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244192-94-7,MFCD10687097
Catalog No.:AA006V56

244192-94-7 | N-[[3-[(2S)-2-HYDROXY-3-[[2-[4-[(PHENYLSULFONYL)AMINO]PHENYL]ETHYL]AMINO]PROPOXY]PHENYL]METHYL]-ACETAMIDE

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1mg
≥98%
in stock  
$53.00   $37.00
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5mg
≥98%
in stock  
$166.00   $116.00
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10mg
≥98%
in stock  
$305.00   $213.00
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25mg
≥98%
in stock  
$632.00   $442.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006V56
Chemical Name:
N-[[3-[(2S)-2-HYDROXY-3-[[2-[4-[(PHENYLSULFONYL)AMINO]PHENYL]ETHYL]AMINO]PROPOXY]PHENYL]METHYL]-ACETAMIDE
CAS Number:
244192-94-7
Molecular Formula:
C26H31N3O5S
Molecular Weight:
497.6064
MDL Number:
MFCD10687097
SMILES:
O[C@H](COc1cccc(c1)CNC(=O)C)CNCCc1ccc(cc1)NS(=O)(=O)c1ccccc1
Properties
Computed Properties
 
Complexity:
715  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
13  
XLogP3:
2  

Literature

Title: Protective effects of the β3-adrenoceptor agonist CL316243 against N-methyl-D-aspartate-induced retinal neurotoxicity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20121101

Title: Role of β3-adrenoceptors in regulation of retinal vascular tone in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20111201

Title: Positive influence of AT(1) receptor antagonism upon the impaired celiprolol-induced vasodilatation in aorta from spontaneously hypertensive rats.

Journal: European journal of pharmacology 20101010

Title: Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man.

Journal: The Journal of pharmacology and experimental therapeutics 20090101

Title: The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.

Journal: Molecular pharmacology 20081101

Title: Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management.

Journal: Journal of the American College of Cardiology 20050719

Title: Endogenous beta3-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20040601

Title: Role of nitric oxide in beta3-adrenoceptor activation on basal tone of internal anal sphincter.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030901

Title: Inhibitory effect of beta3-adrenoceptor agonist in lower esophageal sphincter smooth muscle: in vitro studies.

Journal: The Journal of pharmacology and experimental therapeutics 20030101

Title: Beta3 adrenergic stimulation inhibits the opossum lower esophageal sphincter.

Journal: Gastroenterology 20021101

Title: Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium.

Journal: Circulation research 20010928

Title: Potent and selective human beta(3)-adrenergic receptor antagonists.

Journal: The Journal of pharmacology and experimental therapeutics 19990801

Title: S Neidhold, et al. The function of alpha- and beta-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br J Pharmacol. 2007 Feb;150(3):261-70.

Title: Masaaki Sato, et al. The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonylamino-N---[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propylaminoethyl-phenyl-benzenesulfonamide (L755507) and antagonist (S)-N---[--(acetamidomethyl)phenoxy-2-hydroxypropylamino-ethylphenylbenzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. Mol Pharmacol. 2008 Nov;74(5):1417-28.

Title: Ziwen Wang, et al. The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD). Mol Med. 2020 Jun 5;26(1):54.

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Tags:244192-94-7 Molecular Formula|244192-94-7 MDL|244192-94-7 SMILES|244192-94-7 N-[[3-[(2S)-2-HYDROXY-3-[[2-[4-[(PHENYLSULFONYL)AMINO]PHENYL]ETHYL]AMINO]PROPOXY]PHENYL]METHYL]-ACETAMIDE