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280744-09-4,MFCD09753369
Catalog No.:AA00BCHW

280744-09-4 | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

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5mg
98%(HPLC)
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25mg
98%(HPLC)
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$62.00   $44.00
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100mg
98%(HPLC)
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$158.00   $110.00
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250mg
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1g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BCHW
Chemical Name:
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS Number:
280744-09-4
Molecular Formula:
C19H12Cl2N2O2
Molecular Weight:
371.2168
MDL Number:
MFCD09753369
SMILES:
Clc1ccc(c(c1)Cl)C1=C(C(=O)NC1=O)c1cn(c2c1cccc2)C
Properties
Computed Properties
 
Complexity:
621  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.9  

Literature

Title: Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells.

Journal: Toxicology 20160831

Title: Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases.

Journal: Environmental health perspectives 20160601

Title: Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.

Journal: PloS one 20160101

Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

Journal: The Journal of biological chemistry 20150529

Title: Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.

Journal: Cell death & disease 20140801

Title: Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.

Journal: Acta pharmacologica Sinica 20140701

Title: Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells.

Journal: Toxicology 20140605

Title: Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.

Journal: The Journal of biological chemistry 20140418

Title: Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death.

Journal: Cell death & disease 20140301

Title: PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium.

Journal: Archives of toxicology 20140201

Title: 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Journal: Toxicology and applied pharmacology 20131101

Title: The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells.

Journal: Toxicology letters 20130412

Title: A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

Journal: PloS one 20130101

Title: Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.

Journal: Journal of medicinal chemistry 20121108

Title: IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3β signaling pathway.

Journal: Journal of cellular biochemistry 20121101

Title: WNT/β-catenin-signaling pathway stimulates the proliferation of cultured adult human Sertoli cells via upregulation of C-myc expression.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20121101

Title: Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.

Journal: FEBS letters 20121019

Title: Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling.

Journal: Toxicology and applied pharmacology 20121015

Title: Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat: possible involvement of HSP 72.

Journal: Molecular and cellular biochemistry 20121001

Title: Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization.

Journal: Biochemical and biophysical research communications 20120914

Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Journal: Current Alzheimer research 20120901

Title: Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury.

Journal: Journal of veterinary science 20120901

Title: Ischemic postconditioning mediates cardioprotection via PI3K/GSK-3β/β-catenin signaling pathway in ischemic rat myocardium.

Journal: Shock (Augusta, Ga.) 20120801

Title: Wnt3a upregulates prostaglandin F2α-stimulated vascular endothelial growth factor synthesis in osteoblasts.

Journal: Molecular medicine reports 20120801

Title: GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells.

Journal: Molecular cancer research : MCR 20120801

Title: Glycogen synthase kinase 3β (GSK3β) modulates antiviral activity of zinc-finger antiviral protein (ZAP).

Journal: The Journal of biological chemistry 20120629

Title: Acute inhibition of GSK causes mitochondrial remodeling.

Journal: American journal of physiology. Heart and circulatory physiology 20120601

Title: Inhibition of GSK-3beta ameliorates hepatic ischemia-reperfusion injury through GSK-3beta/beta-catenin signaling pathway in mice.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20120601

Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523

Title: Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse.

Journal: Behavioural brain research 20120516

Title: Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells.

Journal: Neurotoxicity research 20120401

Title: Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine.

Journal: Schizophrenia research 20120401

Title: Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells.

Journal: Blood 20120308

Title: Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.

Journal: Carcinogenesis 20120301

Title: Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors.

Journal: Oncogene 20120209

Title: Phosphorylation of Akt/GSK-3β/eNOS amplifies 5-HT2B receptor blockade mediated anti-hypertrophic effect in rats.

Journal: FEBS letters 20120120

Title: A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

Journal: Toxicology and applied pharmacology 20120115

Title: Muscle FBPase binds to cardiomyocyte mitochondria under glycogen synthase kinase-3 inhibition or elevation of cellular Ca2+ level.

Journal: FEBS letters 20120102

Title: Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells.

Journal: PloS one 20120101

Title: Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis.

Journal: PloS one 20120101

Title: Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.

Journal: The international journal of neuropsychopharmacology 20110901

Title: Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.

Journal: The Biochemical journal 20110715

Title: Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory.

Journal: Journal of neurochemistry 20110701

Title: Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation.

Journal: Oncogene 20110526

Title: GSK3β inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility.

Journal: American journal of physiology. Renal physiology 20110501

Title: Tumor necrosis factor-α induces increased lung vascular permeability: a role for GSK3α/β.

Journal: European journal of pharmacology 20110425

Title: The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue.

Journal: Experimental dermatology 20110301

Title: Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.

Journal: Journal of neurochemistry 20110301

Title: Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.

