1447-88-7,MFCD00143504
Catalog No.:AA001JYA

1447-88-7 | Hispidulin

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Purity
Availability
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Quantity
  
1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$123.00   $86.00
- +
10mg
≥95%
in stock  
$199.00   $139.00
- +
25mg
≥95%
in stock  
$436.00   $305.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001JYA
Chemical Name:
Hispidulin
CAS Number:
1447-88-7
Molecular Formula:
C16H12O6
Molecular Weight:
300.2629
MDL Number:
MFCD00143504
SMILES:
COc1c(O)cc2c(c1O)c(=O)cc(o2)c1ccc(cc1)O
NSC Number:
122415
Properties
Properties
 
Form:
Solid  
MP:
>279°C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
454  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.7  

Downstream Synthesis Route

[1]Phytochemistry,1983,vol.22,p.2057-2060

[1]Kavvadias,Dominique;Sand,Philipp;Youdim,KureshA.;Qaiser,M.Zeeshan;Rice-Evans,Catherine;Baur,Roland;Sigel,Erwin;Rausch,Wolf-Dieter;Riederer,Peter;Schreier,Peter[BritishJournalofPharmacology,2004,vol.142,#5,p.811-820]

[1]LettersinOrganicChemistry,2013,vol.10,p.733-737

[2]EuropeanJournalofMedicinalChemistry,2015,vol.106,p.95-105

[3]JournalofChemicalResearch,2015,vol.39,p.674-676

[4]Patent:CN104311518,2016,B

[5]Molecules,2015,vol.20,p.10184-10191

[6]MedicinalChemistry,2019,vol.15,p.771-780

[1]LettersinOrganicChemistry,2013,vol.10,p.733-737

[2]EuropeanJournalofMedicinalChemistry,2015,vol.106,p.95-105

[3]JournalofChemicalResearch,2015,vol.39,p.674-676

[4]Patent:CN104311518,2016,B

[5]Molecules,2015,vol.20,p.10184-10191

[6]MedicinalChemistry,2019,vol.15,p.771-780

[1]EuropeanJournalofMedicinalChemistry,2015,vol.106,p.95-105

Literature

Title: Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway.

Journal: Chemico-biological interactions 20180925

Title: Sage weed (Salvia plebeia) extract antagonizes foam cell formation and promotes cholesterol efflux in murine macrophages.

Journal: International journal of molecular medicine 20121101

Title: Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals.

Journal: Toxicology and applied pharmacology 20120901

Title: Flavonoids from the Japanese monotypic genus, Nipponanthemum.

Journal: Natural product communications 20120801

Title: Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.

Journal: Fitoterapia 20120701

Title: Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

Journal: European journal of medicinal chemistry 20120601

Title: Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa.

Journal: Molecules (Basel, Switzerland) 20120314

Title: Flavonoids from Algerian endemic Centaurea microcarpa and their chemotaxonomical significance.

Journal: Natural product communications 20111101

Title: An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum.

Journal: Phytochemistry 20110501

Title: Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography.

Journal: Archives of pharmacal research 20110301

Title: Chemical and biological investigation of some Clerodendrum species cultivated in Egypt.

Journal: Pharmaceutical biology 20110101

Title: Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway.

Journal: Cancer science 20110101

Title: The membrane transport of flavonoids from Crossostephium chinense across the Caco-2 monolayer.

Journal: Biopharmaceutics & drug disposition 20110101

Title: A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

Title: Neuropharmacological activity of Lippia nodiflora Linn.

Journal: Pharmacognosy research 20110101

Title: Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea).

Journal: Frontiers in pharmacology 20110101

Title: Is propolis safe as an alternative medicine?

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: [Chemical constituents of Iris dichotoma].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

Title: Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation.

Journal: Journal of agricultural and food chemistry 20100922

Title: Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).

Journal: Journal of agricultural and food chemistry 20100908

Title: Pro-cognitive effects of Cirsium rivulare extracts in rats.

