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199538-99-3,MFCD04039721
Catalog No.:AA002C39

199538-99-3 | tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$99.00   $69.00
- +
1g
98%
in stock  
$241.00   $169.00
- +
5g
98%
in stock  
$808.00   $566.00
- +
10g
98%
in stock  
$1,407.00   $985.00
- +
25g
98%
in stock  
$2,804.00   $1,963.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002C39
Chemical Name:
tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate
CAS Number:
199538-99-3
Molecular Formula:
C12H20N2O2
Molecular Weight:
224.2994
MDL Number:
MFCD04039721
SMILES:
C#CCN1CCN(CC1)C(=O)OC(C)(C)C
Properties
Properties
 
BP:
292.8°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
290  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
1  

Downstream Synthesis Route

[1]Karoli,Tomislav;Mamidyala,SreemanK.;Zuegg,Johannes;Fry,ScottR.;Tee,ErnestH.L.;Bradford,TanyaA.;Madala,PraveenK.;Huang,JohnnyX.;Ramu,Soumya;Butler,MarkS.;Cooper,MatthewA.[BioorganicandMedicinalChemistryLetters,2012,vol.22,#7,p.2428-2433]

[2]CurrentPatentAssignee:MICHIGANTECHNOLOGICALUNIVERSITY-WO2014/63033,2014,A2Locationinpatent:Paragraph00118

[3]Yapici,NazmiyeB.;Mandalapu,Srinivas;MichaelGibson;Bi,Lanrong[BioorganicandMedicinalChemistryLetters,2015,vol.25,#17,p.3476-3480]

[4]Zheng,Hailin;Weiner,LevM.;Bar-Am,Orit;Epsztejn,Silvina;Cabantchik,Z.Ioav;Warshawsky,Abraham;Youdim,MoussaB.H.;Fridkin,Mati[BioorganicandMedicinalChemistry,2005,vol.13,#3,p.773-783]

[5]CurrentPatentAssignee:UNIVERSITYOFGENEVA;THEUNIVERSITYOFMILANO-BICOCCA;UNIVERSITYOFLYON-WO2015/1024,2015,A1Locationinpatent:Page/Pagecolumn62-63

[6]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/41829,2004,A1Locationinpatent:Page68-69

[7]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/56812,2004,A1Locationinpatent:Page61

[8]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/69250,2004,A1Locationinpatent:Page/Pagecolumn57-58

[9]CurrentPatentAssignee:MARUISHIPHARMACEUTICALCO.,LTD.-EP1749817,2007,A1Locationinpatent:Page/Pagecolumn14

[10]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/56801,2004,A1Locationinpatent:Page67-68

[11]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/69249,2004,A1Locationinpatent:Page/Pagecolumn62

[12]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/81000,2004,A1Locationinpatent:Page61

[13]Lowe,PhillipT.;Dall'Angelo,Sergio;Mulder-Krieger,Thea;IJzerman,AdriaanP.;Zanda,Matteo;O'Hagan,David[ChemBioChem,2017,vol.18,#21,p.2156-2164]

[14]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/108711,2004,A1Locationinpatent:Page59

[15]Zheng,Shasha;Lingyue,Gu;Ong,MichelleJuiHsien;Jacquemin,Denis;Romieu,Anthony;Richard,Jean-Alexandre;Srinivasan,Rajavel[OrganicandBiomolecularChemistry,2019,vol.17,#17,p.4291-4300]

[16]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2020/114487,2020,A1Locationinpatent:Paragraph00292-00293

[17]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2020/114494,2020,A1Locationinpatent:Paragraph00230;00340

[18]CurrentPatentAssignee:NEOPHORE-WO2021/148786,2021,A1Locationinpatent:Paragraph00157-00158

[1]CurrentPatentAssignee:ARVINAS-US2018/99940,2018,A1Locationinpatent:Paragraph0449-0453

[2]CurrentPatentAssignee:BIOVENTURESNV;UNIVERSITYOFARKANSASSYSTEM-WO2017/184995,2017,A1Locationinpatent:Paragraph0176

[3]Zheng,Hailin;Weiner,LevM.;Bar-Am,Orit;Epsztejn,Silvina;Cabantchik,Z.Ioav;Warshawsky,Abraham;Youdim,MoussaB.H.;Fridkin,Mati[BioorganicandMedicinalChemistry,2005,vol.13,#3,p.773-783]

[4]Yang,Peng-Yu;Wang,Min;He,CynthiaY.;Yao,ShaoQ.[ChemicalCommunications,2012,vol.48,#6,p.835-837]

[5]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2020/114487,2020,A1Locationinpatent:Paragraph00292

[6]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2020/114494,2020,A1Locationinpatent:Paragraph00230;00339

[7]CurrentPatentAssignee:INSTITUTEOFPHYSICALANDCHEMICALRESEARCH(RIKEN);THEUNIVERSITYOFTOKYO-EP2565192,2013,A1Locationinpatent:Paragraph0506

