[1]Proceedings-IndianAcademyofSciences,SectionA,1948,p.217,220
[1]OrganicProcessResearchandDevelopment,2019,vol.23,p.595-602
[2]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1940,vol.60,p.614;engl.Ref.S.246 Chem.Abstr.,1941,p.7964
[3]Heterocycles,2003,vol.60,p.2775-2784
[4]ChemicalCommunications,2011,vol.47,p.2868-2870
[1]Proceedings-IndianAcademyofSciences,SectionA,1949,p.12
[1]Tetrahedron,2004,vol.60,p.2647-2655
[2]Proceedings-IndianAcademyofSciences,SectionA,1948,p.217,220
[1]JournaloftheChemicalSociety,1938,p.1004
[2]Proceedings-IndianAcademyofSciences,SectionA,1948,p.217,220
Title: Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.
Journal: Biological & pharmaceutical bulletin 20140101
Title: Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
Journal: Biochemical and biophysical research communications 20130215
Title: Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.
Journal: Food chemistry 20121215
Title: Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study.
Journal: Biomedical chromatography : BMC 20121201
Title: Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities.
Journal: Journal of the science of food and agriculture 20121201
Title: Dietary polyphenols and mechanisms of osteoarthritis.
Journal: The Journal of nutritional biochemistry 20121101
Title: Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9.
Journal: Pharmaceutical biology 20121001
Title: Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.
Journal: Journal of agricultural and food chemistry 20120926
Title: Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901
Title: The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.
Journal: Journal of agricultural and food chemistry 20120815
Title: In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.
Journal: Molecular nutrition & food research 20120601
Title: The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease.
Journal: European journal of pharmacology 20120505
Title: Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction.
Journal: Biochimica et biophysica acta 20120401
Title: Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells.
Journal: Journal of agricultural and food chemistry 20120307
Title: Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells.
Journal: Journal of medicinal food 20120201
Title: Phenolic constituents from the heartwood of Artocapus altilis and their tyrosinase inhibitory activity.
Journal: Natural product communications 20120201
Title: The oxidative state of chylomicron remnants influences their modulation of human monocyte activation.
Journal: International journal of vascular medicine 20120101
Title: 3',4'-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells.
Journal: Free radical biology & medicine 20120101
Title: Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.
Journal: International journal of nanomedicine 20120101
Title: Isolation and characterization of activators of ERK/MAPK from citrus plants.
Journal: International journal of molecular sciences 20120101
Title: Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.
Journal: BMC complementary and alternative medicine 20120101
Title: Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention.
Journal: International journal of inflammation 20120101
Title: Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.
Journal: Frontiers in microbiology 20120101
Title: Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation.
Journal: PPAR research 20120101
Title: Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.
Journal: Oxidative medicine and cellular longevity 20120101
Title: Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.
Journal: Journal of pharmacological sciences 20120101
Title: Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes.
Journal: Bioscience, biotechnology, and biochemistry 20120101
Title: Nobiletin suppresses adipogenesis by regulating the expression of adipogenic transcription factors and the activation of AMP-activated protein kinase (AMPK).
Journal: Journal of agricultural and food chemistry 20111228
Title: Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method.
Journal: Fitoterapia 20111201
Title: B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
Journal: Bioorganic & medicinal chemistry 20111201
Title: [Identification of metabolites of nobiletin in rats using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20111201
Title: In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111101
Title: Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model.
Journal: Journal of cellular biochemistry 20111101
Title: Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.
Journal: Analytica chimica acta 20111031
Title: Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability.
Journal: Journal of pharmaceutical sciences 20110901
Title: Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
Journal: Bioorganic & medicinal chemistry letters 20110801
Title: High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.
Journal: Analytical and bioanalytical chemistry 20110701
Title: Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion.
Journal: Journal of agricultural and food chemistry 20110511
Title: Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells.
Journal: Molecular nutrition & food research 20110501
Title: Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.
Journal: Diabetes 20110501
Title: Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
Journal: Bioorganic & medicinal chemistry 20110501
Title: Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.
Journal: Life sciences 20110328
Title: Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Journal: Bioorganic & medicinal chemistry 20110315
Title: PET imaging of nobiletin based on a practical total synthesis.
Journal: Chemical communications (Cambridge, England) 20110314
Title: Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.
Journal: Journal of agricultural and food chemistry 20110309
Title: Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry.
Journal: Journal of agricultural and food chemistry 20110112
Title: Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.
Journal: Physiology & behavior 20110110
Title: Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Suppressive Effect on Lipopolysaccharide-Induced Proinflammatory Mediators by Citrus aurantium L. in Macrophage RAW 264.7 Cells via NF-κB Signal Pathway.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.
