Home Other Building Blocks 1946-82-3
1946-82-3,MFCD00008233
Catalog No.:AA0032DZ

1946-82-3 | Ac-Lys-OH

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$6.00   $4.00
- +
1g
98%
in stock  
$12.00   $8.00
- +
25g
98%
in stock  
$228.00   $160.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0032DZ
Chemical Name:
Ac-Lys-OH
CAS Number:
1946-82-3
Molecular Formula:
C8H16N2O3
Molecular Weight:
188.2242
MDL Number:
MFCD00008233
SMILES:
CC(=O)N[C@H](C(=O)O)CCCCN
Properties
Properties
 
BP:
438.5°C at 760 mmHg  
Form:
Solid  
MP:
256-258 °C (dec.)(lit.)  
Refractive Index:
1.4500 (estimate)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
182  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
-4.4  

Literature

Title: A method to distinguish between lysine acetylation and lysine methylation from protein sequences.

Journal: Journal of theoretical biology 20121007

Title: Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121001

Title: Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.

Journal: Journal of medicinal chemistry 20120913

Title: Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.

Journal: Eukaryotic cell 20120601

Title: Myc proteins in brain tumor development and maintenance.

Journal: Upsala journal of medical sciences 20120501

Title: Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

Journal: PLoS neglected tropical diseases 20120501

Title: Non-histone lysine acetylated proteins in heart failure.

Journal: Biochimica et biophysica acta 20120401

Title: Is histone acetylation the most important physiological function for CBP and p300?

Journal: Aging 20120401

Title: Histone recognition and large-scale structural analysis of the human bromodomain family.

Journal: Cell 20120330

Title: N-acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo.

Journal: FEBS letters 20120323

Title: Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver.

Journal: Molecular biology reports 20120301

Title: Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120201

Title: Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides.

Journal: Journal of medicinal chemistry 20120126

Title: SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.

Journal: The Journal of biological chemistry 20120120

Title: Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach.

Journal: Acta neuropathologica 20120101

Title: Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.

Journal: PloS one 20120101

Title: Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans.

Journal: PloS one 20120101

Title: Sirtuins and disease: the road ahead.

Journal: Frontiers in pharmacology 20120101

Title: Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development.

Journal: Frontiers in pharmacology 20120101

Title: Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.

Journal: PloS one 20120101

Title: Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.

Journal: Molecular systems biology 20120101

Title: Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6.

Journal: PloS one 20120101

Title: Function of the active site lysine autoacetylation in Tip60 catalysis.

Journal: PloS one 20120101

Title: Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.

Journal: PloS one 20120101

Title: Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation.

Journal: PloS one 20120101

Title: Identifying acetylated proteins in mitosis.

Journal: Methods in molecular biology (Clifton, N.J.) 20120101

Title: Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.

Journal: Current opinion in structural biology 20111201

Title: Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions.

Journal: Journal of biomolecular screening 20111201

Title: Druggability of methyl-lysine binding sites.

Journal: Journal of computer-aided molecular design 20111201

Title: Metabolic variation during development in culture of Leishmania donovani promastigotes.

Journal: PLoS neglected tropical diseases 20111201

Title: The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.

Journal: Nature cell biology 20111120

Title: Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets.

Journal: International journal of oncology 20111101

Title: Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.

Journal: Molecular & cellular proteomics : MCP 20111101

Title: Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency.

Journal: PLoS biology 20111101

Title: 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.

Journal: Journal of medicinal chemistry 20111013

Title: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Journal: Nature 20111002

Title: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.

Journal: Cell 20110916

Title: Bromodomains as therapeutic targets.

Journal: Expert reviews in molecular medicine 20110901

Title: Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.

Journal: The Journal of biological chemistry 20110812

Title: SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.

Journal: Aging 20110601

Title: Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.

Journal: PLoS genetics 20110601

Title: TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.

Journal: Nature communications 20110501

Title: Preparation of fully synthetic histone H3 reveals that acetyl-lysine 56 facilitates protein binding within nucleosomes.

Journal: Journal of molecular biology 20110429

Title: A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.

Journal: Chemistry & biology 20110422

Title: CLU blocks HDACI-mediated killing of neuroblastoma.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20110401

Title: Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells.

Journal: The Journal of biological chemistry 20110401

Title: The path to clinical proteomics research: integration of proteomics, genomics, clinical laboratory and regulatory science.

Journal: The Korean journal of laboratory medicine 20110401

Title: Capillary electrophoresis-based sirtuin assay using non-peptide substrates.

Journal: Journal of pharmaceutical and biomedical analysis 20110325

Title: hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF).

Journal: The Journal of biological chemistry 20110304

Title: Enhanced reactivity of Lys182 explains the limited efficacy of biogenic amines in preventing the inactivation of glucose-6-phosphate dehydrogenase by methylglyoxal.

Journal: Bioorganic & medicinal chemistry 20110301

Title: H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation.

Journal: PLoS genetics 20110301

Title: Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors.

Journal: Journal of the American Chemical Society 20110223

Title: SIRT3 substrate specificity determined by peptide arrays and machine learning.

Journal: ACS chemical biology 20110218

Title: Mitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is required.

Journal: Diabetes 20110101

Title: Structure of Sir2Tm bound to a propionylated peptide.

Journal: Protein science : a publication of the Protein Society 20110101

Title: Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?

Journal: Journal of biomedicine & biotechnology 20110101

Title: Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae.

Journal: PLoS genetics 20110101

Title: Histone deacetylase activity modulates alternative splicing.

Journal: PloS one 20110101

Title: The biology of lysine acetylation integrates transcriptional programming and metabolism.

Journal: Nutrition & metabolism 20110101

Title: Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture.

Journal: PloS one 20110101

Title: Mitochondrial acetylation and diseases of aging.

Journal: Journal of aging research 20110101

Title: Post-translational protein modification by carotenoid cleavage products.

Journal: BioFactors (Oxford, England) 20110101

Title: Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome.

Journal: Genome biology 20110101

Title: Rapid temporal control of Foxp3 protein degradation by sirtuin-1.

Journal: PloS one 20110101

Title: Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy.

Journal: Journal of oncology 20110101

Title: Mammalian sirtuins and energy metabolism.

Journal: International journal of biological sciences 20110101

Title: The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells.

Journal: PloS one 20110101

Title: The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model.

Journal: PloS one 20110101

Title: Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl.

Journal: Molecular cancer 20110101

Title: Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling.

Journal: PloS one 20110101

Title: Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

Journal: PloS one 20110101

Title: Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus.

Journal: PloS one 20110101

Title: K-acetylation and its enzymes: overview and new developments.

Journal: Handbook of experimental pharmacology 20110101

Title: Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis.

Journal: PloS one 20110101

Title: Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4.

Journal: PloS one 20110101

Title: Sirt3, mitochondrial ROS, ageing, and carcinogenesis.

Journal: International journal of molecular sciences 20110101

Title: SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies.

Journal: PloS one 20110101

Title: High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.

Journal: PloS one 20110101

Title: Selection of an improved HDAC8 inhibitor through structure-based drug design.

Journal: Bioinformation 20110101

Title: Drug discovery toward antagonists of methyl-lysine binding proteins.

Journal: Current chemical genomics 20110101

Title: Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers.

Journal: PloS one 20110101

Title: IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

Journal: PloS one 20110101

Title: Selective inhibition of BET bromodomains.

Journal: Nature 20101223

Title: Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

Journal: Molecular cell 20101222

Title: Design of a novel nucleoside analog as potent inhibitor of the NAD dependent deacetylase, SIRT2.

Journal: Systems and synthetic biology 20101201

Title: NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets.

Journal: Medicinal research reviews 20101101

Title: Autoacetylation of the Ralstonia solanacearum effector PopP2 targets a lysine residue essential for RRS1-R-mediated immunity in Arabidopsis.

Journal: PLoS pathogens 20101101

Title: Simultaneous chemical and photochemical protein crosslinking induced by irradiation of eye lens proteins in the presence of ascorbate: the photosensitizing role of an UVA-visible-absorbing decomposition product of vitamin C.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20101028

Title: Cell cycle-dependent acetylation of Rb2/p130 in NIH3T3 cells.

Journal: Oncogene 20101021

Title: Structural genomics of histone tail recognition.

Journal: Bioinformatics (Oxford, England) 20101015

Title: Identification of covalent binding sites of ethyl 2-cyanoacrylate, methyl methacrylate and 2-hydroxyethyl methacrylate in human hemoglobin using LC/MS/MS techniques.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101001

Title: Reading chromatin: insights from yeast into YEATS domain structure and function.

