19408-84-5,MFCD00057794
Catalog No.:AA00I2YV

19408-84-5 | Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-

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≥98%
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50mg
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100mg
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250mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00I2YV
Chemical Name:
Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-
CAS Number:
19408-84-5
Molecular Formula:
C18H29NO3
Molecular Weight:
307.4278
MDL Number:
MFCD00057794
SMILES:
COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O
Properties
Computed Properties
 
Complexity:
307  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.4  

Downstream Synthesis Route

[1]Kaga,Harumi;Miura,Masakatsu;Orito,Kazuhiko[Synthesis,1989,#11,p.864-866]

[1]Gallou,Fabrice;Gao,EugeneS.;Lipshutz,BruceH.;Takale,BalaramS.;Thakore,RuchitaR.[GreenChemistry,2020,vol.22,#18,p.6055-6061]

[2]CurrentPatentAssignee:SHANGHAIALADDINBIOCHEMICALTECH-CN105418445,2016,ALocationinpatent:Paragraph0018;0019;0020

[3]Gannett,PeterM.;Nagel,DonaldL.;Reilly,PamJ.;Lawson,Terence;Sharpe,Jody;Toth,Bela[JournalofOrganicChemistry,1988,vol.53,#5,p.1064-1071]

[1]JournalofOrganicChemistry,1988,vol.53,p.1064-1071

19408-84-5   
N-(4,5-dihydroxy-3-methoxybenzyl)-6-nonanylamide 
 
ω-hydroxydihydrocapsaicin 

[1]Surh,Young-Joon;Ahn,SeungHo;Kim,Kee-Cheon;Park,Jeong-Bae;Sohn,YeoWon;Lee,SangSup[LifeSciences,1995,vol.56,#16,p.P305-P312,PL305-PL311]

Literature

Title: Determination of capsaicinoids in Capsicum species using ultra performance liquid chromatography-mass spectrometry.

Journal: Journal of separation science 20121101

Title: Effects of dietary addition of capsicum extract on intake, water consumption, and rumen fermentation of fattening heifers fed a high-concentrate diet.

Journal: Journal of animal science 20120601

Title: Antibacterial activity of Capsicum annuum extract and synthetic capsaicinoid derivatives against Streptococcus mutans.

Journal: Journal of natural medicines 20120401

Title: Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

Journal: Journal of pharmaceutical and biomedical analysis 20120223

Title: Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.

Journal: Journal of Asian natural products research 20120101

Title: Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.

Journal: Bioorganic & medicinal chemistry 20111115

Title: Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography.

Journal: Molecules (Basel, Switzerland) 20111024

Title: Comparative study on the chemical composition, antioxidant properties and hypoglycaemic activities of two Capsicum annuum L. cultivars (Acuminatum small and Cerasiferum).

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20110901

Title: Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: variation in health-related compounds and implications for breeding.

Journal: Phytochemistry 20110801

Title: A novel pseudo simulated moving bed with solvent gradient for ternary separations.

Journal: Journal of chromatography. A 20110520

Title: Simultaneous control of capsaicinoids release from polymeric nanocapsules.

Journal: Journal of nanoscience and nanotechnology 20110301

Title: Antioxidant activity of fresh and processed Jalapeño and Serrano peppers.

Journal: Journal of agricultural and food chemistry 20110112

Title: Recent advances in the study on capsaicinoids and capsinoids.

Journal: European journal of pharmacology 20110110

Title: Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats.

Journal: The Journal of toxicological sciences 20110101

Title: c-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cells.

Journal: PloS one 20110101

Title: Lectotypifications, synonymy, and a new name in Capsicum (Solanoideae, Solanaceae).

Journal: PhytoKeys 20110101

Title: [Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

Title: Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100815

Title: Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines.

Journal: Free radical biology & medicine 20100715

Title: Growth, yield, and fruit quality of pepper plants amended with two sanitized sewage sludges.

Journal: Journal of agricultural and food chemistry 20100609

Title: Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism.

