Home Other Building Blocks 321674-73-1
321674-73-1,MFCD11112195
Catalog No.:AA00C6C6

321674-73-1 | Bibr 1532

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Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$7.00   $5.00
- +
5mg
99%
in stock  
$24.00   $17.00
- +
10mg
99%
in stock  
$35.00   $25.00
- +
50mg
99%
in stock  
$97.00   $68.00
- +
100mg
99%
in stock  
$164.00   $115.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6C6
Chemical Name:
Bibr 1532
CAS Number:
321674-73-1
Molecular Formula:
C21H17NO3
Molecular Weight:
331.3646
MDL Number:
MFCD11112195
SMILES:
O=C(Nc1ccccc1C(=O)O)/C=C(/c1ccc2c(c1)cccc2)\C
Properties
Properties
 
BP:
600.607°C at 760 mmHg  
Form:
Solid  
MP:
>173ºC (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
527  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
5.1  

Literature

Title: BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL.

Journal: Anti-cancer agents in medicinal chemistry 20130901

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A new strategy for detection and development of tractable telomerase inhibitors.

Journal: Journal of medicinal chemistry 20120426

Title: Screening of telomerase inhibitors.

Journal: Methods in molecular biology (Clifton, N.J.) 20070101

Title: Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment.

Journal: Molecular pharmacology 20050901

Title: Pascolo E, et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem. 2002 May 3;277(18):15566-72.

Title: El-Daly H, et al. Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood. 2005 Feb 15;105(4):1742-9.

Title: Ward RJ, et al. Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Mol Pharmacol. 2005 Sep;68(3):779-86.

Title: A Röth, et al. Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. Leukemia. 2007 Dec;21(12):2456-62.

Title: Meng E, et al. Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells. Gynecol Oncol. 2012 Mar;124(3):598-605.

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SDS
Tags:321674-73-1 Molecular Formula|321674-73-1 MDL|321674-73-1 SMILES|321674-73-1 Bibr 1532