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242478-37-1,MFCD18910847
Catalog No.:AA019FPZ

242478-37-1 | Solifenacin

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Purity
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1g
98%
in stock  
$22.00   $15.00
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5g
98%
in stock  
$75.00   $53.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA019FPZ
Chemical Name:
Solifenacin
CAS Number:
242478-37-1
Molecular Formula:
C23H26N2O2
Molecular Weight:
362.4647
MDL Number:
MFCD18910847
SMILES:
O=C(N1CCc2c(C1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2
Properties
Computed Properties
 
Complexity:
525  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CHONGQINGKERUIPHARMACEUTICALGROUP-CN103896938,2016,BLocationinpatent:Paragraph0066

[2]Naito,Ryo;Yonetoku,Yasuhiro;Okamoto,Yoshinori;Toyoshima,Akira;Ikeda,Ken;Takeuchi,Makoto[JournalofMedicinalChemistry,2005,vol.48,#21,p.6597-6606]

[3]Ye,Zhi-Shi;Guo,Ran-Ning;Cai,Xian-Feng;Chen,Mu-Wang;Shi,Lei;Zhou,Yong-Gui[AngewandteChemie-InternationalEdition,2013,vol.52,#13,p.3685-3689][Angew.Chem.,2013,vol.125,#13,p.3773-3777,5]

[4]Babu,R.Anji;Reddy,N.SivaSenkar;Reddy,B.JaganMohan;Reddy,B.V.Subba[Synthesis,2014,vol.46,#20,p.2794-2798]

[5]CurrentPatentAssignee:ShanghaiInstituteofMateriaMedica(in:CAS);CHINESEACADEMYOFSCIENCES-CN108203434,2018,ALocationinpatent:Paragraph0172;0173;0174

[6]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-WO2009/87664,2009,A1Locationinpatent:Page/Pagecolumn26

[7]CurrentPatentAssignee:ADVENTINTERNATIONALCORPORATION-US2009/203914,2009,A1Locationinpatent:Page/Pagecolumn3

[8]CurrentPatentAssignee:ADVENTINTERNATIONALCORPORATION-US2009/203914,2009,A1Locationinpatent:Page/Pagecolumn3

[9]CurrentPatentAssignee:ADVENTINTERNATIONALCORPORATION-US2009/203914,2009,A1Locationinpatent:Page/Pagecolumn3-4

[10]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2008/11462,2008,A2Locationinpatent:Page/Pagecolumn23;24

[11]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2009/11844,2009,A1Locationinpatent:Page/Pagecolumn16

[12]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2009/11844,2009,A1Locationinpatent:Page/Pagecolumn16-17;21;21-22;22-23

[13]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2009/11844,2009,A1Locationinpatent:Page/Pagecolumn17

[14]CurrentPatentAssignee:KRKADDNOVOMESTO-WO2010/12459,2010,A2Locationinpatent:Page/Pagecolumn33-34

[15]CurrentPatentAssignee:ADVENTINTERNATIONALCORPORATION-US2010/145055,2010,A1Locationinpatent:Page/Pagecolumn3

[16]CurrentPatentAssignee:CURIAINC-WO2012/4264,2012,A1Locationinpatent:Page/Pagecolumn17-18

[17]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2008/128028,2008,A2Locationinpatent:Page/Pagecolumn30

[1]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2008/11462,2008,A2Locationinpatent:Page/Pagecolumn22;23

242478-37-1   
Solifenacinhydrochloride 

[1]CurrentPatentAssignee:ADVENTINTERNATIONALCORPORATION-WO2008/77357,2008,A2Locationinpatent:Page/Pagecolumn5-6

[2]CurrentPatentAssignee:ADVENTINTERNATIONALCORPORATION-US2010/145055,2010,A1Locationinpatent:Page/Pagecolumn3

[3]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2008/11462,2008,A2Locationinpatent:Page/Pagecolumn25

[4]CurrentPatentAssignee:KRKADDNOVOMESTO-WO2010/12459,2010,A2Locationinpatent:Page/Pagecolumn38-39

