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177355-84-9,MFCD03691820
Catalog No.:AA00AQ9F

177355-84-9 | DBeQ

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$12.00   $8.00
- +
5mg
98%
in stock  
$27.00   $19.00
- +
10mg
98%
in stock  
$39.00   $28.00
- +
50mg
98%
in stock  
$57.00   $40.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AQ9F
Chemical Name:
DBeQ
CAS Number:
177355-84-9
Molecular Formula:
C22H20N4
Molecular Weight:
340.4210
MDL Number:
MFCD03691820
SMILES:
c1ccc(cc1)CNc1nc(NCc2ccccc2)c2c(n1)cccc2
Properties
Computed Properties
 
Complexity:
403  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
5.3  

Literature

Title: Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression.

Journal: PloS one 20160101

Title: Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Journal: Journal of molecular biology 20140729

Title: Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

Journal: Nature chemical biology 20130901

Title: Development of p97 AAA ATPase inhibitors.

Journal: Autophagy 20110901

Title: New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives.

Journal: European journal of medicinal chemistry 20110901

Title: New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells.

Journal: Cancer biology & therapy 20060701

Title: Chou TF, et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9.

Title: Zhang Y, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016 Jun;181(5-6):329-39.

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SDS
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