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171746-21-7,MFCD00943817
Catalog No.:AA007WJO

171746-21-7 | AGN 193109

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Purity
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1mg
98%
in stock  
$73.00   $51.00
- +
5mg
98%
in stock  
$160.00   $112.00
- +
10mg
98%
in stock  
$251.00   $176.00
- +
25mg
98%
in stock  
$305.00   $213.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007WJO
Chemical Name:
AGN 193109
CAS Number:
171746-21-7
Molecular Formula:
C28H24O2
Molecular Weight:
392.4890
MDL Number:
MFCD00943817
SMILES:
Cc1ccc(cc1)C1=CCC(c2c1cc(cc2)C#Cc1ccc(cc1)C(=O)O)(C)C
Properties
Computed Properties
 
Complexity:
716  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
7  

Literature

Title: Active repression by RARγ signaling is required for vertebrate axial elongation.

Journal: Development (Cambridge, England) 20140601

Title: Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling.

Journal: Stem cells (Dayton, Ohio) 20100901

Title: Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.

Journal: Cancer biology & therapy 20090501

Title: Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis.

Journal: The Journal of pharmacy and pharmacology 20090101

Title: N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153.

Journal: Journal of cellular physiology 20061201

Title: PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.

Journal: The Journal of experimental medicine 20061002

Title: 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes.

Journal: The Journal of investigative dermatology 20061001

Title: Kinase-dependent, retinoic acid receptor-independent up-regulation of cyclooxygenase-2 by all-trans retinoic acid in human mesangial cells.

Journal: British journal of pharmacology 20060901

Title: 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.

Journal: The Journal of biological chemistry 20060602

Title: Retinoid signaling determines germ cell fate in mice.

Journal: Science (New York, N.Y.) 20060428

Title: Retinoic acid is required early during adult neurogenesis in the dentate gyrus.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20060307

Title: Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.

Journal: Oncogene 20060112

Title: Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides.

Journal: Toxicology and applied pharmacology 20050101

Title: All-trans retinoic acid increases transgene expression in MSCV-transduced cells, via a mechanism that is retinoid receptor dependent but independent of cellular differentiation.

Journal: Human gene therapy 20050101

Title: Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis.

Journal: Developmental cell 20040201

Title: PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.

Journal: Journal of lipid research 20030201

Title: Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20030101

Title: Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents.

Journal: Biochemical pharmacology 20011201

Title: The synthetic retinoid AGN 193109 but not retinoic acid elevates CYP1A1 levels in mouse embryos and Hepa-1c1c7 cells.

Journal: Toxicology and applied pharmacology 20010715

Title: Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.

Journal: The Journal of biological chemistry 20010420

Title: Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.

Journal: Bioorganic & medicinal chemistry letters 20010326

Title: Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions.

Journal: The Journal of biological chemistry 20000623

Title: Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir.

Journal: Biochemical pharmacology 20000501

Title: Therapeutic applications for ligands of retinoid receptors.

Journal: Current pharmaceutical design 20000101

Title: Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists.

Journal: The Journal of biological chemistry 19960913

Title: Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7.

Title: Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12.

Title: Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75.

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