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169332-60-9,MFCD00671412
Catalog No.:AA00AC34

169332-60-9 | (4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

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1mg
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$93.00   $65.00
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5mg
97%
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$290.00   $203.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AC34
Chemical Name:
(4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
CAS Number:
169332-60-9
Molecular Formula:
C20H30N4O11
Molecular Weight:
502.4724
MDL Number:
MFCD00671412
SMILES:
O=CC(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(NC(=O)C)CC(=O)O)CCC(=O)O)CC(=O)O
Properties
Computed Properties
 
Complexity:
843  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
16  
XLogP3:
-2.6  

Downstream Synthesis Route
CASUnavailable 
  169332-60-9   
CASUnavailable 

[1]Locationinpatent:experimentalpartVaidya,Sravanti;Velazquez-Delgado,ElihM.;Abbruzzese,Genevieve;Hardy,JeanneA.[JournalofMolecularBiology,2011,vol.406,#1,p.75-91]

CASUnavailable 
  169332-60-9   
CASUnavailable 

[1]Locationinpatent:experimentalpartVaidya,Sravanti;Hardy,JeanneA.[Biochemistry,2011,vol.50,#16,p.3282-3287]

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Title: Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: caspases and endonuclease G (Endo G) pathway.

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Title: HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis.

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Title: Pharmacological activity in growth inhibition and apoptosis of cultured human leiomyomal cells of tropical plant Scutellaria barbata D. Don (Lamiaceae).

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Title: Mechanisms of induction of apoptosis by anthraquinone anticancer drugs aclarubicin and mitoxantrone in comparison with doxorubicin: relation to drug cytotoxicity and caspase-3 activation.

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Title: Amplification loop cascade for increasing caspase activity induced by docetaxel.

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Title: Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF.

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Title: Glycine- and proline-rich glycoprotein isolated from Solanum nigrum Linne activates caspase-3 through cytochrome c in HT-29 cells.

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Title: Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells.

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Journal: Life sciences 20050701

Title: Signal role for activation of caspase-3-like protease and burst of superoxide anions during Ce4+-induced apoptosis of cultured Taxus cuspidata cells.

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Title: Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase.

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Title: Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050301

Title: Mechanism of ricin-induced apoptosis in human cervical cancer cells.

Journal: Biochemical pharmacology 20050301

Title: PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death.

Journal: British journal of cancer 20050227

Title: Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile.

Journal: British journal of cancer 20050227

Title: Molecular mechanisms of apoptosis induced by Scorpio water extract in human hepatoma HepG2 cells.

Journal: World journal of gastroenterology 20050221

Title: Caprine herpesvirus-1 (CapHV-1) induces apoptosis in goat peripheral blood mononuclear cells.

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Title: Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy).

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Title: Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells.

Journal: Cancer letters 20050131

Title: Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells.

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Title: Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.

Journal: Breast cancer research : BCR 20050101

Title: Runx-dependent expression of PKC is critical for cell survival in the sea urchin embryo.

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Title: Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3.

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Title: Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells.

Journal: Archives of pharmacal research 20041101

Title: Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.

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Title: Clinical and experimental study of oxaliplatin in treating human gastric carcinoma.

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Title: Oligonucleosome DNA fragmentation of caspase 3 deficient MCF-7 cells in palmitate-induced apoptosis.

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Journal: Journal of the American Chemical Society 20040922

Title: Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.

Journal: Life sciences 20040903

Title: Anticancer agents are potent neurotoxins in vitro and in vivo.

Journal: Annals of neurology 20040901

Title: Caspase-3-like protease influences but is not essential for DNA fragmentation in Blastocystis undergoing apoptosis.

Journal: European journal of cell biology 20040901

Title: Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.

Journal: Journal of neuroscience research 20040815

Title: Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation.

Journal: British journal of cancer 20040802

Title: Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20040801

Title: The transmembrane domain of hepatitis C virus E1 glycoprotein induces cell death.

Journal: Virus research 20040801

Title: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.

Journal: Journal of neuroscience research 20040515

Title: Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

Journal: Journal of medicinal chemistry 20040506

Title: Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040401

Title: Activation of c-Jun N-terminal kinase is required for ultraviolet B-induced apoptosis of murine peritoneal macrophages in vitro.

