625115-55-1,MFCD19443708
Catalog No.:AA00ECBT

625115-55-1 | methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$10.00   $7.00
- +
5mg
98%
in stock  
$14.00   $10.00
- +
10mg
98%
in stock  
$17.00   $12.00
- +
50mg
98%
in stock  
$29.00   $20.00
- +
100mg
98%
in stock  
$38.00   $27.00
- +
250mg
98%
in stock  
$75.00   $53.00
- +
1g
98%
in stock  
$242.00   $169.00
- +
5g
98%
in stock  
$493.00   $345.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ECBT
Chemical Name:
methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
CAS Number:
625115-55-1
Molecular Formula:
C20H19FN8O2
Molecular Weight:
422.4157
MDL Number:
MFCD19443708
SMILES:
COC(=O)N(c1c(N)nc(nc1N)c1nn(c2c1cccn2)Cc1ccccc1F)C
Properties
Computed Properties
 
Complexity:
618  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.6  

Literature

Title: Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure.

Journal: Handbook of experimental pharmacology 20170101

Title: The molecular targets of approved treatments for pulmonary arterial hypertension.

Journal: Thorax 20160101

Title: Riociguat for the treatment of pulmonary hypertension.

Journal: Expert review of respiratory medicine 20150101

Title: Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Journal: P & T : a peer-reviewed journal for formulary management 20141101

Title: Riociguat: first global approval.

Journal: Drugs 20131101

Title: Pathways in pulmonary arterial hypertension: the future is here.

Journal: European respiratory review : an official journal of the European Respiratory Society 20121201

Title: Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design.

Journal: European journal of heart failure 20120801

Title: BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes.

Journal: British journal of pharmacology 20120701

Title: Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.

Journal: Critical care research and practice 20120101

Title: Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade.

Journal: PloS one 20120101

Title: The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

Journal: PloS one 20120101

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: NOX1, 2, 4, 5: counting out oxidative stress.

Journal: British journal of pharmacology 20111001

Title: Riociguat (BAY 63-2521) and warfarin: a pharmacodynamic and pharmacokinetic interaction study.

Journal: Journal of clinical pharmacology 20110701

Title: New perspectives for the treatment of pulmonary hypertension.

Journal: British journal of pharmacology 20110501

Title: Riociguat for the treatment of pulmonary hypertension.

Journal: Expert opinion on investigational drugs 20110401

Title: Soluble guanylate cyclase modulators in heart failure.

Journal: Current heart failure reports 20110301

Title: Recent trends in pulmonary arterial hypertension.

Journal: Lung India : official organ of Indian Chest Society 20110101

Title: Therapeutic strategies in pulmonary hypertension.

Journal: Frontiers in pharmacology 20110101

Title: Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.

Journal: PloS one 20110101

Title: Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.

Journal: PloS one 20110101

Title: Overview of current therapeutic approaches for pulmonary hypertension.

Journal: Pulmonary circulation 20110101

Title: Lung transplantation for pulmonary hypertension.

Journal: Pulmonary circulation 20110101

Title: Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.

Journal: The European respiratory journal 20101001

Title: Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models.

Journal: Journal of hypertension 20100801

Title: [Pulmonary arterial hypertension--a rare form of pulmonary hypertension].

Journal: Deutsche medizinische Wochenschrift (1946) 20100501

Title: Riociguat for pulmonary hypertension.

Journal: Future cardiology 20100301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100301

Title: Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension?

Journal: European respiratory review : an official journal of the European Respiratory Society 20100301

Title: Animal models related to congenital heart disease and clinical research in pulmonary hypertension.

Journal: Cardiology 20100101

Title: Translating the oxidative stress hypothesis into the clinic: NOX versus NOS.

Journal: Journal of molecular medicine (Berlin, Germany) 20091101

Title: Riociguat, an oral soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090901

Title: Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Journal: ChemMedChem 20090501

Title: First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.

Journal: The European respiratory journal 20090401

Title: Molecule of the month. Riociguat.

Journal: Drug news & perspectives 20090401

Title: Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy.

Journal: European respiratory review : an official journal of the European Respiratory Society 20090301

Title: NO-independent, haem-dependent soluble guanylate cyclase stimulators.

Journal: Handbook of experimental pharmacology 20090101

Title: Pulmonary arterial hypertension: on the way to a manageable disease.

Journal: Current opinion in investigational drugs (London, England : 2000) 20080901

Title: NO-independent regulatory site on soluble guanylate cyclase.

