Name: Name:3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-
Brand: AABLOCKS
SKU: AA00384E
Rating: 90 (10 reviews)

Catalog No.: AA00384E

195733-43-8 | 3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-

Pack Size： 1mg

Purity： 98%

in stock

$56.00 $39.00

Quantity

- +

Add to Card

Order Now

bulk Quotation Request

Technical Information

Catalog Number: AA00384E

Chemical Name: 3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-

CAS Number: 195733-43-8

Molecular Formula: C29H39ClN2O6

Molecular Weight: 547.0828

MDL Number: MFCD00191339

SMILES: CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC.Cl

Properties

Complexity: 734

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 3

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 38

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 12

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.

Journal: Clinical science (London, England : 1979)20020801

Title: Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498(1-3):171-7.

Title: Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 combination in prostate cancer. Cancer Res. 2007 Apr 15;67(8):3818-26.

Title: Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68(4):1093-8.