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2898-76-2,MFCD12910437
Catalog No.:AA00BCGZ

2898-76-2 | 3,5-Diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BCGZ
Chemical Name:
3,5-Diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
CAS Number:
2898-76-2
Molecular Formula:
C13H14ClN7O
Molecular Weight:
319.7496
MDL Number:
MFCD12910437
SMILES:
N/C(=N\Cc1ccccc1)/NC(=O)c1nc(Cl)c(nc1N)N
Properties
Computed Properties
 
Complexity:
413  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
1.7  

Literature

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Title: Acetic acid modulates spike rate and spike latency to salt in peripheral gustatory neurons of rats.

Journal: Journal of neurophysiology 20121101

Title: Salt-induced hypertension in a mouse model of Liddle syndrome is mediated by epithelial sodium channels in the brain.

Journal: Hypertension (Dallas, Tex. : 1979) 20120901

Title: ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.

Journal: American journal of physiology. Renal physiology 20120701

Title: Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting.

Journal: American journal of physiology. Renal physiology 20120515

Title: Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.

Journal: American journal of physiology. Renal physiology 20120515

Title: Epithelial Na+ channel proteins are mechanotransducers of myogenic constriction in rat posterior cerebral arteries.

Journal: Experimental physiology 20120401

Title: Prenatal programming of rat cortical collecting tubule sodium transport.

Journal: American journal of physiology. Renal physiology 20120315

Title: Anion size modulates salt taste in rats.

Journal: Journal of neurophysiology 20120315

Title: Glioma-specific cation conductance regulates migration and cell cycle progression.

Journal: The Journal of biological chemistry 20120203

Title: Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.

Journal: American journal of physiology. Endocrinology and metabolism 20120201

Title: Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes.

Journal: ASN neuro 20120101

Title: Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness.

Journal: Frontiers in systems neuroscience 20120101

Title: Diabetes alters intracellular calcium transients in cardiac endothelial cells.

Journal: PloS one 20120101

Title: Mechanisms mediating sodium-induced pressor responses in the PVN of Dahl rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111101

Title: The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111101

Title: Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.

Journal: American journal of physiology. Renal physiology 20111101

Title: Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.

Journal: Journal of neurophysiology 20111101

Title: Cross-reactivity of acid-sensing ion channel and Na⁺-H⁺ exchanger antagonists with nicotinic acetylcholine receptors.

Journal: The Journal of physiology 20111101

Title: The influence of benzamil hydrochloride on the evolution of hyponatremic brain edema as assessed by in vivo MRI study in rats.

Journal: Acta neurochirurgica 20111001

Title: Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone.

Journal: Experimental physiology 20111001

Title: Hypericum perforatum differentially affects corticosteroid receptor-mRNA expression in human monocytic U-937 cells.

Journal: Journal of psychiatric research 20110901

Title: Increased renal ENaC subunits and sodium retention in rats with chronic heart failure.

Journal: American journal of physiology. Renal physiology 20110301

Title: Stiff endothelial cell syndrome in vascular inflammation and mineralocorticoid excess.

Journal: Hypertension (Dallas, Tex. : 1979) 20110201

Title: C-reactive protein makes human endothelium stiff and tight.

Journal: Hypertension (Dallas, Tex. : 1979) 20110201

Title: Sodium selectivity of Reissner's membrane epithelial cells.

Journal: BMC physiology 20110101

Title: Spike rate and spike timing contributions to coding taste quality information in rat periphery.

Journal: Frontiers in integrative neuroscience 20110101

Title: Sodium selectivity of semicircular canal duct epithelial cells.

Journal: BMC research notes 20110101

Title: Regulation of epithelial sodium transport via epithelial Na+ channel.

Journal: Journal of biomedicine & biotechnology 20110101

Title: AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells.

Journal: PloS one 20110101

Title: Connecting tubule glomerular feedback antagonizes tubuloglomerular feedback in vivo.

Journal: American journal of physiology. Renal physiology 20101201

Title: Effect of intracerebroventricular benzamil on cardiovascular and central autonomic responses to DOCA-salt treatment.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101201

Title: Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress.

Journal: Current cardiology reviews 20101101

Title: Angiotensin II enhances connecting tubule glomerular feedback.

Journal: Hypertension (Dallas, Tex. : 1979) 20101001

Title: Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.

Journal: PLoS pathogens 20101001

Title: The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.

Journal: Journal of lipid research 20100901

Title: Pharmacological profiles of the murine gastric and colonic H,K-ATPases.

Journal: Biochimica et biophysica acta 20100901

Title: Effects of central sodium on epithelial sodium channels in rat brain.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100701

Title: Na+-Ca2+ exchanger contributes to Ca2+ extrusion in ATP-stimulated endothelium of intact rat aorta.