Journal: Hypertension (Dallas, Tex. : 1979) 20100401

Title: The unfolded protein response and its relevance to connective tissue diseases.

Journal: Cell and tissue research 20100101

Title: Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities.

Journal: Natural product communications 20100101

Title: Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study.

Journal: Lipids in health and disease 20100101

Title: Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin.

Journal: BMC cardiovascular disorders 20100101

Title: Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial.

Journal: Nutrition & metabolism 20100101

Title: Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist.

Journal: BMC cardiovascular disorders 20100101

Title: Rapid method for the determination of capsaicin and dihydrocapsaicin in Gochujang using ultra-high-performance liquid chromatography.

Journal: Journal of AOAC International 20100101

Title: Capsaicinoids, chloropicrin and sulfur mustard: possibilities for exposure biomarkers.

Journal: Frontiers in pharmacology 20100101

Title: Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation.

Journal: Thrombosis research 20091201

Title: Preparative separation of capsaicin and dihydrocapsaicin from Capsicum frutescens by high-speed counter-current chromatography.

Journal: Journal of separation science 20090901

Title: Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings.

Journal: Inflammopharmacology 20090601

Title: Acute effects of dihydrocapsaicin and capsaicin on the distribution of white blood cells in rats.

Journal: Journal of nutritional science and vitaminology 20090601

Title: Analysis of capsaicin and dihydrocapsaicin in peppers and pepper sauces by solid phase microextraction-gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20090403

Title: Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: Vanilloid-mediated apoptosis in prostate cancer cells through a TRPV-1 dependent and a TRPV-1-independent mechanism.

Journal: Acta bio-medica : Atenei Parmensis 20090401

Title: Pungency in Capsicum chinense: variation among countries of origin.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090201

Title: Mobility of heavy metals from soil into hot pepper fruits: a field study.

Journal: Bulletin of environmental contamination and toxicology 20090101

Title: Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner.

Journal: Autophagy 20081101

Title: Ultrasound-assisted extraction of capsaicinoids from peppers.

Journal: Talanta 20080615

Title: [Preparation of three capsaicinoid components using preparative high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20080501

Title: Separation of capsaicin from capsaicinoids by simulated moving bed chromatography.

Journal: Journal of chromatography. A 20080411

Title: In vitro hepatic and skin metabolism of capsaicin.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080401

Title: Herbal compounds and toxins modulating TRP channels.

Journal: Current neuropharmacology 20080301

Title: Inheritance of capsaicin and dihydrocapsaicin, determined by HPLC-ESI/MS, in an intraspecific cross of Capsicum annuum L.

Journal: Journal of agricultural and food chemistry 20070822

Title: Determination of capsaicinoids in habanero peppers by chemometric analysis of UV spectral data.

Journal: Journal of agricultural and food chemistry 20070725

Title: Enzymatic synthesis of capsaicin analogs and their effect on the T-type Ca2+ channels.

Journal: Biochemical and biophysical research communications 20070504

Title: Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.

Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20070401

Title: Growing hot pepper for cabbage looper, Trichopulsia ni (Hübner) and spider mite, Tetranychus urticae (Koch) control.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070101

Title: Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry.

Journal: Journal of agricultural and food chemistry 20061213

Title: QTL analysis for capsaicinoid content in Capsicum.

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 20061101

Title: Determination of capsaicinoids in peppers by microwave-assisted extraction-high-performance liquid chromatography with fluorescence detection.

Journal: Analytica chimica acta 20060925

Title: Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids.

Journal: Journal of agricultural and food chemistry 20060823

Title: Purification and structure determination of glucosides of capsaicin and dihydrocapsaicin from various Capsicum fruits.

Journal: Journal of agricultural and food chemistry 20060809

Title: Pressurized liquid extraction of capsaicinoids from peppers.

Journal: Journal of agricultural and food chemistry 20060503

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effective acceleration of atom transfer carbonylation of alkyl iodides by metal complexes. Application to the synthesis of the hinokinin precursor and dihydrocapsaicin.

