175178-82-2,MFCD00270914
Catalog No.:AA00AOYW

175178-82-2 | AG 1478

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Purity
Availability
Price(USD)
Quantity
  
1mg
2 weeks  
$214.00   $150.00
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5mg
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$458.00   $321.00
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Technical Information
Catalog Number:
AA00AOYW
Chemical Name:
AG 1478
CAS Number:
175178-82-2
Molecular Formula:
C17H15ClN2O2
Molecular Weight:
314.7662
MDL Number:
MFCD00270914
SMILES:
COc1cc2c(ncnc2cc1OC)Cc1cccc(c1)Cl
NSC Number:
693255
Properties
Computed Properties
 
Complexity:
360  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4  

Literature

Title: Hijiki and sodium arsenite stimulate growth of human colorectal adenocarcinoma cells through ERK1/2 activation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171201

Title: Low concentration of BPA induces mice spermatocytes apoptosis via GPR30.

Journal: Oncotarget 20170725

Title: Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160701

Title: TCDD promoted EMT of hFPECs via AhR, which involved the activation of EGFR/ERK signaling.

Journal: Toxicology and applied pharmacology 20160501

Title: EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.

Journal: Archives of toxicology 20160401

Title: Brominated flame retardants, hexabromocyclododecane and tetrabromobisphenol A, affect proinflammatory protein expression in human bronchial epithelial cells via disruption of intracellular signaling.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells.

Journal: PloS one 20160101

Title: Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells.

Journal: Toxicology 20151202

Title: Bisphenol A and Related Alkylphenols Exert Nongenomic Estrogenic Actions Through a G Protein-Coupled Estrogen Receptor 1 (Gper)/Epidermal Growth Factor Receptor (Egfr) Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes.

Journal: Biology of reproduction 20151201

Title: Cadmium promotes the proliferation of triple-negative breast cancer cells through EGFR-mediated cell cycle regulation.

Journal: Toxicology and applied pharmacology 20151115

Title: Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene.

Journal: Environmental toxicology 20150901

Title: Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells.

Journal: Toxicology and applied pharmacology 20150815

Title: Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.

Journal: The Journal of biological chemistry 20150619

Title: (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases.

Journal: Chemical research in toxicology 20150518

Title: Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts.

Journal: Environmental health perspectives 20150501

Title: Cadmium at nanomolar concentrations activates Raf-MEK-ERK1/2 MAPKs signaling via EGFR in human cancer cell lines.

Journal: Chemico-biological interactions 20150425

Title: Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways.

Journal: Environmental health perspectives 20150401

Title: Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.

Journal: Environmental toxicology 20150301

Title: Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells.

Journal: Environmental toxicology 20150201

Title: Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER/EGFR/ERK1/2 signal pathway.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20141001

Title: Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling.

Journal: Toxicology and applied pharmacology 20140815

Title: Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes.

Journal: Glia 20140801

Title: Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.

Journal: Cell death & disease 20140801

Title: Penta- and octa-bromodiphenyl ethers promote proinflammatory protein expression in human bronchial epithelial cells in vitro.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140301

Title: Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells.

Journal: Archives of toxicology 20140201

Title: Developmental defects in zebrafish for classification of EGF pathway inhibitors.

Journal: Toxicology and applied pharmacology 20140115

Title: Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

Journal: Respiratory research 20140101

Title: Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium.

Journal: Archives of toxicology 20131201

Title: Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.

Journal: Chemical research in toxicology 20131021

Title: Action of hexachlorobenzene on tumor growth and metastasis in different experimental models.

Journal: Toxicology and applied pharmacology 20130501

Title: On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR-ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells.

Journal: International journal of pharmaceutics 20130501

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Hepatocytes display a compensatory survival response against cadmium toxicity by a mechanism mediated by EGFR and Src.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130401

Title: Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes.

Journal: Toxicology and applied pharmacology 20130215

Title: Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression.

Journal: Toxicology and applied pharmacology 20130215

Title: Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201

Title: Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells.

Journal: PloS one 20130101

Title: Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.

Journal: The Journal of biological chemistry 20121207

Title: Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin.

Journal: Archives of toxicology 20121201

Title: EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.

Journal: Molecular and cellular biochemistry 20121101

Title: The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress.

Journal: Free radical research 20121101

Title: Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.

Journal: Archives of toxicology 20121001

Title: Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.

Journal: Arthritis and rheumatism 20121001

Title: Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.

Journal: Toxicon : official journal of the International Society on Toxinology 20121001

Title: A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.

Journal: Biology of reproduction 20121001

Title: Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer.

Journal: Oncogene 20120913

Title: Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.

Journal: Life sciences 20120904

Title: Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.

Journal: Archives of biochemistry and biophysics 20120901

Title: GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes.

Journal: The Journal of biological chemistry 20120803

Title: Regulated intramembrane cleavage of the EGF receptor.

Journal: Traffic (Copenhagen, Denmark) 20120801

Title: Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120801

Title: Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.

Journal: Environmental health perspectives 20120801

Title: A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.

Journal: Journal of biomolecular screening 20120801

Title: The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction.

Journal: Canadian journal of physiology and pharmacology 20120801

Title: Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer.

Journal: International journal of radiation oncology, biology, physics 20120701

Title: A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus.

Journal: Hypertension (Dallas, Tex. : 1979) 20120701

Title: Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.

Journal: The Journal of allergy and clinical immunology 20120501

Title: Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1.

Journal: The Journal of biological chemistry 20120427

Title: Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.

Journal: ChemMedChem 20120401

Title: Angiotensin AT1 receptor blockers suppress oxidized low-density lipoprotein-derived formation of foam cells.

Journal: European journal of pharmacology 20120315

Title: Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway.

Journal: British journal of pharmacology 20120301

Title: Ovarian expression and regulation of the stromelysins during the periovulatory period in the human and the rat.

Journal: Biology of reproduction 20120301

Title: ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.

Journal: Biochemical and biophysical research communications 20120203

Title: Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120201

Title: Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.

Journal: Phytotherapy research : PTR 20120101

Title: Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells.

Journal: Molecular medicine reports 20120101

Title: Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin.

Journal: Archives of virology 20120101

Title: EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.

Journal: Cellular signalling 20120101

Title: An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs.

Journal: PloS one 20120101

Title: The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.

Journal: Mediators of inflammation 20120101

Title: Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.

Journal: PloS one 20120101

Title: Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.

Journal: Nature neuroscience 20111211

Title: Permissive effect of EGFR-activated pathways on RVI and their anti-apoptotic effect in hypertonicity-exposed mIMCD3 cells.

Journal: Bioscience reports 20111201

Title: Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury.

Journal: Journal of hepatology 20111201

Title: Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α.

Journal: Environmental health perspectives 20111201

Title: The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

Journal: Biochemical pharmacology 20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.

Journal: Molecules and cells 20111031

Title: Angiogenic effect induced by mineral fibres.

Journal: Toxicology 20111009

Title: Bile acids promote HCV replication through the EGFR/ERK pathway in replicon-harboring cells.

Journal: Intervirology 20111001

Title: Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.

Journal: Experimental cell research 20111001

Title: The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.

Journal: Molecular carcinogenesis 20111001

Title: ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.

Journal: Stem cells (Dayton, Ohio) 20111001

Title: Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.

Journal: Experimental lung research 20111001

Title: Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.

Journal: Nature medicine 20111001

Title: ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478.

Journal: Lung cancer (Amsterdam, Netherlands) 20110901

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

Journal: American journal of respiratory cell and molecular biology 20110801

Title: Epithelial growth factor receptor tyrosine kinase inhibitor prevents infiltration and cerebrospinal fluid dissemination in malignant glioma: an experimental study.

Journal: Neurosurgery 20110801

Title: EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.

Journal: British journal of cancer 20110726

Title: Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment.

Journal: Journal of natural products 20110722

Title: Nanospheres delivering the EGFR TKI AG1478 promote optic nerve regeneration: the role of size for intraocular drug delivery.

Journal: ACS nano 20110628

Title: Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.

Journal: Experimental cell research 20110610

Title: The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin.

Journal: Molecular carcinogenesis 20110601

Title: Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.

Journal: Biochimica et biophysica acta 20110601

Title: GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary.

Journal: Molecular endocrinology (Baltimore, Md.) 20110601

Title: Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.

Journal: Molecular reproduction and development 20110601

Title: Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.

Journal: The Journal of clinical investigation 20110601

Title: Expression and regulation of amphiregulin in Gsα-mutated human bone marrow stromal cells of fibrous dysplasia of mandible.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110501

Title: Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration by hexachlorobenzene in MDA-MB-231 human breast cancer cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110401

Title: Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30.

Journal: Hypertension (Dallas, Tex. : 1979) 20110401

Title: Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.

Journal: European journal of pharmacology 20110305

Title: Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.

Journal: The Journal of surgical research 20110301

Title: Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism.

Journal: Molecular pharmacology 20110201

Title: Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology 20110201

Title: Reactive oxygen species are indispensable in ovulation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20110125

Title: Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells.

