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23256-33-9,MFCD00069260
Catalog No.:AA002MM6

23256-33-9 | Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2)

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5mg
98%
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$88.00   $62.00
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50mg
≥95%
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$96.00   $67.00
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100mg
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$153.00   $107.00
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250mg
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1000mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002MM6
Chemical Name:
Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2)
CAS Number:
23256-33-9
Molecular Formula:
C6H17Cl2N3S
Molecular Weight:
234.1903
MDL Number:
MFCD00069260
SMILES:
CN(CCCSC(=N)N)C.Cl.Cl
Properties
Computed Properties
 
Complexity:
103  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  

Literature

Title: Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice.

Journal: Neuroscience 20120816

Title: Excitatory effect of histamine on rat spinal motoneurons by activation of both H₁ and H₂ receptors in vitro.

Journal: Journal of neuroscience research 20120101

Title: Histamine evokes excitatory response of neurons in the cerebellar dentate nucleus via H2 receptors.

Journal: Neuroscience letters 20110920

Title: In vivo electrochemical evidence for simultaneous 5-HT and histamine release in the rat substantia nigra pars reticulata following medial forebrain bundle stimulation.

Journal: Journal of neurochemistry 20110901

Title: Histaminergic modulation of acetylcholine-induced γ oscillations in rat hippocampus.

Journal: Neuroreport 20110803

Title: Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats.

Journal: Journal of psychopharmacology (Oxford, England) 20110201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Control of the flow properties of DNA by topoisomerase II and its targeting inhibitor.

Journal: Biophysical journal 20100922

Title: Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosis.

Journal: Neuroscience letters 20100726

Title: Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091201

Title: Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent.

Journal: Journal of neurochemistry 20081001

Title: Validation of a conscious rat model for the discovery of novel agents that inhibit gastric acid secretion.

Journal: European journal of pharmacology 20080728

Title: The ATPase cycle of the mitochondrial Hsp90 analog Trap1.

Journal: The Journal of biological chemistry 20080425

Title: Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats.

Journal: Basic & clinical pharmacology & toxicology 20080401

Title: The anti-secretory and anti-ulcer activities of esomeprazole in comparison with omeprazole in the stomach of rats and rabbits.

Journal: Molecular and cellular biochemistry 20080201

Title: Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants.

Journal: BMC developmental biology 20080101

Title: Blockade of brain histamine metabolism alters methamphetamine-induced expression pattern of stereotypy in mice via histamine H1 receptors.

Journal: Neuroscience 20070713

Title: Study on the antinociceptive action of Tyr-K-MIF-1, a peptide from the MIF family.

Journal: Autonomic & autacoid pharmacology 20070401

Title: Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats.

Journal: European journal of pharmacology 20060821

Title: Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors.

Journal: Journal of neurophysiology 20060401

Title: Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors.

Journal: Biological & pharmaceutical bulletin 20051201

Title: The protective effect of H2-receptor activation against the duration of myocardial hypoxia/reoxygenation-induced ventricular fibrillation in sensitized guinea-pig hearts.

Journal: Journal of pharmacological sciences 20051201

Title: Effects of activation of central nervous histamine receptors in cardiovascular regulation; studies in H(1) and H(2) receptor gene knockout mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050201

Title: Replacement of amino acid sequence features of a- and c-subunits of ATP synthases of Alkaliphilic Bacillus with the Bacillus consensus sequence results in defective oxidative phosphorylation and non-fermentative growth at pH 10.5.

Journal: The Journal of biological chemistry 20040618

Title: The effects of histamine on rat and monkey retinal ganglion cells.

Journal: Visual neuroscience 20040101

Title: Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.

Journal: Archives of physiology and biochemistry 20031201

Title: Histamine downregulates CD14 expression via H2 receptors on human monocytes.

Journal: Clinical immunology (Orlando, Fla.) 20030901

Title: Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030901

Title: A multi-tyrosinated sst1/2 receptor preferring somatostatin agonist inhibits reflex and immune-mediated secretion in the guinea pig colon.

Journal: Regulatory peptides 20030615

Title: The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine.

Journal: Journal of pharmacological sciences 20030501

Title: Blockade of histamine H2 receptors of the periaqueductal gray and inferior colliculus induces fear-like behaviors.

Journal: Pharmacology, biochemistry, and behavior 20030401

Title: Differential activation of dual signaling responses by human H1 and H2 histamine receptors.

Journal: Journal of receptor and signal transduction research 20030201

Title: Characteristics of histamine tachyphylaxis in rat uterine smooth muscle.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20021201

Title: Endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats--studies with histamine N-methyltransferase inhibitor SKF 91488.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20021101

Title: Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Excitatory effects of histamine on cerebellar interpositus nuclear cells of rats through H(2) receptors in vitro.

Journal: Brain research 20020906

Title: Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis.

Journal: Neuroreport 20020807

Title: Methods to enhance signal using isotopic in situ hybridization.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020801

Title: Effects of histamine on the contractile and electrical activity in isolated lymphatic vessels of the guinea-pig mesentery.

Journal: British journal of pharmacology 20020801

Title: Regulation of cellular oncosis by uncoupling protein 2.

Journal: The Journal of biological chemistry 20020726

Title: The role of guanylyl cyclases in the permeability response to inflammatory mediators in pial venular capillaries in the rat.

Journal: The Journal of physiology 20020401

Title: Expression of diamine oxidase (histaminase) in guinea-pig tissues.

Journal: European journal of pharmacology 20020222

Title: Further evidence for the involvement of histamine H2 receptors in the control of defensive behaviour generated in the midbrain tectum.

Journal: Behavioural pharmacology 20020201

Title: Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats.

Journal: Polish journal of pharmacology 20020101

Title: Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules.

Journal: The EMBO journal 20011115

Title: Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors.

Journal: International immunopharmacology 20010901

Title: Histamine N-methyltransferase regulates histamine-induced phosphoinositide hydrolysis in guinea pig cerebellum.

Journal: Neuroscience letters 20010727

Title: Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats.

Journal: European journal of pharmacology 20010504

Title: Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010315

Title: Phe217 regulates the transfer of allosteric information across the subunit interface of the RecA protein filament.

Journal: Structure (London, England : 1993) 20010110

Title: Regulation of interleukin-6, and macrophage colony-stimulating factor mRNA levels by histamine in stromal cell line (MC3T3-G2/PA6).

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19980501

Title: Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.

Journal: Molecular pharmacology 19970601

Title: Efficacy of a selective histamine H2 receptor agonist, dimaprit, in experimental models of endotoxin shock and hepatitis in mice.

Journal: European journal of pharmacology 19970312

Title: Effect of adenosine and histamine receptor stimulation on canine histamine release to pentagastrin.

Journal: Digestion 19970101

Title: Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.

Journal: The American journal of physiology 19940901

Title: Reduction of DNA synthesis, pigment synthesis, pigmentation gene mRNA and resistance to UVB in human melanoma cells treated with analogues of a histamine (H2) agonist.

Journal: Biochemical pharmacology 19940705

Title: Identification of two H3-histamine receptor subtypes.

Journal: Molecular pharmacology 19901101

Title: Parsons ME, et, al. Dimaprit -(S--(N,N-dimethylamino)prophylisothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7.

Title: Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127(2): 331-4.

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