Journal: Organic letters 20060330

Title: Screening Capsicum accessions for capsaicinoids content.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101

Title: Toxicity and repellency of hot pepper extracts to spider mite, Tetranychus urticae Koch.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101

Title: Hot receptors in the brain.

Journal: Molecular pain 20060101

Title: Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry.

Journal: Journal of agricultural and food chemistry 20051116

Title: Extraction of capsaicins in aerosol defense sprays from fabrics.

Journal: Talanta 20050815

Title: Quantitative determination of capsaicinoids by liquid chromatography-electrospray mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20050401

Title: Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L).

Journal: Journal of agricultural and food chemistry 20050309

Title: Pharmacological effects of fermented red pepper.

Journal: Phytotherapy research : PTR 20041101

Title: Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo.

Journal: Toxicology and applied pharmacology 20041001

Title: Monomeric C18 chromatographic method for the liquid chromatographic determination of lipophilic antioxidants in plants.

Journal: Journal of chromatography. A 20040910

Title: Molecular mapping of capsaicinoid biosynthesis genes and quantitative trait loci analysis for capsaicinoid content in Capsicum.

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 20031201

Title: An alternative method to screen for pepper spray residue.

Journal: Journal of forensic sciences 20030101

Title: Archaeobotanic evidence of the preincaic Chiribaya culture. Determination of capsaicinoids in archaeological samples of Capsicum frutescens and votive foods.

Journal: Phytochemical analysis : PCA 20030101

Title: Antioxidant activity of capsinoids.

Journal: Journal of agricultural and food chemistry 20021204

Title: Determination of capsaicinoids in topical cream by liquid-liquid extraction and liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20021107

Title: Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry.

Journal: Journal of analytical toxicology 20020901

Title: Optimization of high-performance liquid chromatographic parameters for the determination of capsaicinoid compounds using the simplex method.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020601

Title: Ground red peppers: capsaicinoids content, Scoville scores, and discrimination by an electronic nose.

Journal: Journal of agricultural and food chemistry 20020522

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Natural deuterium distribution in branched-chain medium-length fatty acids is nonstatistical: a site-specific study by quantitative 2H NMR spectroscopy of the fatty acids of capsaicinoids.

Journal: Chembiochem : a European journal of chemical biology 20020301

Title: Capsaicinoids in vegetative organs of Capsicum annuum L. in relation to fruiting.

Journal: Journal of agricultural and food chemistry 20020227

Title: Pungency in paprika (Capsicum annuum). 1. Decrease of capsaicinoid content following cellular disruption.

Journal: Journal of agricultural and food chemistry 20020227

Title: Pungency in paprika (Capsicum annuum). 2. Heterogeneity of capsaicinoid content in individual fruits from one plant.

Journal: Journal of agricultural and food chemistry 20020227

Title: Determination of capsaicinoids in salsa by liquid chromatography and enzyme immunoassay.

Journal: Journal of AOAC International 20020101

Title: Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).

Journal: Cancer letters 20010828

Title: Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products.

Journal: Journal of forensic sciences 20010501

Title: Determination of capsaicin, dihydrocapsaicin, and nonivamide in self-defense weapons by liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20010406

Title: Determination of capsaicin and dihydrocapsaicin in air in a pickle and pepper processing plant.

Journal: AIHAJ : a journal for the science of occupational and environmental health and safety 20010101

Title: Interaction of capsaicinoids with drug-metabolizing systems. Relationship to toxicity.

Journal: Biochemical pharmacology 19830201

Title: Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55(4):1018-25.

Title: Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.

Title: Adams MJ, et al. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 2009 Dec;124(6):721-3.