Journal: Toxicology 20110111

Title: Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells.

Journal: Environmental pollution (Barking, Essex : 1987) 20110101

Title: Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.

Journal: Toxicology and applied pharmacology 20110101

Title: Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.

Journal: Microvascular research 20110101

Title: Down-regulation of CYLD as a trigger for NF-κB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells.

Journal: International journal of oncology 20110101

Title: EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.

Journal: PloS one 20110101

Title: Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.

Journal: BMC cancer 20110101

Title: Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.

Journal: PloS one 20110101

Title: The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways.

Journal: The Journal of biological chemistry 20101217

Title: Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives.

Journal: Journal of medicinal chemistry 20101125

Title: Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides.

Journal: The Journal of biological chemistry 20101112

Title: Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.

Journal: Neurochemistry international 20101101

Title: Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.

Journal: Neurochemistry international 20101101

Title: Heparin-binding EGF-like factor augments esophageal epithelial cell proliferation, migration and inhibits TRAIL-mediated apoptosis via EGFR/MAPK signaling.

Journal: Scandinavian journal of gastroenterology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20101101

Title: α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor.

Journal: British journal of pharmacology 20101101

Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

Journal: Journal of medicinal chemistry 20100923

Title: Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.

Journal: The Journal of pharmacology and experimental therapeutics 20100901

Title: Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.

Journal: Experimental eye research 20100901

Title: Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.

Journal: Cancer research 20100901

Title: Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.

Journal: Cancer letters 20100828

Title: 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.

Journal: Toxicology letters 20100816

Title: Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.

Journal: Developmental biology 20100815

Title: ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK.

Journal: Chemico-biological interactions 20100730

Title: Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1.

Journal: Thrombosis research 20100701

Title: [Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100701

Title: Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.

Journal: Nature medicine 20100601

Title: The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.

Journal: Journal of endodontics 20100601

Title: Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway.

Journal: Toxicology and applied pharmacology 20100515

Title: Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells.

Journal: Journal of neuro-oncology 20100501

Title: New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres.

Journal: Journal of microencapsulation 20100501

Title: Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation.

Journal: Molecular carcinogenesis 20100401

Title: Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20100401

Title: RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries.

Journal: Molecular endocrinology (Baltimore, Md.) 20100401

Title: Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells.

Journal: Biochemical pharmacology 20100301

Title: Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100301

Title: c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.

Journal: Oncogene 20100218

Title: The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.

Journal: Stem cells (Dayton, Ohio) 20100201

Title: Effect of urotensin II on PC12 rat pheochromocytoma cells.

Journal: Journal of neuroendocrinology 20100201

Title: [Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20100201

Title: Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors.

Journal: The Journal of biological chemistry 20100129

Title: Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-).

Journal: Toxicology and applied pharmacology 20100115

Title: Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern.

Journal: Developmental biology 20100115

Title: Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.

Journal: The Journal of steroid biochemistry and molecular biology 20100101

Title: JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100101

Title: Cross-talk between bradykinin and epidermal growth factor in regulating IL-6 production in human airway smooth muscle cells.

Journal: Chang Gung medical journal 20100101

Title: EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.

Journal: Journal of experimental therapeutics & oncology 20100101

Title: Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells.

Journal: Cell biology international 20091216

Title: Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium.

Journal: American journal of respiratory cell and molecular biology 20091201

Title: ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.

Journal: Neurochemistry international 20091201

Title: Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor.

Journal: Molecular pharmacology 20091201

Title: Contribution of epidermal growth factor receptor transactivation in angiotensin II-induced enhanced expression of Gi protein and proliferation in A10 vascular smooth muscle cells.

Journal: Canadian journal of physiology and pharmacology 20091201

Title: Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long-term hypoxia.

Journal: High altitude medicine & biology 20091201

Title: Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.

Journal: FEBS letters 20091119

Title: Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.

Journal: Cancer letters 20091118

Title: Role of epidermal growth factor receptor (EGFR) in corneal remodelling in diabetes.

Journal: Acta ophthalmologica 20091101

Title: Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation.

Journal: Microbiology (Reading, England) 20091101

Title: Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

Journal: American journal of respiratory and critical care medicine 20091101

Title: Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.

Journal: Psychopharmacology 20091101

Title: Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.

Journal: Stem cells (Dayton, Ohio) 20091101

Title: Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth.

Journal: Brain : a journal of neurology 20091101

Title: Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.

Journal: Neurobiology of disease 20091001

Title: Effects of cigarette smoking on mucin production in human middle ear epithelial cells.

Journal: International journal of pediatric otorhinolaryngology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Desmoid cell motility is induced in vitro by rhEGF.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20090901

Title: Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor.

Journal: Hepatology (Baltimore, Md.) 20090901

Title: EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.

Journal: American journal of physiology. Renal physiology 20090901

Title: Pleiotropic effects of cadmium in mesangial cells.

Journal: Toxicology and applied pharmacology 20090801

Title: Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells.

Journal: Endocrinology 20090801

Title: Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells.

Journal: Toxicology 20090710

Title: Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090601

Title: A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.

Journal: Circulation research 20090508

Title: Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.

Journal: Journal of vascular surgery 20090501

Title: Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.

Journal: Journal of vascular surgery 20090501

Title: Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle.

Journal: European journal of pharmacology 20090315

Title: p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.

Journal: Circulation research 20090313

Title: Rapamycin induces transactivation of the EGFR and increases cell survival.

Journal: Oncogene 20090305

Title: Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.

Journal: Neuroreport 20090304

Title: Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.

Journal: Biochemical pharmacology 20090301

Title: Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.

Journal: Toxicology and applied pharmacology 20090301

Title: Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor.

Journal: Cancer science 20090301

Title: Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.

Journal: Toxicology letters 20090210

Title: The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

Journal: Biochimica et biophysica acta 20090201

Title: The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.

Journal: Oncology reports 20090201

Title: Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells.

Journal: Zoological science 20090201

Title: Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.

Journal: Journal of periodontal research 20090201

Title: TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.

Journal: Breast cancer research and treatment 20090101

Title: Arsenite suppresses Notch1 signaling in human keratinocytes.

Journal: The Journal of investigative dermatology 20090101

Title: Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.

Journal: The Prostate 20090101

Title: Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?

Journal: The American journal of gastroenterology 20090101

Title: Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis.

Journal: Vascular pharmacology 20090101

Title: [Effects of theaflavins on the signal transduction pathway of epidermal growth factor receptor in airway mucous hypersecretion].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20090101

Title: [Analysis of tyrphostin AG1478 effect on behavior of internalized EGF receptor at different stages of endocytosis].

Journal: Tsitologiia 20090101

Title: Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.

Journal: Experimental & molecular medicine 20081231

Title: Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.

Journal: Psychopharmacology 20081201

Title: Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases.

Journal: Cellular signalling 20081201

Title: Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.

Journal: Translational research : the journal of laboratory and clinical medicine 20081201

Title: c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.

Journal: World journal of gastroenterology 20081107

Title: The epidermal growth factor receptor mediates allergic airway remodelling in the rat.

Journal: The European respiratory journal 20081101

Title: The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.

Journal: The Journal of biological chemistry 20081010

Title: Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20080923

Title: DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies.

Journal: Cancer research 20080915

Title: Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor.

Journal: Molecular pharmacology 20080901

Title: EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080901

Title: Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080901

Title: In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.

Journal: Digestive diseases and sciences 20080801

Title: Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.

Journal: American journal of physiology. Cell physiology 20080801

Title: Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.

Journal: Surgery 20080801

Title: Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.

Journal: Molecular nutrition & food research 20080701

Title: Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.

Journal: European journal of pharmacology 20080610

Title: Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.

Journal: Pflugers Archiv : European journal of physiology 20080601

Title: Role for inhibitor of differentiation/deoxyribonucleic acid-binding (Id) proteins in granulosa cell differentiation.

Journal: Endocrinology 20080601

Title: MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080601

Title: Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion.

Journal: Biochemical pharmacology 20080515

Title: PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.

Journal: Domestic animal endocrinology 20080501

Title: Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.

Journal: Molecular pharmacology 20080501

Title: Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice.

Journal: Toxicology and applied pharmacology 20080501

Title: Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.

Journal: The Journal of endocrinology 20080501

Title: Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.

Journal: Microvascular research 20080501

Title: Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.

Journal: The Journal of biological chemistry 20080418

Title: Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.

Journal: Toxicology and applied pharmacology 20080415

Title: Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells.

Journal: Oral oncology 20080401

Title: Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

Journal: American journal of respiratory cell and molecular biology 20080401

Title: Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.

Journal: Molecular endocrinology (Baltimore, Md.) 20080401

Title: Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma.

Journal: Bulletin of experimental biology and medicine 20080401

Title: Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells.

Journal: American journal of physiology. Renal physiology 20080301

Title: EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines.

Journal: Pathology oncology research : POR 20080301

Title: Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.

Journal: Journal of neuroscience research 20080215

Title: Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.