[8]Karoli,Tomislav;Mamidyala,SreemanK.;Zuegg,Johannes;Fry,ScottR.;Tee,ErnestH.L.;Bradford,TanyaA.;Madala,PraveenK.;Huang,JohnnyX.;Ramu,Soumya;Butler,MarkS.;Cooper,MatthewA.[BioorganicandMedicinalChemistryLetters,2012,vol.22,#7,p.2428-2433]

[9]CurrentPatentAssignee:MICHIGANTECHNOLOGICALUNIVERSITY-WO2014/63033,2014,A2Locationinpatent:Paragraph00117

[10]Yapici,NazmiyeB.;Mandalapu,Srinivas;MichaelGibson;Bi,Lanrong[BioorganicandMedicinalChemistryLetters,2015,vol.25,#17,p.3476-3480]

[11]Locationinpatent:experimentalpartKapić,Samra;ČipčićPaljetak,Hana;PalejJakopović,Ivana;Fajdetić,Andrea;Ilijaš,Marina;Štimac,Vlado;Brajša,Karmen;Holmes,DavidJ.;Berge,John;Alihodžić,Sulejman[BioorganicandMedicinalChemistry,2011,vol.19,#23,p.7281-7298]

[12]CurrentPatentAssignee:NEOPHORE-WO2021/148786,2021,A1Locationinpatent:Paragraph00155-00156

[13]Lv,Xiaoqing;Ying,Huazhou;Ma,Xiaodong;Qiu,Ni;Wu,Peng;Yang,Bo;Hu,Yongzhou[EuropeanJournalofMedicinalChemistry,2015,vol.99,p.36-50]

[14]CurrentPatentAssignee:UNIVERSITYOFVIRGINIA;ABBVIEINC-US2006/40889,2006,A1Locationinpatent:Page/Pagecolumn27

[15]CurrentPatentAssignee:UNIVERSITYOFVIRGINIA-WO2006/15357,2006,A2Locationinpatent:Page/Pagecolumn75

[16]Yuan,Yue;Subedi,Lalita;Lim,Daesung;Jung,Jae-Kyung;Kim,SunYeou;Seo,Seung-Yong[BioorganicandMedicinalChemistryLetters,2019,vol.29,#2,p.329-333]

[17]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-WO2021/188948,2021,A1Locationinpatent:Paragraph00877-00878

[18]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-WO2021/188948,2021,A1Locationinpatent:Paragraph00877-00878

[19]Nieman,JamesA.;Nair,SajivK.;Heasley,StevenE.;Schultz,BrendaL.;Zerth,HerbertM.;Nugent,RichardA.;Chen,Ke;Stephanski,KevinJ.;Hopkins,ToddA.;Knechtel,MaryL.;Oien,NanceeL.;Wieber,JanetL.;Wathen,MichaelW.[BioorganicandMedicinalChemistryLetters,2010,vol.20,#10,p.3039-3042]

[20]CurrentPatentAssignee:QILUREGORTHERAPEUTICS-WO2020/103815,2020,A1Locationinpatent:Page/Pagecolumn64;104

[21]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/41829,2004,A1Locationinpatent:Page68

[22]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/56812,2004,A1Locationinpatent:Page61

[23]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/69250,2004,A1Locationinpatent:Page/Pagecolumn57

[24]CurrentPatentAssignee:MARUISHIPHARMACEUTICALCO.,LTD.-EP1749817,2007,A1Locationinpatent:Page/Pagecolumn13-14

[25]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/56801,2004,A1Locationinpatent:Page67

[26]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/69249,2004,A1Locationinpatent:Page/Pagecolumn62

[27]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/81000,2004,A1Locationinpatent:Page60

[28]CurrentPatentAssignee:BIOGENIDECINC.-WO2004/92177,2004,A1Locationinpatent:Page33

[29]CurrentPatentAssignee:THEUNIVERSITYOFMILANO-BICOCCA;UNIVERSITYOFLYON;UNIVERSITYOFGENEVA-WO2015/1024,2015,A1Locationinpatent:Page/Pagecolumn62

[30]Lowe,PhillipT.;Dall'Angelo,Sergio;Mulder-Krieger,Thea;IJzerman,AdriaanP.;Zanda,Matteo;O'Hagan,David[ChemBioChem,2017,vol.18,#21,p.2156-2164]

[31]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/108711,2004,A1Locationinpatent:Page58;59

[32]CurrentPatentAssignee:GALAPAGOS-WO2005/108413,2005,A1Locationinpatent:Page/Pagecolumn39-40;46-47

[33]Zheng,Shasha;Lingyue,Gu;Ong,MichelleJuiHsien;Jacquemin,Denis;Romieu,Anthony;Richard,Jean-Alexandre;Srinivasan,Rajavel[OrganicandBiomolecularChemistry,2019,vol.17,#17,p.4291-4300]

[34]CurrentPatentAssignee:THEUNIVERSITYOFTEXASSYSTEM;TEXASA&MUNIVERSITYSYSTEM-WO2022/47054,2022,A2Locationinpatent:Paragraph0007;00200;00209-00210

199538-99-3    927801-23-8   
tert-butyl4-(3-(6-bromoquinolin-4-yl)prop-2-ynyl)piperazine-1-carboxylate 

[1]EuropeanJournalofMedicinalChemistry,2015,vol.99,p.36-50

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