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Title: Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study.
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Title: Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
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Title: Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye.
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Title: Diquafosol tetrasodium: a novel dry eye therapy.
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Title: Diquafosol elicits increases in net Cl- transport through P2Y2 receptor stimulation in rabbit conjunctiva.
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Title: INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model.
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Title: Ocular safety of INS365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease.
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Title: Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study.
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Title: Ocular safety of INS365 ophthalmic solution: a P2Y(2) agonist in healthy subjects.
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Title: Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model.
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Title: The medicinal chemistry of the P2 receptor family.
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