Journal: Journal of cellular physiology 20080201

Title: Thrombin increases hyposmotic taurine efflux and accelerates ICI-swell and RVD in 3T3 fibroblasts by a src-dependent EGFR transactivation.

Journal: Pflugers Archiv : European journal of physiology 20080201

Title: Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080201

Title: Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.

Journal: The Journal of biological chemistry 20080104

Title: EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes.

Journal: Molecular reproduction and development 20080101

Title: Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance.

Journal: Anticancer research 20080101

Title: Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.

Journal: Journal of receptor and signal transduction research 20080101

Title: HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.

Journal: PloS one 20080101

Title: A role for SNX5 in the regulation of macropinocytosis.

Journal: BMC cell biology 20080101

Title: Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice.

Journal: Diabetes/metabolism research and reviews 20080101

Title: Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.

Journal: British journal of biomedical science 20080101

Title: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.

Journal: Cellular signalling 20071201

Title: The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.

Journal: Cancer research 20071201

Title: Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.

Journal: European journal of pharmacology 20071114

Title: Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

Journal: The Journal of biological chemistry 20071102

Title: Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.

Journal: Biochimica et biophysica acta 20071101

Title: The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.

Journal: Cancer research 20071101

Title: Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20071001

Title: Lysophosphatidic acid decreases epidermal growth factor receptor binding in airway epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20070901

Title: Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070901

Title: Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility.

Journal: Asian journal of andrology 20070901

Title: Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

Journal: Cancer research 20070901

Title: Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.

Journal: The Biochemical journal 20070715

Title: Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.

Journal: The Journal of physiology 20070715

Title: Epiregulin promotes proliferation and migration of renal proximal tubular cells.

Journal: American journal of physiology. Renal physiology 20070701

Title: Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.

Journal: Endocrinology 20070701

Title: Depolarization-induced, glutamate receptor-mediated, and transactivation-dependent extracellular-signal regulated kinase phosphorylation in cultured cerebellar granule neurons.

Journal: Neuroscience 20070629

Title: Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.

Journal: Journal of cellular physiology 20070601

Title: Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070601

Title: The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.

Journal: Neuron 20070524

Title: Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.

Journal: Toxicology and applied pharmacology 20070515

Title: ERK-dependent and -independent pathways trigger human neural progenitor cell migration.

Journal: Toxicology and applied pharmacology 20070515

Title: Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells.

Journal: Endocrinology 20070501

Title: Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.

Journal: Cancer science 20070501

Title: The control of tissue architecture over nuclear organization is crucial for epithelial cell fate.

Journal: Journal of cell science 20070501

Title: Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.

Journal: Journal of pharmacological sciences 20070401

Title: Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1.

Journal: Chest 20070401

Title: Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.

Journal: Life sciences 20070320

Title: EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.

Journal: American journal of respiratory cell and molecular biology 20070301

Title: Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.

Journal: American journal of physiology. Renal physiology 20070301

Title: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

Journal: The Journal of biological chemistry 20070202

Title: Signaling of mitochondrial biogenesis following oxidant injury.

Journal: The Journal of biological chemistry 20070126

Title: Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence.

Journal: Experimental cell research 20070115

Title: Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production.

Journal: Toxicology and applied pharmacology 20070115

Title: Histone deacetylase inhibitors in combinations: will the preclinical promises be kept?

Journal: Cancer journal (Sudbury, Mass.) 20070101

Title: Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.

Journal: Cancer journal (Sudbury, Mass.) 20070101

Title: Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.

Journal: The international journal of biochemistry & cell biology 20070101

Title: Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line.

Journal: The Journal of steroid biochemistry and molecular biology 20070101

Title: Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.

Journal: The Journal of biological chemistry 20061208

Title: Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.

Journal: Endocrine-related cancer 20061201

Title: EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.

Journal: Oncogene 20061019

Title: NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.

Journal: International journal of cancer 20061001

Title: GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.

Journal: Molecular reproduction and development 20061001

Title: Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.

Journal: Leukemia 20061001

Title: Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.

Journal: FEBS letters 20060904

Title: Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060901

Title: Gefitinib prevents bleomycin-induced lung fibrosis in mice.

Journal: American journal of respiratory and critical care medicine 20060901

Title: Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.

Journal: Toxicology letters 20060820

Title: Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.

Journal: European journal of pharmacology 20060807

Title: STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.

Journal: Kidney international 20060801

Title: Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060701

Title: Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).

Journal: Endocrinology 20060701

Title: Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.

Journal: International journal of oncology 20060701

Title: [Involvement of epidermal growth factor receptor signaling pathway in tamoxifen resistance of MCF-7 cells].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060701

Title: Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells.

Journal: Canadian journal of physiology and pharmacology 20060701

Title: Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.

Journal: Life sciences 20060522

Title: Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

Journal: Biochemical pharmacology 20060514

Title: Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor.

Journal: The Journal of surgical research 20060501

Title: Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy.

Journal: Journal of molecular and cellular cardiology 20060501

Title: Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060501

Title: Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.

Journal: Kidney international 20060501

Title: Transcription levels of invasion-related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20060501

Title: HER2 expression as a potential marker for response to therapy targeted to the EGFR.

Journal: British journal of cancer 20060424

Title: Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E.

Journal: Pflugers Archiv : European journal of physiology 20060401

Title: Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway.

Journal: Endocrinology 20060401

Title: Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts.

Journal: Molecular pharmacology 20060401

Title: Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20060401

Title: PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.

Journal: Oncology reports 20060401

Title: Urokinase plasminogen activator receptor (uPAR) expression is reduced by tyrosine kinase inhibitors.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20060401

Title: EGFR signaling pathway negatively regulates PSA expression and secretion via the PI3K-Akt pathway in LNCaP prostate cancer cells.

Journal: Biochemical and biophysical research communications 20060331

Title: Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.

Journal: Biochemical and biophysical research communications 20060310

Title: A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling.

Journal: Cancer research 20060301

Title: Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20060301

Title: Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.

Journal: Experimental cell research 20060215

Title: Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa.

Journal: Molecular reproduction and development 20060201

Title: Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure.

Journal: Endocrinology 20060201

Title: Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro.

Journal: British journal of pharmacology 20060201

Title: Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat.

Journal: Digestive diseases and sciences 20060201

Title: Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.

Journal: FEBS letters 20060123

Title: Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.

Journal: Journal of cellular physiology 20060101

Title: Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.

Journal: Journal of biomedical science 20060101

Title: Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.

Journal: Cancer research 20060101

Title: The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20060101

Title: Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC).

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Title: Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion.

Journal: Anticancer research 20060101

Title: [Oxidized glutathione induces activation of the epidermal growth factor receptor and MAP kinases ERK 1,2].

Journal: Tsitologiia 20060101

Title: Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways.

Journal: Experimental lung research 20060101

Title: Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.

Journal: Cancer chemotherapy and pharmacology 20051201

Title: PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis.

Journal: Biochemical and biophysical research communications 20051104

Title: Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.

Journal: Digestive diseases and sciences 20051101

Title: Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.

Journal: Cancer research 20051015

Title: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.

Journal: Science (New York, N.Y.) 20051007

Title: Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.

Journal: American journal of respiratory cell and molecular biology 20051001

Title: Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces.

Journal: Toxicology and applied pharmacology 20051001

Title: Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

Title: beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

Journal: The Journal of biological chemistry 20050916

Title: Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells.

Journal: Endocrinology 20050901

Title: Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells.

Journal: International journal of oncology 20050901

Title: EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.

Journal: Molecular reproduction and development 20050801

Title: Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.

Journal: Circulation 20050719

Title: Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.

Journal: Analytical biochemistry 20050715

Title: Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.

Journal: Journal of cellular physiology 20050701

Title: EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.

Journal: American journal of physiology. Heart and circulatory physiology 20050701

Title: Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.

Journal: Molecular pharmacology 20050701

Title: Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed.

Journal: British journal of pharmacology 20050701

Title: A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.

Journal: Experimental cell research 20050701

Title: Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.

Journal: Investigative ophthalmology & visual science 20050601

Title: Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.

Journal: Investigative ophthalmology & visual science 20050601

Title: DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.

Journal: Molecular and cellular biology 20050601

Title: PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.

Journal: Experimental oncology 20050601

Title: Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.

Journal: Journal of neurochemistry 20050501

Title: Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.

Journal: Cancer research 20050501

Title: Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.

Journal: Breast cancer research and treatment 20050501

Title: Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.

Journal: Oral oncology 20050501

Title: Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20050501

Title: The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery.

Journal: Autonomic & autacoid pharmacology 20050401

Title: Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.

Journal: The Journal of biological chemistry 20050304

Title: Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells.

Journal: Biological chemistry 20050301

Title: Amphiregulin acts as an autocrine survival factor for adult sensory neurons.

Journal: Neuroreport 20050227

Title: Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

Journal: American journal of respiratory and critical care medicine 20050215

Title: Growth of intestinal epithelium in organ culture is dependent on EGF signalling.

Journal: Experimental cell research 20050215

Title: Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.

Journal: Cancer research 20050215

Title: Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.