Journal: Journal of photochemistry and photobiology. B, Biology 20040220

Title: Role of caspases-3 and -7 in Apaf-1 proteolytic cleavage and degradation events during cisplatin-induced apoptosis in melanoma cells.

Journal: Experimental cell research 20040215

Title: Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040209

Title: Rapid annexin-V labeling in synaptosomes.

Journal: Neurochemistry international 20040201

Title: GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways.

Journal: International journal of molecular medicine 20040101

Title: Mechanism of mahanine-induced apoptosis in human leukemia cells (HL-60).

Journal: Biochemical pharmacology 20040101

Title: A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score.

Journal: BMC pharmacology 20040101

Title: Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression.

Journal: Arthritis research & therapy 20040101

Title: Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2.

Journal: Cell biology international 20040101

Title: Role of mitochondria in neuron apoptosis during ischemia-reperfusion injury.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

Title: Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.

Journal: Toxicology and applied pharmacology 20031215

Title: Oligonucleosomal DNA fragmentation in MCF-7 cells undergoing palmitate-induced apoptosis.

Journal: Biochemistry. Biokhimiia 20031201

Title: Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells.

Journal: Cancer research 20031101

Title: JNK/SAPK is required in nitric oxide-induced apoptosis in osteoblasts.

Journal: Archives of pharmacal research 20031101

Title: [Effect of tumor necrosis factor-alpha and interleukin-1beta on bovine pulmonary arterial endothelial cell apoptosis].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20031101

Title: Involvement of nucleophosmin/B23 in TPA-induced megakaryocytic differentiation of K562 cells.

Journal: British journal of cancer 20031006

Title: Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway.

Journal: Radiation research 20031001

Title: Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.

Journal: The Journal of biological chemistry 20030912

Title: Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030903

Title: The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

Journal: The Journal of pharmacology and experimental therapeutics 20030901

Title: Mechanisms of sodium nitroprusside-induced death in human chondrocytes.

Journal: Rheumatology international 20030901

Title: Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.

Journal: Blood 20030801

Title: Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: involvement of cytochrome C oxidase inhibition and the production of reactive oxygen species in mitochondria.

Journal: Journal of neuroscience research 20030801

Title: Enhancement of sensitivity to cisplatin by orobol is associated with increased mitochondrial cytochrome c release in human ovarian carcinoma cells.

Journal: Gynecologic oncology 20030801

Title: Caspase-mediated cleavage of JNK during stress-induced apoptosis.

Journal: Biochemical and biophysical research communications 20030711

Title: Nicotinyl aspartyl ketones as inhibitors of caspase-3.

Journal: Bioorganic & medicinal chemistry letters 20030707

Title: Proteasome inhibitors induce growth inhibition and apoptosis in myeloma cell lines and in human bone marrow myeloma cells irrespective of chromosome 13 deletion.

Journal: Journal of cancer research and clinical oncology 20030701

Title: Caspase-3 and its inhibitor Ac-DEVD-CHO in rat lens epithelial cell apoptosis induced by hydrogen in vitro.

Journal: Chinese medical journal 20030701

Title: beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells.

Journal: Cellular and molecular life sciences : CMLS 20030701

Title: Differential modulation of apoptosis-associated proteins by ethanol in rat cerebral cortex and cerebellum.

Journal: European journal of pharmacology 20030606

Title: Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats.

Journal: Experimental neurology 20030601

Title: High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

Title: Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis.

Journal: Acta neuropathologica 20030501

Title: Activation of caspases-3/7 is dispensable for idarubicin-induced apoptotic DNA fragmentation in human leukemia cells.

Journal: International journal of oncology 20030501

Title: Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid beta-protein-induced cell death in nerve growth factor-differentiated PC12 cells.

Journal: Neuroscience research 20030501

Title: Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.

Journal: Experimental & molecular medicine 20030430

Title: Oxidative stress-induced cell death of human oral neutrophils.

Journal: American journal of physiology. Cell physiology 20030401

Title: Molecular dynamics studies of caspase-3.

Journal: Biophysical journal 20030401

Title: Expression of dominant-negative Fas-associated death domain blocks human keratinocyte apoptosis and vesication induced by sulfur mustard.

Journal: The Journal of biological chemistry 20030307

Title: Apoptosis of bladder cancer cells induced by short-term and low-dose Mitomycin-C: potential molecular mechanism and clinical implication.