[1]Naito,Ryo;Yonetoku,Yasuhiro;Okamoto,Yoshinori;Toyoshima,Akira;Ikeda,Ken;Takeuchi,Makoto[JournalofMedicinalChemistry,2005,vol.48,#21,p.6597-6606]

[2]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2008/128028,2008,A2

[1]Naito,Ryo;Yonetoku,Yasuhiro;Okamoto,Yoshinori;Toyoshima,Akira;Ikeda,Ken;Takeuchi,Makoto[JournalofMedicinalChemistry,2005,vol.48,#21,p.6597-6606]

[2]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2008/128028,2008,A2

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Title: Effects of solifenacin on overactive bladder symptoms, symptom bother and other patient-reported outcomes: results from VIBRANT - a double-blind, placebo-controlled trial.

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Title: Treatment of dysautonomia associated with Parkinson's disease.

Journal: Parkinsonism & related disorders 20091201

Title: Impact of solifenacin on quality of life, medical care use, work productivity, and health utility in the elderly: an exploratory subgroup analysis.

Journal: The American journal of geriatric pharmacotherapy 20091201

Title: Anticholinergic drug use for overactive bladder in Sweden: a nationwide pharmacoepidemiological study.

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Title: Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg.

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Title: Listening to the patient: a flexible approach to the use of antimuscarinic agents in overactive bladder syndrome.

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Title: Solifenacin for therapy resistant overactive bladder.

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Journal: The Journal of urology 20091001

Title: Solifenacin for overactive bladder: patient-reported outcomes from a large placebo-controlled trial.

Journal: Postgraduate medicine 20090901

Title: Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice.

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Title: Treatment with solifenacin increases warning time and improves symptoms of overactive bladder: results from VENUS, a randomized, double-blind, placebo-controlled trial.

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Journal: Clinical drug investigation 20090101

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Title: The safety and efficacy of tolterodine extended release in the treatment of overactive bladder in the elderly.

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Title: Clinical pharmacokinetics and pharmacodynamics of solifenacin.

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Title: Oxybutynin extended release for the management of overactive bladder: a clinical review.

Journal: Drug design, development and therapy 20090101

Title: Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence.

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Title: Fesoterodine for the treatment of urinary incontinence and overactive bladder.

Journal: Therapeutics and clinical risk management 20090101

Title: Behavioral intervention versus pharmacotherapy or their combinations in the management of overactive bladder dysfunction.

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Title: The symptomatic management of multiple sclerosis.

Journal: Annals of Indian Academy of Neurology 20090101

Title: Highly sensitive and rapid LC-ESI-MS/MS method for the simultaneous quantification of uroselective alpha1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215

Title: QT prolongation and torsade de pointes associated with solifenacin in an 81-year-old woman.

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Title: [Efficacy and safety of solifenacin in daily clinical practice--clinical study phase IV].

Journal: Ceska gynekologie 20081201

Title: Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro.

Journal: International journal of chronic obstructive pulmonary disease 20081201

Title: Preserving cognitive function for patients with overactive bladder: evidence for a differential effect with darifenacin.

Journal: International journal of clinical practice 20081101

Title: Darifenacin treatment for overactive bladder in patients who expressed dissatisfaction with prior extended-release antimuscarinic therapy.

Journal: International journal of clinical practice 20081101

Title: Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial.

Journal: BJU international 20081101

Title: Solifenacin at 3 years: a review of efficacy and safety. Commentary.

Journal: Postgraduate medicine 20081101

Title: [Economic impact of overactive bladder symptoms in Japan].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20081101

Title: Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.

Journal: International journal of clinical practice 20081101

Title: Human urine with solifenacin intake but not tolterodine or darifenacin intake blocks detrusor overactivity.

Journal: International urogynecology journal and pelvic floor dysfunction 20081001

Title: Efficacy of solifenacin in patients previously treated with tolterodine extended release 4 mg: results of a 12-week, multicenter, open-label, flexible-dose study.

Journal: Clinical therapeutics 20081001

Title: The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis.

Journal: European urology 20080901

Title: Choice of antimuscarinic agents for overactive bladder in the older patient: focus on darifenacin.

Journal: Clinical interventions in aging 20080901

Title: Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080801

Title: A cost-utility analysis of once daily solifenacin compared to tolterodine in the treatment of overactive bladder syndrome.