Journal: Epigenetics 20101001

Title: A novel predicted bromodomain-related protein affects coordination between meiosis and spermiogenesis in Drosophila and is required for male meiotic cytokinesis.

Journal: DNA and cell biology 20100901

Title: Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes.

Journal: Epigenetics 20100816

Title: Sirtuin chemical mechanisms.

Journal: Biochimica et biophysica acta 20100801

Title: NMR-based detection of acetylation sites in peptides.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20100801

Title: Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

Journal: Journal of the American Chemical Society 20100728

Title: Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents.

Journal: Chemical research in toxicology 20100719

Title: Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.

Journal: Nature 20100708

Title: CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY.

Journal: Molecular microbiology 20100601

Title: Protein acyltransferase function of purified calreticulin. Part 1: characterization of propionylation of protein utilizing propoxycoumarin as the propionyl group donor.

Journal: Journal of biochemistry 20100501

Title: Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.

Journal: Cell research 20100501

Title: Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.

Journal: Journal of the National Cancer Institute 20100317

Title: Deciphering normal blood gene expression variation--The NOWAC postgenome study.

Journal: PLoS genetics 20100301

Title: Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

Journal: PLoS pathogens 20100301

Title: Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse.

Journal: Cell death & disease 20100201

Title: Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression.

Journal: BMC genomics 20100101

Title: Biochemical profiling of histone binding selectivity of the yeast bromodomain family.

Journal: PloS one 20100101

Title: Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.

Journal: BMC genomics 20100101

Title: Behaviour of 4-(-2-hydroxyethyl)-1-piperazineethanesulfonic acid under electrospray ionization mass spectrometry conditions.

Journal: European journal of mass spectrometry (Chichester, England) 20100101

Title: GCN5-dependent acetylation of HIV-1 integrase enhances viral integration.

Journal: Retrovirology 20100101

Title: Single cell analysis of transcriptional activation dynamics.

Journal: PloS one 20100101

Title: In vivo chromatin organization of mouse rod photoreceptors correlates with histone modifications.

Journal: PloS one 20100101

Title: Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Journal: Biochimica et biophysica acta 20100101

Title: Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Extensive lysine methylation in hyperthermophilic crenarchaea: potential implications for protein stability and recombinant enzymes.

Journal: Archaea (Vancouver, B.C.) 20100101

Title: Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line.

Journal: Molecular cancer 20100101

Title: Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.

Journal: International journal of cell biology 20100101

Title: Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila.

Journal: BMC molecular biology 20100101

Title: Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.

Journal: Epigenetics & chromatin 20100101

Title: Expanding the landscape of chromatin modification (CM)-related functional domains and genes in human.

Journal: PloS one 20100101

Title: 1A6/DRIM, a novel t-UTP, activates RNA polymerase I transcription and promotes cell proliferation.

Journal: PloS one 20100101

Title: Structure-based mechanism of ADP-ribosylation by sirtuins.

Journal: The Journal of biological chemistry 20091127

Title: A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.

Journal: Molecular cell 20091009

Title: Identification and characterization of novel sirtuin inhibitor scaffolds.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.

Journal: Nature 20091001

Title: The role of human bromodomains in chromatin biology and gene transcription.

Journal: Current opinion in drug discovery & development 20090901

Title: A stabilized demethoxyviridin derivative inhibits PI3 kinase.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol.

Journal: Chemical research in toxicology 20090701

Title: Two chromatin remodeling activities cooperate during activation of hormone responsive promoters.

Journal: PLoS genetics 20090701

Title: Mass spectral analyses of hydroxymethylvinyl ketone-hemoglobin adducts formed after in vivo exposure of Sprague-Dawley rats to 3-butene-1,2-diol.

Journal: Chemical research in toxicology 20090601

Title: A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.

Journal: Chemical research in toxicology 20090601

Title: Lacticin 481 synthetase as a general serine/threonine kinase.

Journal: ACS chemical biology 20090515

Title: Autoacetylation of purified calreticulin transacetylase utilizing acetoxycoumarin as the acetyl group donor.

Journal: Applied biochemistry and biotechnology 20090501

Title: Formation of mono- and bis-Michael adducts by the reaction of nucleophilic amino acids with hydroxymethylvinyl ketone, a reactive metabolite of 1,3-butadiene.