Journal: Molecular and cellular biochemistry 20110101
Title: Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products.
Journal: Osteoarthritis and cartilage 20110101
Title: Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.
Journal: Journal of pharmacological sciences 20110101
Title: Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.
Journal: Nutrition and cancer 20110101
Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.
Journal: International journal of molecular sciences 20110101
Title: Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.
Journal: Lipids in health and disease 20110101
Title: Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation.
Journal: Molecular vision 20110101
Title: Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells.
Journal: Journal of pharmacological sciences 20110101
Title: Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.
Journal: PloS one 20110101
Title: Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance.
Journal: Cardiovascular diabetology 20110101
Title: Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root.
Journal: Indian journal of pharmacology 20110101
Title: Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.
Journal: PloS one 20110101
Title: Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice.
Journal: Pharmacognosy research 20110101
Title: A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.
Journal: PloS one 20110101
Title: Flavonoids: A versatile source of anticancer drugs.
Journal: Pharmacognosy reviews 20110101
Title: Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells.
Journal: PloS one 20110101
Title: Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.
Journal: Archives of toxicology 20101201
Title: Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo.
Journal: Cancer science 20101101
Title: Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide.
Journal: Neuroscience letters 20101022
Title: Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong.
Journal: Journal of agricultural and food chemistry 20100908
Title: Study of nobiletin binding to bovine serum albumin by capillary electrophoresis-frontal analysis and circular dichroism.
Journal: Biomedical chromatography : BMC 20100901
Title: Simultaneous determination of flavonoids in different parts of Citrus reticulata 'Chachi' fruit by high performance liquid chromatography-photodiode array detection.
Journal: Molecules (Basel, Switzerland) 20100805
Title: Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.
Journal: Journal of neurochemistry 20100801
Title: Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice.
Journal: Biochemical pharmacology 20100601
Title: Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats.
Journal: Experimental biology and medicine (Maywood, N.J.) 20100601
Title: Prevention of UV-induced skin damages by 11,14,17-eicosatrienoic acid in hairless mice in vivo.
Journal: Journal of Korean medical science 20100601
Title: Overcoming multidrug resistance in human cancer cells by natural compounds.
Journal: Toxins 20100601
Title: Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand.
Journal: Journal of agricultural and food chemistry 20100526
Title: [Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100401
Title: [Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography].
Journal: Se pu = Chinese journal of chromatography 20100401
Title: Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.
Journal: Cancer investigation 20100301
Title: Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook.
Journal: Molecules (Basel, Switzerland) 20100226
Title: Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells.
Journal: Biochimica et biophysica acta 20100201
Title: [Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100201
Title: Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Journal: Chemico-biological interactions 20100127
Title: Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice.
Journal: Journal of biomedicine & biotechnology 20100101
Title: Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats.
Journal: Journal of nutritional science and vitaminology 20100101
Title: Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.
Journal: BMC pharmacology 20100101
Title: Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101
Title: Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.
Journal: Oxidative medicine and cellular longevity 20100101
Title: Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin.
Journal: Journal of young pharmacists : JYP 20100101
Title: Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.
Journal: International journal of molecular sciences 20091101
Title: Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Journal: Brain research 20091027
Title: Modified Wendan Decoction can Attenuate Neurotoxic Action Associated with Alzheimer's Disease.
Journal: Evidence-based complementary and alternative medicine : eCAM 20090901
Title: Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods.
Journal: Analytica chimica acta 20090901
Title: 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Journal: Biochemistry 20090818
Title: Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection.
Journal: Journal of agricultural and food chemistry 20090812
Title: Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway.
Journal: European journal of pharmacology 20090801
Title: An updated review of tyrosinase inhibitors.
Journal: International journal of molecular sciences 20090601
Title: [Effect of nobiletin on K562 cells xenograft in nude mice].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601
Title: [Inhibition effect and its mechanism of nobiletin on proliferation of lung cancer cells].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090501
Title: Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion.
Journal: Bioorganic & medicinal chemistry letters 20090401
Title: Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis.
Journal: Molecular nutrition & food research 20090301
Title: [Preparation of self-assemble nobiletin proliposomes and its pharmacokinetics in rats].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090201
Title: Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.
Journal: Bioorganic & medicinal chemistry 20090101
Title: Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells.
Journal: The Journal of pharmacy and pharmacology 20090101
Title: Characterization of SV-40 Tag rats as a model to study prostate cancer.
Journal: BMC cancer 20090101
Title: Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells.
Journal: Lipids in health and disease 20090101
Title: Colorectal carcinogenesis: Review of human and experimental animal studies.
Journal: Journal of carcinogenesis 20090101
Title: Chemoprevention with phytochemicals targeting inducible nitric oxide synthase.