Journal: Current medical research and opinion 20080801

Title: [Urinary urgency].

Journal: MMW Fortschritte der Medizin 20080731

Title: Solifenacin at 3 years: a review of efficacy and safety.

Journal: Postgraduate medicine 20080701

Title: In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment.

Journal: The Journal of pharmacology and experimental therapeutics 20080601

Title: Impact of solifenacin on resource utilization, work productivity and health utility in overactive bladder patients switching from tolterodine ER.

Journal: Current medical research and opinion 20080601

Title: [Overactive bladder. When it's pressing, immediate help is indicated].

Journal: MMW Fortschritte der Medizin 20080515

Title: Photodistributed lichenoid drug eruption secondary to solifenacin.

Journal: Clinical and experimental dermatology 20080501

Title: Urgency in overactive bladder: translating experimental data into clinical practice.

Journal: Drugs of today (Barcelona, Spain : 1998) 20080501

Title: Is solifenacin succinate safe and effective for the treatment of overactive bladder?

Journal: Nature clinical practice. Urology 20080301

Title: A simple validated scale to measure urgency.

Journal: The Journal of urology 20080301

Title: Solifenacin-induced small bowel pseudo-obstruction.

Journal: Journal of hospital medicine 20080301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080301

Title: A review of solifenacin in the treatment of urinary incontinence.

Journal: Therapeutics and clinical risk management 20080201

Title: Solifenacin treatment for overactive bladder in Hispanic patients: patient-reported symptom bother and quality of life outcomes from the VESIcare Open-Label Trial.

Journal: International journal of clinical practice 20080101

Title: Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080101

Title: [Anticholinergic drugs in overactive bladder].

Journal: Gynecologie, obstetrique & fertilite 20080101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080101

Title: Pharmacological effects of solifenacin on human isolated urinary bladder.

Journal: Pharmacology 20080101

Title: Cardiovascular safety and overall tolerability of solifenacin in routine clinical use: a 12-week, open-label, post-marketing surveillance study.

Journal: Drug safety 20080101

Title: Gateways to clinical trials. July-August 2008.

Journal: Methods and findings in experimental and clinical pharmacology 20080101

Title: [Assessment of symptoms severity in patients with overactive bladder].

Journal: Urologiia (Moscow, Russia : 1999) 20080101

Title: Practical management of nocturia in urology.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20080101

Title: Effects of intravenously and orally administered solifenacin succinate (YM905) on carbachol-induced intravesical pressure elevation and salivary secretion in mice.

Journal: Biological & pharmaceutical bulletin 20071201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20071201

Title: Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

Title: Muscarinic receptor antagonists for overactive bladder.

Journal: BJU international 20071101

Title: Comparative in vivo uroselectivity profiles of anticholinergics, tested in a novel anesthetized rabbit model.

Journal: European journal of pharmacology 20071031

Title: An unusual cause of postoperative detrusor overactivity.

Journal: International urogynecology journal and pelvic floor dysfunction 20071001

Title: Treatment outcomes in the STAR study: a subanalysis of solifenacin 5 mg and tolterodine ER 4 mg.

Journal: European urology 20071001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20071001

Title: Comparison of the efficacy and tolerability of solifenacin succinate with or without previous use of trospium chloride.

Journal: International urogynecology journal and pelvic floor dysfunction 20070901

Title: Randomized, double-blind, placebo- and propiverine-controlled trial of the once-daily antimuscarinic agent solifenacin in Japanese patients with overactive bladder.

Journal: BJU international 20070901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070901

Title: Pharmacologic management of overactive bladder.

Journal: Clinical interventions in aging 20070901

Title: Number of daytime micturitions and volume voided per micturition in the evaluation of efficacy of drugs for overactive bladder: findings from randomized clinical trials.

Journal: European urology 20070801

Title: Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms.

Journal: International urogynecology journal and pelvic floor dysfunction 20070701

Title: Overactive bladder treatments in early phase clinical trials.

Journal: Expert opinion on investigational drugs 20070701

Title: Agents for treatment of overactive bladder: a therapeutic class review.