Journal: International journal of molecular medicine 20030301

Title: Apoptotic cell death induction by F 11782 a novel dual catalytic inhibitor of topoisomerases I and II.

Journal: Biochemical pharmacology 20030301

Title: Caspase-mediated apoptosis in sponges: cloning and function of the phylogenetic oldest apoptotic proteases from Metazoa.

Journal: Biochimica et biophysica acta 20030217

Title: Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.

Journal: International journal of cancer 20030210

Title: Mechanisms of glucocorticoid-induced Leydig cell apoptosis.

Journal: Molecular and cellular endocrinology 20030131

Title: Caspase-9 takes part in programmed cell death in developing mouse kidney.

Journal: Nephron. Experimental nephrology 20030101

Title: Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells.

Journal: Immunobiology 20030101

Title: A common pathway for chemotherapy-induced apoptosis in human squamous cell carcinoma lines distinct from that of receptor-mediated cell death.

Journal: Anticancer research 20030101

Title: Delineation of signalling pathway leading to antioxidant-dependent inhibition of dexamethasone-mediated muscle cell death.

Journal: Journal of muscle research and cell motility 20030101

Title: Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20030101

Title: Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma.

Journal: Neuroscience letters 20021216

Title: Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.

Journal: Biochemical pharmacology 20021215

Title: Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease.

Journal: Cancer letters 20021205

Title: Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase.

Journal: Journal of cell science 20021201

Title: Time sequence analysis of caspase-3-independent programmed cell death and apoptosis in X-irradiated human leukemic MOLT-4 cells.

Journal: Cell and tissue research 20021201

Title: Caspase-3-dependent pathway mediates apoptosis of human mononuclear cells induced by cellulosic haemodialysis membranes.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021101

Title: Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer.

Journal: Experimental cell research 20021101

Title: Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases.

Journal: Biological chemistry 20021101

Title: Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.

Journal: Japanese journal of cancer research : Gann 20021001

Title: Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.

Journal: The Journal of biological chemistry 20020913

Title: Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.

Journal: FEBS letters 20020911

Title: Inhibitor specificity of recombinant and endogenous caspase-9.

Journal: The Biochemical journal 20020901

Title: Hydrogen peroxide induces apoptosis of osteocytes: involvement of calcium ion and caspase activity.

Journal: Calcified tissue international 20020901

Title: Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020901

Title: Avian encephalomyelitis virus induces apoptosis via major structural protein VP3.

Journal: Virology 20020815

Title: Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.

Journal: Biochemical and biophysical research communications 20020809

Title: Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.

Journal: International journal of cancer 20020701

Title: Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.

Journal: Human molecular genetics 20020615

Title: Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.

Journal: The Journal of biological chemistry 20020614

Title: Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020601

Title: Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

Journal: Archives of toxicology 20020601

Title: Caspase inhibition protects nerve terminals from in vitro degradation.

Journal: Neurochemical research 20020601

Title: The protection of hybridoma cells from apoptosis by caspase inhibition allows culture recovery when exposed to non-inducing conditions.

Journal: Journal of biotechnology 20020523

Title: Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.

Journal: Journal of neuroscience research 20020515

Title: Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells.

Journal: Archives of toxicology 20020501

Title: Apoptosis during ectromelia orthopoxvirus infection is DEVDase dependent: in vitro and in vivo studies.

Journal: Microbes and infection 20020501

Title: Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.

Journal: Biotechnology and bioengineering 20020420

Title: Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.

Journal: Molecular and cellular biology 20020401

Title: D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells.

Journal: Experimental & molecular medicine 20020331

Title: Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.

Journal: Oncogene 20020327

Title: Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells.

Journal: Journal of neuroscience research 20020315

Title: Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

Journal: The Journal of pharmacology and experimental therapeutics 20020301

Title: Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors.

Journal: British journal of pharmacology 20020301

Title: Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Title: Caspase-3 inhibitor transiently delays inherited retinal degeneration in C3H mice carrying the rd gene.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20020301

Title: Caspase activation in equine influenza virus induced apoptotic cell death.

Journal: Veterinary microbiology 20020204

Title: Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.

Journal: Journal of neurochemistry 20020201

Title: Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

Journal: Biochemical pharmacology 20020115

Title: Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development.

Journal: British journal of cancer 20020107

Title: Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2.

