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215918-21-1,MFCD12755205
Catalog No.:AA00CFZE

215918-21-1 | (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
97.0%
in stock  
$131.00   $92.00
- +
250mg
97.0%
in stock  
$195.00   $137.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00CFZE
Chemical Name:
(S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS Number:
215918-21-1
Molecular Formula:
C10H17F2NO3
Molecular Weight:
237.2437
MDL Number:
MFCD12755205
SMILES:
OC[C@@H]1CC(CN1C(=O)OC(C)(C)C)(F)F
Properties
Properties
 
BP:
293.4°C at 760 mmHg  
Form:
Liquid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
276  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.3  

Downstream Synthesis Route

[1]EuropeanJournalofMedicinalChemistry,2013,vol.64,p.562-578

[2]Patent:WO2015/109109,2015,A1.Locationinpatent:Paragraph1247

[3]Patent:US2017/44182,2017,A1.Locationinpatent:Paragraph1813

[4]TetrahedronLetters,2003,vol.44,p.7809-7812

[5]Patent:US2009/275573,2009,A1.Locationinpatent:Page/Pagecolumn23

[6]Patent:WO2012/158795,2012,A1.Locationinpatent:Page/Pagecolumn97

[7]Patent:WO2012/158764,2012,A1.Locationinpatent:Page/Pagecolumn209

[8]Patent:WO2013/191965,2013,A1.Locationinpatent:Page/Pagecolumn187

[9]Patent:WO2014/19344,2014,A1

[10]Patent:WO2014/22569,2014,A1.Locationinpatent:Page/Pagecolumn90

[11]Patent:US8673925,2014,B1.Locationinpatent:Page/Pagecolumn236

[12]Patent:WO2014/131315,2014,A1

[13]Patent:US2015/79028,2015,A1

[14]Patent:WO2016/8411,2016,A1.Locationinpatent:Paragraph0281

[15]Patent:CN103880823,2017,B

[16]Patent:EP3450430,2019,A1.Locationinpatent:Paragraph0272;0275

[1]Patent:US2011/82165,2011,A1.Locationinpatent:Page/Pagecolumn29-30

[2]ChemicalCommunications,2011,vol.47,p.10040-10042

[3]Patent:US2011/105520,2011,A1.Locationinpatent:Page/Pagecolumn36

[4]ChemMedChem,2015,vol.10,p.1071-1078

[5]Patent:WO2014/19344,2014,A1.Locationinpatent:Paragraph00452

[6]Patent:WO2014/131315,2014,A1.Locationinpatent:Page/Pagecolumn125

[7]Patent:US2015/79028,2015,A1.Locationinpatent:Paragraph1117;1128;1129;1130

[8]Patent:CN103880823,2017,B.Locationinpatent:Paragraph1612;1631;1632

[9]Patent:WO2013/152198,2013,A1.Locationinpatent:Paragraph00463;00464

[10]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.1515-1529

[11]Patent:WO2011/88045,2011,A1.Locationinpatent:Page/Pagecolumn161

[12]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.5296-5300

[13]Patent:WO2015/109109,2015,A1

[14]Patent:US2017/44182,2017,A1

695-96-5    215918-21-1   
tert-butyl2-(2-bromo-4-chlorophenoxy)methyl-4,4-difluoropyrrolidine-1-carboxylate 

[1]CurrentPatentAssignee:ANNEXONINC-WO2022/20244,2022,A1Locationinpatent:Page/Pagecolumn361-362

[2]CurrentPatentAssignee:ANNEXONINC-WO2022/20244,2022,A1Locationinpatent:Page/Pagecolumn361-362

Literature
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SDS
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Tags:215918-21-1 Molecular Formula|215918-21-1 MDL|215918-21-1 SMILES|215918-21-1 (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate