Name: Name:N-Boc-4,4-difluoro-l-proline
Brand: AABLOCKS
SKU: AA00292X
Rating: 90 (10 reviews)

Catalog No.: AA00292X

203866-15-3 | N-Boc-4,4-difluoro-l-proline

Pack Size： 1g

Purity： 97%

in stock

$16.00 $11.00

Pack Size： 5g

Purity： 95%

in stock

$38.00 $27.00

Pack Size： 10g

Purity： 95%

in stock

$69.00 $48.00

Pack Size： 25g

Purity： 95%

in stock

$158.00 $110.00

Pack Size： 50g

Purity： 95%

in stock

$308.00 $216.00

Pack Size： 100g

Purity： 95%

in stock

$553.00 $387.00

Pack Size： 250g

Purity： 95%

in stock

$1,229.00 $861.00

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Technical Information

Catalog Number: AA00292X

Chemical Name: N-Boc-4,4-difluoro-l-proline

CAS Number: 203866-15-3

Molecular Formula: C10H15F2NO4

Molecular Weight: 251.2272

MDL Number: MFCD03094917

SMILES: O=C(N1CC(C[C@H]1C(=O)O)(F)F)OC(C)(C)C

Properties

BP: 340.4°C at 760 mmHg

Form: Solid

MP: 120-124°C

Storage: Keep in dry area;Room Temperature;

Complexity: 338

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 17

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.5

Upstream Synthesis Route

203866-15-3

52683-81-5

[1]Patent:US2008/9497,2008,A1,.Locationinpatent:Page/Pagecolumn109

[2]Patent:WO2014/82379,2014,A1,.Locationinpatent:Page/Pagecolumn158;159;163

[3]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

67-56-1

203866-15-3

156046-05-8

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,#14,p.3859-3862

203866-17-5

203866-15-3

[1]Patent:WO2012/146666,2012,A1,.Locationinpatent:Page/Pagecolumn138-139

[2]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[3]Patent:WO2014/19344,2014,A1,.Locationinpatent:Paragraph00451

[4]Patent:WO2014/82380,2014,A1,.Locationinpatent:Paragraph00427;00430

[5]Patent:WO2014/82379,2014,A1,.Locationinpatent:Page/Pagecolumn158;159;161

[6]Patent:WO2014/131315,2014,A1,.Locationinpatent:Page/Pagecolumn124;125

[7]Patent:US2015/79028,2015,A1,.Locationinpatent:Paragraph1117;1124;1125;1126;1127

[8]Patent:CN103880823,2017,B,.Locationinpatent:Paragraph1612;1627;1628

[9]BioorganicandMedicinalChemistry,2006,vol.14,#8,p.2725-2746

[10]Patent:US2014/357650,2014,A1,.Locationinpatent:Paragraph0281;0290;0291;0292;0293

[11]Patent:WO2005/23762,2005,A1,.Locationinpatent:Page/Pagecolumn72

[12]Patent:EP1659121,2006,A1,.Locationinpatent:Page/Pagecolumn19-20

[13]Patent:WO2004/99185,2004,A1,.Locationinpatent:Page48

[14]Patent:US2005/131019,2005,A1,.Locationinpatent:Page/Pagecolumn31;34

[15]Patent:WO2013/107820,2013,A1,.Locationinpatent:Page/Pagecolumn45

[16]JournalofMedicinalChemistry,2014,vol.57,#7,p.3053-3074

[17]Patent:WO2015/28095,2015,A1,.Locationinpatent:Paragraph00222

[18]Patent:US2016/297830,2016,A1,.Locationinpatent:Paragraph0303

102195-80-2

203866-15-3

[1]BioorganicandMedicinalChemistry,2006,vol.14,#8,p.2725-2746

[2]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[3]Patent:WO2013/107820,2013,A1,

[4]Patent:WO2014/19344,2014,A1,

[5]JournalofMedicinalChemistry,2014,vol.57,#7,p.3053-3074

[6]Patent:WO2014/82380,2014,A1,

[7]Patent:WO2014/82379,2014,A1,

[8]Patent:WO2014/131315,2014,A1,

[9]Patent:US2014/357650,2014,A1,

[10]Patent:US2015/79028,2015,A1,

[11]Patent:CN103880823,2017,B,

74844-91-0

203866-15-3

[1]BioorganicandMedicinalChemistry,2006,vol.14,#8,p.2725-2746

[2]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[3]JournalofMedicinalChemistry,2014,vol.57,#7,p.3053-3074

[4]Patent:WO2014/131315,2014,A1,

Downstream Synthesis Route

40004-08-8

203866-15-3

886447-88-7

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.2725-2746

203866-15-3

449756-95-0

681128-16-5

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.6900-6916

203866-15-3

404922-72-1

911831-66-8

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.6900-6916

203866-15-3

215918-21-1

[1]Patent:US2011/82165,2011,A1.Locationinpatent:Page/Pagecolumn29-30

[2]ChemicalCommunications,2011,vol.47,p.10040-10042

[3]Patent:US2011/105520,2011,A1.Locationinpatent:Page/Pagecolumn36

[4]ChemMedChem,2015,vol.10,p.1071-1078

[5]Patent:WO2014/19344,2014,A1.Locationinpatent:Paragraph00452

[6]Patent:WO2014/131315,2014,A1.Locationinpatent:Page/Pagecolumn125

[7]Patent:US2015/79028,2015,A1.Locationinpatent:Paragraph1117;1128;1129;1130

[8]Patent:CN103880823,2017,B.Locationinpatent:Paragraph1612;1631;1632

[9]Patent:WO2013/152198,2013,A1.Locationinpatent:Paragraph00463;00464

[10]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.1515-1529

[11]Patent:WO2011/88045,2011,A1.Locationinpatent:Page/Pagecolumn161

[12]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.5296-5300

[13]Patent:WO2015/109109,2015,A1

[14]Patent:US2017/44182,2017,A1

203866-15-3

317357-75-8

[1]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.1515-1529

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