Name: Name:AC-RYYRWK-NH2
Brand: AABLOCKS
SKU: AA00BDQ3
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BDQ3

Chemical Name: AC-RYYRWK-NH2

CAS Number: 200959-47-3

Molecular Formula: C49H69N15O9

Molecular Weight: 1012.1673

MDL Number: MFCD06659097

SMILES: NCCCC[C@@H](C(=O)N)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CCCNC(=N)N)Cc1ccc(cc1)O)Cc1ccc(cc1)O)CCCNC(=N)N

Properties

Complexity: 1850

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 6

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 73

Hydrogen Bond Acceptor Count: 12

Hydrogen Bond Donor Count: 15

Isotope Atom Count: 0

Rotatable Bond Count: 30

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: -1.3

Literature fold

Title: Synthesis and analgesic effects of novel β2-tryptophan hexapeptide analogs.

Journal: Amino acids20131001

Title: In vitro studies of the activity of newly sinthesized nociceptin / orphanin FQ receptor ligand analogues.

Journal: Protein and peptide letters20100501

Title: Pharmacodynamic characterization of ZP120 (Ac-RYYRWKKKKKKK-NH2), a novel, functionally selective nociceptin/orphanin FQ peptide receptor partial agonist with sodium-potassium-sparing aquaretic activity.

Journal: The Journal of pharmacology and experimental therapeutics20050801

Title: Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

Journal: The journal of peptide research : official journal of the American Peptide Society20050701

Title: In vitro characterization of Ac-RYYRWK-NH(2), Ac-RYYRIK-NH(2) and [Phe1Psi(CH(2)-NH)Gly2] nociceptin(1-13)NH(2) at rat native and recombinant ORL(1) receptors.

Journal: Neuropeptides20010101

Title: Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle.

Journal: British journal of pharmacology20000901

Title: Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor.

Journal: Neuroscience letters20000107

Title: C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

Title: M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.

200959-47-3 | AC-RYYRWK-NH2