Journal: Proceedings (Baylor University. Medical Center) 20070701

Title: Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached?

Journal: BJU international 20070601

Title: Update on drugs for overactive bladder syndrome.

Journal: Drug and therapeutics bulletin 20070601

Title: Treatment of overactive bladder: selective use of anticholinergic agents with low drug-drug interaction potential.

Journal: Geriatrics 20070501

Title: [How do medications used to treat urinary incontinence affect the cerebral function of the elderly?].

Journal: Der Urologe. Ausg. A 20070401

Title: [Comment on the STAR study: Comparison of the efficacy and tolerance of solifenacin and tolterodine retard in the treatment of overactive bladder].

Journal: Der Urologe. Ausg. A 20070401

Title: Solifenacin treatment for overactive bladder in black patients: patient-reported symptom bother and health-related quality of life outcomes.

Journal: Current medical research and opinion 20070401

Title: Solifenacin for overactive bladder with incontinence: symptom bother and health-related quality of life outcomes.

Journal: The Annals of pharmacotherapy 20070301

Title: Effect of antimuscarinic drugs used for overactive bladder on learning in a rat passive avoidance response test.

Journal: European journal of pharmacology 20070227

Title: Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.

Journal: Biological & pharmaceutical bulletin 20070101

Title: Redefining response in overactive bladder syndrome.

Journal: BJU international 20070101

Title: Pharmacokinetics, safety, and tolerability of solifenacin in patients with renal insufficiency.

Journal: Journal of pharmacological sciences 20070101

Title: Identification of the patient with enlarged prostate: diagnosis and guidelines for management.

Journal: Osteopathic medicine and primary care 20070101

Title: [Solifenacin in the treatment of patients with hyperactive urinary bladder].

Journal: Urologiia (Moscow, Russia : 1999) 20070101

Title: [A placebo-controlled, double-blind, randomized trial of single daily dose of anti-muscarinic drug solifenacin succinate in patients with overactive bladder].

Journal: Akusherstvo i ginekologiia 20070101

Title: Application of evidence-based urology in improving quality of care.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20070101

Title: Newer agents for the management of overactive bladder.

Journal: American family physician 20061215

Title: Solifenacin provides effective antimuscarinic therapy for the complete management of overactive bladder.

Journal: Expert opinion on pharmacotherapy 20061201

Title: Pharmacoeconomic evaluation of antimuscarinic agents for the treatment of overactive bladder.

Journal: Pharmacotherapy 20061201

Title: [Pharmacological and clinical profile of solifenacin succinate (Vesicare) developed as a new therapeutic agent for overactive bladder].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20061201

Title: Open-label study of the safety and pharmacokinetics of solifenacin in subjects with hepatic impairment.

Journal: Journal of pharmacological sciences 20061201

Title: Solifenacin succinate (VESIcare): overactive bladder therapy.

Journal: Urologic nursing 20061201

Title: New developments in the treatment of urinary incontinence.

Journal: Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20061201

Title: Treatment of overactive bladder in the aging population: focus on darifenacin.

Journal: Clinical interventions in aging 20061201

Title: Solifenacin.

Journal: The Urologic clinics of North America 20061101

Title: Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20061101

Title: Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: the VESIcare Open-Label Trial (VOLT).

Journal: Clinical therapeutics 20061101

Title: Anticholinergic drugs versus placebo for overactive bladder syndrome in adults.

Journal: The Cochrane database of systematic reviews 20061018

Title: Reductions in overactive bladder-related incontinence from pooled analysis of phase III trials evaluating treatment with solifenacin.

Journal: International urogynecology journal and pelvic floor dysfunction 20060901

Title: Solifenacin succinate for the treatment of symptoms of overactive bladder.

Journal: Clinical therapeutics 20060901

Title: Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: A pooled analysis.

Journal: The American journal of geriatric pharmacotherapy 20060901

Title: Multiple doses of the antimuscarinic agent solifenacin do not affect the pharmacodynamics or pharmacokinetics of warfarin or the steady-state pharmacokinetics of digoxin in healthy subjects.

Journal: British journal of clinical pharmacology 20060801

Title: Solifenacin significantly improves all symptoms of overactive bladder syndrome.

