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21852-80-2,MFCD00210503
Catalog No.:AA003834

21852-80-2 | Falcarinol

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1mg
≥60%
in stock  
$98.00   $68.00
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5mg
≥60%
in stock  
$456.00   $319.00
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10mg
≥60%
in stock  
$815.00   $570.00
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25mg
≥60%
in stock  
$1,906.00   $1,334.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003834
Chemical Name:
Falcarinol
CAS Number:
21852-80-2
Molecular Formula:
C17H24O
Molecular Weight:
244.3719
MDL Number:
MFCD00210503
SMILES:
CCCCCCC/C=C\CC#CC#C[C@@H](C=C)O
Properties
Computed Properties
 
Complexity:
363  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
5.5  

Literature

Title: A new polyacetylene glucoside from Vernonia scorpioides and its potential antihyperglycemic effect.

Journal: Chemico-biological interactions 20180105

Title: Polyacetylenes in fresh and stored carrots (Daucus carota): relations to root morphology and sugar content.

Journal: Journal of the science of food and agriculture 20120601

Title: Anti-mycobacterial diynes from the Canadian medicinal plant Aralia nudicaulis.

Journal: Journal of ethnopharmacology 20120306

Title: [Simultaneous determination of panaxynol and panaxydol in fibrous root of Panax ginseng by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110901

Title: Spectroscopic studies on bioactive polyacetylenes and other plant components in wild carrot root.

Journal: Journal of natural products 20110826

Title: Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20110815

Title: Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol.

Journal: Molecules (Basel, Switzerland) 20110629

Title: Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille.

Journal: Phytotherapy research : PTR 20110501

Title: Aliphatic C(17)-polyacetylenes of the falcarinol type as potential health promoting compounds in food plants of the Apiaceae family.

Journal: Recent patents on food, nutrition & agriculture 20110101

Title: Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin.

Journal: Biochemical pharmacology 20100615

Title: Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future.

Journal: Contact dermatitis 20100401

Title: [Inhibition of panaxynol on experimental delayed type hypersensitivity].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

Title: A new prenylated flavanonol from Seseli annuum roots showing protective effect on human lymphocytes DNA.

Journal: Chemistry & biodiversity 20100301

Title: Panaxynol protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade.

Journal: Chemico-biological interactions 20100105

Title: Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation.

Journal: Journal of agricultural and food chemistry 20090923

Title: Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds.

Journal: Journal of natural medicines 20090401

Title: Antimycobacterial polyacetylenes from Levisticum officinale.

Journal: Phytotherapy research : PTR 20080501

Title: Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity.

Journal: Neuropharmacology 20080401

Title: Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB.

Journal: Chemico-biological interactions 20080215

Title: Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric method.

Journal: Journal of agricultural and food chemistry 20071031

Title: Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosis.

Journal: Journal of agricultural and food chemistry 20070207

Title: Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons.

Journal: Chemico-biological interactions 20060415

Title: Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms.

Journal: Chemico-biological interactions 20060105

Title: Up-regulation of M1 muscarinic receptors expressed in CHOm1 cells by panaxynol via cAMP pathway.

Journal: Neuroscience letters 20050701

Title: Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon.

Journal: Journal of agricultural and food chemistry 20050309

Title: [Allergic contact dermatitis to common ivy (Hedera helix L.)].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20031001

Title: Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree.

Journal: Journal of agricultural and food chemistry 20030618

Title: Chemoenzymatic asymmetric total syntheses of antitumor agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol from Panax ginseng using an enantioconvergent enzyme-triggered cascade reaction.

Journal: The Journal of organic chemistry 20021227

Title: Occupational allergic contact dermatitis from falcarinol.

Journal: Contact dermatitis 20020801

Title: Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis.

Journal: Journal of natural products 20020601

Title: A tumor cell growth inhibitor from Saposhnikovae divaricata.

Journal: Cancer investigation 20020101

Title: Le HT, et al. Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells. Cancer Lett. 2018 Jan 1;412:297-307.

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