Journal: Biochemical and biophysical research communications 20100423

Title: Change in intracellular pH causes the toxic Ca2+ entry via NCX1 in neuron- and glia-derived cells.

Journal: Cellular and molecular neurobiology 20100401

Title: Response latency to lingual taste stimulation distinguishes neuron types within the geniculate ganglion.

Journal: Journal of neurophysiology 20100401

Title: Role of epithelial sodium channels in the renal myogenic response?

Journal: Hypertension (Dallas, Tex. : 1979) 20100201

Title: Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles.

Journal: The Journal of physiology 20100101

Title: Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Title: Endolymphatic sodium homeostasis by extramacular epithelium of the saccule.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20091216

Title: Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.

Journal: Hypertension (Dallas, Tex. : 1979) 20091101

Title: Sodium transport in the choroid plexus and salt-sensitive hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20091001

Title: Benzamil prevents brain water accumulation in hyponatraemic rats.

Journal: Acta neurochirurgica 20090901

Title: Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin.

Journal: Journal of neurophysiology 20090901

Title: The ubiquitin proteasome system in neuropathology.

Journal: Acta neuropathologica 20090901

Title: ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry.

Journal: American journal of physiology. Lung cellular and molecular physiology 20090801

Title: Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium.

Journal: The Journal of physiology 20090715

Title: HCO 3--dependent volume regulation in alpha-cells of the rat endocrine pancreas.

Journal: Pflugers Archiv : European journal of physiology 20090701

Title: Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.

Journal: Kidney international 20090701

Title: CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.

Journal: PLoS biology 20090701

Title: Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cells.

Journal: European journal of pharmacology 20090624

Title: Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20090601

Title: Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors.

Journal: Journal of neurochemistry 20090601

Title: Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes.

Journal: Microvascular research 20090501

Title: Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload.

Journal: Circulation research 20090424

Title: Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401

Title: Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090301

Title: Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium.

Journal: American journal of physiology. Cell physiology 20090301

Title: Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors.

Journal: European journal of pharmacology 20090128

Title: Understanding sensory nerve mechanotransduction through localized elastomeric matrix control.

Journal: PloS one 20090101

Title: Regulation of the epithelial sodium channel [ENaC] in kidneys of salt-sensitive Dahl rats: insights on alternative splicing.

Journal: International archives of medicine 20090101

Title: The guinea-pig tracheal potential difference as an in vivo model for the study of epithelial sodium channel function in the airways.

Journal: British journal of pharmacology 20081201

Title: Epileptiform activity induces distance-dependent alterations of the Ca2+ extrusion mechanism in the apical dendrites of subicular pyramidal neurons.

Journal: The European journal of neuroscience 20081201

Title: Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.

Journal: Human molecular genetics 20081015

Title: Functional ABCG1 expression induces apoptosis in macrophages and other cell types.

Journal: Biochimica et biophysica acta 20081001

Title: Effect of Maillard reacted peptides on human salt taste and the amiloride-insensitive salt taste receptor (TRPV1t).

Journal: Chemical senses 20080901

Title: Epithelial Na+ channel delta subunit mediates acid-induced ATP release in the human skin.

Journal: Biochemical and biophysical research communications 20080815

Title: Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response.

Journal: American journal of physiology. Renal physiology 20080701

Title: Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity.

Journal: American journal of physiology. Renal physiology 20080601

Title: Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat.

Journal: American journal of physiology. Renal physiology 20080501

Title: A role for benzamil-sensitive proteins of the central nervous system in the pathogenesis of salt-dependent hypertension.

Journal: Clinical and experimental pharmacology & physiology 20080501

Title: Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes.

Journal: American journal of physiology. Heart and circulatory physiology 20080401

Title: Dietary salt enhances benzamil-sensitive component of myogenic constriction in mesenteric arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil.

Journal: Pain 20071215

Title: Inhibition of TRPP3 channel by amiloride and analogs.

Journal: Molecular pharmacology 20071201

Title: Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.

Journal: Biochemical and biophysical research communications 20071123

Title: P2Y receptor regulation of sodium transport in human mammary epithelial cells.

Journal: American journal of physiology. Cell physiology 20071101

Title: Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly.

Journal: American journal of physiology. Cell physiology 20071101

Title: Epithelial Na+ channel and ion transport in human nasal polyp and paranasal sinus mucosa.

Journal: Biochemical and biophysical research communications 20071026

Title: Aldosterone-induced modification of osmoregulated ENaC trafficking.

Journal: Biochemical and biophysical research communications 20070914

Title: Corneal endothelium transports fluid in the absence of net solute transport.

Journal: Biochimica et biophysica acta 20070901

Title: [Effect of Na(+)/Ca(2+) exchange blocker, Benzamil, on alveolar macrophage function in patients with chronic obstructive pulmonary disease].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20070901

Title: Trafficking of ENaC subunits in response to acute insulin in mouse kidney.