Journal: The Journal of biological chemistry 20050128

Title: Epidermal growth factor family members: endogenous mediators of the ovulatory response.

Journal: Endocrinology 20050101

Title: Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.

Journal: International journal of radiation oncology, biology, physics 20050101

Title: [Effect of tyrosine kinase inhibitors on airway remodeling in bronchial asthma].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050101

Title: Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.

Journal: BMC cancer 20050101

Title: The effects of S-phase kinase-associated protein 2 (SKP2) on cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells.

Journal: Experimental lung research 20041201

Title: Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.

Journal: Circulation research 20041112

Title: Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells.

Journal: Endocrinology 20041101

Title: Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.

Journal: Molecular endocrinology (Baltimore, Md.) 20041101

Title: Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production.

Journal: Toxicology and applied pharmacology 20041101

Title: Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells.

Journal: Journal of hepatology 20041101

Title: Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes.

Journal: The Journal of biological chemistry 20041029

Title: Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells.

Journal: The Journal of biological chemistry 20041015

Title: Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.

Journal: Oncogene 20041014

Title: Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.

Journal: FEBS letters 20041008

Title: Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.

Journal: Molecular and cellular endocrinology 20040930

Title: Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve.

Journal: Developmental biology 20040915

Title: Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae.

Journal: Oncogene 20040909

Title: The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth.

Journal: Human reproduction (Oxford, England) 20040901

Title: Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor.

Journal: Journal of cellular physiology 20040901

Title: L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040901

Title: Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040901

Title: Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.

Journal: Regulatory peptides 20040815

Title: Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.

Journal: Molecular pharmacology 20040801

Title: The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human keratinocytes.

Journal: Journal of molecular medicine (Berlin, Germany) 20040801

Title: Activation of epidermal growth factor receptor via CCR3 in bronchial epithelial cells.

Journal: Biochemical and biophysical research communications 20040723

Title: Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism.

Journal: Biochemical and biophysical research communications 20040723

Title: The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells.

Journal: Thrombosis and haemostasis 20040701

Title: Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas.

Journal: Neuro-oncology 20040701

Title: The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

Journal: The Journal of biological chemistry 20040625

Title: Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.

Journal: Biochemical and biophysical research communications 20040611

Title: Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.

Journal: British journal of pharmacology 20040601

Title: Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry 20040514

Title: Synthesis and biological evaluation of benzamides and benzamidines: structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.

Journal: Circulation research 20040430

Title: gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.

Journal: Circulation 20040413

Title: Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20040401

Title: Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.

Journal: Molecular cancer therapeutics 20040401

Title: UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide.

Journal: The Journal of biological chemistry 20040305

Title: Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death.

Journal: Cancer research 20040301

Title: Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.

Journal: The Journal of biological chemistry 20040220

Title: Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos.

Journal: Oncogene 20040122

Title: Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20040101

Title: Salicylanilides as inhibitors of the protein tyrosine kinase epidermal growth factor receptor.

Journal: European journal of medicinal chemistry 20040101

Title: Selective inhibition of survival signal transduction pathways enhanced radiosensitivity in human esophageal cancer cell lines in vitro.

Journal: Anticancer research 20040101

Title: Biglycan is internalized via a chlorpromazine-sensitive route.

Journal: Cellular & molecular biology letters 20040101

Title: Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.

Journal: Annals of clinical and laboratory science 20040101

Title: Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.

Journal: The Journal of biological chemistry 20031226

Title: Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

Journal: The Journal of biological chemistry 20031226

Title: Synthesis of a prodrug designed to release multiple inhibitors of the epidermal growth factor receptor tyrosine kinase and an alkylating agent: a novel tumor targeting concept.

Journal: Journal of medicinal chemistry 20031204

Title: Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.

Journal: Cellular signalling 20031201

Title: Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes.

Journal: The British journal of dermatology 20031201

Title: Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.

Journal: Cancer research 20031015

Title: Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.

Journal: American journal of physiology. Lung cellular and molecular physiology 20031001

Title: Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.

Journal: Experimental cell research 20031001

Title: Expression of ErbB receptors in ES cell-derived cardiomyocytes.

Journal: Biochemical and biophysical research communications 20030912

Title: Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains.

Journal: Oncogene 20030904

Title: EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.

Journal: Oncogene 20030904

Title: Activation of ERK1/2 by platelet-activating factor receptor is independent of receptor internalisation and G-protein activation.

Journal: Cellular signalling 20030901

Title: Epidermal growth factor receptor regulates normal urothelial regeneration.

Journal: Laboratory investigation; a journal of technical methods and pathology 20030901

Title: Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030801

Title: Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.

Journal: Molecular endocrinology (Baltimore, Md.) 20030801

Title: Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.

Journal: Molecular pharmacology 20030801

Title: Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation.

Journal: Brain research 20030718

Title: Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.

Journal: Mechanisms of development 20030701

Title: Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes.

Journal: Journal of cellular biochemistry 20030601

Title: Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.

Journal: Investigative ophthalmology & visual science 20030601

Title: Inhibitors that target protein kinases for the treatment of ovarian carcinoma.

Journal: American journal of obstetrics and gynecology 20030501

Title: Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

Title: Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.

Journal: Journal of cellular physiology 20030301

Title: Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.

Journal: Investigative ophthalmology & visual science 20030301

Title: P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.

Journal: Investigative ophthalmology & visual science 20030301

Title: Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

Title: Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines.

Journal: Methods in molecular medicine 20030101

Title: Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.

Journal: Cell and tissue research 20030101

Title: [Effect of EGF on the intracellular distribution of heat-shock proteins in A431 cells].

Journal: Tsitologiia 20030101

Title: Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor.

Journal: The Journal of biological chemistry 20021220

Title: Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Epidermal growth factor.

Journal: Science's STKE : signal transduction knowledge environment 20021203

Title: ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.

Journal: American journal of physiology. Heart and circulatory physiology 20021201

Title: Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.

Journal: American journal of respiratory cell and molecular biology 20021201

Title: Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury.

Journal: American journal of physiology. Cell physiology 20021101

Title: Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Angiotensin II triggers EGFR tyrosine kinase-dependent Ca2+ influx in afferent arterioles.

Journal: Hypertension (Dallas, Tex. : 1979) 20021101

Title: Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.

Journal: Cancer research 20021101

Title: Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.

Journal: Cancer research 20021101

Title: 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.

Journal: Toxicology and applied pharmacology 20021101

Title: Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20021001

Title: Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20021001

Title: Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20021001

Title: Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function.

Journal: International journal of cancer 20020910

Title: Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.

Journal: The Journal of biological chemistry 20020830

Title: A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression.

Journal: Cancer research 20020801

Title: The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner.

Journal: Cancer research 20020801

Title: Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Journal: Cancer research 20020615

Title: Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor.

Journal: American journal of physiology. Cell physiology 20020601

Title: Inhibitory effect and its kinetic analysis of tyrphostin AG1478 on recombinant human protein kinase CK2 holoenzyme.

Journal: Acta pharmacologica Sinica 20020601

Title: Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes.

Journal: The Journal of endocrinology 20020601

Title: EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.

Journal: Cancer cell 20020601

Title: alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry 20020531

Title: Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.

Journal: FEBS letters 20020424

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes.

Journal: Molecular endocrinology (Baltimore, Md.) 20020301

Title: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.

Journal: Nature medicine 20020301

Title: Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.

Journal: The Journal of biological chemistry 20020222

Title: Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

Journal: Cardiovascular research 20020201

Title: TGF-alpha-driven tumor growth is inhibited by an EGF receptor tyrosine kinase inhibitor.

Journal: Biochemical and biophysical research communications 20020111

Title: CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity.

Journal: Brain pathology (Zurich, Switzerland) 20020101

Title: Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

Journal: Cancer research 20020101

Title: Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215

Title: Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.

Journal: The Journal of biological chemistry 20011214

Title: Arterial epidermal growth factor receptor expression in deoxycorticosterone acetate-salt hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20011201

Title: Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.

Journal: DNA and cell biology 20011201

Title: Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.

Journal: Journal of the American College of Cardiology 20011101

Title: EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.

Journal: American journal of physiology. Cell physiology 20010901

Title: Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.

Journal: Investigative ophthalmology & visual science 20010901

Title: Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor.

Journal: Journal of neurosurgery 20010901

Title: Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010801

Title: Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.

Journal: European journal of biochemistry 20010801

Title: Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.

Journal: Cancer research 20010715

Title: Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010701

Title: Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse.

Journal: Nature 20010517

Title: c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry 20010511

Title: Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.

Journal: Cancer research 20010415

Title: High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010415

Title: Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.

Journal: British journal of cancer 20010401

Title: Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway.

Journal: British journal of pharmacology 20010401

Title: The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.

Journal: Oncogene 20010315

Title: Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.

Journal: International journal of molecular medicine 20010301

Title: BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.

Journal: Biochemical and biophysical research communications 20010216

Title: STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.

Journal: Blood 20010215

Title: Activation of extracellular-regulated kinases by normal and mutant EGF receptors.

