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264622-53-9,MFCD28160689
Catalog No.:AA00C4F3

264622-53-9 | MRS 1706

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$44.00   $31.00
- +
5mg
98%
in stock  
$109.00   $76.00
- +
10mg
98%
in stock  
$179.00   $125.00
- +
50mg
98%
in stock  
$571.00   $400.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C4F3
Chemical Name:
MRS 1706
CAS Number:
264622-53-9
Molecular Formula:
C27H29N5O5
Molecular Weight:
503.5497
MDL Number:
MFCD28160689
SMILES:
CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C
Properties
Computed Properties
 
Complexity:
837  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
4.9  

Literature

Title: Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts.

Journal: Cardiovascular drugs and therapy 20160101

Title: Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.

Journal: European journal of medicinal chemistry 20100801

Title: Angiotensin II enhances the afferent arteriolar response to adenosine through increases in cytosolic calcium.

Journal: Acta physiologica (Oxford, England) 20090801

Title: Adenosine receptor subtypes in the airways responses to 5'-adenosine monophosphate inhalation of sensitized guinea-pigs.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20080901

Title: Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080601

Title: Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study.

Journal: Journal of neurochemistry 20080501

Title: In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma.

Journal: European journal of pharmacology 20071201

Title: A(2b) receptor mediates adenosine inhibition of taurine efflux from pituicytes.

Journal: Biology of the cell 20070801

Title: Determination of adenosine effects and adenosine receptors in murine corpus cavernosum.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20070201

Title: Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction.

Journal: Kidney international 20060801

Title: Characterization of adenosine receptors in the human bladder carcinoma T24 cell line.

Journal: European journal of pharmacology 20060424

Title: Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.

Journal: Molecular pharmacology 20050501

Title: Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells.

Journal: Journal of neurochemistry 20041201

Title: Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery.

Journal: European journal of pharmacology 20041103

Title: Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.

Journal: Journal of medicinal chemistry 20000323

Title: Li Q, et, al. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J Pharmacol Exp Ther. 2007 Feb;320(2):637-45.

Title: Mi T, et, al. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest. 2008 Apr;118(4):1491-501.

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