Journal: Neuroscience 20110203

Title: The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3).

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.

Journal: PloS one 20110101

Title: Dendritic cell maturation occurs through the inhibition of GSK-3β.

Journal: Cellular immunology 20110101

Title: AP-1 is a component of the transcriptional network regulated by GSK-3 in quiescent cells.

Journal: PloS one 20110101

Title: Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling.

Journal: Cell & bioscience 20110101

Title: Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta.

Journal: PloS one 20110101

Title: Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.

Journal: PloS one 20110101

Title: Inhibition of glycogen synthase kinase-3β counteracts ligand-independent activity of the androgen receptor in castration resistant prostate cancer.

Journal: PloS one 20110101

Title: Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis.

Journal: Neuropharmacology 20101101

Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

Journal: Molecular cell 20101008

Title: Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.

Journal: Bioorganic & medicinal chemistry 20100915

Title: Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

Journal: Cellular and molecular neurobiology 20100801

Title: {beta}-Catenin regulates airway smooth muscle contraction.

Journal: American journal of physiology. Lung cellular and molecular physiology 20100801

Title: Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.

Journal: Clinical and experimental pharmacology & physiology 20100701

Title: Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100630

Title: 4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.

Journal: Journal of cellular and molecular medicine 20100601

Title: Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload.

Journal: Cardiovascular research 20100601

Title: Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase.

Journal: American journal of physiology. Lung cellular and molecular physiology 20100601

Title: Effects of areca nut extract on the apoptosis pathways in human neutrophils.

Journal: Journal of periodontal research 20100601

Title: Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1.

Journal: Journal of neurochemistry 20100601

Title: Inhibition of GSK3 attenuates dopamine D1 receptor agonist-induced hyperactivity in mice.

Journal: Brain research bulletin 20100531

Title: GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100421

Title: Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

Journal: Cellular and molecular neurobiology 20100301

Title: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.

Journal: The Journal of pharmacology and experimental therapeutics 20100301

Title: Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode.

Journal: Journal of medicinal chemistry 20100211

Title: A new class of molecular targeted radioprotectors: GSK-3beta inhibitors.

Journal: International journal of radiation oncology, biology, physics 20100201

Title: Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70.

Journal: PloS one 20100101

Title: Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes.

Journal: PloS one 20100101

Title: Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.

Journal: Vascular pharmacology 20100101

Title: Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway.

Journal: Cell proliferation 20091201

Title: Regulation of serotonin 1B receptor by glycogen synthase kinase-3.

Journal: Molecular pharmacology 20091201

Title: Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization.

Journal: Journal of neurochemistry 20091201

Title: Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway.

Journal: Molecular pharmacology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.

Journal: Neuropharmacology 20090901

Title: The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090801

Title: Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.

Journal: European journal of medicinal chemistry 20090601

Title: Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells.

Journal: Biochimica et biophysica acta 20090601

Title: The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening.

Journal: The Journal of pharmacology and experimental therapeutics 20090601

Title: Cocaine-induced hyperactivity and sensitization are dependent on GSK3.

Journal: Neuropharmacology 20090601

Title: Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.

Journal: Cellular signalling 20090401

Title: TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta.

Journal: American journal of physiology. Lung cellular and molecular physiology 20090401

Title: Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090301

Title: Knockin of mutant PIK3CA activates multiple oncogenic pathways.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20090224

Title: Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.

Journal: Neuropharmacology 20090201

Title: GSK3beta regulates differentiation and growth arrest in glioblastoma.

Journal: PloS one 20090101

Title: Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.

Journal: Circulation research 20081024

Title: Advanced glycation end-product-inhibited cell proliferation and protein expression of beta-catenin and cyclin D1 are dependent on glycogen synthase kinase 3beta in LLC-PK1 cells.

Journal: Archives of biochemistry and biophysics 20080901

Title: A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.

Journal: American journal of physiology. Cell physiology 20080901

Title: Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition.

Journal: Anesthesia and analgesia 20080901

Title: Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore.

Journal: The Journal of pharmacology and experimental therapeutics 20080701

Title: Inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines: are GSK inhibitors therapeutically useful?

Journal: Neoplasia (New York, N.Y.) 20080601

Title: Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763.

Journal: European journal of pharmacology 20080531

Title: Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion.

Journal: Circulation 20080527

Title: GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption.

Journal: Journal of applied toxicology : JAT 20080501

Title: Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.

Journal: American journal of hypertension 20080501

Title: Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion.

Journal: American journal of physiology. Heart and circulatory physiology 20080301

Title: Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes.

Journal: Cardiovascular toxicology 20080101

Title: The selectivity of protein kinase inhibitors: a further update.

Journal: The Biochemical journal 20071215

Title: Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration.

Journal: Journal of cellular biochemistry 20071201

Title: MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.