Journal: Forum of nutrition 20090101
Title: Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.
Journal: BMC cancer 20090101
Title: Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model.
Journal: Mediators of inflammation 20090101
Title: Chinese medicines as a resource for liver fibrosis treatment.
Journal: Chinese medicine 20090101
Title: Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-beta.
Journal: Journal of neuroinflammation 20090101
Title: Alleviation and prevention of severe allergic rhinitis and conjunctivitis following long-term lemon juice use: a case report.
Journal: Cases journal 20090101
Title: Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1.
Journal: European journal of pharmacology 20081214
Title: Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3',4'-didemethylnobiletin, derived from nobiletin.
Journal: Carcinogenesis 20081201
Title: Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels.
Journal: Journal of agricultural and food chemistry 20080910
Title: Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.
Journal: The Journal of pharmacology and experimental therapeutics 20080901
Title: [Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080901
Title: Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.
Journal: Journal of clinical biochemistry and nutrition 20080901
Title: [Effect of nobiletin on tubulin polymerization in vitro].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901
Title: Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.
Journal: Biochemical and biophysical research communications 20080822
Title: Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo.
Journal: Cancer biology & therapy 20080601
Title: Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.
Journal: Carcinogenesis 20080501
Title: Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation.
Journal: Biochemical pharmacology 20080401
Title: Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice.
Journal: International journal of pharmaceutics 20080320
Title: Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells.
Journal: Bioorganic & medicinal chemistry 20080315
Title: LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 expression in human lymphatic endothelium.
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080201
Title: A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells.
Journal: Biochemical and biophysical research communications 20080201
Title: Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.
Journal: European journal of pharmacology 20080114
Title: Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts.
Journal: Journal of separation science 20080101
Title: Minerals, phenolic compounds, and antioxidant capacity of citrus peel extract by hot water.
Journal: Journal of food science 20080101
Title: Inhibition of oral carcinogenesis by citrus flavonoids.
Journal: Nutrition and cancer 20080101
Title: Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models.
Journal: Chinese medicine 20080101
Title: Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101
Title: Inflammaging as a prodrome to Alzheimer's disease.
Journal: Journal of neuroinflammation 20080101
Title: A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters.
Journal: The Journal of investigative dermatology 20071201
Title: Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
Journal: Biopharmaceutics & drug disposition 20071201
Title: Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450.
Journal: Biological & pharmaceutical bulletin 20071201
Title: Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells.
Journal: Pharmaceutical research 20071001
Title: Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
Journal: Seminars in cancer biology 20071001
Title: Comparison of two sample preconcentration strategies for the sensitivity enhancement of flavonoids found in Chinese herbal medicine in micellar electrokinetic chromatography with UV detection.
Journal: Journal of chromatography. A 20070928
Title: Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
Journal: Bioorganic & medicinal chemistry letters 20070915
Title: Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
Journal: Journal of pharmacological sciences 20070901
Title: Antimicrobial activity of wax and hexane extracts from Citrus spp. peels.
Journal: Memorias do Instituto Oswaldo Cruz 20070901
Title: Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells.
Journal: Journal of ethnopharmacology 20070815
Title: Effects of TNF-alpha on leukocyte adhesion molecule expressions in cultured human lymphatic endothelium.
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20070701
Title: Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.
Journal: Bioscience, biotechnology, and biochemistry 20070701
Title: Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.
Journal: Cancer letters 20070618
Title: Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes.
Journal: Biochemical and biophysical research communications 20070601
Title: [Characteristics of nobiletin-loaded nanoemulsion and its in vivo distribution in mice].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070601
Title: Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Journal: Bioorganic & medicinal chemistry 20070515
Title: Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques.
Journal: Journal of pharmaceutical and biomedical analysis 20070509
Title: Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.
Journal: The Journal of pharmacology and experimental therapeutics 20070501
Title: Quality control and discrimination of pericarpium citri reticulatae and pericarpium citri reticulatae viride based on high-performance liquid chromatographic fingerprints and multivariate statistical analysis.
Journal: Analytica chimica acta 20070411
Title: Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.
Journal: Journal of agricultural and food chemistry 20070404
Title: Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.
Journal: Cancer science 20070401
Title: Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits.
Journal: Biological & pharmaceutical bulletin 20070401
Title: Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice.
Journal: Journal of medicinal food 20070301
Title: Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.
Journal: Journal of medicinal food 20070301
Title: Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV.
Journal: Journal of pharmaceutical and biomedical analysis 20070219
Title: Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201
Title: Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.
Journal: Journal of enzyme inhibition and medicinal chemistry 20070201
Title: Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.
Journal: Journal of enzyme inhibition and medicinal chemistry 20070201
Title: Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells.