Journal: Biochimica et biophysica acta 20010205

Title: N-acetylcysteine inhibits angiotensin ii-mediated activation of extracellular signal-regulated kinase and epidermal growth factor receptor.

Journal: Biochemical and biophysical research communications 20010202

Title: Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor: a mitogen for lung fibroblasts.

Journal: American journal of respiratory cell and molecular biology 20010201

Title: Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin II.

Journal: Hypertension (Dallas, Tex. : 1979) 20010201

Title: Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation.

Journal: Circulation research 20010119

Title: Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.

Journal: Bioorganic & medicinal chemistry letters 20010108

Title: Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.

Journal: Cancer letters 20010101

Title: Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.

Journal: Journal of cellular biochemistry 20010101

Title: Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.

Journal: Cancer journal (Sudbury, Mass.) 20010101

Title: Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20000201

Title: Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.

Journal: Journal of medicinal chemistry 19990325

Title: Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.

Journal: Molecular and cellular biology 19980901

Title: Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Journal: Journal of medicinal chemistry 19960105

Title: G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.

Journal: Molecular endocrinology (Baltimore, Md.)

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Tags:175178-82-2 Molecular Formula|175178-82-2 MDL|175178-82-2 SMILES|175178-82-2 AG 1478
Catalog No.: AA00AOYW
175178-82-2,MFCD00270914
175178-82-2 | AG 1478
Pack Size: 1mg
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Technical Information
Catalog Number: AA00AOYW
Chemical Name: AG 1478
CAS Number: 175178-82-2
Molecular Formula: C17H15ClN2O2
Molecular Weight: 314.7662
MDL Number: MFCD00270914
SMILES: COc1cc2c(ncnc2cc1OC)Cc1cccc(c1)Cl
NSC Number: 693255
Properties
Complexity: 360  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4  
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Title: Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin.

Journal: Archives of toxicology20121201

Title: EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.

Journal: Molecular and cellular biochemistry20121101

Title: The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress.

Journal: Free radical research20121101

Title: Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.

Journal: Archives of toxicology20121001

Title: Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.

Journal: Arthritis and rheumatism20121001

Title: Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.

Journal: Toxicon : official journal of the International Society on Toxinology20121001

Title: A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.

Journal: Biology of reproduction20121001

Title: Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer.

Journal: Oncogene20120913

Title: Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.

Journal: Life sciences20120904

Title: Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.

Journal: Archives of biochemistry and biophysics20120901

Title: GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes.

Journal: The Journal of biological chemistry20120803

Title: Regulated intramembrane cleavage of the EGF receptor.

Journal: Traffic (Copenhagen, Denmark)20120801

Title: Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20120801

Title: Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.

Journal: Environmental health perspectives20120801

Title: A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.

Journal: Journal of biomolecular screening20120801

Title: The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction.

Journal: Canadian journal of physiology and pharmacology20120801

Title: Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer.

Journal: International journal of radiation oncology, biology, physics20120701

Title: A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus.

Journal: Hypertension (Dallas, Tex. : 1979)20120701

Title: Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.

Journal: The Journal of allergy and clinical immunology20120501

Title: Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1.

Journal: The Journal of biological chemistry20120427

Title: Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.

Journal: ChemMedChem20120401

Title: Angiotensin AT1 receptor blockers suppress oxidized low-density lipoprotein-derived formation of foam cells.

Journal: European journal of pharmacology20120315

Title: Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway.

Journal: British journal of pharmacology20120301

Title: Ovarian expression and regulation of the stromelysins during the periovulatory period in the human and the rat.

Journal: Biology of reproduction20120301

Title: ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.

Journal: Biochemical and biophysical research communications20120203

Title: Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20120201

Title: Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.

Journal: Phytotherapy research : PTR20120101

Title: Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells.

Journal: Molecular medicine reports20120101

Title: Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin.

Journal: Archives of virology20120101

Title: EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.

Journal: Cellular signalling20120101

Title: An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs.

Journal: PloS one20120101

Title: The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.

Journal: Mediators of inflammation20120101

Title: Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.

Journal: PloS one20120101

Title: Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.

Journal: Nature neuroscience20111211

Title: Permissive effect of EGFR-activated pathways on RVI and their anti-apoptotic effect in hypertonicity-exposed mIMCD3 cells.

Journal: Bioscience reports20111201

Title: Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury.

Journal: Journal of hepatology20111201

Title: Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α.

Journal: Environmental health perspectives20111201

Title: The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

Journal: Biochemical pharmacology20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.

Journal: Molecules and cells20111031

Title: Angiogenic effect induced by mineral fibres.

Journal: Toxicology20111009

Title: Bile acids promote HCV replication through the EGFR/ERK pathway in replicon-harboring cells.

Journal: Intervirology20111001

Title: Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.

Journal: Experimental cell research20111001

Title: The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.

Journal: Molecular carcinogenesis20111001

Title: ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.

Journal: Stem cells (Dayton, Ohio)20111001

Title: Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.

Journal: Experimental lung research20111001

Title: Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.

Journal: Nature medicine20111001

Title: ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478.

Journal: Lung cancer (Amsterdam, Netherlands)20110901

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

Journal: American journal of respiratory cell and molecular biology20110801

Title: Epithelial growth factor receptor tyrosine kinase inhibitor prevents infiltration and cerebrospinal fluid dissemination in malignant glioma: an experimental study.

Journal: Neurosurgery20110801

Title: EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.

Journal: British journal of cancer20110726

Title: Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment.

Journal: Journal of natural products20110722

Title: Nanospheres delivering the EGFR TKI AG1478 promote optic nerve regeneration: the role of size for intraocular drug delivery.

Journal: ACS nano20110628

Title: Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.

Journal: Experimental cell research20110610

Title: The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin.

Journal: Molecular carcinogenesis20110601

Title: Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.

Journal: Biochimica et biophysica acta20110601

Title: GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary.

Journal: Molecular endocrinology (Baltimore, Md.)20110601

Title: Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.

Journal: Molecular reproduction and development20110601

Title: Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.

Journal: The Journal of clinical investigation20110601

Title: Expression and regulation of amphiregulin in Gsα-mutated human bone marrow stromal cells of fibrous dysplasia of mandible.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics20110501

Title: Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration by hexachlorobenzene in MDA-MB-231 human breast cancer cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20110401

Title: Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30.

Journal: Hypertension (Dallas, Tex. : 1979)20110401

Title: Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.

Journal: European journal of pharmacology20110305

Title: Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.

Journal: The Journal of surgical research20110301

Title: Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism.

Journal: Molecular pharmacology20110201

Title: Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology20110201

Title: Reactive oxygen species are indispensable in ovulation.

Journal: Proceedings of the National Academy of Sciences of the United States of America20110125

Title: Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells.

Journal: Toxicology20110111

Title: Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells.

Journal: Environmental pollution (Barking, Essex : 1987)20110101

Title: Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.

Journal: Toxicology and applied pharmacology20110101

Title: Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.

Journal: Microvascular research20110101

Title: Down-regulation of CYLD as a trigger for NF-κB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells.

Journal: International journal of oncology20110101

Title: EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.

Journal: PloS one20110101

Title: Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.

Journal: BMC cancer20110101

Title: Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.

Journal: PloS one20110101

Title: The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways.

Journal: The Journal of biological chemistry20101217

Title: Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives.

Journal: Journal of medicinal chemistry20101125

Title: Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides.

Journal: The Journal of biological chemistry20101112

Title: Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.

Journal: Neurochemistry international20101101

Title: Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.

Journal: Neurochemistry international20101101

Title: Heparin-binding EGF-like factor augments esophageal epithelial cell proliferation, migration and inhibits TRAIL-mediated apoptosis via EGFR/MAPK signaling.

Journal: Scandinavian journal of gastroenterology20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer20101101

Title: α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor.

Journal: British journal of pharmacology20101101

Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

Journal: Journal of medicinal chemistry20100923

Title: Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.

Journal: The Journal of pharmacology and experimental therapeutics20100901

Title: Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.

Journal: Experimental eye research20100901

Title: Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.

Journal: Cancer research20100901

Title: Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.

Journal: Cancer letters20100828

Title: 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.

Journal: Toxicology letters20100816

Title: Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.

Journal: Developmental biology20100815

Title: ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK.

Journal: Chemico-biological interactions20100730

Title: Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1.

Journal: Thrombosis research20100701

Title: [Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20100701

Title: Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.

Journal: Nature medicine20100601

Title: The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.

Journal: Journal of endodontics20100601

Title: Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway.

Journal: Toxicology and applied pharmacology20100515

Title: Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells.

Journal: Journal of neuro-oncology20100501

Title: New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres.

Journal: Journal of microencapsulation20100501

Title: Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation.

Journal: Molecular carcinogenesis20100401

Title: Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.

Journal: American journal of physiology. Lung cellular and molecular physiology20100401

Title: RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries.

Journal: Molecular endocrinology (Baltimore, Md.)20100401

Title: Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells.

Journal: Biochemical pharmacology20100301

Title: Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry20100301

Title: c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.

