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24365-65-9,MFCD00192043
Catalog No.:AA00C3DL

24365-65-9 | 3,4-Dihydro-3-methyl-2(1h)-quinazolinone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$45.00   $32.00
- +
5g
98%
in stock  
$112.00   $78.00
- +
10g
98%
in stock  
$178.00   $125.00
- +
25g
98%
in stock  
$278.00   $195.00
- +
100g
98%
in stock  
$677.00   $474.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C3DL
Chemical Name:
3,4-Dihydro-3-methyl-2(1h)-quinazolinone
CAS Number:
24365-65-9
Molecular Formula:
C9H10N2O
Molecular Weight:
162.1885
MDL Number:
MFCD00192043
SMILES:
O=C1Nc2ccccc2CN1C
Properties
Properties
 
Form:
Solid  
MP:
200-203°C(lit.)  

Computed Properties
 
Complexity:
193  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.7  

Downstream Synthesis Route

[1]Fish,PaulV.;Filippakopoulos,Panagis;Bish,Gerwyn;Brennan,PaulE.;Bunnage,MarkE.;Cook,AndrewS.;Federov,Oleg;Gerstenberger,BrianS.;Jones,Hannah;Knapp,Stefan;Marsden,Brian;Nocka,Karl;Owen,DafyddR.;Philpott,Martin;Picaud,Sarah;Primiano,MichaelJ.;Ralph,MichaelJ.;Sciammetta,Nunzio;Trzupek,JohnD.[JournalofMedicinalChemistry,2012,vol.55,#22,p.9831-9837]

[2]CurrentPatentAssignee:PFIZERINC-WO2013/27168,2013,A1

[1]ArchivderPharmazie,2016,p.638-650

24365-65-9    60076-09-7   
1-(3-iodobenzyl)-3-methyl-3,4-dihydroquinazolin-2(1H,3H)-dione 

[1]MolecularDiversity,2020,vol.24,p.391-406

Literature

Title: Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.

Journal: Journal of medicinal chemistry 20121126

Title: Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery.

Journal: Journal of medicinal chemistry 20120126

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SDS
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