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22089-22-1,MFCD00866435
Catalog No.:AA0037RB

22089-22-1 | Trofosfamide

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5mg
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10mg
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037RB
Chemical Name:
Trofosfamide
CAS Number:
22089-22-1
Molecular Formula:
C9H18Cl3N2O2P
Molecular Weight:
323.5842
MDL Number:
MFCD00866435
SMILES:
ClCCN(P1(=O)OCCCN1CCCl)CCCl
Properties
Computed Properties
 
Complexity:
265  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.8  

Literature

Title: Efficacy and safety of metronomic chemotherapy for patients with advanced primary hepatocellular carcinoma with major portal vein tumor thrombosis.

Journal: The Korean journal of hepatology 20120301

Title: Oral low-dose chemotherapy: successful treatment of an alveolar rhabdomyosarcoma during pregnancy.

Journal: Pediatric blood & cancer 20120101

Title: Fourteen non-CODIS autosomal short tandem repeat loci multiplex data from Taiwanese.

Journal: International journal of legal medicine 20110301

Title: Recent advances in anti-angiogenic therapy of cancer.

Journal: Oncotarget 20110301

Title: Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial.

Journal: BMC research notes 20110101

Title: Oxazaphosphorines: new therapeutic strategies for an old class of drugs.

Journal: Expert opinion on drug metabolism & toxicology 20100801

Title: SRD5A2 V89L polymorphism and prostate cancer risk: a meta-analysis.

Journal: The Prostate 20100201

Title: Herpesvirus type 7 infection may play an important role in individuals with a genetic profile of susceptibility to Graves' disease.

Journal: European journal of endocrinology 20100201

Title: Circulating tumor cells: a window into cancer biology and metastasis.

Journal: Current opinion in genetics & development 20100201

Title: Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma.

Journal: PPAR research 20100101

Title: Sclerosing epithelioid fibrosarcoma of the bone: a case report of high resistance to chemotherapy and a survey of the literature.

Journal: Sarcoma 20100101

Title: Metronomic treatment with low-dose trofosfamide leads to a long-term remission in a patient with docetaxel-refractory advanced metastatic prostate cancer.

Journal: Case reports in medicine 20100101

Title: Clinical benefit of second-line palliative chemotherapy in advanced soft-tissue sarcoma.

Journal: Sarcoma 20100101

Title: Bleomycin, vinorelbine and trofosfamide in relapsed stage IV cutaneous malignant melanoma patients.

Journal: Cancer chemotherapy and pharmacology 20091001

Title: Principles of modular tumor therapy.

Journal: Cancer microenvironment : official journal of the International Cancer Microenvironment Society 20090901

Title: Ifosfamide or trofosfamide in patients with intraocular lymphoma.

Journal: Journal of neuro-oncology 20090601

Title: [Choroidal metastasis from a breast carcinoma. Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with HRA-II (Heidelberg Retina Angiograph)].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20090501

Title: Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes.

Journal: BMC cancer 20090101

Title: Systems biology: a therapeutic target for tumor therapy.

Journal: Cancer microenvironment : official journal of the International Cancer Microenvironment Society 20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients.

Journal: British journal of cancer 20080422

Title: Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial.

Journal: Pediatric blood & cancer 20080401

Title: A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC).

Journal: Onkologie 20080401

Title: Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer.

Journal: PPAR research 20080101

Title: Potential combination chemotherapy approaches for advanced adult-type soft-tissue sarcoma.

Journal: American journal of clinical dermatology 20080101

Title: PPARgamma and MEK Interactions in Cancer.

Journal: PPAR research 20080101

Title: Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma.

Journal: Head & face medicine 20080101

Title: The Role of PPARs in the Endothelium: Implications for Cancer Therapy.

Journal: PPAR research 20080101

Title: Clinical Use of PPARgamma Ligands in Cancer.

Journal: PPAR research 20080101

Title: PPARs Mediate Lipid Signaling in Inflammation and Cancer.

Journal: PPAR research 20080101

Title: Low-dose oral metronomic chemotherapy prevents mobilization of endothelial progenitor cells into the blood of cancer patients.

Journal: In vivo (Athens, Greece) 20080101

Title: Targeted combined anti-inflammatory and angiostatic therapy in advanced melanoma: a randomized phase II trial.

Journal: Melanoma research 20071201

Title: Diagnosis and management of primary intraocular lymphoma: an update.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20070901

Title: Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System.

Journal: Clinical endocrinology 20070501

Title: Recurrent low- to intermediate-grade chondrosarcoma of the thumb with lung metastases: an objective response to trofosfamide.

Journal: Onkologie 20070401

Title: Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines.

Journal: Anti-cancer drugs 20070301

Title: Simultaneous determination of gemcitabine, taxol, cyclophosphamide and ifosfamide in wipe samples by high-performance liquid chromatography/tandem mass spectrometry: protocol of validation and uncertainty of measurement.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Design of new oxazaphosphorine anticancer drugs.

Journal: Current pharmaceutical design 20070101

Title: Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas.

Journal: British journal of cancer 20061023

Title: Metronomic trofosfamide inhibits progression of human lung cancer xenografts by exerting anti-angiogenic effects.

Journal: Journal of cancer research and clinical oncology 20061001

Title: Complete remission of relapsing high-grade angiosarcoma with single-agent metronomic trofosfamide.

Journal: Anti-cancer drugs 20060901

Title: Antiangiogenic therapy in metastatic prostate carcinoma complicated by cutaneous lupus erythematodes.

Journal: The Lancet. Oncology 20060801

Title: Reversal of resistance to oxazaphosphorines.

Journal: Current cancer drug targets 20060801

Title: Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Palliative chemotherapy with trofosfamide in advanced prostate cancer.

Journal: Anticancer research 20060101

Title: The radiation response of sarcomas by histologic subtypes: a review with special emphasis given to results achieved with razoxane.

Journal: Sarcoma 20060101

Title: C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation.

Journal: Biomarker insights 20060101

Title: Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20051201

Title: A new therapeutic approach in patients with advanced sarcoma.

Journal: International journal of clinical oncology 20051201

Title: Insights into oxazaphosphorine resistance and possible approaches to its circumvention.

Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20051001

Title: Primary dissemination of high-grade gliomas in children: experiences from four studies of the Pediatric Oncology and Hematology Society of the German Language Group (GPOH).

Journal: Journal of neuro-oncology 20050401

Title: Anti-inflammatory and angiostatic therapy in chemorefractory multisystem Langerhans' cell histiocytosis of adults.

Journal: British journal of haematology 20050301

Title: Recent developments in salvage chemotherapy for patients with metastatic soft tissue sarcoma.

Journal: Drugs 20050101

Title: [Metronomic chemotherapy. Should we change our thinking in the treatment of advanced tumors?].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050101

Title: Dose escalation study for defining the maximum tolerated dose of continuous oral trofosfamide in pretreated patients with metastatic lung cancer.

Journal: Onkologie 20041201

Title: Trofosfamide in the palliative treatment of cancer: a review of the literature.

Journal: Onkologie 20041201

Title: Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma.

Journal: Archives of dermatology 20041201

Title: Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma.

Journal: Cancer 20041115

Title: Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study.

Journal: British journal of cancer 20041101

Title: Metronomic scheduling of trofosfamide chemotherapy in human NSCLC xenografts highly increases therapeutic efficacy compared to conventional scheduling by inhibition of angiogenesis.

Journal: International journal of clinical pharmacology and therapeutics 20041101

Title: Treatment of primary intraocular lymphoma with oral trofosfamide: report of two cases and review of the literature.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20040901

Title: Hypersensitivity pneumonitis associated with the use of trofosfamide.

Journal: Anti-cancer drugs 20040701

Title: Investigations on the pharmacokinetics of trofosfamide and its metabolites-first report of 4-hydroxy-trofosfamide kinetics in humans.

Journal: Cancer chemotherapy and pharmacology 20040601

Title: Enzyme-catalyzed activation of anticancer prodrugs.

Journal: Pharmacological reviews 20040301

Title: Relapse after high-dose therapy in relapsed Ewing's tumor patients: effects of maintenance chemotherapy in two selected patients?

Journal: Onkologie 20031201

Title: Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors.

Journal: Cancer 20031115

Title: [Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma].

Journal: Deutsche medizinische Wochenschrift (1946) 20030207

Title: Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas.

Journal: Anticancer research 20030101

Title: High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma.

Journal: Bone marrow transplantation 20021201

Title: Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas. Results of a retrospective analysis.

Journal: Onkologie 20021201

Title: Trofosfamide as salvage therapy for anaplastic large cell lymphoma relapsing after high-dose chemotherapy.

Journal: Leukemia & lymphoma 20021201

Title: Treatment of paediatric pontine glioma with oral trophosphamide and etoposide.

Journal: British journal of cancer 20021021

Title: New insights into the clinical pharmacokinetics of trofosfamide.

Journal: International journal of clinical pharmacology and therapeutics 20020801

Title: Cyclophosphamide and related anticancer drugs.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011125

Title: Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010615

Title: Feasibility of intraventricular administration of etoposide in patients with metastatic brain tumours.

Journal: British journal of cancer 20010601

Title: Palliative chemotherapy in pretreated patients with advanced cancer: oral trofosfamide is effective in ovarian carcinoma.

Journal: Cancer investigation 20010101

Title: Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.

Journal: Cancer research 19890101

Title: Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--I. Experimental studies on the urotoxicity of alkylating compounds.

Journal: European journal of cancer 19810601

Title: Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds.

Journal: Journal of cancer research and clinical oncology 19810101

Title: [Cyclophosphamide and bladder carcinoma (case report) (author's transl)].

Journal: Deutsche medizinische Wochenschrift (1946) 19780106

Title: Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136.

Title: Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9.

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Tags:22089-22-1 Molecular Formula|22089-22-1 MDL|22089-22-1 SMILES|22089-22-1 Trofosfamide