+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
273404-37-8,MFCD11100350
Catalog No.:AA0039FF

273404-37-8 | (2S)-1-[(2S)-2-[(4-amino-3-chlorophenyl)formamido]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$24.00   $17.00
- +
5mg
99%
in stock  
$79.00   $56.00
- +
10mg
99%
in stock  
$119.00   $83.00
- +
100mg
95%
in stock  
$369.00   $258.00
- +
250mg
95%
in stock  
$774.00 $542.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0039FF
Chemical Name:
(2S)-1-[(2S)-2-[(4-amino-3-chlorophenyl)formamido]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide
CAS Number:
273404-37-8
Molecular Formula:
C24H33ClN4O6
Molecular Weight:
508.9950
MDL Number:
MFCD11100350
SMILES:
CCO[C@@H]1OC(=O)C[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)(C)C)NC(=O)c1ccc(c(c1)Cl)N
Properties
Computed Properties
 
Complexity:
818  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.3  

Downstream Synthesis Route
CASUnavailable 
 
CASUnavailable 
  273404-37-8 

[1]CurrentPatentAssignee:VERTEXPHARMACEUTICALS(OLD)-WO2005/90334,2005,A2Locationinpatent:Page/Pagecolumn77-78

865839-06-1    2486-71-7   
(S)-1-((S)-2-1-(4-amino-3-chlorophenyl)methanoylamino}-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylicacid((2R,3S)-2-ethoxy-5-oxo-tetrahydrofuran-3-yl)amide 

[1]OrganicLetters,2008,vol.10,p.185-188

62965-10-0   
(S)-1-((S)-2-1-(4-amino-3-chlorophenyl)methanoylamino}-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylicacid((2R,3S)-2-ethoxy-5-oxo-tetrahydrofuran-3-yl)amide 

[1]Patent:US9487555,2016,B2

[1]CurrentPatentAssignee:VERTEXPHARMACEUTICALS(OLD)-US9487555,2016,B2

2486-71-7   
(S)-1-((S)-2-1-(4-amino-3-chlorophenyl)methanoylamino}-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylicacid((2R,3S)-2-ethoxy-5-oxo-tetrahydrofuran-3-yl)amide 

[1]Patent:US9487555,2016,B2

Literature

Title: Stack JH, et al. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol. 2005 Aug 15;175(4):2630-4.

Title: Wannamaker W, et al. (S)-1-((S)-2-{-(4-amino-3-chloro-phenyl)-methanoyl-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. J Pharmacol Exp Ther. 2007 May;321(2):509-16.

Title: Ravizza T, et al. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia. 2006 Jul;47(7):1160-8.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 273404-37-8
Building Blocks
More >
Historical Records
394215-51-1

394215-51-1

 1627693-21-3

1627693-21-3
Tags:273404-37-8 Molecular Formula|273404-37-8 MDL|273404-37-8 SMILES|273404-37-8 (2S)-1-[(2S)-2-[(4-amino-3-chlorophenyl)formamido]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide
Catalog No.: AA0039FF
273404-37-8,MFCD11100350
273404-37-8 | (2S)-1-[(2S)-2-[(4-amino-3-chlorophenyl)formamido]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide
Pack Size： 1mg
Purity： 99%
in stock
$24.00 $17.00
Pack Size： 5mg
Purity： 99%
in stock
$79.00 $56.00
Pack Size： 10mg
Purity： 99%
in stock
$119.00 $83.00
Pack Size： 100mg
Purity： 95%
in stock
$369.00 $258.00
Pack Size： 250mg
Purity： 95%
in stock
$774.00 $542.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0039FF
Chemical Name: (2S)-1-[(2S)-2-[(4-amino-3-chlorophenyl)formamido]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide
CAS Number: 273404-37-8
Molecular Formula: C24H33ClN4O6
Molecular Weight: 508.9950
MDL Number: MFCD11100350
SMILES: CCO[C@@H]1OC(=O)C[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)(C)C)NC(=O)c1ccc(c(c1)Cl)N
Properties
Complexity: 818  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.3  
Downstream Synthesis Route
CASUnavailable 
 
CASUnavailable 
  273404-37-8 

[1]CurrentPatentAssignee:VERTEXPHARMACEUTICALS(OLD)-WO2005/90334,2005,A2Locationinpatent:Page/Pagecolumn77-78

865839-06-1    2486-71-7   
(S)-1-((S)-2-1-(4-amino-3-chlorophenyl)methanoylamino}-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylicacid((2R,3S)-2-ethoxy-5-oxo-tetrahydrofuran-3-yl)amide 

[1]OrganicLetters,2008,vol.10,p.185-188

62965-10-0   
(S)-1-((S)-2-1-(4-amino-3-chlorophenyl)methanoylamino}-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylicacid((2R,3S)-2-ethoxy-5-oxo-tetrahydrofuran-3-yl)amide 

[1]Patent:US9487555,2016,B2

374773-66-7    273404-37-8 

[1]CurrentPatentAssignee:VERTEXPHARMACEUTICALS(OLD)-US9487555,2016,B2

2486-71-7   
(S)-1-((S)-2-1-(4-amino-3-chlorophenyl)methanoylamino}-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylicacid((2R,3S)-2-ethoxy-5-oxo-tetrahydrofuran-3-yl)amide 

[1]Patent:US9487555,2016,B2

Related Products of of 273404-37-8
Building Blocks More >
348-51-6
348-51-6
1-Chloro-2-fluorobenzene
AA0039JQ | MFCD00000533
561314-52-1
561314-52-1
1,3,8-Triazaspiro[4.5]decan-2-one
AA0039MY | MFCD17169839
84163-22-4
84163-22-4
3-(4-Piperidinyl)-1,2-benzisoxazole hydrochloride
AA0039Q9 | MFCD27978162
6358-30-1
6358-30-1
Pigment Violet 23
AA0039TI | MFCD00071998
1347760-82-0
1347760-82-0
Propargyl-peg3-acid
AA0039X9 | MFCD22201521
937272-79-2
937272-79-2
(16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
AA003A1H | MFCD22572772
56933-57-4
56933-57-4
2-(1,3-Thiazol-2-yl)ethanamine dihydrochloride
AA003A56 | MFCD06739034
957061-01-7
957061-01-7
3-(2-N,N-Diethylaminoethylaminocarbonyl)phenylboronic acid, HCl
AA003A8L | MFCD09027256
737790-46-4
737790-46-4
1-[(tert-Butyldimethylsilyl)oxymethyl]cyclopropane methanol
AA003AD0 | MFCD22056253
875337-44-3
875337-44-3
Mgcd-265
AA003AI4 | MFCD17779287
Historical Records
394215-51-1
394215-51-1
1627693-21-3
1627693-21-3
Submit
© 2017 AA BLOCKS, INC. All rights reserved.