Name: Name:Sutezolid
Brand: AABLOCKS
SKU: AA001Y8I
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA001Y8I

Chemical Name: Sutezolid

CAS Number: 168828-58-8

Molecular Formula: C16H20FN3O3S

Molecular Weight: 353.4117

MDL Number: MFCD00937821

SMILES: CC(=O)NC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)N1CCSCC1

NSC Number: 742407

Properties

Complexity: 476

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 24

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.5

Downstream Synthesis Route

168828-70-4

168828-58-8

[1]Barbachyn,MichaelR.;Hutchinson,DouglasK.;Brickner,StevenJ.;Cynamon,MichaelH.;Kilburn,JamesO.;etal.[JournalofMedicinalChemistry,1996,vol.39,#3,p.680-685]

[2]Barbachyn,MichaelR.;Hutchinson,DouglasK.;Brickner,StevenJ.;Cynamon,MichaelH.;Kilburn,JamesO.;etal.[JournalofMedicinalChemistry,1996,vol.39,#3,p.680-685]

Literature fold

Title: In vitro activities of PNU-100480 and linezolid against drug-susceptible and drug-resistant Mycobacterium tuberculosis isolates.

Journal: International journal of antimicrobial agents20130701

Title: SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro.

Journal: The Journal of antimicrobial chemotherapy20120501

Title: Tuberculosis: the drug development pipeline at a glance.

Journal: European journal of medicinal chemistry20120501

Title: Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide.

Journal: PloS one20120101

Title: Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.

Journal: The Journal of infectious diseases20100901

Title: Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis.

Journal: American journal of respiratory and critical care medicine20090815

Title: Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

Journal: Journal of medicinal chemistry20080410

Title: New small-molecule synthetic antimycobacterials.

Journal: Antimicrobial agents and chemotherapy20050601

Title: Short-course treatment regimen to identify potential antituberculous agents in a murine model of tuberculosis.

Journal: The Journal of antimicrobial chemotherapy20040401

Title: Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480.

Journal: Bioorganic & medicinal chemistry letters20040322

Title: Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model.

Journal: Antimicrobial agents and chemotherapy19990501

Title: Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity.

Journal: Journal of medicinal chemistry19960202

Title: Barbachyn MR, et al. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem. 1996;39(3):680-685.

Title: Nicole Salazar-Austin, et al. Sutezolid. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 2559-2563). CRC Press.

Title: Zhu T, et al. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis. Antimicrob Agents Chemother. 2014;58(6):3306-3311.

168828-58-8 | Sutezolid