor-operated osteoclast calcium sensing.

Journal: Endocrinology 20010501

Title: Enzymatic autocatalysis of botulinum A neurotoxin light chain.

Journal: Journal of protein chemistry 20010401

Title: Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc.

Journal: The Journal of pharmacology and experimental therapeutics 20010301

Title: Comparative effects of metal chelating agents on the neuronal cytotoxicity induced by copper (Cu+2), iron (Fe+3) and zinc in the hippocampus.

Journal: Brain research 20010216

Title: Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells.

Journal: Investigative ophthalmology & visual science 20010201

Title: High-affinity zinc potentiation of inhibitory postsynaptic glycinergic currents in the zebrafish hindbrain.

Journal: Journal of neurophysiology 20010201

Title: [Transition metals and nitric oxide production in human endothelial cells].

Journal: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 20010101

Title: 2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors.

Journal: Receptors & channels 20010101

Title: Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria- dependent pathways.

Journal: The Journal of biological chemistry 20001215

Title: Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.

Journal: Journal of cell science 20000901

Title: Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha.

Journal: The American journal of clinical nutrition 20000101

Title: Ohkubo M, et al. Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. J Vet Med Sci. 2016 Jun 1;78(5):761-7.

Title: Rahal ON, et al. Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. Cancer Biol Ther. 2016 Nov;17(11):1139-1148.

Title: E Aizenman, et al. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. J Neurochem. 2000 Nov;75(5):1878-88.

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Tags:16858-02-9 Molecular Formula|16858-02-9 MDL|16858-02-9 SMILES|16858-02-9 Tpen