Journal: Nature 20010308

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Additional Info:
SDS
Tags:625115-55-1 Molecular Formula|625115-55-1 MDL|625115-55-1 SMILES|625115-55-1 methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
Catalog No.: AA00ECBT
625115-55-1,MFCD19443708
625115-55-1 | methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
Pack Size: 1mg
Purity: 98%
in stock
$10.00 $7.00
Pack Size: 5mg
Purity: 98%
in stock
$14.00 $10.00
Pack Size: 10mg
Purity: 98%
in stock
$17.00 $12.00
Pack Size: 50mg
Purity: 98%
in stock
$29.00 $20.00
Pack Size: 100mg
Purity: 98%
in stock
$38.00 $27.00
Pack Size: 250mg
Purity: 98%
in stock
$75.00 $53.00
Pack Size: 1g
Purity: 98%
in stock
$242.00 $169.00
Pack Size: 5g
Purity: 98%
in stock
$493.00 $345.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00ECBT
Chemical Name: methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
CAS Number: 625115-55-1
Molecular Formula: C20H19FN8O2
Molecular Weight: 422.4157
MDL Number: MFCD19443708
SMILES: COC(=O)N(c1c(N)nc(nc1N)c1nn(c2c1cccn2)Cc1ccccc1F)C
Properties
Complexity: 618  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.6  
Literature fold

Title: Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure.

Journal: Handbook of experimental pharmacology20170101

Title: The molecular targets of approved treatments for pulmonary arterial hypertension.

Journal: Thorax20160101

Title: Riociguat for the treatment of pulmonary hypertension.

Journal: Expert review of respiratory medicine20150101

Title: Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Journal: P & T : a peer-reviewed journal for formulary management20141101

Title: Riociguat: first global approval.

Journal: Drugs20131101

Title: Pathways in pulmonary arterial hypertension: the future is here.

Journal: European respiratory review : an official journal of the European Respiratory Society20121201

Title: Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design.

Journal: European journal of heart failure20120801

Title: BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes.

Journal: British journal of pharmacology20120701

Title: Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.

Journal: Critical care research and practice20120101

Title: Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade.

Journal: PloS one20120101

Title: The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

Journal: PloS one20120101

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology20111201

Title: NOX1, 2, 4, 5: counting out oxidative stress.

Journal: British journal of pharmacology20111001

Title: Riociguat (BAY 63-2521) and warfarin: a pharmacodynamic and pharmacokinetic interaction study.

Journal: Journal of clinical pharmacology20110701

Title: New perspectives for the treatment of pulmonary hypertension.

Journal: British journal of pharmacology20110501

Title: Riociguat for the treatment of pulmonary hypertension.

Journal: Expert opinion on investigational drugs20110401

Title: Soluble guanylate cyclase modulators in heart failure.

Journal: Current heart failure reports20110301

Title: Recent trends in pulmonary arterial hypertension.

Journal: Lung India : official organ of Indian Chest Society20110101

Title: Therapeutic strategies in pulmonary hypertension.

Journal: Frontiers in pharmacology20110101

Title: Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.

Journal: PloS one20110101

Title: Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.

Journal: PloS one20110101

Title: Overview of current therapeutic approaches for pulmonary hypertension.

Journal: Pulmonary circulation20110101

Title: Lung transplantation for pulmonary hypertension.

Journal: Pulmonary circulation20110101

Title: Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.

Journal: The European respiratory journal20101001

Title: Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models.

Journal: Journal of hypertension20100801

Title: [Pulmonary arterial hypertension--a rare form of pulmonary hypertension].

Journal: Deutsche medizinische Wochenschrift (1946)20100501

Title: Riociguat for pulmonary hypertension.

Journal: Future cardiology20100301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20100301

Title: Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension?

Journal: European respiratory review : an official journal of the European Respiratory Society20100301

Title: Animal models related to congenital heart disease and clinical research in pulmonary hypertension.

Journal: Cardiology20100101

Title: Translating the oxidative stress hypothesis into the clinic: NOX versus NOS.

Journal: Journal of molecular medicine (Berlin, Germany)20091101

Title: Riociguat, an oral soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension.

Journal: Current opinion in investigational drugs (London, England : 2000)20090901

Title: Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Journal: ChemMedChem20090501

Title: First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.

Journal: The European respiratory journal20090401

Title: Molecule of the month. Riociguat.

Journal: Drug news & perspectives20090401

Title: Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy.

Journal: European respiratory review : an official journal of the European Respiratory Society20090301

Title: NO-independent, haem-dependent soluble guanylate cyclase stimulators.

Journal: Handbook of experimental pharmacology20090101

Title: Pulmonary arterial hypertension: on the way to a manageable disease.

Journal: Current opinion in investigational drugs (London, England : 2000)20080901

Title: NO-independent regulatory site on soluble guanylate cyclase.

Journal: Nature20010308

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