Catalog No.:AA01EODT

1802148-05-5 | AZD7986

Name: Name:AZD7986
Brand: AABLOCKS
SKU: AA01EODT
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

1mg

≥98%

in stock

$123.00 $86.00

- +

5mg

>98% (or refer to the Certificate of Analysis)

in stock

$218.00 $153.00

- +

50mg

98%

in stock

$335.00 $234.00

- +

Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01EODT

Chemical Name:

AZD7986

CAS Number:

1802148-05-5

Molecular Formula:

C23H24N4O4

Molecular Weight:

420.4611

MDL Number:

MFCD31619232

SMILES:

N#C[C@H](Cc1ccc(cc1)c1ccc2c(c1)n(C)c(=O)o2)NC(=O)[C@@H]1CNCCCO1

Properties

Computed Properties

Complexity:

699

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

Downstream Synthesis Route

1802150-04-4

1802148-05-5

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[4]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[5]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[6]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[7]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[8]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[9]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[10]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[11]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[12]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[13]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[14]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[15]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[16]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

1802150-08-8

1802148-05-5

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[4]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[5]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[6]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[7]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[8]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

911223-02-4

1802148-05-5

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[4]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

1802150-57-7

1802148-05-5

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1Locationinpatent:Paragraph0409-0411

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2Locationinpatent:Page/Pagecolumn52

[3]Doyle,Kevin;Lönn,Hans;Käck,Helena;VanDePoël,Amanda;Swallow,Steve;Gardiner,Philip;Connolly,Stephen;Root,James;Wikell,Cecilia;Dahl,Göran;Stenvall,Kristina;Johannesson,Petra[JournalofMedicinalChemistry,2016,vol.59,#20,p.9457-9472]

95-25-0

1802148-05-5

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2015/210655,2015,A1

[3]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

[4]CurrentPatentAssignee:ASTRAZENECAPLC-US9522894,2016,B2

Literature

Title: Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).

Journal: Journal of medicinal chemistry 20161027

Title: Doyle K, et al. Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem. 2016 Oct 27;59(20):9457-9472.

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