Journal: Oncogene20100218

Title: The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.

Journal: Stem cells (Dayton, Ohio)20100201

Title: Effect of urotensin II on PC12 rat pheochromocytoma cells.

Journal: Journal of neuroendocrinology20100201

Title: [Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics20100201

Title: Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors.

Journal: The Journal of biological chemistry20100129

Title: Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-).

Journal: Toxicology and applied pharmacology20100115

Title: Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern.

Journal: Developmental biology20100115

Title: Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.

Journal: The Journal of pharmacology and experimental therapeutics20100101

Title: Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.

Journal: The Journal of steroid biochemistry and molecular biology20100101

Title: JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology20100101

Title: Cross-talk between bradykinin and epidermal growth factor in regulating IL-6 production in human airway smooth muscle cells.

Journal: Chang Gung medical journal20100101

Title: EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.

Journal: Journal of experimental therapeutics & oncology20100101

Title: Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells.

Journal: Cell biology international20091216

Title: Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium.

Journal: American journal of respiratory cell and molecular biology20091201

Title: ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.

Journal: Neurochemistry international20091201

Title: Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor.

Journal: Molecular pharmacology20091201

Title: Contribution of epidermal growth factor receptor transactivation in angiotensin II-induced enhanced expression of Gi protein and proliferation in A10 vascular smooth muscle cells.

Journal: Canadian journal of physiology and pharmacology20091201

Title: Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long-term hypoxia.

Journal: High altitude medicine & biology20091201

Title: Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.

Journal: FEBS letters20091119

Title: Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.

Journal: Cancer letters20091118

Title: Role of epidermal growth factor receptor (EGFR) in corneal remodelling in diabetes.

Journal: Acta ophthalmologica20091101

Title: Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation.

Journal: Microbiology (Reading, England)20091101

Title: Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

Journal: American journal of respiratory and critical care medicine20091101

Title: Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.

Journal: Psychopharmacology20091101

Title: Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.

Journal: Stem cells (Dayton, Ohio)20091101

Title: Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth.

Journal: Brain : a journal of neurology20091101

Title: Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.

Journal: Neurobiology of disease20091001

Title: Effects of cigarette smoking on mucin production in human middle ear epithelial cells.

Journal: International journal of pediatric otorhinolaryngology20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Desmoid cell motility is induced in vitro by rhEGF.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society20090901

Title: Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor.

Journal: Hepatology (Baltimore, Md.)20090901

Title: EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.

Journal: American journal of physiology. Renal physiology20090901

Title: Pleiotropic effects of cadmium in mesangial cells.

Journal: Toxicology and applied pharmacology20090801

Title: Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells.

Journal: Endocrinology20090801

Title: Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells.

Journal: Toxicology20090710

Title: Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20090601

Title: A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.

Journal: Circulation research20090508

Title: Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.

Journal: Journal of vascular surgery20090501

Title: Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.

Journal: Journal of vascular surgery20090501

Title: Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle.

Journal: European journal of pharmacology20090315

Title: p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.

Journal: Circulation research20090313

Title: Rapamycin induces transactivation of the EGFR and increases cell survival.

Journal: Oncogene20090305

Title: Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.

Journal: Neuroreport20090304

Title: Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.

Journal: Biochemical pharmacology20090301

Title: Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.

Journal: Toxicology and applied pharmacology20090301

Title: Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor.

Journal: Cancer science20090301

Title: Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.

Journal: Toxicology letters20090210

Title: The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

Journal: Biochimica et biophysica acta20090201

Title: The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.

Journal: Oncology reports20090201

Title: Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells.

Journal: Zoological science20090201

Title: Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.

Journal: Journal of periodontal research20090201

Title: TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.

Journal: Breast cancer research and treatment20090101

Title: Arsenite suppresses Notch1 signaling in human keratinocytes.

Journal: The Journal of investigative dermatology20090101

Title: Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.

Journal: The Prostate20090101

Title: Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?

Journal: The American journal of gastroenterology20090101

Title: Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis.

Journal: Vascular pharmacology20090101

Title: [Effects of theaflavins on the signal transduction pathway of epidermal growth factor receptor in airway mucous hypersecretion].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases20090101

Title: [Analysis of tyrphostin AG1478 effect on behavior of internalized EGF receptor at different stages of endocytosis].

Journal: Tsitologiia20090101

Title: Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.

Journal: Experimental & molecular medicine20081231

Title: Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.

Journal: Psychopharmacology20081201

Title: Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases.

Journal: Cellular signalling20081201

Title: Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.

Journal: Translational research : the journal of laboratory and clinical medicine20081201

Title: c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.

Journal: World journal of gastroenterology20081107

Title: The epidermal growth factor receptor mediates allergic airway remodelling in the rat.

Journal: The European respiratory journal20081101

Title: The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.

Journal: The Journal of biological chemistry20081010

Title: Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

Journal: Proceedings of the National Academy of Sciences of the United States of America20080923

Title: DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies.

Journal: Cancer research20080915

Title: Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor.

Journal: Molecular pharmacology20080901

Title: EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.

Journal: American journal of physiology. Lung cellular and molecular physiology20080901

Title: Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology20080901

Title: In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.

Journal: Digestive diseases and sciences20080801

Title: Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.

Journal: American journal of physiology. Cell physiology20080801

Title: Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.

Journal: Surgery20080801

Title: Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.

Journal: Molecular nutrition & food research20080701

Title: Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.

Journal: European journal of pharmacology20080610

Title: Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.

Journal: Pflugers Archiv : European journal of physiology20080601

Title: Role for inhibitor of differentiation/deoxyribonucleic acid-binding (Id) proteins in granulosa cell differentiation.

Journal: Endocrinology20080601

Title: MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology20080601

Title: Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion.

Journal: Biochemical pharmacology20080515

Title: PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.

Journal: Domestic animal endocrinology20080501

Title: Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.

Journal: Molecular pharmacology20080501

Title: Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice.

Journal: Toxicology and applied pharmacology20080501

Title: Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.

Journal: The Journal of endocrinology20080501

Title: Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.

Journal: Microvascular research20080501

Title: Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.

Journal: The Journal of biological chemistry20080418

Title: Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.

Journal: Toxicology and applied pharmacology20080415

Title: Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells.

Journal: Oral oncology20080401

Title: Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

Journal: American journal of respiratory cell and molecular biology20080401

Title: Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.

Journal: Molecular endocrinology (Baltimore, Md.)20080401

Title: Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma.

Journal: Bulletin of experimental biology and medicine20080401

Title: Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells.

Journal: American journal of physiology. Renal physiology20080301

Title: EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines.

Journal: Pathology oncology research : POR20080301

Title: Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.

Journal: Journal of neuroscience research20080215

Title: Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.

Journal: Journal of cellular physiology20080201

Title: Thrombin increases hyposmotic taurine efflux and accelerates ICI-swell and RVD in 3T3 fibroblasts by a src-dependent EGFR transactivation.

Journal: Pflugers Archiv : European journal of physiology20080201

Title: Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20080201

Title: Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.

Journal: The Journal of biological chemistry20080104

Title: EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes.

Journal: Molecular reproduction and development20080101

Title: Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.

Journal: The Journal of pharmacology and experimental therapeutics20080101

Title: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance.

Journal: Anticancer research20080101

Title: Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.

Journal: Journal of receptor and signal transduction research20080101

Title: HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.

Journal: PloS one20080101

Title: A role for SNX5 in the regulation of macropinocytosis.

Journal: BMC cell biology20080101

Title: Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice.

Journal: Diabetes/metabolism research and reviews20080101

Title: Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.

Journal: British journal of biomedical science20080101

Title: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.

Journal: Cellular signalling20071201

Title: The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.

Journal: Cancer research20071201

Title: Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.

Journal: European journal of pharmacology20071114

Title: Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

Journal: The Journal of biological chemistry20071102

Title: Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.

Journal: Biochimica et biophysica acta20071101

Title: The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.

Journal: Cancer research20071101

Title: Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.

Journal: American journal of physiology. Lung cellular and molecular physiology20071001

Title: Lysophosphatidic acid decreases epidermal growth factor receptor binding in airway epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics20071001

Title: Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes.

Journal: American journal of physiology. Heart and circulatory physiology20070901

Title: Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology20070901

Title: Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility.

Journal: Asian journal of andrology20070901

Title: Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

Journal: Cancer research20070901

Title: Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.

Journal: The Biochemical journal20070715

Title: Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.

Journal: The Journal of physiology20070715

Title: Epiregulin promotes proliferation and migration of renal proximal tubular cells.

Journal: American journal of physiology. Renal physiology20070701

Title: Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.

Journal: Endocrinology20070701

Title: Depolarization-induced, glutamate receptor-mediated, and transactivation-dependent extracellular-signal regulated kinase phosphorylation in cultured cerebellar granule neurons.

Journal: Neuroscience20070629

Title: Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.

Journal: Journal of cellular physiology20070601

Title: Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.

Journal: American journal of physiology. Lung cellular and molecular physiology20070601

Title: The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.

Journal: Neuron20070524

Title: Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.

Journal: Toxicology and applied pharmacology20070515

Title: ERK-dependent and -independent pathways trigger human neural progenitor cell migration.

Journal: Toxicology and applied pharmacology20070515

Title: Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells.

Journal: Endocrinology20070501

Title: Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.

Journal: Cancer science20070501

Title: The control of tissue architecture over nuclear organization is crucial for epithelial cell fate.

Journal: Journal of cell science20070501

Title: Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.

Journal: Journal of pharmacological sciences20070401

Title: Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1.

Journal: Chest20070401

Title: Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.

Journal: Life sciences20070320

Title: EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.

Journal: American journal of respiratory cell and molecular biology20070301

Title: Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.

Journal: American journal of physiology. Renal physiology20070301

Title: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.

Journal: The Journal of biological chemistry20070202

Title: Signaling of mitochondrial biogenesis following oxidant injury.

Journal: The Journal of biological chemistry20070126

Title: Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence.

Journal: Experimental cell research20070115

Title: Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production.

Journal: Toxicology and applied pharmacology20070115

Title: Histone deacetylase inhibitors in combinations: will the preclinical promises be kept?

Journal: Cancer journal (Sudbury, Mass.)20070101

Title: Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.

Journal: Cancer journal (Sudbury, Mass.)20070101

Title: Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.

Journal: The international journal of biochemistry & cell biology20070101

Title: Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line.

Journal: The Journal of steroid biochemistry and molecular biology20070101

Title: Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.

Journal: The Journal of biological chemistry20061208

Title: Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.

Journal: Endocrine-related cancer20061201

Title: EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.

Journal: Oncogene20061019

Title: NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.

Journal: International journal of cancer20061001

Title: GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.

Journal: Molecular reproduction and development20061001

Title: Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.

Journal: Leukemia20061001

Title: Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.

Journal: FEBS letters20060904

Title: Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells.

Journal: The Journal of pharmacology and experimental therapeutics20060901

Title: Gefitinib prevents bleomycin-induced lung fibrosis in mice.

Journal: American journal of respiratory and critical care medicine20060901

Title: Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.

Journal: Toxicology letters20060820

Title: Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.

Journal: European journal of pharmacology20060807

Title: STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.

Journal: Kidney international20060801

Title: Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.

Journal: American journal of physiology. Lung cellular and molecular physiology20060701

Title: Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).

Journal: Endocrinology20060701

Title: Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.

Journal: International journal of oncology20060701

Title: [Involvement of epidermal growth factor receptor signaling pathway in tamoxifen resistance of MCF-7 cells].

Journal: Ai zheng = Aizheng = Chinese journal of cancer20060701

Title: Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells.

Journal: Canadian journal of physiology and pharmacology20060701

Title: Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.

Journal: Life sciences20060522

Title: Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

Journal: Biochemical pharmacology20060514

Title: Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor.

Journal: The Journal of surgical research20060501

Title: Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy.

Journal: Journal of molecular and cellular cardiology20060501

Title: Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20060501

Title: Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.

Journal: Kidney international20060501

Title: Transcription levels of invasion-related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica20060501

Title: HER2 expression as a potential marker for response to therapy targeted to the EGFR.

Journal: British journal of cancer20060424

Title: Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E.

Journal: Pflugers Archiv : European journal of physiology20060401

Title: Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway.

Journal: Endocrinology20060401

Title: Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts.

Journal: Molecular pharmacology20060401

Title: Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species.

Journal: Arteriosclerosis, thrombosis, and vascular biology20060401

Title: PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.

Journal: Oncology reports20060401

Title: Urokinase plasminogen activator receptor (uPAR) expression is reduced by tyrosine kinase inhibitors.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica20060401

Title: EGFR signaling pathway negatively regulates PSA expression and secretion via the PI3K-Akt pathway in LNCaP prostate cancer cells.

Journal: Biochemical and biophysical research communications20060331

Title: Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.

Journal: Biochemical and biophysical research communications20060310

Title: A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling.

Journal: Cancer research20060301

Title: Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica20060301

Title: Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.

Journal: Experimental cell research20060215

Title: Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa.

Journal: Molecular reproduction and development20060201

Title: Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure.

Journal: Endocrinology20060201

Title: Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro.

Journal: British journal of pharmacology20060201

Title: Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat.

Journal: Digestive diseases and sciences20060201

Title: Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.

Journal: FEBS letters20060123

Title: Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.

Journal: Journal of cellular physiology20060101

Title: Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.

Journal: Journal of biomedical science20060101

Title: Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.

Journal: Cancer research20060101

Title: The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica20060101

Title: Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC).

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20060101

Title: Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion.

Journal: Anticancer research20060101

Title: [Oxidized glutathione induces activation of the epidermal growth factor receptor and MAP kinases ERK 1,2].

Journal: Tsitologiia20060101

Title: Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways.

Journal: Experimental lung research20060101

Title: Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.

Journal: Cancer chemotherapy and pharmacology20051201

Title: PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis.

Journal: Biochemical and biophysical research communications20051104

Title: Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.

Journal: Digestive diseases and sciences20051101

Title: Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.

Journal: Cancer research20051015

Title: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.

Journal: Science (New York, N.Y.)20051007

Title: Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.

Journal: American journal of respiratory cell and molecular biology20051001

Title: Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces.

Journal: Toxicology and applied pharmacology20051001

Title: Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20051001

Title: beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

Journal: The Journal of biological chemistry20050916

Title: Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells.

Journal: Endocrinology20050901

Title: Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells.

Journal: International journal of oncology20050901

Title: EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.

Journal: Molecular reproduction and development20050801

Title: Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.

Journal: Circulation20050719

Title: Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.

Journal: Analytical biochemistry20050715

Title: Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.

Journal: Journal of cellular physiology20050701

Title: EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.

Journal: American journal of physiology. Heart and circulatory physiology20050701

Title: Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.

Journal: Molecular pharmacology20050701

Title: Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed.

Journal: British journal of pharmacology20050701

Title: A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.

Journal: Experimental cell research20050701

Title: Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.

Journal: Investigative ophthalmology & visual science20050601

Title: Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.

Journal: Investigative ophthalmology & visual science20050601

Title: DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.

Journal: Molecular and cellular biology20050601

Title: PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.

Journal: Experimental oncology20050601

Title: Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.

Journal: Journal of neurochemistry20050501

Title: Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.

Journal: Cancer research20050501

Title: Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.

Journal: Breast cancer research and treatment20050501

Title: Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.

Journal: Oral oncology20050501

Title: Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica20050501

Title: The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery.

Journal: Autonomic & autacoid pharmacology20050401

Title: Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.

Journal: The Journal of biological chemistry20050304

Title: Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts.

Journal: The Journal of pharmacology and experimental therapeutics20050301

Title: Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells.

Journal: Biological chemistry20050301

Title: Amphiregulin acts as an autocrine survival factor for adult sensory neurons.

Journal: Neuroreport20050227

Title: Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

Journal: American journal of respiratory and critical care medicine20050215

Title: Growth of intestinal epithelium in organ culture is dependent on EGF signalling.

Journal: Experimental cell research20050215

Title: Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.

Journal: Cancer research20050215

Title: Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.

Journal: The Journal of biological chemistry20050128

Title: Epidermal growth factor family members: endogenous mediators of the ovulatory response.

Journal: Endocrinology20050101

Title: Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.

Journal: International journal of radiation oncology, biology, physics20050101

Title: [Effect of tyrosine kinase inhibitors on airway remodeling in bronchial asthma].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20050101

Title: Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.

Journal: BMC cancer20050101

Title: The effects of S-phase kinase-associated protein 2 (SKP2) on cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells.

Journal: Experimental lung research20041201

Title: Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.

Journal: Circulation research20041112

Title: Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells.

Journal: Endocrinology20041101

Title: Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.

Journal: Molecular endocrinology (Baltimore, Md.)20041101

Title: Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.

Journal: Bioorganic & medicinal chemistry letters20041101

Title: Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production.

Journal: Toxicology and applied pharmacology20041101

Title: Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells.

Journal: Journal of hepatology20041101

Title: Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.

Journal: Journal of cardiovascular pharmacology20041101

Title: Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes.

Journal: The Journal of biological chemistry20041029

Title: Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells.

Journal: The Journal of biological chemistry20041015

Title: Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.

Journal: Oncogene20041014

Title: Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.

Journal: FEBS letters20041008

Title: Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.

Journal: Molecular and cellular endocrinology20040930

Title: Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve.

Journal: Developmental biology20040915

Title: Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae.

Journal: Oncogene20040909

Title: The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth.

Journal: Human reproduction (Oxford, England)20040901

Title: Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor.

Journal: Journal of cellular physiology20040901

Title: L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer.

Journal: American journal of physiology. Gastrointestinal and liver physiology20040901

Title: Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040901

Title: Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.

Journal: Regulatory peptides20040815

Title: Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.

Journal: Molecular pharmacology20040801

Title: The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human keratinocytes.

