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176161-24-3,MFCD00945570
Catalog No.:AA00AQ2G

176161-24-3 | Maribavir

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5mg
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$708.00   $495.00
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10mg
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$1,092.00   $764.00
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50mg
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$2,863.00   $2,004.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AQ2G
Chemical Name:
Maribavir
CAS Number:
176161-24-3
Molecular Formula:
C15H19Cl2N3O4
Molecular Weight:
376.2351
MDL Number:
MFCD00945570
SMILES:
OC[C@@H]1O[C@@H]([C@H]([C@H]1O)O)n1c(NC(C)C)nc2c1cc(Cl)c(c2)Cl
Properties
Computed Properties
 
Complexity:
447  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
2.2  

Literature

Title: The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants.

Journal: Antiviral research 20111101

Title: Genotypic characterization of human cytomegalovirus UL97 phosphotransferase natural polymorphism in the era of ganciclovir and maribavir.

Journal: Antiviral research 20110701

Title: Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.

Journal: Cell host & microbe 20110217

Title: Oral maribavir for treatment of refractory or resistant cytomegalovirus infections in transplant recipients.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20101201

Title: Leflunomide: a small step forward in meeting the urgent need for treatment of drug-resistant cytomegalovirus infection.

Journal: Transplantation 20100827

Title: Virologic characterization of multidrug-resistant cytomegalovirus infection in 2 transplant recipients treated with maribavir.

Journal: The Journal of infectious diseases 20100701

Title: Antiviral prophylaxis in haematological patients: systematic review and meta-analysis.

Journal: European journal of cancer (Oxford, England : 1990) 20091201

Title: A randomized, double-blind, pharmacokinetic study of oral maribavir with tacrolimus in stable renal transplant recipients.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20091001

Title: Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.

Journal: Reviews in medical virology 20090701

Title: Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir.

Journal: Virology journal 20090101

Title: Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.

Journal: PLoS pathogens 20090101

Title: Conserved domains and structure prediction of human cytomegalovirus UL27 protein.

Journal: Antiviral therapy 20090101

Title: Maribavir: a novel antiviral agent with activity against cytomegalovirus.

Journal: The Annals of pharmacotherapy 20081001

Title: Cytomegalovirus infection after liver transplantation: current concepts and challenges.

Journal: World journal of gastroenterology 20080821

Title: Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study.

Journal: Blood 20080601

Title: Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir.

Journal: Antiviral research 20080601

Title: Prevention and early treatment of opportunistic viral infections in patients with leukemia and allogeneic stem cell transplantation recipients.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20080201

Title: Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir.

Journal: Reviews in medical virology 20080101

Title: Cytomegalovirus UL97 kinase mutations that confer maribavir resistance.

Journal: The Journal of infectious diseases 20070701

Title: Pharmacokinetics of maribavir, a novel oral anticytomegalovirus agent, in subjects with varying degrees of renal impairment.

Journal: Journal of clinical pharmacology 20070201

Title: Maribavir: 1263W94, Benzimidavir, GW 1263, GW 1263W94, VP41263.

Journal: Drugs in R&D 20070101

Title: Maribavir sensitivity of cytomegalovirus isolates resistant to ganciclovir, cidofovir or foscarnet.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061001

Title: N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060601

Title: [Therapeutic approach to EBV infection].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060301

Title: In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication.

Journal: Antimicrobial agents and chemotherapy 20050301

Title: Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.

Journal: Antimicrobial agents and chemotherapy 20041001

Title: Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.

Journal: Antimicrobial agents and chemotherapy 20040501

Title: Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.

Journal: Antimicrobial agents and chemotherapy 20040501

Title: Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication.

Journal: Antimicrobial agents and chemotherapy 20040501

Title: In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.

Journal: Antimicrobial agents and chemotherapy 20030701

Title: Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication.

Journal: Antimicrobial agents and chemotherapy 20030401

Title: Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Interactions among antiviral drugs acting late in the replication cycle of human cytomegalovirus.

Journal: Antiviral research 20021001

Title: Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.

Journal: Antimicrobial agents and chemotherapy 20020801

Title: Inhibition of ganciclovir-susceptible and -resistant human cytomegalovirus clinical isolates by the benzimidazole L-riboside 1263W94.

Journal: Clinical and diagnostic laboratory immunology 20011101

Title: A novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products.

Journal: Journal of virology 20011001

Title: Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles.

Journal: Journal of medicinal chemistry 20000615

Title: Synthesis and evaluation of a series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94).

Journal: Nucleosides, nucleotides & nucleic acids 20000101

Title: Inhibition of Epstein-Barr virus replication by a benzimidazole L-riboside: novel antiviral mechanism of 5, 6-dichloro-2-(isopropylamino)-1-beta-L-ribofuranosyl-1H-benzimidazole.

Journal: Journal of virology 19990901

Title: Human cytomegalovirus: challenges, opportunities and new drug development.

Journal: Antiviral chemistry & chemotherapy 19990901

Title: Development of novel benzimidazole riboside compounds for treatment of cytomegalovirus disease.

Journal: Advances in experimental medicine and biology 19990101

Title: Shannon-Lowe CD, et al. The effects of Maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein. Herpesviridae. 2010 Dec 7;1(1):4.

Title: Biron KK, et al. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72.

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