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SDS
Tags:19408-84-5 Molecular Formula|19408-84-5 MDL|19408-84-5 SMILES|19408-84-5 Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-
Catalog No.: AA00I2YV
19408-84-5,MFCD00057794
19408-84-5 | Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-
Pack Size: 5mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 10mg
Purity: ≥98%
in stock
$88.00 $61.00
Pack Size: 50mg
Purity: 98%
in stock
$153.00 $107.00
Pack Size: 100mg
Purity: 98%
in stock
$231.00 $162.00
Pack Size: 250mg
Purity: 98%
in stock
$348.00 $244.00
Pack Size: 1g
Purity: 98%
in stock
$877.00 $614.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00I2YV
Chemical Name: Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-
CAS Number: 19408-84-5
Molecular Formula: C18H29NO3
Molecular Weight: 307.4278
MDL Number: MFCD00057794
SMILES: COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O
Properties
Complexity: 307  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 10  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.4  
Downstream Synthesis Route
1196-92-5    205651-88-3    19408-84-5 

[1]Kaga,Harumi;Miura,Masakatsu;Orito,Kazuhiko[Synthesis,1989,#11,p.864-866]

404-86-4    19408-84-5 

[1]Gallou,Fabrice;Gao,EugeneS.;Lipshutz,BruceH.;Takale,BalaramS.;Thakore,RuchitaR.[GreenChemistry,2020,vol.22,#18,p.6055-6061]

[2]CurrentPatentAssignee:SHANGHAIALADDINBIOCHEMICALTECH-CN105418445,2016,ALocationinpatent:Paragraph0018;0019;0020

[3]Gannett,PeterM.;Nagel,DonaldL.;Reilly,PamJ.;Lawson,Terence;Sharpe,Jody;Toth,Bela[JournalofOrganicChemistry,1988,vol.53,#5,p.1064-1071]

25775-90-0    19408-84-5 

[1]JournalofOrganicChemistry,1988,vol.53,p.1064-1071

19408-84-5   
N-(4,5-dihydroxy-3-methoxybenzyl)-6-nonanylamide 
 
ω-hydroxydihydrocapsaicin 

[1]Surh,Young-Joon;Ahn,SeungHo;Kim,Kee-Cheon;Park,Jeong-Bae;Sohn,YeoWon;Lee,SangSup[LifeSciences,1995,vol.56,#16,p.P305-P312,PL305-PL311]

Literature fold

Title: Determination of capsaicinoids in Capsicum species using ultra performance liquid chromatography-mass spectrometry.

Journal: Journal of separation science20121101

Title: Effects of dietary addition of capsicum extract on intake, water consumption, and rumen fermentation of fattening heifers fed a high-concentrate diet.

Journal: Journal of animal science20120601

Title: Antibacterial activity of Capsicum annuum extract and synthetic capsaicinoid derivatives against Streptococcus mutans.

Journal: Journal of natural medicines20120401

Title: Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

Journal: Journal of pharmaceutical and biomedical analysis20120223

Title: Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.

Journal: Journal of Asian natural products research20120101

Title: Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.

Journal: Bioorganic & medicinal chemistry20111115

Title: Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography.

Journal: Molecules (Basel, Switzerland)20111024

Title: Comparative study on the chemical composition, antioxidant properties and hypoglycaemic activities of two Capsicum annuum L. cultivars (Acuminatum small and Cerasiferum).

Journal: Plant foods for human nutrition (Dordrecht, Netherlands)20110901

Title: Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: variation in health-related compounds and implications for breeding.

Journal: Phytochemistry20110801

Title: A novel pseudo simulated moving bed with solvent gradient for ternary separations.

Journal: Journal of chromatography. A20110520

Title: Simultaneous control of capsaicinoids release from polymeric nanocapsules.

Journal: Journal of nanoscience and nanotechnology20110301

Title: Antioxidant activity of fresh and processed Jalapeño and Serrano peppers.

Journal: Journal of agricultural and food chemistry20110112

Title: Recent advances in the study on capsaicinoids and capsinoids.

Journal: European journal of pharmacology20110110

Title: Capsaicinoids-induced changes of plasma glucose, free fatty acid and glycerol concentrations in rats.

Journal: The Journal of toxicological sciences20110101

Title: c-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cells.

Journal: PloS one20110101

Title: Lectotypifications, synonymy, and a new name in Capsicum (Solanoideae, Solanaceae).

Journal: PhytoKeys20110101

Title: [Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20101101

Title: Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20100815

Title: Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines.