Journal: Journal of molecular medicine (Berlin, Germany)20040801

Title: Activation of epidermal growth factor receptor via CCR3 in bronchial epithelial cells.

Journal: Biochemical and biophysical research communications20040723

Title: Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism.

Journal: Biochemical and biophysical research communications20040723

Title: The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells.

Journal: Thrombosis and haemostasis20040701

Title: Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas.

Journal: Neuro-oncology20040701

Title: The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

Journal: The Journal of biological chemistry20040625

Title: Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.

Journal: Biochemical and biophysical research communications20040611

Title: Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.

Journal: British journal of pharmacology20040601

Title: Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry20040514

Title: Synthesis and biological evaluation of benzamides and benzamidines: structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase.

Journal: Bioorganic & medicinal chemistry letters20040503

Title: Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.

Journal: Circulation research20040430

Title: gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.

Journal: Circulation20040413

Title: Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology20040401

Title: Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.

Journal: Molecular cancer therapeutics20040401

Title: UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide.

Journal: The Journal of biological chemistry20040305

Title: Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death.

Journal: Cancer research20040301

Title: Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.

Journal: The Journal of biological chemistry20040220

Title: Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos.

Journal: Oncogene20040122

Title: Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.

Journal: The Journal of pharmacology and experimental therapeutics20040101

Title: Salicylanilides as inhibitors of the protein tyrosine kinase epidermal growth factor receptor.

Journal: European journal of medicinal chemistry20040101

Title: Selective inhibition of survival signal transduction pathways enhanced radiosensitivity in human esophageal cancer cell lines in vitro.

Journal: Anticancer research20040101

Title: Biglycan is internalized via a chlorpromazine-sensitive route.

Journal: Cellular & molecular biology letters20040101

Title: Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.

Journal: Annals of clinical and laboratory science20040101

Title: Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.

Journal: The Journal of biological chemistry20031226

Title: Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

Journal: The Journal of biological chemistry20031226

Title: Synthesis of a prodrug designed to release multiple inhibitors of the epidermal growth factor receptor tyrosine kinase and an alkylating agent: a novel tumor targeting concept.

Journal: Journal of medicinal chemistry20031204

Title: Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.

Journal: Cellular signalling20031201

Title: Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes.

Journal: The British journal of dermatology20031201

Title: Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.

Journal: Cancer research20031015

Title: Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.

Journal: American journal of physiology. Lung cellular and molecular physiology20031001

Title: Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.

Journal: Experimental cell research20031001

Title: Expression of ErbB receptors in ES cell-derived cardiomyocytes.

Journal: Biochemical and biophysical research communications20030912

Title: Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains.

Journal: Oncogene20030904

Title: EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.

Journal: Oncogene20030904

Title: Activation of ERK1/2 by platelet-activating factor receptor is independent of receptor internalisation and G-protein activation.

Journal: Cellular signalling20030901

Title: Epidermal growth factor receptor regulates normal urothelial regeneration.

Journal: Laboratory investigation; a journal of technical methods and pathology20030901

Title: Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20030801

Title: Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.

Journal: Molecular endocrinology (Baltimore, Md.)20030801

Title: Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.

Journal: Molecular pharmacology20030801

Title: Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation.

Journal: Brain research20030718

Title: Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.

Journal: Mechanisms of development20030701

Title: Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes.

Journal: Journal of cellular biochemistry20030601

Title: Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.

Journal: Investigative ophthalmology & visual science20030601

Title: Inhibitors that target protein kinases for the treatment of ovarian carcinoma.

Journal: American journal of obstetrics and gynecology20030501

Title: Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20030401

Title: Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.

Journal: Journal of cellular physiology20030301

Title: Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.

Journal: Investigative ophthalmology & visual science20030301

Title: P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.

Journal: Investigative ophthalmology & visual science20030301

Title: Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20030201

Title: Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines.

Journal: Methods in molecular medicine20030101

Title: Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.

Journal: Cell and tissue research20030101

Title: [Effect of EGF on the intracellular distribution of heat-shock proteins in A431 cells].

Journal: Tsitologiia20030101

Title: Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor.

Journal: The Journal of biological chemistry20021220

Title: Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Epidermal growth factor.

Journal: Science's STKE : signal transduction knowledge environment20021203

Title: ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.

Journal: American journal of physiology. Heart and circulatory physiology20021201

Title: Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.

Journal: American journal of respiratory cell and molecular biology20021201

Title: Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury.

Journal: American journal of physiology. Cell physiology20021101

Title: Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases.

Journal: The Journal of pharmacology and experimental therapeutics20021101

Title: Angiotensin II triggers EGFR tyrosine kinase-dependent Ca2+ influx in afferent arterioles.

Journal: Hypertension (Dallas, Tex. : 1979)20021101

Title: Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.

Journal: Cancer research20021101

Title: Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.

Journal: Cancer research20021101

Title: 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.

Journal: Toxicology and applied pharmacology20021101

Title: Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

Journal: American journal of physiology. Gastrointestinal and liver physiology20021001

Title: Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion.

Journal: American journal of physiology. Gastrointestinal and liver physiology20021001

Title: Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.

Journal: American journal of physiology. Heart and circulatory physiology20021001

Title: Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function.

Journal: International journal of cancer20020910

Title: Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.

Journal: The Journal of biological chemistry20020830

Title: A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression.

Journal: Cancer research20020801

Title: The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner.

Journal: Cancer research20020801

Title: Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Journal: Cancer research20020615

Title: Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor.

Journal: American journal of physiology. Cell physiology20020601

Title: Inhibitory effect and its kinetic analysis of tyrphostin AG1478 on recombinant human protein kinase CK2 holoenzyme.

Journal: Acta pharmacologica Sinica20020601

Title: Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes.

Journal: The Journal of endocrinology20020601

Title: EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.

Journal: Cancer cell20020601

Title: alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry20020531

Title: Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.

Journal: FEBS letters20020424

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes.

Journal: Molecular endocrinology (Baltimore, Md.)20020301

Title: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.

Journal: Nature medicine20020301

Title: Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.

Journal: The Journal of biological chemistry20020222

Title: Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

Journal: Cardiovascular research20020201

Title: TGF-alpha-driven tumor growth is inhibited by an EGF receptor tyrosine kinase inhibitor.

Journal: Biochemical and biophysical research communications20020111

Title: CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity.

Journal: Brain pathology (Zurich, Switzerland)20020101

Title: Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

Journal: Cancer research20020101

Title: Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20011215

Title: Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.

Journal: The Journal of biological chemistry20011214

Title: Arterial epidermal growth factor receptor expression in deoxycorticosterone acetate-salt hypertension.

Journal: Hypertension (Dallas, Tex. : 1979)20011201

Title: Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.

Journal: DNA and cell biology20011201

Title: Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.

Journal: Journal of the American College of Cardiology20011101

Title: EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.

Journal: American journal of physiology. Cell physiology20010901

Title: Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.

Journal: Investigative ophthalmology & visual science20010901

Title: Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor.

Journal: Journal of neurosurgery20010901

Title: Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.

Journal: American journal of physiology. Lung cellular and molecular physiology20010801

Title: Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.

Journal: European journal of biochemistry20010801

Title: Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.

Journal: Cancer research20010715

Title: Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release.

Journal: Journal of immunology (Baltimore, Md. : 1950)20010701

Title: Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse.

Journal: Nature20010517

Title: c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.

Journal: The Journal of biological chemistry20010511

Title: Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.

Journal: Cancer research20010415

Title: High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.

Journal: Journal of chromatography. B, Biomedical sciences and applications20010415

Title: Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.

Journal: British journal of cancer20010401

Title: Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway.

Journal: British journal of pharmacology20010401

Title: The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.

Journal: Oncogene20010315

Title: Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.

Journal: International journal of molecular medicine20010301

Title: BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.

Journal: Biochemical and biophysical research communications20010216

Title: STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.

Journal: Blood20010215

Title: Activation of extracellular-regulated kinases by normal and mutant EGF receptors.

Journal: Biochimica et biophysica acta20010205

Title: N-acetylcysteine inhibits angiotensin ii-mediated activation of extracellular signal-regulated kinase and epidermal growth factor receptor.

Journal: Biochemical and biophysical research communications20010202

Title: Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor: a mitogen for lung fibroblasts.

Journal: American journal of respiratory cell and molecular biology20010201

Title: Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin II.

Journal: Hypertension (Dallas, Tex. : 1979)20010201

Title: Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation.

Journal: Circulation research20010119

Title: Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.

Journal: Bioorganic & medicinal chemistry letters20010108

Title: Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.

Journal: Cancer letters20010101

Title: Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.

Journal: Journal of cellular biochemistry20010101

Title: Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.

Journal: Cancer journal (Sudbury, Mass.)20010101

Title: Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.

Journal: Journal of immunology (Baltimore, Md. : 1950)20000201

Title: Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.

Journal: Journal of medicinal chemistry19990325

Title: Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.

Journal: Molecular and cellular biology19980901

Title: Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Journal: Journal of medicinal chemistry19960105

Title: G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.

Journal: Molecular endocrinology (Baltimore, Md.)

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