256498-66-5,MFCD18382081
Catalog No.:AA00BE7A

256498-66-5 | Bay-41-8543

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$50.00   $35.00
- +
5mg
≥98%
in stock  
$163.00   $114.00
- +
10mg
≥98%
in stock  
$300.00   $210.00
- +
25mg
97%
in stock  
$497.00   $348.00
- +
100mg
97%
in stock  
$1,585.00   $1,109.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BE7A
Chemical Name:
Bay-41-8543
CAS Number:
256498-66-5
Molecular Formula:
C21H21FN8O
Molecular Weight:
420.4428
MDL Number:
MFCD18382081
SMILES:
Nc1nc(nc(c1N1CCOCC1)N)c1nn(c2c1cccn2)Cc1ccccc1F
Properties
Computed Properties
 
Complexity:
584  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.6  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: sGC stimulation totally reverses hypoxia-induced pulmonary vasoconstriction alone and combined with dual endothelin-receptor blockade in a porcine model.

Journal: Acta physiologica (Oxford, England) 20121101

Title: Impact of biological gender and soluble guanylate cyclase stimulation on renal recovery after relief of unilateral ureteral obstruction.

Journal: The Journal of urology 20120701

Title: Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension.

Journal: Nitric oxide : biology and chemistry 20120630

Title: Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543.

Journal: Critical care medicine 20111201

Title: Is there a role for soluble guanylate cyclase stimulators in acute pulmonary embolism?

Journal: Critical care medicine 20111201

Title: Acidic triazoles as soluble guanylate cyclase stimulators.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: Stimulation of soluble guanylate cyclase improves renal recovery after relief of unilateral ureteral obstruction.

Journal: The Journal of urology 20110901

Title: Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide.

Journal: American journal of physiology. Heart and circulatory physiology 20101001

Title: Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.

Journal: The journal of sexual medicine 20100101

Title: Soluble guanylate cyclase: not a dull enzyme.

Journal: Circulation 20090602

Title: Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Journal: ChemMedChem 20090501

Title: Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil.

Journal: The Journal of pharmacology and experimental therapeutics 20080801

Title: Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.

Journal: American journal of respiratory and critical care medicine 20071201

Title: Clinical potential of nitric oxide-independent soluble guanylate cyclase activators.

Journal: Current opinion in investigational drugs (London, England : 2000) 20050901

Title: Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.

Journal: European journal of pharmacology 20030516

Title: Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Journal: Bioorganic & medicinal chemistry 20020601

Title: Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.

Journal: British journal of pharmacology 20020101

Title: Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies.

Journal: British journal of pharmacology 20020101

Title: Adeleke M Badejo Jr, et al. Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide. Am J Physiol Heart Circ Physiol.

Title: Johannes-Peter Stasch, et al. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br J Pharmacol. 2002 Jan;135(2):344-55.

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Additional Info:
SDS
Historical Records
Tags:256498-66-5 Molecular Formula|256498-66-5 MDL|256498-66-5 SMILES|256498-66-5 Bay-41-8543
Catalog No.: AA00BE7A
256498-66-5,MFCD18382081
256498-66-5 | Bay-41-8543
Pack Size: 1mg
Purity: ≥98%
in stock
$50.00 $35.00
Pack Size: 5mg
Purity: ≥98%
in stock
$163.00 $114.00
Pack Size: 10mg
Purity: ≥98%
in stock
$300.00 $210.00
Pack Size: 25mg
Purity: 97%
in stock
$497.00 $348.00
Pack Size: 100mg
Purity: 97%
in stock
$1,585.00 $1,109.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00BE7A
Chemical Name: Bay-41-8543
CAS Number: 256498-66-5
Molecular Formula: C21H21FN8O
Molecular Weight: 420.4428
MDL Number: MFCD18382081
SMILES: Nc1nc(nc(c1N1CCOCC1)N)c1nn(c2c1cccn2)Cc1ccccc1F
Properties
Complexity: 584  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.6  
Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: sGC stimulation totally reverses hypoxia-induced pulmonary vasoconstriction alone and combined with dual endothelin-receptor blockade in a porcine model.

Journal: Acta physiologica (Oxford, England)20121101

Title: Impact of biological gender and soluble guanylate cyclase stimulation on renal recovery after relief of unilateral ureteral obstruction.

Journal: The Journal of urology20120701

Title: Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension.

Journal: Nitric oxide : biology and chemistry20120630

Title: Pulmonary vascular reserve during experimental pulmonary embolism: effects of a soluble guanylate cyclase stimulator, BAY 41-8543.

Journal: Critical care medicine20111201

Title: Is there a role for soluble guanylate cyclase stimulators in acute pulmonary embolism?

Journal: Critical care medicine20111201

Title: Acidic triazoles as soluble guanylate cyclase stimulators.

Journal: Bioorganic & medicinal chemistry letters20111101

Title: The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.

Journal: The Journal of pharmacology and experimental therapeutics20110901

Title: Stimulation of soluble guanylate cyclase improves renal recovery after relief of unilateral ureteral obstruction.

Journal: The Journal of urology20110901

Title: Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide.

Journal: American journal of physiology. Heart and circulatory physiology20101001

Title: Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.

Journal: The journal of sexual medicine20100101

Title: Soluble guanylate cyclase: not a dull enzyme.

Journal: Circulation20090602

Title: Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Journal: ChemMedChem20090501

Title: Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil.

Journal: The Journal of pharmacology and experimental therapeutics20080801

Title: Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.

Journal: American journal of respiratory and critical care medicine20071201

Title: Clinical potential of nitric oxide-independent soluble guanylate cyclase activators.

Journal: Current opinion in investigational drugs (London, England : 2000)20050901

Title: Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.

Journal: European journal of pharmacology20030516

Title: Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Journal: Bioorganic & medicinal chemistry20020601

Title: Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.

Journal: British journal of pharmacology20020101

Title: Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies.

Journal: British journal of pharmacology20020101

Title: Adeleke M Badejo Jr, et al. Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide. Am J Physiol Heart Circ Physiol.

Title: Johannes-Peter Stasch, et al. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br J Pharmacol. 2002 Jan;135(2):344-55.

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