Title: CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150601
Title: Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment.
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20121001
Title: Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.
Journal: European journal of pharmacology 20120905
Title: Protective effect of crocetin on hemorrhagic shock-induced acute renal failure in rats.
Journal: Shock (Augusta, Ga.) 20120701
Title: Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies.
Journal: Journal of agricultural and food chemistry 20120620
Title: Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation.
Journal: Current neurovascular research 20120501
Title: UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
Journal: FEBS letters 20120405
Title: Crocin promotes non-rapid eye movement sleep in mice.
Journal: Molecular nutrition & food research 20120201
Title: Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice.
Journal: European journal of pharmacology 20120115
Title: Crocetin: an agent derived from saffron for prevention and therapy for cancer.
Journal: Current pharmaceutical biotechnology 20120101
Title: Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms.
Journal: Acta pharmacologica Sinica 20111201
Title: Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers.
Journal: Biochemical and biophysical research communications 20111014
Title: The role of crocetin in protection following cerebral contusion and in the enhancement of angiogenesis in rats.
Journal: Fitoterapia 20111001
Title: Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection.
Journal: Behavioural brain research 20110601
Title: A new validated SPE-HPLC method for monitoring crocetin in human plasma--application after saffron tea consumption.
Journal: Journal of pharmaceutical and biomedical analysis 20110601
Title: The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110515
Title: [Determination of geniposide, crocin and crocetin in different processing products of fructus gardeniae by HPLC-ELSD].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501
Title: Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices.
Journal: Neuroscience 20110428
Title: Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity.
Journal: European journal of pharmacology 20110110
Title: Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases.
Journal: Planta medica 20110101
Title: Crocetin reduces activation of hepatic apoptotic pathways and improves survival in experimental hemorrhagic shock.
Journal: JPEN. Journal of parenteral and enteral nutrition 20110101
Title: Conjugation to the cell-penetrating peptide TAT potentiates the photodynamic effect of carboxytetramethylrhodamine.
Journal: PloS one 20110101
Title: Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells.
Journal: European journal of pharmacology 20101201
Title: β-cyclocitral, a grazer defence signal unique to the cyanobacterium Microcystis.
Journal: Journal of chemical ecology 20101201
Title: Protein kinase C pathway is involved in the inhibition by crocetin of vascular smooth muscle cells proliferation.
Journal: Phytotherapy research : PTR 20101101
Title: [Partial endothelium-dependent vasorelaxation of crocetin and its mechanism].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20101101
Title: Crocetin from the tubular calyx of Nyctanthes arbor-tristis.
Journal: Natural product research 20101001
Title: Inhibitory effect on protein kinase Ctheta by Crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes.
Journal: European journal of pharmacology 20100910
Title: Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100901
Title: Crocetin inhibits cell cycle G1/S transition through suppressing cyclin D1 and elevating p27kip1 in vascular smooth muscle cells.
Journal: Phytotherapy research : PTR 20100701
Title: Quantification of crocetin esters in saffron (Crocus sativus L.) using Raman spectroscopy and chemometrics.
Journal: Journal of agricultural and food chemistry 20100526
Title: Effects of mild temperature conditions during dehydration procedures on saffron quality parameters.
Journal: Journal of the science of food and agriculture 20100315
Title: Effect of crocetin on blood pressure restoration and synthesis of inflammatory mediators in heart after hemorrhagic shock in anesthetized rats.
Journal: Shock (Augusta, Ga.) 20100101
Title: Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB.
Journal: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20090701
Title: An overview of structural features of DNA and RNA complexes with saffron compounds: Models and antioxidant activity.
Journal: Journal of photochemistry and photobiology. B, Biology 20090603
Title: Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway.
Journal: Journal of cellular and molecular medicine 20090501
Title: Further examination of antiradical properties of Crocus sativus stigmas extract rich in crocins.
Journal: Journal of agricultural and food chemistry 20090422
Title: In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Journal: Phytotherapy research : PTR 20090401
Title: Parabens as agents for improving crocetin esters' shelf-life in aqueous saffron extracts.
Journal: Molecules (Basel, Switzerland) 20090316
Title: Daily oral administration of crocetin attenuates physical fatigue in human subjects.
