Catalog No.:AA01V4SQ

1800046-97-2 | Lanraplenib monosuccinate

Name: Name:Lanraplenib monosuccinate
Brand: AABLOCKS
SKU: AA01V4SQ
Rating: 90 (10 reviews)

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA01V4SQ

Chemical Name:

Lanraplenib monosuccinate

CAS Number:

1800046-97-2

Molecular Formula:

C27H31N9O5

Molecular Weight:

561.5923

SMILES:

C1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N.C(CC(=O)O)C(=O)O

Properties

Literature

Title: Di Paolo J, et al. FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis.Annals of the Rheumatic Diseases 2016;75:443-444.

Title: Clarke AS, et al. Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis. Thromb Res. 2018 Oct;170:109-118.

Title: Kivitz AJ, et al. GS-9876, a Novel, Highly Selective, SYK Inhibitor in Patients with Active Rheumatoid Arthritis: Safety, Tolerability and Efficacy Results of a Phase 2 Study [abstract Arthritis Rheumatol.2018; 70 (suppl 10).

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