Journal: Chemical research in toxicology 20090501

Title: 9-Fluorenylmethoxycarbonyl-labeled peptides as substrates in a capillary electrophoresis-based assay for sirtuin enzymes.

Journal: Analytical biochemistry 20090415

Title: Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway.

Journal: Diabetes 20090201

Title: Histone methylation sets the stage for meiotic DNA breaks.

Journal: The EMBO journal 20090121

Title: Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090101

Title: The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.

Journal: Molecular cancer 20090101

Title: Computational screening of molecular targets in Plasmodium for novel non resistant anti-malarial drugs.

Journal: Bioinformation 20090101

Title: Peptide microarrays for profiling of modification state-specific antibodies.

Journal: Methods in molecular biology (Clifton, N.J.) 20090101

Title: In vitro nuclear interactome of the HIV-1 Tat protein.

Journal: Retrovirology 20090101

Title: Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Journal: PloS one 20090101

Title: Multiple aspects of ATP-dependent nucleosome translocation by RSC and Mi-2 are directed by the underlying DNA sequence.

Journal: PloS one 20090101

Title: Human sirt-1: molecular modeling and structure-function relationships of an unordered protein.

Journal: PloS one 20090101

Title: Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.

Journal: PloS one 20090101

Title: Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks.

Journal: PloS one 20090101

Title: Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.

Journal: F1000 biology reports 20090101

Title: Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations.

Journal: Journal of the American Chemical Society 20081210

Title: Establishment of glutamine synthetase of Mycobacterium smegmatis as a protein acetyltransferase utilizing polyphenolic acetates as the acetyl group donors.

Journal: Journal of biochemistry 20081201

Title: Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry.

Journal: Journal of proteome research 20081201

Title: Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines.

Journal: Chemical research in toxicology 20080901

Title: Development of a capillary electrophoresis-based assay of sirtuin enzymes.

Journal: Electrophoresis 20080901

Title: The diversity of lysine-acetylated proteins in Escherichia coli.

Journal: Journal of microbiology and biotechnology 20080901

Title: Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.

Journal: PLoS genetics 20080801

Title: Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.

Journal: Structure (London, England : 1993) 20080401

Title: Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions.

Journal: Analytical biochemistry 20080315

Title: In vivo acetylation of CheY, a response regulator in chemotaxis of Escherichia coli.

Journal: Journal of molecular biology 20080307

Title: Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis.

Journal: Chemical research in toxicology 20080301

Title: Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis.

Journal: PLoS biology 20080301

Title: SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.

Journal: PLoS genetics 20080301

Title: Chemical properties of oxopropenyl adducts of purine and pyrimidine nucleosides and their reactivity toward amino acid cross-link formation.

Journal: Journal of the American Chemical Society 20080220

Title: The formation of argpyrimidine in glyceraldehyde-related glycation.

Journal: Bioscience, biotechnology, and biochemistry 20080201

Title: Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein.

Journal: BMC cell biology 20080101

Title: The BRG1 transcriptional coregulator.

Journal: Nuclear receptor signaling 20080101

Title: Acetylation regulates WRN catalytic activities and affects base excision DNA repair.

Journal: PloS one 20080101

Title: Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.

Journal: BMC developmental biology 20080101

Title: EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.

Journal: PloS one 20080101

Title: Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins.

Journal: Angewandte Chemie (International ed. in English) 20080101

Title: Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?

Journal: Arthritis research & therapy 20080101

Title: Analysis of Myc-induced histone modifications on target chromatin.

Journal: PloS one 20080101

Title: Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase.

Journal: BMC molecular biology 20080101

Title: Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Journal: Genome biology 20080101

Title: Tumor microvasculature: endothelial leakiness and endothelial pore size distribution in a breast cancer model.

Journal: Breast cancer : basic and clinical research 20080101

Title: Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases.

Journal: The Journal of biological chemistry 20071221

Title: Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.

Journal: Biochemistry 20071218

Title: The multiple Maillard reactions of ribose and deoxyribose sugars and sugar phosphates.

Journal: Carbohydrate research 20071210

Title: Formation of three N-acetyl-L-cysteine monoadducts and one diadduct by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with N-acetyl-L-cysteine at physiological conditions: chemical mechanisms and toxicological implications.

Journal: Chemical research in toxicology 20071001

Title: Characterization of Nalpha-benzyloxycarbonyl-L-lysine oxidizing enzyme from Rhodococcus sp. AIU Z-35-1.