Journal: Free radical biology & medicine20100715

Title: Growth, yield, and fruit quality of pepper plants amended with two sanitized sewage sludges.

Journal: Journal of agricultural and food chemistry20100609

Title: Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism.

Journal: Hypertension (Dallas, Tex. : 1979)20100401

Title: The unfolded protein response and its relevance to connective tissue diseases.

Journal: Cell and tissue research20100101

Title: Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities.

Journal: Natural product communications20100101

Title: Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study.

Journal: Lipids in health and disease20100101

Title: Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin.

Journal: BMC cardiovascular disorders20100101

Title: Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial.

Journal: Nutrition & metabolism20100101

Title: Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist.

Journal: BMC cardiovascular disorders20100101

Title: Rapid method for the determination of capsaicin and dihydrocapsaicin in Gochujang using ultra-high-performance liquid chromatography.

Journal: Journal of AOAC International20100101

Title: Capsaicinoids, chloropicrin and sulfur mustard: possibilities for exposure biomarkers.

Journal: Frontiers in pharmacology20100101

Title: Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation.

Journal: Thrombosis research20091201

Title: Preparative separation of capsaicin and dihydrocapsaicin from Capsicum frutescens by high-speed counter-current chromatography.

Journal: Journal of separation science20090901

Title: Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings.

Journal: Inflammopharmacology20090601

Title: Acute effects of dihydrocapsaicin and capsaicin on the distribution of white blood cells in rats.

Journal: Journal of nutritional science and vitaminology20090601

Title: Analysis of capsaicin and dihydrocapsaicin in peppers and pepper sauces by solid phase microextraction-gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A20090403

Title: Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells.

Journal: The Journal of pharmacology and experimental therapeutics20090401

Title: Vanilloid-mediated apoptosis in prostate cancer cells through a TRPV-1 dependent and a TRPV-1-independent mechanism.

Journal: Acta bio-medica : Atenei Parmensis20090401

Title: Pungency in Capsicum chinense: variation among countries of origin.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes20090201

Title: Mobility of heavy metals from soil into hot pepper fruits: a field study.

Journal: Bulletin of environmental contamination and toxicology20090101

Title: Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner.

Journal: Autophagy20081101

Title: Ultrasound-assisted extraction of capsaicinoids from peppers.

Journal: Talanta20080615

Title: [Preparation of three capsaicinoid components using preparative high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography20080501

Title: Separation of capsaicin from capsaicinoids by simulated moving bed chromatography.

Journal: Journal of chromatography. A20080411

Title: In vitro hepatic and skin metabolism of capsaicin.

Journal: Drug metabolism and disposition: the biological fate of chemicals20080401

Title: Herbal compounds and toxins modulating TRP channels.

Journal: Current neuropharmacology20080301

Title: Inheritance of capsaicin and dihydrocapsaicin, determined by HPLC-ESI/MS, in an intraspecific cross of Capsicum annuum L.

Journal: Journal of agricultural and food chemistry20070822

Title: Determination of capsaicinoids in habanero peppers by chemometric analysis of UV spectral data.

Journal: Journal of agricultural and food chemistry20070725

Title: Enzymatic synthesis of capsaicin analogs and their effect on the T-type Ca2+ channels.

Journal: Biochemical and biophysical research communications20070504

Title: Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.

Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society20070401

Title: Growing hot pepper for cabbage looper, Trichopulsia ni (Hübner) and spider mite, Tetranychus urticae (Koch) control.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes20070101

Title: Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry.

Journal: Journal of agricultural and food chemistry20061213

Title: QTL analysis for capsaicinoid content in Capsicum.

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik20061101

Title: Determination of capsaicinoids in peppers by microwave-assisted extraction-high-performance liquid chromatography with fluorescence detection.

Journal: Analytica chimica acta20060925

Title: Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids.

Journal: Journal of agricultural and food chemistry20060823

Title: Purification and structure determination of glucosides of capsaicin and dihydrocapsaicin from various Capsicum fruits.

