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174634-09-4,MFCD00943251
Catalog No.:AA001ZRK

174634-09-4 | TAS-103 dihydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥98%
in stock  
$173.00   $121.00
- +
25mg
≥98%
in stock  
$410.00   $287.00
- +
50mg
≥98%
in stock  
$776.00   $543.00
- +
100mg
≥98%
in stock  
$1,373.00   $961.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001ZRK
Chemical Name:
TAS-103 dihydrochloride
CAS Number:
174634-09-4
Molecular Formula:
C20H21Cl2N3O2
Molecular Weight:
406.3056
MDL Number:
MFCD00943251
SMILES:
CN(CCNc1nc2cc(O)ccc2c2c1C(=O)c1c2cccc1)C.Cl.Cl
Properties
Properties
 
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
497  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  

Literature

Title: Padget K, et al. An investigation into the formation of N- -(dimethylamino)ethylacridine-4-carboxamide (DACA) and 6--(dimethylamino)ethylamino- 3-hydroxy-7H-indeno, 1-Cquinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000 Sep 15;60(6):817-21.

Title: Shimizu K, et al. Cancer chemotherapy by liposomal 6-2-(dimethylamino)ethylaminol-3-hydroxy-7H-indeno,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25(10):1385-7.

Title: Yoshida M, et al. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73(3):987-94. Epub 2007 Dec 18.

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