Journal: Journal of bioscience and bioengineering 20070901

Title: Structure and acetyl-lysine recognition of the bromodomain.

Journal: Oncogene 20070813

Title: Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parameters.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070801

Title: Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae.

Journal: PLoS genetics 20070801

Title: Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.

Journal: Chembiochem : a European journal of chemical biology 20070723

Title: Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.

Journal: Biochemistry 20070717

Title: Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

Journal: Journal of the American Chemical Society 20070509

Title: Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions.

Journal: Biochemical and biophysical research communications 20070413

Title: Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4.

Journal: The Journal of biological chemistry 20070209

Title: Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes.

Journal: Molecular cell 20070209

Title: Antibacterial lysine analogs that target lysine riboswitches.

Journal: Nature chemical biology 20070101

Title: Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation.

Journal: Molecular cancer 20070101

Title: Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors.

Journal: Cell biochemistry and biophysics 20070101

Title: Requirement of histone deacetylase activity for the expression of critical photoreceptor genes.

Journal: BMC developmental biology 20070101

Title: Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails.

Journal: BMC structural biology 20070101

Title: Expression, purification and characterization of individual bromodomains from human Polybromo-1.

Journal: Protein expression and purification 20061101

Title: SWI/SNF displaces SAGA-acetylated nucleosomes.

Journal: Eukaryotic cell 20061001

Title: Characterization of the amino acid adducts of the enedial derivative of teucrin A.

Journal: Chemical research in toxicology 20061001

Title: Structural basis for D-amino acid transamination by the pyridoxal 5'-phosphate-dependent catalytic antibody 15A9.

Journal: The Journal of biological chemistry 20060818

Title: Kinetics and mechanism of the addition of nucleophiles to alpha,beta-unsaturated thiol esters.

Journal: The Journal of organic chemistry 20060818

Title: pH dependency of the carboxyl oxygen exchange reaction catalyzed by lysyl endopeptidase and trypsin.

Journal: Journal of proteome research 20060701

Title: Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases.

Journal: The Journal of biological chemistry 20060428

Title: Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells.

Journal: Journal of pediatric gastroenterology and nutrition 20060201

Title: The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins.

Journal: BMC genomics 20060101

Title: Target structure-based discovery of small molecules that block human p53 and CREB binding protein association.

Journal: Chemistry & biology 20060101

Title: Hydralazine target: from blood vessels to the epigenome.

Journal: Journal of translational medicine 20060101

Title: Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine.

Journal: Molecular pain 20060101

Title: Limited proteolysis of human histone deacetylase 1.

Journal: BMC biochemistry 20060101

Title: DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein.

Journal: Biological chemistry 20060101

Title: Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies.

Journal: Proteomics 20051201

Title: Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun.

Journal: PLoS biology 20051201

Title: Unstructured conformations are a substrate requirement for the Sir2 family of NAD-dependent protein deacetylases.

Journal: The Journal of biological chemistry 20051028

Title: Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.

Journal: Molecular genetics and genomics : MGG 20051001

Title: Single-nucleosome mapping of histone modifications in S. cerevisiae.

Journal: PLoS biology 20051001

Title: A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo.

Journal: Chemical research in toxicology 20050901

Title: 3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.

Journal: The Journal of biological chemistry 20050610

Title: Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.

Journal: Chemical research in toxicology 20050501

Title: Histone modifications: from genome-wide maps to functional insights.

Journal: Genome biology 20050101

Title: Acetylation of the chemotaxis response regulator CheY by acetyl-CoA synthetase purified from Escherichia coli.

Journal: Journal of molecular biology 20040910

Title: Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis.

Journal: Gene expression patterns : GEP 20040901

Title: Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction.

Journal: Analytical biochemistry 20040901

Title: Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis.

Journal: Stroke 20040601

Title: Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli.

Journal: Journal of molecular biology 20040326

Title: Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.

Journal: The EMBO journal 20040324

Title: Structural basis for the mechanism and regulation of Sir2 enzymes.

Journal: Molecular cell 20040312

Title: Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls.

Journal: Chemical research in toxicology 20040301

Title: Cytotoxicity and oxidative stress induced by the glyceraldehyde-related Maillard reaction products for HL-60 cells.

Journal: Bioscience, biotechnology, and biochemistry 20040201

Title: Study of peptides containing modified lysine residues by tandem mass spectrometry: precursor ion scanning of hexanal-modified peptides.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Sam68 exerts separable effects on cell cycle progression and apoptosis.