Journal: The Journal of biological chemistry 20071019

Title: Media conditioned by retinal pigment epithelial cells suppress the canonical Wnt pathway.

Journal: Neuroscience letters 20070913

Title: Cyclosporine A- and FK506-induced apoptosis in PC12 cells.

Journal: Cell biology and toxicology 20070901

Title: Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

Journal: Cellular and molecular neurobiology 20070901

Title: GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion.

Journal: Basic research in cardiology 20070701

Title: Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway.

Journal: Cancer letters 20070628

Title: Structure based de novo design of novel glycogen synthase kinase 3 inhibitors.

Journal: Bioorganic & medicinal chemistry 20070601

Title: Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis.

Journal: Biochemical and biophysical research communications 20070309

Title: Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates.

Journal: Molecular cancer therapeutics 20070301

Title: An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

Journal: Cancer research 20070101

Title: Inhibiting glycogen synthase kinase 3beta in sepsis.

Journal: Novartis Foundation symposium 20070101

Title: Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis.

Journal: Journal of vascular research 20070101

Title: Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.

Journal: Neuroscience letters 20061113

Title: Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels.

Journal: Experimental cell research 20061101

Title: [Glycogen synthase kinase-3beta (GSK-3beta) promotes proliferation of ovarian cancer cells in vitro].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061101

Title: Modulation of key elements of the Wnt pathway by apple polyphenols.

Journal: Journal of agricultural and food chemistry 20060920

Title: Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells.

Journal: Journal of agricultural and food chemistry 20060920

Title: Constitutive activity of glycogen synthase kinase-3beta: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells.

Journal: Brain research 20060919

Title: A cellular assay for measuring the inhibition of glycogen synthase kinase-3 via the accumulation of beta-catenin in Chinese hamster ovary clone K1 cells.

Journal: Assay and drug development technologies 20060801

Title: Prevention of rat cortical neurons from prostaglandin E2-induced apoptosis by glycogen synthase kinase-3 inhibitors.

Journal: Neuroscience letters 20060529

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation.

Journal: Shock (Augusta, Ga.) 20060501

Title: Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells.

Journal: The Journal of biological chemistry 20060224

Title: Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.

Journal: Oncogene 20060105

Title: Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium.

Journal: Journal of molecular and cellular cardiology 20060101

Title: The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

Journal: IDrugs : the investigational drugs journal 20060101

Title: Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells.

Journal: Cancer research 20051001

Title: Glycogen synthase kinase 3 controls endochondral bone development: contribution of fibroblast growth factor 18.

Journal: Developmental biology 20050915

Title: GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.

Journal: Critical care medicine 20050901

Title: Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas.

Journal: Molecular cancer therapeutics 20050901

Title: Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms.

Journal: Cancer research 20050715

Title: Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050615

Title: Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.

Journal: Cancer research 20050301

Title: Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium.

Journal: Neuroscience 20050101

Title: Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c.

Journal: The Journal of biological chemistry 20041210

Title: Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth.

Journal: Oncogene 20041014

Title: Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons.

Journal: European journal of pharmacology 20040924

Title: Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.

Journal: European journal of pharmacology 20040714

Title: Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.

Journal: Circulation research 20040416

Title: An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.

Journal: Oncogene 20040401

Title: Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin.

Journal: Biochemical and biophysical research communications 20040319

Title: Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

Journal: Bioorganic & medicinal chemistry letters 20030915

Title: Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity.

Journal: Neuroreport 20030806

Title: Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.

Journal: The Biochemical journal 20021015

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective.

Journal: Circulation research 20020308

Title: GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity.

Journal: FEBS letters 20011102

Title: Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.

Journal: Journal of neurochemistry 20010401

Title: Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

Journal: Chemistry & biology 20001001

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Journal: Diabetes 20000201

Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

Journal: Diabetes 19990801

Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930815

Title: Glycogen synthase kinase-3β is involved in ligand-dependent activation of transcription and cellular localization of the glucocorticoid receptor.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Gurrieri, et al. 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. J.Pharmacol.Exp.Ther.2010

Title: Kirby LA, et al. Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.PLoS One. 2012;7(6):e39329. Epub 2012 Jun 26.

Title: Wang M, et al. The first synthesis of [(11)CSB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3).Bioorg Med Chem Lett. 2011 Jan 1;21(1):245-9. Epub 2010 Nov 11.

Title: The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 -(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione through mitochondrial ATP-dependent potassium channel opening.

Title: Coghlan MP, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol. 2000 Oct;7(10):793-803.

Title: Wang W, et al. Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition. Toxicol Appl Pharmacol. 2016 Dec 15;313:195-203.

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Tags:280744-09-4 Molecular Formula|280744-09-4 MDL|280744-09-4 SMILES|280744-09-4 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione