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2140-72-9,MFCD11519076
Catalog No.:AA00I41W

2140-72-9 | 2'-O-Methylcytidine

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Purity
Availability
Price(USD)
Quantity
  
250mg
97%
in stock  
$11.00   $8.00
- +
1g
98%
in stock  
$39.00   $27.00
- +
5g
97%
in stock  
$66.00   $47.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I41W
Chemical Name:
2'-O-Methylcytidine
CAS Number:
2140-72-9
Molecular Formula:
C10H15N3O5
Molecular Weight:
257.2432
MDL Number:
MFCD11519076
SMILES:
CO[C@@H]1[C@H](O)[C@H](O[C@H]1n1ccc(nc1=O)N)CO
Properties
Properties
 
BP:
506 °C at 760 mmHg  
Form:
Solid  
MP:
252-253 °C  
Solubility:
Soluble in DMSO.  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
397  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-1.6  

Literature

Title: Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group.

Journal: Organic & biomolecular chemistry 20100507

Title: The transition from noncoded to coded protein synthesis: did coding mRNAs arise from stability-enhancing binding partners to tRNA?

Journal: Biology direct 20100101

Title: Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.

Journal: BMC plant biology 20100101

Title: Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.

Journal: Bioorganic & medicinal chemistry 20080301

Title: Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA.

Journal: Journal of molecular biology 20080125

Title: Control of gag-pol gene expression in the Candida albicans retrotransposon Tca2.

Journal: BMC molecular biology 20070101

Title: Inhibitory effect of 2'-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells.

Journal: Antimicrobial agents and chemotherapy 20050501

Title: Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.

Journal: Journal of medicinal chemistry 20050224

Title: Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

Journal: The Journal of biological chemistry 20031205

Title: Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.

Journal: The Journal of biological chemistry 20030404

Title: Using capillary electrophoresis to study methylation effect on RNA-peptide interaction.

Journal: Acta biochimica Polonica 20030101

Title: Synthesis of new 3'-, 5-, and N(4)-modified 2'-O-methylcytidine libraries on solid support.

Journal: Journal of combinatorial chemistry 20030101

Title: Interaction of RNA with phage display selected peptides analyzed by capillary electrophoresis mobility shift assay.

Journal: RNA (New York, N.Y.) 20020501

Title: Anticodon domain methylated nucleosides of yeast tRNA(Phe) are significant recognition determinants in the binding of a phage display selected peptide.

Journal: Biochemistry 20011127

Title: Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84

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