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1807861-48-8,MFCD31619281
Catalog No.:AA01EOJZ

1807861-48-8 | ONC212

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1mg
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$82.00   $57.00
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5mg
≥98%
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$238.00   $166.00
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10mg
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$432.00   $302.00
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25mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EOJZ
Chemical Name:
ONC212
CAS Number:
1807861-48-8
Molecular Formula:
C24H23F3N4O
Molecular Weight:
440.4608
MDL Number:
MFCD31619281
SMILES:
O=c1c2CN(CCc2n2c(=NCC2)n1Cc1ccc(cc1)C(F)(F)F)Cc1ccccc1
Properties
Computed Properties
 
Complexity:
779  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
4  
XLogP3:
2.8  

Downstream Synthesis Route

[1]Bárány,Péter;Oláh,RitaSzabó;Kovács,Imre;Czuczi,Tamás;Szabó,CsengeLilla;Takács,Angéla;Lajkó,Eszter;Láng,Orsolya;Ohidai,LászlóK.;Schlosser,Gitta;Osze,SzilviaB.;Mezo,Gábor;Hudecz,Ferenc;Csámpai,Antal[Molecules,2018,vol.23,#9]

[1]Bárány,Péter;Oláh,RitaSzabó;Kovács,Imre;Czuczi,Tamás;Szabó,CsengeLilla;Takács,Angéla;Lajkó,Eszter;Láng,Orsolya;Ohidai,LászlóK.;Schlosser,Gitta;Osze,SzilviaB.;Mezo,Gábor;Hudecz,Ferenc;Csámpai,Antal[Molecules,2018,vol.23,#9]

[1]CurrentPatentAssignee:SHAANXINORMALUNIVERSITY-CN115477613,2022,ALocationinpatent:Paragraph0097-0099

Literature

Title: Fatty acid and carbohydrate storage in the annual reproductive cyclice of Echinaster.

Journal: Comparative biochemistry and physiology. A, Comparative physiology 19751201

Title: Takenobu Nii, et al. The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199. ASH. 2017.

Title: Lev A, et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. Oncotarget. 2017 Sep 12;8(47):81776-81793.

Title: Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799.

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SDS
Tags:1807861-48-8 Molecular Formula|1807861-48-8 MDL|1807861-48-8 SMILES|1807861-48-8 ONC212