Home Fluorides 198474-05-4
198474-05-4,MFCD25121820
Catalog No.:AA002BG4

198474-05-4 | 3-(5-Fluoro-1h-indol-3-yl)pyrrolidine-2,5-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$28.00   $20.00
- +
5mg
≥98%
in stock  
$38.00   $26.00
- +
10mg
≥98%
in stock  
$63.00   $44.00
- +
25mg
98%
in stock  
$116.00   $82.00
- +
100mg
98%
in stock  
$267.00   $187.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002BG4
Chemical Name:
3-(5-Fluoro-1h-indol-3-yl)pyrrolidine-2,5-dione
CAS Number:
198474-05-4
Molecular Formula:
C12H9FN2O2
Molecular Weight:
232.2105
MDL Number:
MFCD25121820
SMILES:
Fc1cc2c(C3CC(=O)NC3=O)c[nH]c2cc1
Properties
Computed Properties
 
Complexity:
360  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.9  

Literature

Title: Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. [abstract In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr4863.

Title: Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J Med Chem. 2017 Dec 14;60(23):9617-9629.

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SDS
Tags:198474-05-4 Molecular Formula|198474-05-4 MDL|198474-05-4 SMILES|198474-05-4 3-(5-Fluoro-1h-indol-3-yl)pyrrolidine-2,5-dione