Journal: Nutrition research (New York, N.Y.) 20090301
Title: Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model.
Journal: Molecular cancer therapeutics 20090201
Title: Crocetin attenuates norepinephrine-induced cytotoxicity in primary cultured rat cardiac myocytes by antioxidant in vitro.
Journal: Journal of Asian natural products research 20090101
Title: [Content comparison of diterpenoid pigments in different processed products of Gardenia jasminoides].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101
Title: Involvement of Ca2+ in the inhibition by crocetin of platelet activity and thrombosis formation.
Journal: Journal of agricultural and food chemistry 20081022
Title: Reduction of mitochondrial oxidative damage and improved mitochondrial efficiency by administration of crocetin against benzo[a]pyrene induced experimental animals.
Journal: Biological & pharmaceutical bulletin 20080901
Title: Effect of centrifugal ultrafiltration on the composition of aqueous extracts of saffron spice (Crocus sativus L.).
Journal: Journal of agricultural and food chemistry 20080827
Title: Bacillus subtilis FZB24 affects flower quantity and quality of saffron (Crocus sativus).
Journal: Planta medica 20080801
Title: Crocetin improves the insulin resistance induced by high-fat diet in rats.
Journal: British journal of pharmacology 20080701
Title: Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors.
Journal: Planta medica 20080601
Title: Rapid determination of crocetin esters and picrocrocin from saffron spice (Crocus sativus L.) using UV-visible spectrophotometry for quality control.
Journal: Journal of agricultural and food chemistry 20080514
Title: Use of trans sodium crocetinate for sensitizing glioblastoma multiforme to radiation: laboratory investigation.
Journal: Journal of neurosurgery 20080501
Title: Kinetics of individual crocetin ester degradation in aqueous extracts of saffron (Crocus sativus L.) upon thermal treatment in the dark.
Journal: Journal of agricultural and food chemistry 20080312
Title: Inhibitory effects of crocetin on high glucose-induced apoptosis in cultured human umbilical vein endothelial cells and its mechanism.
Journal: Archives of pharmacal research 20080301
Title: Neocrocin A: a novel crocetin glycoside with a unique system for binding sugars isolated from gardenia yellow.
Journal: Chemical & pharmaceutical bulletin 20071101
Title: Crocetin suppresses angiotensin II-induced vascular smooth-muscle cell proliferation through inhibition of ERK1/2 activation and cell-cycle progression.
Journal: Journal of cardiovascular pharmacology 20071101
Title: Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus Gardenia.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
Title: Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15.
Journal: DNA and cell biology 20070801
Title: Crocetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-alpha and adiponectin expression in rat adipocytes.
Journal: British journal of pharmacology 20070701
Title: Interaction of tRNA with Safranal, Crocetin, and Dimethylcrocetin.
Journal: Journal of biomolecular structure & dynamics 20070601
Title: [Studies on chemical constituents in fruit of Gardenia jasminoides].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601
Title: Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.
Journal: Biochimica et biophysica acta 20070401
Title: Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties.
Journal: Journal of agricultural and food chemistry 20070207
Title: Influence of Crocetin on experimental atherosclerosis in hyperlipidamic-diet quails.
Journal: European journal of pharmacology 20070112
Title: Involvement of Ca2+ in the inhibition by crocetin of angiotensin II-induced ERK1/2 activation in vascular smooth muscle cells.
Journal: European journal of pharmacology 20070112
Title: Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats.
Journal: The Journal of nutritional biochemistry 20070101
Title: DNA interaction with saffron's secondary metabolites safranal, crocetin, and dimethylcrocetin.
Journal: DNA and cell biology 20070101
Title: Inhibition of breast cancer cell proliferation by style constituents of different Crocus species.
Journal: Anticancer research 20070101
Title: Crocetin prevents AGEs-induced vascular endothelial cell apoptosis.
Journal: Pharmacological research 20061001
Title: Generation of saffron volatiles by thermal carotenoid degradation.
Journal: Journal of agricultural and food chemistry 20060906
Title: Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity.