Journal: Molecular pharmacology 20020101

Title: Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.

Journal: Neuro-oncology 20020101

Title: Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.

Journal: Haematologica 20020101

Title: Blockade of maitotoxin-induced oncotic cell death reveals zeiosis.

Journal: BMC physiology 20020101

Title: The antimicrotubule drug estramustine but not irradiation induces apoptosis in malignant glioma involving AKT and caspase pathways.

Journal: Journal of neuro-oncology 20020101

Title: Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells.

Journal: Anticancer research 20020101

Title: Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage.

Journal: Blood 20011215

Title: Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells.

Journal: The Journal of biological chemistry 20011214

Title: Inhibition of caspase-3 improves contractile recovery of stunned myocardium, independent of apoptosis-inhibitory effects.

Journal: Journal of the American College of Cardiology 20011201

Title: Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria.

Journal: Cell death and differentiation 20011201

Title: Roles of caspases in the programmed cell death of motoneurons in vivo.

Journal: Archives of histology and cytology 20011201

Title: Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture.

Journal: Journal of neuroscience research 20011115

Title: Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.

Journal: British journal of pharmacology 20011101

Title: Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.

Journal: British journal of cancer 20011101

Title: Platelet-activating factor (PAF) enhances apoptosis induced by ultraviolet radiation in corneal epithelial cells through cytochrome c-caspase activation.

Journal: Current eye research 20011101

Title: Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells.

Journal: Journal of biochemistry 20011001

Title: Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line.

Journal: FEBS letters 20010914

Title: Fas-mediated apoptosis in a rat acinar cell line is dependent on caspase-1 activity.

Journal: Cellular signalling 20010901

Title: Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons.

Journal: Experimental neurology 20010901

Title: Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.

Journal: Oncogene 20010816

Title: p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription.

Journal: Journal of molecular and cellular cardiology 20010801

Title: Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death.

Journal: Virology 20010801

Title: Caspase activity is involved in, but is dispensable for, early motoneuron death in the chick embryo cervical spinal cord.

Journal: Molecular and cellular neurosciences 20010801

Title: Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis.

Journal: The Journal of biological chemistry 20010706

Title: Cocaine-mediated apoptosis in bovine coronary artery endothelial cells: role of nitric oxide.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

Journal: Journal of neuroscience research 20010701

Title: [Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010701

Title: Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis.

Journal: Experimental cell research 20010610

Title: Caspase activity in newt spermatogonial apoptosis induced by prolactin and cycloheximide.

Journal: Molecular reproduction and development 20010601

Title: Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes.

Journal: Journal of molecular and cellular cardiology 20010501

Title: Sodium nitroprusside induces apoptosis of H9C2 cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner.

Journal: International immunopharmacology 20010501

Title: Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells.

Journal: Archives of pharmacal research 20010401

Title: Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats.

Journal: Neuroreport 20010305

Title: Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.

Journal: Journal of neuroscience research 20010301

Title: Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation.

Journal: European journal of immunology 20010301

Title: Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20010301

Title: Caspase-dependent cleavage of cadherins and catenins during osteoblast apoptosis.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010301

Title: Homology modeling of nematode Caenorhabditis elegans CED3 protein-inhibitor complex.

Journal: Biochemical and biophysical research communications 20010216

Title: Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis.

Journal: Journal of neurochemistry 20010201

Title: Effects of a novel hepatoprotective drug, ZNC-2381, on fas-induced hepatocellular caspase-3 activity and apoptosis in mice.

Journal: Pharmacology 20010201

Title: Growth inhibition and apoptosis of gastric cancer cell lines by Anemarrhena asphodeloides Bunge.

Journal: Journal of gastroenterology 20010201

Title: [Induction of apoptosis of splenic lymphocytes in mice by accelerated carbon ions].

Journal: Canadian journal of physiology and pharmacology 20010201

Title: Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.

Journal: The Journal of biological chemistry 20010126

Title: Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay.

Journal: Bioorganic & medicinal chemistry letters 20010108

Title: Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010101

Title: DNA-dependent protein kinase catalytic subunit is cleaved during UV-induced apoptosis.

Journal: Journal of dermatological science 20010101

Title: Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells.

Journal: Anticancer research 20010101

Title: Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entry.

Journal: BMC cell biology 20010101

Title: Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea.