Journal: American journal of physiology. Renal physiology 20070701

Title: Integrated microsystem for non-invasive electrophysiological measurements on Xenopus oocytes.

Journal: Biosensors & bioelectronics 20070615

Title: A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070501

Title: Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium.

Journal: American journal of physiology. Cell physiology 20070501

Title: Epithelial ion transport of human nasal polyp and paranasal sinus mucosa.

Journal: American journal of respiratory cell and molecular biology 20070401

Title: Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism.

Journal: American journal of physiology. Renal physiology 20070301

Title: Involvement of Na,K-pump in SEPYLRFamide-mediated reduction of cholinosensitivity in Helix neurons.

Journal: Regulatory peptides 20070201

Title: Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats.

Journal: BMC genetics 20070101

Title: Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.

Journal: PloS one 20070101

Title: ENaC proteins contribute to VSMC migration.

Journal: American journal of physiology. Heart and circulatory physiology 20061201

Title: Sex and body-type interactions in the regulation of renal sodium transporter levels, urinary excretion, and activity in lean and obese Zucker rats.

Journal: Gender medicine 20061201

Title: The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase.

Journal: Kidney international 20061101

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Title: Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct.

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Title: Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis.

Journal: Journal of medicinal chemistry 20060713

Title: Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats.

Journal: American journal of physiology. Renal physiology 20060501

Title: Intraganglionic laminar endings act as mechanoreceptors of vagal afferent nerve in guinea pig esophagus.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20060425

Title: Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia.

Journal: American journal of physiology. Cell physiology 20060401

Title: Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts.

Journal: European journal of medical research 20060327

Title: Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands.

Journal: The Journal of biological chemistry 20060317

Title: ENaC proteins are required for NGF-induced neurite growth.

Journal: American journal of physiology. Cell physiology 20060201

Title: Enhanced central hypertonic saline-induced activation of angiotensin II-sensitive neurons in the anterior hypothalamic area of spontaneously hypertensive and Dahl S rats.

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Journal: Respiratory research 20060101

Title: Electrophysiological demonstration of Na+/Ca2+ exchange in bovine articular chondrocytes.

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Title: Alpha1-adrenoceptor-mediated negative inotropic effect caused by intracellular ionic activities in guinea-pig papillary muscle.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20051201

Title: Transport of sodium and chloride across earthworm skin in vitro.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20051101

Title: Vascular ENaC proteins are required for renal myogenic constriction.

Journal: American journal of physiology. Renal physiology 20051001

Title: Mechanisms of mechanotransduction by specialized low-threshold mechanoreceptors in the guinea pig rectum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050901

Title: Hemin induces active chloride secretion in Caco-2 cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050801

Title: On the interaction between amiloride and its putative alpha-subunit epithelial Na+ channel binding site.

Journal: The Journal of biological chemistry 20050715

Title: Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium.

Journal: Biochemical and biophysical research communications 20050715

Title: Central injection of hypertonic saline activates angiotensin II-sensitive neurons in the anterior hypothalamic area of rats.

Journal: Brain research 20050607

Title: Characterization of active ion transport across primary rabbit corneal epithelial cell layers (RCrECL) cultured at an air-interface.

Journal: Experimental eye research 20050601

Title: Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI.

Journal: American journal of physiology. Heart and circulatory physiology 20050501

Title: Benzamil, a blocker of epithelial Na(+) channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation.

Journal: Biochemical and biophysical research communications 20050218

Title: Sodium and anion transport across the avian uterine (shell gland) epithelium.

Journal: The Journal of experimental biology 20050201

Title: Catecholamine clearance from alveolar spaces of rat and human lungs.

Journal: Respiration; international review of thoracic diseases 20050101

Title: Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease.

Journal: The Journal of pharmacology and experimental therapeutics 20041201

Title: Involvement of cytosolic Cl- in osmoregulation of alpha-ENaC gene expression.

Journal: American journal of physiology. Renal physiology 20041101

Title: Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor.

Journal: Hypertension (Dallas, Tex. : 1979) 20041101

Title: Effects of blockers of Ca2+ channels and other ion channels on in vitro excystment of Paragonimus ohirai metacercariae induced by sodium cholate.

Journal: Parasitology research 20041101

Title: Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.

Journal: The Journal of biological chemistry 20041022

Title: Sodium-calcium exchanger contributes to membrane hyperpolarization of intact endothelial cells from rat aorta during acetylcholine stimulation.

Journal: British journal of pharmacology 20040901

Title: A regulated apical Na(+) conductance in dexamethasone-treated H441 airway epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040801

Title: Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.

