Title: Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Journal: Experimental lung research 20121101
Title: Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Journal: International journal of biological macromolecules 20121001
Title: Recent advancements of total aortic arch replacement.
Journal: The Journal of thoracic and cardiovascular surgery 20120701
Title: The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
Journal: Surgery today 20120701
Title: Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601
Title: Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.
Journal: Journal of perinatology : official journal of the California Perinatal Association 20120601
Title: The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection.
Journal: World journal of surgery 20120501
Title: Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9.
Journal: Journal of leukocyte biology 20120401
Title: Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120401
Title: Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Journal: Experimental lung research 20120201
Title: Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Journal: Pulmonary pharmacology & therapeutics 20120201
Title: Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
Journal: Anticancer research 20120101
Title: Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.
Journal: Journal of biomedical science 20120101
Title: Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
Journal: Drug design, development and therapy 20120101
Title: Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.
Journal: Journal of physiology and biochemistry 20111201
Title: Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.
Journal: Pulmonary pharmacology & therapeutics 20111001
Title: AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
Journal: The Journal of pharmacology and experimental therapeutics 20111001
Title: Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.
Journal: Shock (Augusta, Ga.) 20110901
Title: The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.
Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20110801
Title: Effects of sivelestat on bronchial inflammatory responses after esophagectomy.
Journal: International journal of molecular medicine 20110801
Title: Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy.
Journal: World journal of surgery 20110701
Title: Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.
Journal: The British journal of surgery 20110701
Title: Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes.
Journal: Digestive diseases and sciences 20110601
Title: Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats.
Journal: BJU international 20110101
Title: The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20110101
Title: Influence of neutrophil elastase inhibitor on the postoperative course in patients with esophageal cancer after transthoracic esophagectomy.
Journal: Hepato-gastroenterology 20110101
Title: Prognostic factors in gastrointestinal perforation.
Journal: Hepato-gastroenterology 20110101
Title: The effect of selective neutrophil elastase inhibitor on pancreatic islet yields and functions in rat with hypercytokinemia.
Journal: Annals of transplantation 20110101
Title: Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice.
Journal: Surgical infections 20101201
Title: Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture.
Journal: Journal of anesthesia 20101201
Title: A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction.
Journal: Surgery today 20101101
Title: Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
Journal: The American journal of pathology 20101001
Title: In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Journal: Experimental lung research 20101001
Title: Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
Journal: European journal of pharmacology 20100901
Title: Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.
Journal: International journal of dermatology 20100901
Title: Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.
Journal: Transplantation 20100815
Title: Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.
Journal: Journal of anesthesia 20100801
Title: Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100701
Title: Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
Journal: Interactive cardiovascular and thoracic surgery 20100601
Title: Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
Journal: Translational research : the journal of laboratory and clinical medicine 20100601
Title: The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Journal: Transplantation 20100515
Title: Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100501
Title: Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Journal: Shock (Augusta, Ga.) 20100501
Title: The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
Journal: The Journal of trauma 20100401
Title: Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection.
Journal: The Thoracic and cardiovascular surgeon 20100401
Title: Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
Journal: Shock (Augusta, Ga.) 20100101
Title: Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion.
Journal: Platelets 20100101
Title: Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.
Journal: Experimental lung research 20091201
Title: A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery.
Journal: Interactive cardiovascular and thoracic surgery 20090801
Title: Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
Journal: The Journal of surgical research 20090801
Title: Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia.
Journal: Interactive cardiovascular and thoracic surgery 20090601
Title: Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
Journal: Interactive cardiovascular and thoracic surgery 20090601
Title: Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401
Title: Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
Journal: Brain research 20090309
Title: Sivelestat treatment for acute respiratory distress syndrome in an infant.
Journal: Journal of anesthesia 20090101
Title: Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Journal: Pulmonary pharmacology & therapeutics 20081201
Title: The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model.
Journal: Interactive cardiovascular and thoracic surgery 20081001
Title: Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study.
Journal: The Journal of cardiovascular surgery 20081001
Title: Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20081001
Title: [Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20081001
Title: A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Journal: Inflammation 20080801
Title: Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.
Journal: Clinical and experimental pharmacology & physiology 20080701
Title: Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.
Journal: General thoracic and cardiovascular surgery 20080701
Title: Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.
Journal: European journal of pharmacology 20080610
Title: Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Journal: Respirology (Carlton, Vic.) 20080601
Title: Sivelestat and its role in tissue reperfusion injury.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080601
Title: [Effect of sivelestat sodium on acute lung injury after acute aortic dissection].
Journal: Kyobu geka. The Japanese journal of thoracic surgery 20080601
Title: [Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080601
Title: Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist.
Journal: Journal of cardiovascular pharmacology 20080501
Title: Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.
Journal: Molecular and cellular biochemistry 20080401
Title: [Case of severe transfusion-related acute lung injury during coronary artery bypass surgery].
Journal: Masui. The Japanese journal of anesthesiology 20080401
Title: [A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080301
Title: Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Journal: Nephrology (Carlton, Vic.) 20080201
Title: Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.
Journal: Internal medicine (Tokyo, Japan) 20080101
Title: Usefulness of a selective neutrophil elastase inhibitor (sivelestat) in septic ARDS patients after gastrointestinal surgery.
Journal: Hepato-gastroenterology 20080101
Title: A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass.
Journal: Journal of anesthesia 20080101
Title: Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase.
Journal: Biochemical and biophysical research communications 20071214
Title: Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis.