Journal: Biochemical pharmacology 20070115
Title: Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography.
Journal: Biomedical chromatography : BMC 20070101
Title: Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.
Journal: BioFactors (Oxford, England) 20070101
Title: Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
Journal: BioFactors (Oxford, England) 20070101
Title: Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases.
Journal: Biomedical chromatography : BMC 20061101
Title: Insulin-sensitizing and anti-proliferative effects of Argania spinosa seed extracts.
Journal: Evidence-based complementary and alternative medicine : eCAM 20060901
Title: [Antitumor effects of nobiletin on Heps and its mechanism].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801
Title: Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.
Journal: Neuroscience letters 20060612
Title: Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.
Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20060601
Title: Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
Journal: FEBS letters 20060529
Title: Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms.
Journal: Life sciences 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.
Journal: Biological chemistry 20060401
Title: Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.
Journal: International journal of molecular medicine 20060301
Title: Identification of nobiletin metabolites in mouse urine.
Journal: Molecular nutrition & food research 20060301
Title: Liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance as complementary analytical techniques for unambiguous identification of polymethoxylated flavones in residues from molecular distillation of orange peel oils (Citrus sinensis).
Journal: Journal of agricultural and food chemistry 20060125
Title: Nobiletin: efficient and large quantity isolation from orange peel extract.
Journal: Biomedical chromatography : BMC 20060101
Title: Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.
Journal: Biochemical and biophysical research communications 20051202
Title: Mechanism of neurotrophic action of nobiletin in PC12D cells.
Journal: Biochemistry 20051025
Title: Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography.
Journal: Journal of chromatography. A 20051007
Title: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050401
Title: Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography.
Journal: The Journal of pharmacy and pharmacology 20050401
Title: [Chemical study of citrus plants in the search for cancer chemopreventive agents].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301
Title: Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.
Journal: Bioscience, biotechnology, and biochemistry 20050201
Title: Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
Journal: Atherosclerosis 20050101
Title: Anti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin.
Journal: The American journal of Chinese medicine 20050101
Title: Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene.
Journal: Journal of biomedicine & biotechnology 20050101
Title: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
Journal: British journal of pharmacology 20041201
Title: Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo.
Journal: Cancer science 20041201
Title: Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
Journal: Journal of natural products 20041101
Title: Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro.
Journal: Biochemical pharmacology 20040801
Title: Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.
Journal: Mutation research 20040713
Title: Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.
Journal: Molecular cancer therapeutics 20040701
Title: Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation.
Journal: Alimentary pharmacology & therapeutics 20040701
Title: Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.
Journal: Journal of agricultural and food chemistry 20040407
Title: ZD6126 inhibits orthotopic growth and peritoneal carcinomatosis in a mouse model of human gastric cancer.
Journal: British journal of cancer 20040209
Title: Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system.
Journal: Cancer science 20040201
Title: Cancer prevention by antioxidants.
Journal: BioFactors (Oxford, England) 20040101
Title: Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.
Journal: BioFactors (Oxford, England) 20040101
Title: Effect of extraction method on the concentrations of selected bioactive compounds in mandarin juice.
Journal: Journal of agricultural and food chemistry 20031203
Title: Urinary metabolites of nobiletin orally administered to rats.
Journal: Chemical & pharmaceutical bulletin 20031201
Title: Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits.
Journal: Pest management science 20031101
Title: Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages.
Journal: Biochemical pharmacology 20030615
Title: Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.
Journal: Cancer letters 20030530
Title: Insect antifeedant activity of flavones and chromones against Spodoptera litura.
Journal: Journal of agricultural and food chemistry 20030115
Title: Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.
Journal: Journal of cancer research and clinical oncology 20021001
Title: Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.
Journal: Biological & pharmaceutical bulletin 20020601
Title: Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels.
Journal: Journal of agricultural and food chemistry 20020508
Title: Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020501
Title: Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.
Journal: Cancer research 20020215
Title: Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.
Journal: Biochemical pharmacology 20020115
Title: Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.
Journal: BioFactors (Oxford, England) 20020101
Title: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
Journal: Chemical research in toxicology 20011201
Title: The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice.
Journal: Japanese journal of cancer research : Gann 20011201
Title: Immunotoxicity of a standardized citrus polymethoxylated flavone extract.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011101
Title: Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Journal: Life sciences 20010713
Title: Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
Journal: Cancer letters 20010210
Title: Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro.
Journal: Neuropathology and applied neurobiology 20010201
Title: In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits.
Journal: Bioscience, biotechnology, and biochemistry 20010101
Title: Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.
Journal: Biochemical pharmacology 19940803
Title: Inhibition of reverse transcriptases by flavonoids.
Journal: Antiviral research 19890901