Journal: BMC cell biology 20040101

Title: Sirtuins: Sir2-related NAD-dependent protein deacetylases.

Journal: Genome biology 20040101

Title: Coactivators p300 and PCAF physically and functionally interact with the foamy viral trans-activator.

Journal: BMC molecular biology 20040101

Title: Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation.

Journal: BMC biology 20040101

Title: N(epsilon)-(3-methylpyridinium)lysine, a major antigenic adduct generated in acrolein-modified protein.

Journal: The Journal of biological chemistry 20031205

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

Journal: The EMBO journal 20031201

Title: Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide.

Journal: Structure (London, England : 1993) 20031101

Title: Structure and autoregulation of the yeast Hst2 homolog of Sir2.

Journal: Nature structural biology 20031001

Title: Identification of N epsilon-(carboxyethyl)lysine, one of the methylglyoxal-derived AGE structures, in glucose-modified protein: mechanism for protein modification by reactive aldehydes.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030505

Title: Model studies on protein side chain modification by 4-oxo-2-nonenal.

Journal: Chemical research in toxicology 20030401

Title: Structural/functional characterization of the alpha 2-plasmin inhibitor C-terminal peptide.

Journal: Biochemistry 20030204

Title: Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure.

Journal: Journal of immunological methods 20030115

Title: Relative quantification of N(epsilon)-(Carboxymethyl)lysine, imidazolone A, and the Amadori product in glycated lysozyme by MALDI-TOF mass spectrometry.

Journal: Journal of agricultural and food chemistry 20030101

Title: Intracellular ion and organic solute concentrations of the extremely halophilic bacterium Salinibacter ruber.

Journal: Extremophiles : life under extreme conditions 20021201

Title: Spectrophotometric assay of superoxide anion formed in Maillard reaction based on highly water-soluble tetrazolium salt.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021001

Title: Structure of a Sir2 enzyme bound to an acetylated p53 peptide.

Journal: Molecular cell 20020901

Title: Thiolation of protein-bound carcinogenic aldehyde. An electrophilic acrolein-lysine adduct that covalently binds to thiols.

Journal: The Journal of biological chemistry 20020802

Title: Reaction of aflatoxin B(1) oxidation products with lysine.

Journal: Chemical research in toxicology 20020601

Title: Bromodomain: an acetyl-lysine binding domain.

Journal: FEBS letters 20020220

Title: Characterization of a lysK gene as an argE homolog in Thermus thermophilus HB27.

Journal: FEBS letters 20020213

Title: Generation of intramolecular and intermolecular sulfenamides, sulfinamides, and sulfonamides by hypochlorous acid: a potential pathway for oxidative cross-linking of low-density lipoprotein by myeloperoxidase.

Journal: Biochemistry 20020129

Title: The diversity of acetylated proteins.

Journal: Genome biology 20020101

Title: Capillary electrophoretic separation by double-strand polyaniline-coate capillaries of the advanced glycation endproducts formed from N-alpha-acetyl-L-lysine with reducing sugars.

Journal: Journal of capillary electrophoresis and microchip technology 20020101

Title: Structure of histone deacetylases: insights into substrate recognition and catalysis.

Journal: Structure (London, England : 1993) 20011201

Title: Duality in bromodomain-containing protein complexes.

Journal: Frontiers in bioscience : a journal and virtual library 20010801

Title: Acetyllysine-binding and function of bromodomain-containing proteins in chromatin.

Journal: Frontiers in bioscience : a journal and virtual library 20010801

Title: The bromodomain: a chromatin browser?

Journal: Frontiers in bioscience : a journal and virtual library 20010801

Title: The bromodomain: a regulator of ATP-dependent chromatin remodeling?

Journal: Frontiers in bioscience : a journal and virtual library 20010801

Title: Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.

Journal: The Journal of biological chemistry 20010406

Title: Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate.

Journal: Free radical biology & medicine 20010301

Title: Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation.

Journal: The Journal of biological chemistry 20010209

Title: Enzyme immunoassay for aflatoxin B1-lysine adduct and its validation.

Journal: Journal of AOAC International 20010101

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:1946-82-3 Molecular Formula|1946-82-3 MDL|1946-82-3 SMILES|1946-82-3 Ac-Lys-OH