Journal: International journal of clinical practice 20060801

Title: Patient-reported outcomes in overactive bladder: importance for determining clinical effectiveness of treatment.

Journal: Urology 20060801

Title: [Oral anticholinergics in overactive bladder].

Journal: Der Urologe. Ausg. A 20060701

Title: [Comment on the STAR study: Comparison of the efficacy and tolerance of solifenacin and tolterodine retard in the treatment of overactive bladder].

Journal: Der Urologe. Ausg. A 20060701

Title: Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifenacin in mice.

Journal: Biological & pharmaceutical bulletin 20060701

Title: Pharmacokinetic effect of ketoconazole on solifenacin in healthy volunteers.

Journal: Basic & clinical pharmacology & toxicology 20060701

Title: Solifenacin: as effective in mixed urinary incontinence as in urge urinary incontinence.

Journal: International urogynecology journal and pelvic floor dysfunction 20060601

Title: Short- and long-term efficacy of solifenacin treatment in patients with symptoms of mixed urinary incontinence.

Journal: BJU international 20060601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060501

Title: The causes and consequences of overactive bladder.

Journal: Journal of women's health (2002) 20060401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060401

Title: Using anticholinergics to treat overactive bladder: the issue of treatment tolerability.

Journal: The American journal of medicine 20060301

Title: Pharmacologic management of overactive bladder: practical options for the primary care physician.

Journal: The American journal of medicine 20060301

Title: Management of overactive bladder and urge urinary incontinence in the elderly patient.

Journal: The American journal of medicine 20060301

Title: The emergence of new drugs for overactive bladder.

Journal: Expert opinion on emerging drugs 20060301

Title: Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: a pooled analysis.

Journal: The American journal of geriatric pharmacotherapy 20060301

Title: New drugs 06, part I.

Journal: Nursing 20060201

Title: Muscarinic receptors in the bladder: from basic research to therapeutics.

Journal: British journal of pharmacology 20060201

Title: Re: Chapple CR, Martinez-Garcia R, Selvaggi L, Toozs-Hobson P, Warnack W, Drogendijk T, Wright DM, Bolodeoku J. A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial. Eur Urol 2005;48:464-70.

Journal: European urology 20060101

Title: Efficacy of solifenacin in patients with severe symptoms of overactive bladder: a pooled analysis.

Journal: Current medical research and opinion 20060101

Title: Solifenacin in overactive bladder syndrome.

Journal: Drugs 20060101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060101

Title: Solifenacin versus tolterodine--a head-to-head study: finally! But not final?

Journal: Current urology reports 20051101

Title: The Q-T interval and antimuscarinic drugs.

Journal: Current urology reports 20051101

Title: [Drug discovery in the fields of urology: tamsulosin and solifenacin].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20051101

Title: Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.

Journal: Journal of medicinal chemistry 20051020

Title: Solifenacin in the management of the overactive bladder syndrome.

Journal: International journal of clinical practice 20051001

Title: A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial.

Journal: European urology 20050901

Title: Solifenacin is effective for the treatment of OAB dry patients: a pooled analysis.

Journal: European urology 20050901

Title: Role of muscarinic receptor antagonists in urgency and nocturia.

Journal: BJU international 20050901

Title: Pharmacokinetic interaction of solifenacin with an oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women: a double-blind, placebo-controlled study.

Journal: Clinical therapeutics 20050901

Title: Solifenacin and darifenacin for overactive bladder.

Journal: Obstetrics and gynecology 20050801

Title: Darifenacin in the treatment of overactive bladder.

Journal: International journal of clinical practice 20050701

Title: New treatment options for overactive bladder.

Journal: South Dakota journal of medicine 20050601

Title: Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence.

Journal: Therapeutics and clinical risk management 20050601

Title: Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice.

Journal: British journal of pharmacology 20050501

Title: Effect of age on the pharmacokinetics of solifenacin in men and women.

Journal: International journal of clinical pharmacology and therapeutics 20050501

Title: Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarcted rats.

Journal: European journal of pharmacology 20050404

Title: Solifenacin and darifenacin for overactive bladder.

