Title: Combination effects of arsenic trioxide and fibroblast growth factor receptor inhibitor in squamous cell lung carcinoma.
Journal: Lung cancer (Amsterdam, Netherlands) 20161101
Title: Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells.
Journal: PloS one 20160101
Title: Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.
Journal: The Journal of biological chemistry 20150626
Title: FGF16 promotes invasive behavior of SKOV-3 ovarian cancer cells through activation of mitogen-activated protein kinase (MAPK) signaling pathway.
Journal: The Journal of biological chemistry 20140117
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: Fibroblast growth factor receptor inhibition synergizes with Paclitaxel and Doxorubicin in endometrial cancer cells.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20121101
Title: Fibroblast growth factor receptor 3 (FGFR3) associated with the CD20 antigen regulates the rituximab-induced proliferation inhibition in B-cell lymphoma cells.
Journal: The Journal of biological chemistry 20121026
Title: Transforming fusions of FGFR and TACC genes in human glioblastoma.
Journal: Science (New York, N.Y.) 20120907
Title: FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120715
Title: Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
Journal: Nature medicine 20120701
Title: Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.
Journal: British journal of cancer 20120410
Title: Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
Journal: Phytotherapy research : PTR 20120101
Title: FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation.
Journal: Journal of bone and mineral metabolism 20120101
Title: Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase.
Journal: Journal of biochemistry 20120101
Title: Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development.
Journal: PloS one 20120101
Title: Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma.
Journal: Leukemia research 20110901
Title: FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110815
Title: MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.
Journal: Oncogene 20110811
Title: Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast.
Journal: Biology of reproduction 20110501
Title: Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.
Journal: British journal of cancer 20110104
Title: Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20101214
Title: Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells.
Journal: Growth factors (Chur, Switzerland) 20100801
Title: Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation.
Journal: Development (Cambridge, England) 20100315
Title: 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Glioblastoma cell growth is suppressed by disruption of Fibroblast Growth Factor pathway signaling.
Journal: Journal of neuro-oncology 20090901
Title: Synthesis of 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-one as analgesic and anti-inflammatory agents.
Journal: Bioorganic & medicinal chemistry letters 20090701
Title: Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes.
Journal: American journal of physiology. Endocrinology and metabolism 20090101
Title: Expression profiles of protein tyrosine kinase genes in human embryonic stem cells.
Journal: Reproduction (Cambridge, England) 20081001
Title: Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080903
Title: FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.
Journal: Cancer research 20080401
Title: An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives and related compounds under ultrasound irradiation without catalyst.
Journal: Ultrasonics sonochemistry 20080301
Title: Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy.
Journal: Clinical & experimental metastasis 20080101
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
Journal: Arthritis and rheumatism 20071101
Title: Novel inhibitor for fibroblast growth factor receptor tyrosine kinase.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer.
Journal: Neoplasia (New York, N.Y.) 20070201
Title: Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications.
Journal: Molecular endocrinology (Baltimore, Md.) 20061101
Title: A model for the pharmacological treatment of crouzon syndrome.
Journal: Neurosurgery 20060701
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Differential phosphoprotein mapping in cancer cells using protein microarrays produced from 2-D liquid fractionation.
Journal: Analytical chemistry 20060201
Title: Guanosine analog in the pyrido[2,3-d]pyrimidine ring system as a potential toll-like receptor agonist.
Journal: Nucleosides, nucleotides & nucleic acids 20060101
Title: Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Journal: Journal of medicinal chemistry 20050714
Title: Synthesis and in vitro examination of [124I]-, [125I]- and [131I]-2-(4-iodophenylamino) pyrido[2,3-d]pyrimidin-7-one radiolabeled Abl kinase inhibitors.
Journal: Nuclear medicine and biology 20050501
Title: Fibroblast growth factor receptors as molecular targets in thyroid carcinoma.
Journal: Endocrinology 20050301
Title: Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050201
Title: Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation.
Journal: The Journal of biological chemistry 20041126
Title: [An alternative Abl-kinase inhibitor overcomes imatinib resistance mutations of Bcr-Abl oncogenes].
Journal: Deutsche medizinische Wochenschrift (1946) 20041001
Title: Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074.
Journal: Leukemia 20040501
Title: Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins.
Journal: Oncogene 20040429
Title: Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells.
Journal: Journal of neuroscience research 20031115
Title: A one-pot microwave-assisted synthesis of pyrido[2,3-d]pyrimidines.
Journal: Molecular diversity 20030101
Title: Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Journal: Acta crystallographica. Section D, Biological crystallography 20020901
Title: Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20010820
Title: Mohammadi M, et al. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J. 1998 Oct 15;17(20):5896-904.
Title: Skaper SD, et al. The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. J Neurochem. 2000 Oct;75(4):1520-7.
Title: Bansal R, et al. Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells. J Neurosci Res. 2003 Nov 15;74(4):486-93.
Title: Trudel S, et al. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood. 2004 May 1;103(9):3521-8.
Title: Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.
Title: Zheng Y, et al. Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression. J Cardiovasc Pharmacol. 2015 Nov;66(5):504-14.
