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475-83-2,MFCD01664592
Catalog No.:AA0035CC

475-83-2 | Nuciferine

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5mg
≥98%
in stock  
$63.00   $44.00
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10mg
99%(HPLC)
in stock  
$112.00   $78.00
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25mg
99%(HPLC)
in stock  
$239.00   $167.00
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50mg
99%(HPLC)
in stock  
$381.00   $267.00
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100mg
99%(HPLC)
in stock  
$610.00   $427.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035CC
Chemical Name:
Nuciferine
CAS Number:
475-83-2
Molecular Formula:
C19H21NO2
Molecular Weight:
295.3755
MDL Number:
MFCD01664592
SMILES:
COc1cc2CCN([C@H]3c2c(c1OC)c1ccccc1C3)C
Properties
Properties
 
BP:
430.7°C at 760 mmHg  
Form:
Solid  
MP:
161-165ºC  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
401  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
3.4  

Literature

Title: Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.

Journal: Journal of ethnopharmacology 20120713

Title: Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals.

Journal: Acta pharmacologica Sinica 20101201

Title: Preparative separation of alkaloids from Nelumbo nucifera leaves by conventional and pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Title: In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine.

Journal: The Journal of pharmacy and pharmacology 20100501

Title: [Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001

Title: [HPLC determination of 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine in Nelumbo nucifera and its alkaloid fraction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

Title: Antipoliovirus structure-activity relationships of some aporphine alkaloids.

Journal: Journal of natural products 19980401

Title: Psychopharmacological studies on (--)-nuciferine and its Hofmann degradation product atherosperminine.

Journal: Psychopharmacology 19780915

Title: Farrell MS, et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602.

Title: Chan JD, et al. Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):364-370.

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SDS
Tags:475-83-2 Molecular Formula|475-83-2 MDL|475-83-2 SMILES|475-83-2 Nuciferine