Journal: The Medical letter on drugs and therapeutics 20050314

Title: Long-term open-label solifenacin treatment associated with persistence with therapy in patients with overactive bladder syndrome.

Journal: European urology 20050301

Title: [Medical therapy of urinary incontinence].

Journal: Der Internist 20050101

Title: Improved quality of life in patients with overactive bladder symptoms treated with solifenacin.

Journal: BJU international 20050101

Title: New molecular entity: Vesicare, Yamanouchi/GlaxoSmithKline solifenacin.

Journal: Geriatrics 20050101

Title: New drugs: acamprosate calcium and solifenacin succinate.

Journal: Journal of the American Pharmacists Association : JAPhA 20050101

Title: Recent developments in the management of overactive bladder: focus on the efficacy and tolerability of once daily solifenacin succinate 5 mg.

Journal: Current medical research and opinion 20050101

Title: Improving the tolerability of anticholinergic agents in the treatment of overactive bladder.

Journal: Drug safety 20050101

Title: [Neurological aspect of the hyperactive urinary bladder syndrome].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: Overactive bladder in the elderly: a guide to pharmacological management.

Journal: Drugs & aging 20050101

Title: Solifenacin in overactive bladder syndrome.

Journal: Drugs & aging 20050101

Title: Solifenacin in overactive bladder syndrome: a viewpoint by Scott Serels.

Journal: Drugs & aging 20050101

Title: Solifenacin in overactive bladder: a viewpoint by Hashim Hashim.

Journal: Drugs & aging 20050101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20041201

Title: Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder.

Journal: The Journal of urology 20041101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20041101

Title: The emerging role of solifenacin in the treatment of overactive bladder.

Journal: Expert opinion on investigational drugs 20041001

Title: Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine.

Journal: Current urology reports 20041001

Title: Elevating our therapeutic expectations in overactive bladder.

Journal: Journal of the American Academy of Nurse Practitioners 20041001

Title: Pharmacokinetics and safety of solifenacin succinate in healthy young men.

Journal: Journal of clinical pharmacology 20040901

Title: [Overactive bladder. New anticholinergic drug controls urinary urge].

Journal: MMW Fortschritte der Medizin 20040708

Title: Food does not affect the pharmacokinetics of solifenacin, a new muscarinic receptor antagonist: results of a randomized crossover trial.

Journal: British journal of clinical pharmacology 20040701

Title: [In overactive bladder, above all urgency is stressful. The patients know the site of each toilet].

Journal: MMW Fortschritte der Medizin 20040527

Title: In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats.

Journal: European journal of pharmacology 20040525

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040501

Title: Drug forecast--solifenacin: an investigational anticholinergic for overactive bladder.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20040501

Title: Solifenacin: treatment of overactive bladder.

Journal: Drugs of today (Barcelona, Spain : 1998) 20040401

Title: Role of antimuscarinics in the treatment of nonneurogenic daytime urinary incontinence in children.

Journal: Urology 20040301

Title: Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder.

Journal: BJU international 20040201

Title: Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells.

Journal: Life sciences 20040102

Title: Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase 2 dose-finding study.

Journal: BJU international 20040101

Title: Drug treatment of overactive bladder: efficacy, cost and quality-of-life considerations.

Journal: Drugs 20040101

Title: Solifenacin demonstrates high absolute bioavailability in healthy men.

Journal: Drugs in R&D 20040101

Title: [Urinary incontinence: anticholinergic treatment].

Journal: Revista de medicina de la Universidad de Navarra 20040101

Title: [Urinary incontinence: new pharmacologic therapies].

Journal: Revista de medicina de la Universidad de Navarra 20040101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20031101

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Journal: Methods and findings in experimental and clinical pharmacology 20030601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20030101

Title: M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020801

Title: Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo.

Journal: Japanese journal of pharmacology 20010701

Title: Ikeda K, et al. M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366(2):97-103.

Title: Suzuki M, et al. Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarctedrats. Eur J Pharmacol. 2005 Apr 4;512(1):61-6.

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Tags:242478-37-1 Molecular Formula|242478-37-1 MDL|242478-37-1 SMILES|242478-37-1 Solifenacin