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2241337-84-6
Catalog No.:AA01V7EU

2241337-84-6 | AT-527

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$189.00   $132.00
- +
5mg
95%
1 week  
$340.00   $238.00
- +
10mg
95%
1 week  
$530.00   $371.00
- +
25mg
95%
1 week  
$848.00   $594.00
- +
50mg
95%
1 week  
$1,183.00   $828.00
- +
100mg
95%
1 week  
$1,578.00   $1,104.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01V7EU
Chemical Name:
AT-527
CAS Number:
2241337-84-6
Molecular Formula:
C24H35FN7O11PS
Molecular Weight:
679.6122
SMILES:
OS(=O)(=O)O.CNc1nc(N)nc2c1ncn2C1OC(C(C1(C)F)O)COP(=O)(NC(C(=O)OC(C)C)C)Oc1ccccc1
Properties

Literature

Title: Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104.

Title: Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20.

Title: Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19.

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SDS
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