Journal: Reproduction, fertility, and development 20010101

Title: New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'.

Journal: Journal of cellular and molecular medicine 20010101

Title: The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20001121

Title: Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.

Journal: Cancer research 20001101

Title: Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells.

Journal: Toxicology and applied pharmacology 20001015

Title: Different mechanisms between premitotic apoptosis and postmitotic apoptosis in X-irradiated U937 cells.

Journal: International journal of radiation oncology, biology, physics 20000601

Title: Paclitaxel-induced apoptosis in non-small cell lung cancer cell lines is associated with increased caspase-3 activity.

Journal: The Journal of thoracic and cardiovascular surgery 20000401

Title: Induction of apoptosis by the O-hydroxyethyl-D(Ser)(8)-cyclosporine A derivative SDZ IMM 125 in rat hepatocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20000401

Title: Cocaine induces apoptosis in human coronary artery endothelial cells.

Journal: Journal of cardiovascular pharmacology 20000401

Title: Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20000101

Title: Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons.

Journal: Journal of neurochemistry 20000101

Title: The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons.

Journal: Journal of neurochemistry 20000101

Title: Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20000101

Title: Effect of heat stress on serotonin-2A receptor-mediated intracellular calcium mobilization in rat C6 glioma cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20000101

Title: Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors.

Journal: Biochemical pharmacology 19991215

Title: The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells.

Journal: Cancer research 19991101

Title: Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

Journal: Cancer research 19991001

Title: Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells.

Journal: Photochemistry and photobiology 19991001

Title: Induction of apoptosis by penta-O-galloyl-beta-D-glucose through activation of caspase-3 in human leukemia HL-60 cells.

Journal: European journal of pharmacology 19990924

Title: Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19990815

Title: Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19990815

Title: Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.

Journal: Oncogene 19990708

Title: A predominant apoptotic death pathway of neuronal PC12 cells induced by activated microglia is displaced by a non-apoptotic death pathway following blockage of caspase-3-dependent cascade.

Journal: The Journal of biological chemistry 19990528

Title: Caspase-3 activation during apoptosis caused by glutathione-doxorubicin conjugate.

Journal: British journal of cancer 19990501

Title: Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3.

Journal: The Journal of biological chemistry 19990409

Title: Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes.

Journal: Toxicology and applied pharmacology 19990401

Title: Caspase-dependent activation of calpain during drug-induced apoptosis.

Journal: The Journal of biological chemistry 19990319

Title: Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3.

Journal: Cell proliferation 19990201

Title: Menadione-induced apoptosis and the degradation of lamin-like proteins in tobacco protoplasts.

Journal: Cellular and molecular life sciences : CMLS 19990201

Title: Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation.

Journal: Free radical research 19990101

Title: Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.

Journal: Cell death and differentiation 19981201

Title: Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3.

Journal: Cell death and differentiation 19981201

Title: Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19981015

Title: Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine.

Journal: Journal of neuroscience research 19981015

Title: Caspase-3-like activity is necessary for IL-2 release in activated Jurkat T-cells.

Journal: Experimental cell research 19981010

Title: Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide.

Journal: Cell death and differentiation 19981001

Title: Proteolytic activation of PKN by caspase-3 or related protease during apoptosis.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19980929

Title: Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19980815

Title: Distinct steps in DNA fragmentation pathway during camptothecin-induced apoptosis involved caspase-, benzyloxycarbonyl- and N-tosyl-L-phenylalanylchloromethyl ketone-sensitive activities.

Journal: Cancer research 19980715

Title: Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19980615

Title: Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19980615

Title: Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases.

Journal: Hepatology (Baltimore, Md.) 19980601

Title: Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19980515

Title: The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells.

Journal: Journal of neuroscience research 19980515

Title: Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.

Journal: Cancer research 19980515

Title: Proteolytic cleavage of HsRad51 during apoptosis.

Journal: FEBS letters 19980508

Title: Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease.

Journal: The American journal of physiology 19980401

Title: Preparation and imaging of nuclear spreads from cells of the zebrafish embryo. Evidence for large degradation intermediates in apoptosis.

Journal: Chromosoma 19980301

Title: Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

Journal: Cancer research 19980201

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Tags:169332-60-9 Molecular Formula|169332-60-9 MDL|169332-60-9 SMILES|169332-60-9 (4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid