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2393-59-1,MFCD00271403
Catalog No.:AA00C2QO

2393-59-1 | (3a,5b,6b,7b)-3,6,7-trihydroxy-Cholan-24-oic acid

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1mg
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5mg
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10mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C2QO
Chemical Name:
(3a,5b,6b,7b)-3,6,7-trihydroxy-Cholan-24-oic acid
CAS Number:
2393-59-1
Molecular Formula:
C24H40O5
Molecular Weight:
408.5714
MDL Number:
MFCD00271403
SMILES:
O[C@@H]1CC[C@]2([C@@H](C1)[C@H](O)[C@@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C
Properties
Computed Properties
 
Complexity:
637  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
3.9  

Literature

Title: Characterization of urinary bile acids in a pediatric BRIC-1 patient: effect of rifampicin treatment.

Journal: Clinica chimica acta; international journal of clinical chemistry 20120816

Title: C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia.

Journal: BMC genomics 20120101

Title: Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.

Journal: PloS one 20120101

Title: Effects of human and porcine bile on the proteome of Helicobacter hepaticus.

Journal: Proteome science 20120101

Title: Trade-off between bile resistance and nutritional competence drives Escherichia coli diversification in the mouse gut.

Journal: PLoS genetics 20110601

Title: Colonization-induced host-gut microbial metabolic interaction.

Journal: mBio 20110101

Title: FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways.

Journal: PloS one 20110101

Title: Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS.

Journal: Journal of lipid research 20090101

Title: Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081001

Title: Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080401

Title: Perinatal bile acid metabolism: bile acid analysis of meconium of preterm and full-term infants.

Journal: Journal of gastroenterology 20071101

Title: Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis.

Journal: Journal of lipid research 20070601

Title: A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.

Journal: Molecular systems biology 20070101

Title: Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit.

Journal: Journal of lipid research 20060901

Title: Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

Journal: Journal of hepatology 20060401

Title: Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.

Journal: The Journal of pharmacology and experimental therapeutics 20050501

Title: Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21).

Journal: Biochimica et biophysica acta 20031115

Title: Steroids in the intestinal tract of rats are affected by dietary-fibre-rich barley-based diets.

Journal: The British journal of nutrition 20031101

Title: Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes.

Journal: The Journal of biological chemistry 20021213

Title: Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice.

Journal: Journal of lipid research 20021101

Title: Ontogenetic development and spatial distribution of the ileal apical sodium-dependent bile acid transporter and the ileal lipid-binding protein in apoE knockout and C57BL/6 mice.

Journal: Scandinavian journal of gastroenterology 20020901

Title: Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.

Journal: Gut 20020701

Title: Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.

Journal: Gastroenterology 20010601

Title: Differences in the efficacy of ursodeoxycholic acid and bile acid metabolism between viral liver diseases and primary biliary cirrhosis.

Journal: Journal of gastroenterology and hepatology 20010501

Title: Metabolism and effects on cholestasis of isoursodeoxycholic and ursodeoxycholic acids in bile duct ligated rats.

Journal: Biochimica et biophysica acta 20010403

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Tags:2393-59-1 Molecular Formula|2393-59-1 MDL|2393-59-1 SMILES|2393-59-1 (3a,5b,6b,7b)-3,6,7-trihydroxy-Cholan-24-oic acid