Journal: Biochemical pharmacology 20060828
Title: Crocetin inhibits leukocyte adherence to vascular endothelial cells induced by AGEs.
Journal: Journal of ethnopharmacology 20060811
Title: Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies.
Journal: Molecular and cellular biochemistry 20060701
Title: Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats.
Journal: Die Pharmazie 20060401
Title: ERK1/2 pathway is involved in the inhibitory effect of crocetin on angiotensin II-induced vascular smooth muscle cell proliferation.
Journal: European journal of pharmacology 20060327
Title: Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS.
Journal: Journal of agricultural and food chemistry 20060208
Title: Crocetin attenuates atherosclerosis in hyperlipidemic rabbits through inhibition of LDL oxidation.
Journal: Journal of cardiovascular pharmacology 20060101
Title: Crocetin inhibits mRNA expression for tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in hemorrhagic shock.
Journal: JPEN. Journal of parenteral and enteral nutrition 20060101
Title: Effects of crocetin on the matrix metalloproteinases in cardiac hypertrophy induced by norepinephrine in rats.
Journal: Journal of Asian natural products research 20060101
Title: Near-infrared spectroscopy in saffron quality control: determination of chemical composition and geographical origin.
Journal: Journal of agricultural and food chemistry 20051130
Title: Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin.
Journal: Biological & pharmaceutical bulletin 20051101
Title: Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits.
Journal: Biochemical pharmacology 20051015
Title: Molecular basis of protective effect by crocetin on survival and liver tissue damage following hemorrhagic shock.
Journal: Molecular and cellular biochemistry 20051001
Title: Crocetin prevents dexamethasone-induced insulin resistance in rats.
Journal: Planta medica 20051001
Title: Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice.
Journal: Journal of agricultural and food chemistry 20050907
Title: Neuroprotection by crocetin in a hemi-parkinsonian rat model.
Journal: Pharmacology, biochemistry, and behavior 20050801
Title: Screening method for the detection of artificial colours in saffron using derivative UV-Vis spectrometry after precipitation of crocetin.
Journal: Food additives and contaminants 20050701
Title: The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury.
Journal: Pulmonary pharmacology & therapeutics 20050101
Title: Glucosylation of the saffron apocarotenoid crocetin by a glucosyltransferase isolated from Crocus sativus stigmas.
Journal: Planta 20041001
Title: [Protective effect of crocetin on primary culture of cardiac myocyte treated with noradrenaline in vitro].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041001
Title: Effect of crocetin on cardiac hypertrophy induced by overloading pressure in rats.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040301
Title: Crocetin from saffron: an active component of an ancient spice.
Journal: Critical reviews in food science and nutrition 20040101
Title: Cellular energetics in hemorrhagic shock: restoring adenosine triphosphate to the cells.
Journal: The Journal of trauma 20030501
Title: Sodium crocetinate does not alter gut hypercapnic responses or renal energy stores during transient sub-diaphragmatic ischaemia.
Journal: Intensive care medicine 20030401
Title: Oxidative remodeling of chromoplast carotenoids: identification of the carotenoid dioxygenase CsCCD and CsZCD genes involved in Crocus secondary metabolite biogenesis.
Journal: The Plant cell 20030101
Title: Hemorrahagic shock: a new look at an old problem.
Journal: Missouri medicine 20030101
Title: Effects of oral administration of Gardeniae fructus extract and intravenous injection of crocetin on lipopolysaccharide- and prostaglandin E2-induced elevation of aqueous flare in pigmented rabbits.
Journal: The American journal of Chinese medicine 20030101
Title: Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy.
Journal: Shock (Augusta, Ga.) 20021201
Title: Genotoxicity of gardenia yellow and its components.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021101
Title: Evaluation of the developmental toxicity of crocetin on Xenopus.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020701
Title: [Pharmacokinetics of crocetin in rats].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020501
Title: Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock.
Journal: The Journal of trauma 20011101
Title: Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent.
Journal: Photochemistry and photobiology 20010401
Title: Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44.
Title: José Bagur M, et al. Saffron: An Old Medicinal Plant and a Potential Novel Functional Food. Molecules. 2017 Dec 23;23(1). pii: E30.