Journal: Journal of agricultural and food chemistry20060809

Title: Pressurized liquid extraction of capsaicinoids from peppers.

Journal: Journal of agricultural and food chemistry20060503

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Effective acceleration of atom transfer carbonylation of alkyl iodides by metal complexes. Application to the synthesis of the hinokinin precursor and dihydrocapsaicin.

Journal: Organic letters20060330

Title: Screening Capsicum accessions for capsaicinoids content.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes20060101

Title: Toxicity and repellency of hot pepper extracts to spider mite, Tetranychus urticae Koch.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes20060101

Title: Hot receptors in the brain.

Journal: Molecular pain20060101

Title: Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry.

Journal: Journal of agricultural and food chemistry20051116

Title: Extraction of capsaicins in aerosol defense sprays from fabrics.

Journal: Talanta20050815

Title: Quantitative determination of capsaicinoids by liquid chromatography-electrospray mass spectrometry.

Journal: Analytical and bioanalytical chemistry20050401

Title: Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L).

Journal: Journal of agricultural and food chemistry20050309

Title: Pharmacological effects of fermented red pepper.

Journal: Phytotherapy research : PTR20041101

Title: Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo.

Journal: Toxicology and applied pharmacology20041001

Title: Monomeric C18 chromatographic method for the liquid chromatographic determination of lipophilic antioxidants in plants.

Journal: Journal of chromatography. A20040910

Title: Molecular mapping of capsaicinoid biosynthesis genes and quantitative trait loci analysis for capsaicinoid content in Capsicum.

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik20031201

Title: An alternative method to screen for pepper spray residue.

Journal: Journal of forensic sciences20030101

Title: Archaeobotanic evidence of the preincaic Chiribaya culture. Determination of capsaicinoids in archaeological samples of Capsicum frutescens and votive foods.

Journal: Phytochemical analysis : PCA20030101

Title: Antioxidant activity of capsinoids.

Journal: Journal of agricultural and food chemistry20021204

Title: Determination of capsaicinoids in topical cream by liquid-liquid extraction and liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20021107

Title: Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry.

Journal: Journal of analytical toxicology20020901

Title: Optimization of high-performance liquid chromatographic parameters for the determination of capsaicinoid compounds using the simplex method.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry20020601

Title: Ground red peppers: capsaicinoids content, Scoville scores, and discrimination by an electronic nose.

Journal: Journal of agricultural and food chemistry20020522

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Natural deuterium distribution in branched-chain medium-length fatty acids is nonstatistical: a site-specific study by quantitative 2H NMR spectroscopy of the fatty acids of capsaicinoids.

Journal: Chembiochem : a European journal of chemical biology20020301

Title: Capsaicinoids in vegetative organs of Capsicum annuum L. in relation to fruiting.

Journal: Journal of agricultural and food chemistry20020227

Title: Pungency in paprika (Capsicum annuum). 1. Decrease of capsaicinoid content following cellular disruption.

Journal: Journal of agricultural and food chemistry20020227

Title: Pungency in paprika (Capsicum annuum). 2. Heterogeneity of capsaicinoid content in individual fruits from one plant.

Journal: Journal of agricultural and food chemistry20020227

Title: Determination of capsaicinoids in salsa by liquid chromatography and enzyme immunoassay.

Journal: Journal of AOAC International20020101

Title: Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).

Journal: Cancer letters20010828

Title: Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products.

Journal: Journal of forensic sciences20010501

Title: Determination of capsaicin, dihydrocapsaicin, and nonivamide in self-defense weapons by liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A20010406

Title: Determination of capsaicin and dihydrocapsaicin in air in a pickle and pepper processing plant.

Journal: AIHAJ : a journal for the science of occupational and environmental health and safety20010101

Title: Interaction of capsaicinoids with drug-metabolizing systems. Relationship to toxicity.

Journal: Biochemical pharmacology19830201

Title: Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55(4):1018-25.

Title: Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.

Title: Adams MJ, et al. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 2009 Dec;124(6):721-3.

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