Journal: International journal of molecular medicine 20071201
Title: Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20071101
Title: [Case of fulminant idiopathic interstitial pneumonia treated by sodium siverlestat (Elaspol) and steroid pulse therapy following extracorporeal lung assist (ECLA)].
Journal: Masui. The Japanese journal of anesthesiology 20071001
Title: Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
Journal: European journal of pharmacology 20070924
Title: [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070801
Title: Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
Journal: British journal of pharmacology 20070701
Title: Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits.
Journal: Shock (Augusta, Ga.) 20070701
Title: [Outcome of patients with acute exacerbation of idiopathic interstitial fibrosis (IPF) treated with sivelestat and the prognostic value of serum KL-6 and surfactant protein D].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070601
Title: Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy.
Journal: The British journal of surgery 20070501
Title: [A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070501
Title: Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070401
Title: Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Journal: Experimental lung research 20070301
Title: A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.
Journal: International journal of molecular medicine 20070201
Title: Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines.
Journal: Oncology reports 20070101
Title: Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Journal: The Annals of thoracic surgery 20070101
Title: Invited commentary.
Journal: The Annals of thoracic surgery 20070101
Title: Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.
Journal: Surgery today 20070101
Title: Neutrophil elastase as a predicting factor for development of acute lung injury.
Journal: Internal medicine (Tokyo, Japan) 20070101
Title: Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.
Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20070101
Title: [A case of idiopathic ARDS treated by sivelestat sodium and fluid management based on extravascular lung water index].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20061201
Title: Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases.
Journal: European journal of haematology 20061101
Title: ICAM-1 signal transduction in cells stimulated with neutrophil elastase.
Journal: Digestive diseases and sciences 20061101
Title: [Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].
Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20061101
Title: Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.
Journal: Cancer science 20061001
Title: The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
Journal: The Thoracic and cardiovascular surgeon 20060901
Title: Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Journal: Transplantation proceedings 20060901
Title: [Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study].
Journal: Masui. The Japanese journal of anesthesiology 20060801
Title: Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters.
Journal: Shock (Augusta, Ga.) 20060701
Title: [Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports].
Journal: Masui. The Japanese journal of anesthesiology 20060601
Title: Application of chemical arrays in screening elastase inhibitors.
Journal: Combinatorial chemistry & high throughput screening 20060601
Title: A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
Journal: The Journal of trauma 20060501
Title: Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Journal: Journal of gastroenterology 20060401
Title: ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits.
Journal: The Journal of thoracic and cardiovascular surgery 20060301
Title: Update in ARDS management: recent randomized controlled trials that changed our practice.
Journal: Cleveland Clinic journal of medicine 20060301
Title: Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.
Journal: Journal of anesthesia 20060101
Title: [Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060101
Title: Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
Journal: Surgery today 20060101
Title: Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.
Journal: Journal of anesthesia 20060101
Title: Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.
Journal: Journal of anesthesia 20060101
Title: Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate.
Journal: Internal medicine (Tokyo, Japan) 20060101
Title: Usefulness of sivelestat sodium administration in patients with aspiration pneumonia.
Journal: Journal of anesthesia 20060101
Title: Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).
Journal: Internal medicine (Tokyo, Japan) 20060101
Title: Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction.
Journal: Research communications in molecular pathology and pharmacology 20060101
Title: Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients.
Journal: The Tohoku journal of experimental medicine 20051001
Title: [Clinical experience of sivelestat sodium hydrate for severe reexpansion pulmonary edema; report of a case].
Journal: Kyobu geka. The Japanese journal of thoracic surgery 20051001
Title: Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs.
Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20051001
Title: Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation.
Journal: The Annals of thoracic surgery 20050801
Title: Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
Journal: Critical care medicine 20050801
Title: [Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].
Journal: Masui. The Japanese journal of anesthesiology 20050801
Title: Case with bromine exposure leading to respiratory insufficiency.
Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20050401
Title: Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
Journal: Shock (Augusta, Ga.) 20050201
Title: Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome.
Journal: PharmacoEconomics 20050101
Title: Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
Journal: Pulmonary pharmacology & therapeutics 20050101
Title: Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation.
Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20050101
Title: Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20041201
Title: Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Journal: Inflammation 20041201
Title: [A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20041101
Title: Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.
Journal: Anesthesia and analgesia 20040901
Title: [Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy].
Journal: Masui. The Japanese journal of anesthesiology 20040901
Title: Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.
Journal: Critical care medicine 20040801
Title: Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
Journal: Intensive care medicine 20040501
Title: Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Journal: European journal of pharmacology 20040319
Title: Relationship between neutrophil elastase and acute lung injury in humans.
Journal: Pulmonary pharmacology & therapeutics 20040101
Title: Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046.
Journal: Biochemical and biophysical research communications 20031003
Title: [Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030801
Title: Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis.
Journal: Clinical nephrology 20030801
Title: The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20030501
Title: A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
Journal: Chest 20030401
Title: Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.
Journal: Bioorganic & medicinal chemistry letters 20020902
Title: Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice.
Journal: Shock (Augusta, Ga.) 20020801
Title: Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Journal: Critical care medicine 20020501
Title: Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.
Journal: Alimentary pharmacology & therapeutics 20020401
Title: Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.
Journal: The European journal of surgery = Acta chirurgica 20020101
Title: Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20011001
Title: A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
Journal: Journal of neurochemistry 20010901
Title: Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
Journal: European journal of pharmacology 20010824
Title: Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20010801
Title: Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.
Journal: Journal of leukocyte biology 20010201
Title: Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.
Title: Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43.
Title: Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92.
Title: Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28.
