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Home Amines 1350653-20-1
1350653-20-1,MFCD28502029
Catalog No.:AA00HTSO

1350653-20-1 | Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate

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Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$95.00   $66.00
- +
10mg
≥98%
in stock  
$152.00   $106.00
- +
50mg
99%
in stock  
$192.00   $135.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HTSO
Chemical Name:
Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate
CAS Number:
1350653-20-1
Molecular Formula:
C19H16F2N8O2
Molecular Weight:
426.3795
MDL Number:
MFCD28502029
SMILES:
COC(=O)Nc1c(N)nc(nc1N)c1nn(c2c1cc(F)cn2)Cc1ccccc1F
Properties
Computed Properties
 
Complexity:
622  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
1.5  

Downstream Synthesis Route

[1]Patent:WO2011/147810,2011,A1.Locationinpatent:Page/Pagecolumn34

[2]Patent:US2012/22084,2012,A1.Locationinpatent:Page/Pagecolumn17-18

[3]Patent:US2013/158028,2013,A1.Locationinpatent:Paragraph0162-0167

[1]Patent:WO2011/147810,2011,A1

[2]Patent:WO2011/147810,2011,A1

[3]Patent:US2012/22084,2012,A1

[4]Patent:US2013/158028,2013,A1

[5]Patent:US2013/158028,2013,A1

[6]Patent:US2014/148433,2014,A1

[1]Patent:WO2011/147810,2011,A1.Locationinpatent:Page/Pagecolumn33

[2]Patent:US2012/22084,2012,A1.Locationinpatent:Page/Pagecolumn17

[3]Patent:US2013/158028,2013,A1.Locationinpatent:Paragraph0156-0161

[4]Patent:US2014/148433,2014,A1.Locationinpatent:Paragraph0726;0727;0728;0729

[5]Patent:US2013/143900,2013,A1.Locationinpatent:Paragraph0229;0235;0236

[6]JournalofMedicinalChemistry,2017,vol.60,p.5146-5161

[1]Patent:WO2011/147810,2011,A1

[2]Patent:WO2011/147810,2011,A1

[3]Patent:US2012/22084,2012,A1

[4]Patent:US2013/158028,2013,A1

[5]Patent:US2013/158028,2013,A1

[6]Patent:US2014/148433,2014,A1

[1]Patent:WO2011/147810,2011,A1

[2]Patent:WO2011/147810,2011,A1

[3]Patent:US2012/22084,2012,A1

[4]Patent:US2013/158028,2013,A1

[5]Patent:US2013/158028,2013,A1

[6]Patent:US2014/148433,2014,A1

Literature

Title: Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.

Journal: Journal of medicinal chemistry 20170622

Title: Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure.

Journal: Handbook of experimental pharmacology 20170101

Title: Follmann M, et al. Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure. J Med Chem. 2017 Jun 22;60(12):5146-5161.

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SDS
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Tags:1350653-20-1 Molecular Formula|1350653-20-1 MDL|1350653-20-1 SMILES|1350653-20-1 Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate