Catalog No.:AA003AON

1708971-55-4 | Fgf401

Name: Name:Fgf401
Brand: AABLOCKS
SKU: AA003AON
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

1mg

98%

in stock

$26.00 $18.00

- +

2mg

98%

in stock

$43.00 $30.00

- +

5mg

98%

in stock

$64.00 $45.00

- +

10mg

98%

in stock

$95.00 $67.00

- +

25mg

98%

in stock

$161.00 $113.00

- +

250mg

95%

in stock

$1,077.00 $754.00

- +

95%

in stock

$2,950.00 $2,065.00

- +

Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA003AON

Chemical Name:

Fgf401

CAS Number:

1708971-55-4

Molecular Formula:

C25H30N8O4

Molecular Weight:

506.5569

MDL Number:

MFCD31381923

SMILES:

COCCNc1cc(ncc1C#N)NC(=O)N1CCCc2c1nc(C=O)c(c2)CN1CCN(CC1=O)C

Properties

Computed Properties

Complexity:

865

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

0.6

Downstream Synthesis Route

1708974-11-1

1708971-55-4

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2015/119385,2015,A1

[2]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2015/59668,2015,A1

[3]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2016/151501,2016,A1

[4]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2016/151500,2016,A1

[5]Fairhurst,RobinA.;Knoepfel,Thomas;Buschmann,Nicole;Leblanc,Catherine;Mah,Robert;Todorov,Milen;Nimsgern,Pierre;Ripoche,Sebastien;Niklaus,Michel;Warin,Nicolas;Luu,VanHuy;Madoerin,Mario;Wirth,Jasmin;Graus-Porta,Diana;Weiss,Andreas;Kiffe,Michael;Wartmann,Markus;Kinyamu-Akunda,Jacqueline;Sterker,Dario;Stamm,Christelle;Adler,Flavia;Buhles,Alexandra;Schadt,Heiko;Couttet,Philippe;Blank,Jutta;Galuba,Inga;Trappe,Jörg;Voshol,Johannes;Ostermann,Nils;Zou,Chao;Berghausen,Jörg;DelRioEspinola,Alberto;Jahnke,Wolfgang;Furet,Pascal[JournalofMedicinalChemistry,2020,vol.63,#21,p.12542-12573]

1708974-12-2

1708971-55-4

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2015/119385,2015,A1

[2]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2015/59668,2015,A1

[3]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2016/151501,2016,A1

[4]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2016/151500,2016,A1

204452-90-4

7-formyl-6-(4-methyl-2-oxo-piperazin-1-ylmethyl)-3,4-dihydro-2H-1,8naphthyridine-1-carboxylicacid5-cyano-4-(2-methoxy-ethylamino)-pyridin-2-ylamide

[1]Patent:US2015/119385,2015,A1

[2]Patent:WO2015/59668,2015,A1

[3]Patent:WO2016/151501,2016,A1

[4]Patent:WO2016/151500,2016,A1

7521-41-7

1708971-55-4

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2015/119385,2015,A1

[2]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2015/59668,2015,A1

[3]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2016/151501,2016,A1

[4]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2016/151500,2016,A1

1708974-02-0

1708971-55-4

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2015/119385,2015,A1

[2]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2015/59668,2015,A1

[3]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2016/151501,2016,A1

[4]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2016/151500,2016,A1

Literature

Title: Nicole Buschmann, et al. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO2015059668A1.

Title: Robin A Fairhurst, et al. Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4. J Med Chem. 2020 Nov 12;63(21):12542-12573.

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SDS