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214358-33-5,MFCD03428622
Catalog No.:AA003S7F

214358-33-5 | 1400W Dihydrochloride

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1mg
95%
in stock  
$24.00   $17.00
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5mg
95%
in stock  
$58.00   $41.00
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10mg
95%
in stock  
$87.00   $61.00
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50mg
95%
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$279.00   $195.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003S7F
Chemical Name:
1400W Dihydrochloride
CAS Number:
214358-33-5
Molecular Formula:
C10H17Cl2N3
Molecular Weight:
250.1681
MDL Number:
MFCD03428622
SMILES:
NCc1cccc(c1)CNC(=N)C.Cl.Cl
Properties
Properties
 
BP:
329°C at 760 mmHg  
Form:
Solid  
MP:
213-220°C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
177  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Literature

Title: The role S-nitrosylation in manganese-induced autophagy dysregulation in SH-SY5Y cells.

Journal: Environmental toxicology 20171201

Title: Role of NOS2 in pulmonary injury and repair in response to bleomycin.

Journal: Free radical biology & medicine 20160201

Title: NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150701

Title: The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.

Journal: American journal of physiology. Endocrinology and metabolism 20121001

Title: Delineation of the effects of angiotensin type 1 and 2 receptors on HL-1 cardiomyocyte apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20120801

Title: Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.

Journal: Toxicology and applied pharmacology 20120615

Title: Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.

Journal: Stroke 20120601

Title: Mechanism of the relaxant effect of rosuvastatin lactone on rat aortic rings.

Journal: Frontiers in bioscience (Elite edition) 20120101

Title: Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction.

Journal: Respiratory research 20120101

Title: Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.

Journal: Environmental health perspectives 20110601

Title: Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing.

Journal: Journal of gastroenterology 20110501

Title: Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20110419

Title: Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart.

Journal: Journal of molecular and cellular cardiology 20110301

Title: Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide.

Journal: Cellular signalling 20110201

Title: Inhibition of inducible nitric oxide synthase promotes vein graft neoadventitial inflammation and remodelling.

Journal: Journal of vascular research 20110101

Title: Inhibition of nNOS prevents and inhibition of iNOS reverses α,β-meATP-induced facilitation of neck muscle nociception in mice.

Journal: European journal of pharmacology 20101125

Title: Involvement of nitric oxide in lipopolysaccharide induced anorexia.

Journal: Pharmacology, biochemistry, and behavior 20101101

Title: Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20101101

Title: Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses.

Journal: Experimental & molecular medicine 20101031

Title: Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation.

Journal: American journal of physiology. Heart and circulatory physiology 20100801

Title: Augmentation of platelet and endothelial cell eNOS activity decreases sepsis-related neutrophil-endothelial cell interactions.

Journal: Shock (Augusta, Ga.) 20100301

Title: Inducible NOS inhibitor 1400W reduces hypoxia/re-oxygenation injury in rat lung.

Journal: Redox report : communications in free radical research 20100101

Title: A cellular model for screening neuronal nitric oxide synthase inhibitors.

Journal: Analytical biochemistry 20090701

Title: The dynamic detection of NO during stroke and reperfusion in vivo.

Journal: Brain injury 20090501

Title: Human neutrophil-pulmonary microvascular endothelial cell interactions in vitro: differential effects of nitric oxide vs. peroxynitrite.

Journal: Microvascular research 20080801

Title: Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats.

Journal: Experimental biology and medicine (Maywood, N.J.) 20080301

Title: Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins.

Journal: The Journal of biological chemistry 20080222

Title: Inducible nitric oxide synthase mediates retinal DNA damage in Goto-Kakizaki rat retina.

Journal: Japanese journal of ophthalmology 20080101

Title: [No-synthase activity in primary cultured frog urinary bladder epithielial cells and no-dependent antimicrobial effect].

Journal: Tsitologiia 20080101

Title: Nitrosative stress and corneal transplant endothelial cell death during acute graft rejection.

Journal: Transplantation 20070815

Title: TNF-alpha downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation.

Journal: American journal of physiology. Heart and circulatory physiology 20070701

Title: A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus.

Journal: Neuropharmacology 20070601

Title: Functional characterization of the mechanisms underlying bradykinin-induced relaxation in the isolated rat carotid artery.

Journal: Life sciences 20070417

Title: Acute and conditioned hypoxic tolerance augmented by endothelial nitric oxide synthase inhibition in mice.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20070201

Title: Ibuprofen or ozagrel increases NO release and l-nitro arginine induces TXA(2) release from cultured porcine basilar arterial endothelial cells.

Journal: Vascular pharmacology 20070201

Title: Dual action of nitric oxide in the pathogenesis of ischemia/reperfusion-induced mucosal injury in mouse stomach.

Journal: Digestion 20070101

Title: Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction.

Journal: The European journal of neuroscience 20060901

Title: [The presence of nitric oxide synthase in mucosal epithelial cells of the frog urinary bladder].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20060801

Title: Lipopolysaccharide exposure makes allergic airway inflammation and hyper-responsiveness less responsive to dexamethasone and inhibition of iNOS.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060701

Title: Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20060601

Title: Inhibition of inducible nitric oxide synthase attenuates platelet adhesion in subpleural arterioles caused by lung ischemia-reperfusion in rabbits.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20051201

Title: Regulation of interleukin-6 secretion in murine pituicytes.

Journal: European journal of pharmacology 20050905

Title: Rat gastric injury after lipopolysaccharide: role of inducible nitric oxide synthase.

Journal: Surgery 20050901

Title: Protection from experimental asthma by an endogenous bronchodilator.

Journal: Science (New York, N.Y.) 20050610

Title: Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration.

Journal: Surgery 20050401

Title: Coexposure of lead- and lipopolysaccharide-induced liver injury in rats: involvement of nitric oxide-initiated oxidative stress and TNF-alpha.

Journal: Shock (Augusta, Ga.) 20050401

Title: Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy?

Journal: American journal of obstetrics and gynecology 20050401

Title: Expression of inducible nitric oxide synthase in cultured smooth muscle cells from rat mesenteric lymphatic vessels.

Journal: Microcirculation (New York, N.Y. : 1994) 20040901

Title: Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages.

Journal: British journal of pharmacology 20010701

Title: N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.

Journal: Journal of medicinal chemistry 19980716

Title: Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63.

Title: Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199.

Title: Rus A, et al. Inducible NOS inhibitor 1400W reduces hypoxia/re-oxygenation injury in rat lung. Redox Rep. 2010;15(4):169-78.

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