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2196-14-7,MFCD00017694
Catalog No.:AA00BEBF

2196-14-7 | 4',7-Dihydroxyflavone

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500mg
≥98%
in stock  
$78.00   $54.00
- +
1g
95%
in stock  
$120.00   $84.00
- +
5g
95%
in stock  
$319.00   $224.00
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10g
95%
in stock  
$510.00   $357.00
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25g
95%
in stock  
$1,009.00   $706.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BEBF
Chemical Name:
4',7-Dihydroxyflavone
CAS Number:
2196-14-7
Molecular Formula:
C15H10O4
Molecular Weight:
254.2375
MDL Number:
MFCD00017694
SMILES:
Oc1ccc(cc1)c1cc(=O)c2c(o1)cc(cc2)O
Properties
Computed Properties
 
Complexity:
382  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.3  

Literature

Title: Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: [Simultaneous determination of five active components in resina draconis and its extract by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

Title: C5-hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110501

Title: Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.

Journal: Bioorganic & medicinal chemistry 20110501

Title: Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Flavone synthase II (CYP93B16) from soybean (Glycine max L.).

Journal: Phytochemistry 20100401

Title: Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

Journal: Bioorganic & medicinal chemistry 20100215

Title: 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.

Journal: Journal of medicinal chemistry 20091112

Title: Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

Journal: Molecular and cellular endocrinology 20090325

Title: Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro.

Journal: Journal of agricultural and food chemistry 20090211

Title: Intestinal first-pass glucuronidation activities of selected dihydroxyflavones.

Journal: International journal of pharmaceutics 20090121

Title: Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti.

Journal: The Plant journal : for cell and molecular biology 20090101

Title: Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081101

Title: Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.

Journal: Molecules (Basel, Switzerland) 20080803

Title: Estrogenic activities of isoflavones and flavones and their structure-activity relationships.

Journal: Planta medica 20080101

Title: Aromatase inhibition by bioavailable methylated flavones.

Journal: The Journal of steroid biochemistry and molecular biology 20071001

Title: Methylated flavonoids have greatly improved intestinal absorption and metabolic stability.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061001

Title: A new meta-homoisoflavane from the fresh stems of dracaena cochinchinensis.

Journal: Journal of Asian natural products research 20060901

Title: Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones.

Journal: Chemical & pharmaceutical bulletin 20060301

Title: Human gut microbial degradation of flavonoids: structure-function relationships.

Journal: Journal of agricultural and food chemistry 20050518

Title: Flavonoids of Crotalaria sessiliflora.

Journal: Archives of pharmacal research 20040501

Title: Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Effect of flavonoids on feeding preference and development of the crucifer pest Mamestra configurata Walker.

Journal: Journal of chemical ecology 20040101

Title: Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors.

Journal: Planta 20031201

Title: A new pterocarpan, (-)-maackiain sulfate, from the roots of Sophora subprostrata.

Journal: Archives of pharmacal research 20031201

Title: Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.

Journal: Journal of medicinal chemistry 20010927

Title: Flavonoids induced in cells undergoing nodule organogenesis in white clover are regulators of auxin breakdown by peroxidase.

Journal: Journal of experimental botany 20010301

Title: Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458.

Title: Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32.

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