Journal: Journal of ethnopharmacology 20100527

Title: High-performance liquid chromatographic quantification of flavonoids in Eriocaulaceae species and their antimicrobial activity.

Journal: Molecules (Basel, Switzerland) 20091116

Title: [Bioactivity guided isolation of alpha-glucosidase inhibitor from whole herbs of Crossostephium chinense].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901

Title: Determination of flavonoid compounds from Saussurea involucrata by liquid chromatography electrospray ionisation mass spectrometry.

Journal: Natural product research 20090101

Title: Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.

Journal: Journal of ethnopharmacology 20081030

Title: Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20080910

Title: QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

Journal: European journal of medicinal chemistry 20080801

Title: Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae.

Journal: Journal of enzyme inhibition and medicinal chemistry 20080401

Title: Enhanced carnosic acid levels in two rosemary accessions exposed to cold stress conditions.

Journal: Journal of agricultural and food chemistry 20071003

Title: Trypanocidal and leishmanicidal activities of flavonoids from Argentine medicinal plants.

Journal: The American journal of tropical medicine and hygiene 20071001

Title: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents.

Journal: Phytotherapy research : PTR 20070901

Title: Anti-inflammatory activity of flavonoids from Eupatorium arnottianum.

Journal: Journal of ethnopharmacology 20070725

Title: Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana.

Journal: Phytochemistry 20070301

Title: Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa.

Journal: Applied biochemistry and biotechnology 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: A comparison between hairy root cultures and wild plants of Saussurea involucrata in phenylpropanoids production.

Journal: Plant cell reports 20060101

Title: Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.

Journal: Molecular nutrition & food research 20060101

Title: Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism.

Journal: Free radical research 20051201

Title: Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers.

Journal: Journal of ethnopharmacology 20051114

Title: Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity.

Journal: Journal of ethnopharmacology 20050513

Title: Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa.

Journal: Biotechnology letters 20050101

Title: Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS.

Journal: Phytochemical analysis : PCA 20050101

Title: Free radical scavengers and antioxidants from Baccharis grisebachii.

Journal: Journal of ethnopharmacology 20041201

Title: Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.

Journal: Journal of agricultural and food chemistry 20040811

Title: Flavonoids: some of the wisdom of sage?

Journal: British journal of pharmacology 20040701

Title: The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.

Journal: British journal of pharmacology 20040701

Title: Effects of natural flavones and flavonols on the kinase activity of Cdk5.

Journal: Journal of natural products 20040301

Title: Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats.

Journal: Phytotherapy research : PTR 20040101

Title: Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.).

Journal: Journal of plant physiology 20030901

Title: Antitumor activity of flavones isolated from Artemisia argyi.

Journal: Planta medica 20030301

Title: Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor.

Journal: Planta medica 20030201

Title: Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All.

Journal: Acta poloniae pharmaceutica 20030101

Title: Flavonoids from the aquatic plant Eriocaulon buergerianum.

Journal: Phytochemistry 20021001

Title: Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.

Journal: Biological & pharmaceutical bulletin 20020701

Title: Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites.

Journal: Journal of ethnopharmacology 20011101

Title: 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.

Journal: Journal of medicinal chemistry 20010607

Title: [Compounds from roots of Chirita fimbrisepala Hand.-Mazz].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010201

Title: Interactions of flavonoids and other phytochemicals with adenosine receptors.

Journal: Journal of medicinal chemistry 19960202

Title: Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice.

Journal: Life sciences 19940101

Title: Chao SW, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76.

Title: Gao H, et al. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69(1):27-34.

Title: Zhou R, et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69(2):311-7.

Title: Lin TY, et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15.

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SDS
Tags:1447-88-7 Molecular Formula|1447-88-7 MDL|1447-88-7 SMILES|1447-88-7 Hispidulin
Catalog No.: AA001JYA
1447-88-7,MFCD00143504
1447-88-7 | Hispidulin
Pack Size: 1mg
Purity: ≥95%
in stock
$46.00 $32.00
Pack Size: 5mg
Purity: ≥95%
in stock
$123.00 $86.00
Pack Size: 10mg
Purity: ≥95%
in stock
$199.00 $139.00
Pack Size: 25mg
Purity: ≥95%
in stock
$436.00 $305.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001JYA
Chemical Name: Hispidulin
CAS Number: 1447-88-7
Molecular Formula: C16H12O6
Molecular Weight: 300.2629
MDL Number: MFCD00143504
SMILES: COc1c(O)cc2c(c1O)c(=O)cc(o2)c1ccc(cc1)O
NSC Number: 122415
Properties
Form: Solid  
MP: >279°C (dec.)  
Storage: Keep in dry area;-20 ℃;  
Complexity: 454  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.7  
Downstream Synthesis Route
1447-88-7    529-53-3 

[1]Phytochemistry,1983,vol.22,p.2057-2060

3602-54-8    1447-88-7 

[1]Kavvadias,Dominique;Sand,Philipp;Youdim,KureshA.;Qaiser,M.Zeeshan;Rice-Evans,Catherine;Baur,Roland;Sigel,Erwin;Rausch,Wolf-Dieter;Riederer,Peter;Schreier,Peter[BritishJournalofPharmacology,2004,vol.142,#5,p.811-820]

27740-01-8    1447-88-7 

[1]LettersinOrganicChemistry,2013,vol.10,p.733-737

[2]EuropeanJournalofMedicinalChemistry,2015,vol.106,p.95-105

[3]JournalofChemicalResearch,2015,vol.39,p.674-676

[4]Patent:CN104311518,2016,B

[5]Molecules,2015,vol.20,p.10184-10191

[6]MedicinalChemistry,2019,vol.15,p.771-780

529-53-3    1447-88-7 

[1]LettersinOrganicChemistry,2013,vol.10,p.733-737

[2]EuropeanJournalofMedicinalChemistry,2015,vol.106,p.95-105

[3]JournalofChemicalResearch,2015,vol.39,p.674-676

[4]Patent:CN104311518,2016,B

[5]Molecules,2015,vol.20,p.10184-10191

[6]MedicinalChemistry,2019,vol.15,p.771-780

1447-88-7    74-88-4    6601-62-3    520-12-7 

[1]EuropeanJournalofMedicinalChemistry,2015,vol.106,p.95-105

Literature fold

Title: Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway.

Journal: Chemico-biological interactions20180925

Title: Sage weed (Salvia plebeia) extract antagonizes foam cell formation and promotes cholesterol efflux in murine macrophages.

Journal: International journal of molecular medicine20121101

Title: Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals.

Journal: Toxicology and applied pharmacology20120901

Title: Flavonoids from the Japanese monotypic genus, Nipponanthemum.

Journal: Natural product communications20120801

Title: Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.

Journal: Fitoterapia20120701

Title: Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

Journal: European journal of medicinal chemistry20120601

Title: Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa.

Journal: Molecules (Basel, Switzerland)20120314

Title: Flavonoids from Algerian endemic Centaurea microcarpa and their chemotaxonomical significance.

Journal: Natural product communications20111101

Title: An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum.

Journal: Phytochemistry20110501

Title: Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography.

Journal: Archives of pharmacal research20110301

Title: Chemical and biological investigation of some Clerodendrum species cultivated in Egypt.

Journal: Pharmaceutical biology20110101

Title: Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway.

Journal: Cancer science20110101

Title: The membrane transport of flavonoids from Crossostephium chinense across the Caco-2 monolayer.

Journal: Biopharmaceutics & drug disposition20110101

Title: A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20110101

Title: Neuropharmacological activity of Lippia nodiflora Linn.

Journal: Pharmacognosy research20110101

Title: Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea).

Journal: Frontiers in pharmacology20110101

Title: Is propolis safe as an alternative medicine?

