Catalog No.:AA00231S

1818339-66-0 | 2-Pyridinecarboxamide, N-[2-[(4aR,6S,8aR)-2-amino-4,4a,5,6-tetrahydro-6-methylpyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-thiazolyl]-5-(difluoromethoxy)-

Name: Name:2-Pyridinecarboxamide, N-[2-[(4aR,6S,8aR)-2-amino-4,4a,5,6-tetrahydro-6-methylpyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-thiazolyl]-5-(difluoromethoxy)-
Brand: AABLOCKS
SKU: AA00231S
Availability: InStock
Rating: 90 (10 reviews)

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Purity

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5mg

99%

1 week

$654.00 $458.00

- +

10mg

99%

1 week

$971.00 $680.00

- +

25mg

99%

1 week

$1,892.00 $1,324.00

- +

50mg

99%

1 week

$2,987.00 $2,091.00

- +

100mg

99%

1 week

$4,098.00 $2,869.00

- +

Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00231S

Chemical Name:

2-Pyridinecarboxamide, N-[2-[(4aR,6S,8aR)-2-amino-4,4a,5,6-tetrahydro-6-methylpyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-thiazolyl]-5-(difluoromethoxy)-

CAS Number:

1818339-66-0

Molecular Formula:

C18H19F2N5O3S2

Molecular Weight:

455.5020

MDL Number:

MFCD31657420

SMILES:

FC(Oc1ccc(nc1)C(=O)Nc1csc(n1)[C@@]12CO[C@H](C[C@H]2CSC(=N1)N)C)F

Properties

Computed Properties

Complexity:

676

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.4

Literature

Title: O'Neill BT, et al. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61(10):4476-4504.

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SDS