Journal: Journal of pharmacy & bioallied sciences20110101

Title: [Chemical constituents of Iris dichotoma].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20101201

Title: Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation.

Journal: Journal of agricultural and food chemistry20100922

Title: Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).

Journal: Journal of agricultural and food chemistry20100908

Title: Pro-cognitive effects of Cirsium rivulare extracts in rats.

Journal: Journal of ethnopharmacology20100527

Title: High-performance liquid chromatographic quantification of flavonoids in Eriocaulaceae species and their antimicrobial activity.

Journal: Molecules (Basel, Switzerland)20091116

Title: [Bioactivity guided isolation of alpha-glucosidase inhibitor from whole herbs of Crossostephium chinense].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090901

Title: Determination of flavonoid compounds from Saussurea involucrata by liquid chromatography electrospray ionisation mass spectrometry.

Journal: Natural product research20090101

Title: Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.

Journal: Journal of ethnopharmacology20081030

Title: Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20080910

Title: QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

Journal: European journal of medicinal chemistry20080801

Title: Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae.

Journal: Journal of enzyme inhibition and medicinal chemistry20080401

Title: Enhanced carnosic acid levels in two rosemary accessions exposed to cold stress conditions.

Journal: Journal of agricultural and food chemistry20071003

Title: Trypanocidal and leishmanicidal activities of flavonoids from Argentine medicinal plants.

Journal: The American journal of tropical medicine and hygiene20071001

Title: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents.

Journal: Phytotherapy research : PTR20070901

Title: Anti-inflammatory activity of flavonoids from Eupatorium arnottianum.

Journal: Journal of ethnopharmacology20070725

Title: Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana.

Journal: Phytochemistry20070301

Title: Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa.

Journal: Applied biochemistry and biotechnology20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: A comparison between hairy root cultures and wild plants of Saussurea involucrata in phenylpropanoids production.

Journal: Plant cell reports20060101

Title: Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.

Journal: Molecular nutrition & food research20060101

Title: Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism.

Journal: Free radical research20051201

Title: Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers.

Journal: Journal of ethnopharmacology20051114

Title: Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity.

Journal: Journal of ethnopharmacology20050513

Title: Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa.

Journal: Biotechnology letters20050101

Title: Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20050101

Title: Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS.

Journal: Phytochemical analysis : PCA20050101

Title: Free radical scavengers and antioxidants from Baccharis grisebachii.

Journal: Journal of ethnopharmacology20041201

Title: Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.

Journal: Journal of agricultural and food chemistry20040811

Title: Flavonoids: some of the wisdom of sage?

Journal: British journal of pharmacology20040701

Title: The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.

Journal: British journal of pharmacology20040701

Title: Effects of natural flavones and flavonols on the kinase activity of Cdk5.

Journal: Journal of natural products20040301

Title: Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats.

Journal: Phytotherapy research : PTR20040101

Title: Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.).

Journal: Journal of plant physiology20030901

Title: Antitumor activity of flavones isolated from Artemisia argyi.

Journal: Planta medica20030301

Title: Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor.

Journal: Planta medica20030201

Title: Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All.

Journal: Acta poloniae pharmaceutica20030101

Title: Flavonoids from the aquatic plant Eriocaulon buergerianum.

Journal: Phytochemistry20021001

Title: Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.

Journal: Biological & pharmaceutical bulletin20020701

Title: Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites.

Journal: Journal of ethnopharmacology20011101

Title: 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.

Journal: Journal of medicinal chemistry20010607

Title: [Compounds from roots of Chirita fimbrisepala Hand.-Mazz].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20010201

Title: Interactions of flavonoids and other phytochemicals with adenosine receptors.

Journal: Journal of medicinal chemistry19960202

Title: Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice.

Journal: Life sciences19940101

Title: Chao SW, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76.

Title: Gao H, et al. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69(1):27-34.

Title: Zhou R, et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69(2):311-7.

Title: Lin TY, et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15.

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