Journal: Biochemical and biophysical research communications 20040730

Title: Delayed shrinkage triggered by the Na+-K+ pump in terbutaline-stimulated rat alveolar type II cells.

Journal: Experimental physiology 20040701

Title: Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats.

Journal: American journal of physiology. Renal physiology 20040601

Title: Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel.

Journal: American journal of physiology. Renal physiology 20040601

Title: Specific Na+ sensors are functionally expressed in a neuronal population of the median preoptic nucleus of the rat.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040421

Title: Vasodilation of brain surface arterioles by blockade of Na-H+ antiport and its inhibition by inhibitors of KATP channel openers.

Journal: Brain research 20040416

Title: Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats.

Journal: Neuropharmacology 20040301

Title: Mechanism of apoptosis induced by diazoxide, a K+ channel opener, in HepG2 human hepatoma cells.

Journal: Archives of pharmacal research 20040301

Title: Epithelial Na+ channels are activated by laminar shear stress.

Journal: The Journal of biological chemistry 20040206

Title: Mechanisms underlying the effects of amphetamine on particulate PKC activity.

Journal: Synapse (New York, N.Y.) 20040201

Title: Role of sodium in intracellular calcium elevation and leukotriene B4 formation by receptor-mediated activation of human neutrophils.

Journal: Biochemical pharmacology 20040115

Title: Changes in intracellular calcium concentration in response to hypertonicity in bovine articular chondrocytes.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040101

Title: [Effect of inhibitors of sodium-calcium exchangers on acetylcholine-induced hyperpolarization of endothelial cells in rat aorta].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20040101

Title: Glutamate-induced homocysteic acid release from astrocytes: possible implication in glia-neuron signaling.

Journal: Neuroscience 20040101

Title: Brain sodium channels and ouabainlike compounds mediate central aldosterone-induced hypertension.

Journal: American journal of physiology. Heart and circulatory physiology 20031201

Title: Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus.

Journal: The Journal of physiology 20031201

Title: Putative role of epithelial sodium channels (ENaC) in the afferent limb of cardio renal reflexes in rats.

Journal: Basic research in cardiology 20031101

Title: Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate.

Journal: Molecular pharmacology 20031001

Title: Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin.

Journal: American journal of physiology. Renal physiology 20030901

Title: Brain sodium channels and central sodium-induced increases in brain ouabain-like compound and blood pressure.

Journal: Journal of hypertension 20030801

Title: Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation.

Journal: Journal of cellular biochemistry 20030801

Title: Ca2+ mobilization induced by ouabain in thymocytes involves intracellular and extracellular Ca2+ pools.

Journal: Hypertension (Dallas, Tex. : 1979) 20030601

Title: Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery.

Journal: British journal of pharmacology 20030201

Title: Involvement of Na/Ca exchange and intracellular mobilized Ca2+ in Na,K-pump-mediated control of depression of the cholinosensitivy of common snail neurons [correction of neorons] using a cellular analog of habituation.

Journal: Neuroscience and behavioral physiology 20030201

Title: Endolymphatic sodium homeostasis by Reissner's membrane.

Journal: Neuroscience 20030101

Title: Electrolyte and fluid secretion by cultured human inner medullary collecting duct cells.

Journal: American journal of physiology. Renal physiology 20021201

Title: Potentiation of spermicidal activity of 2',4'-dichlorobenzamil by lidocaine.

Journal: Indian journal of experimental biology 20021201

Title: Where have all the Na+ channels gone? In search of functional ENaC in exocrine pancreas.

Journal: Biochimica et biophysica acta 20021113

Title: Characterization of a Na(+)-Ca(2+) exchanger in podocytes.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021001

Title: Liquid secretion inhibitors reduce mucociliary transport in glandular airways.

Journal: American journal of physiology. Lung cellular and molecular physiology 20020801

Title: Involvement of Na(+)/Ca(2+) exchanger in endothelial NO production and endothelium-dependent relaxation.

Journal: American journal of physiology. Heart and circulatory physiology 20020801

Title: Activation of CFTR Cl(-) channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells.

Journal: Life sciences 20020726

Title: Brain sodium channels mediate increases in brain 'ouabain' and blood pressure in Dahl S rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20020701

Title: Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells.

Journal: The Biochemical journal 20020515

Title: Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors.

Journal: Journal of the American Society of Nephrology : JASN 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Ionic mechanisms of regulatory volume increase (RVI) in the human hepatoma cell-line HepG2.

Journal: Pflugers Archiv : European journal of physiology 20020301

Title: Physiological characterization of the Na(+)/Ca(2+) exchanger (NCX) in hepatopancreatic and antennal gland basolateral membrane vesicles isolated from the freshwater crayfish Procambarus clarkii.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020201

Title: Brain amiloride-sensitive Phe-Met-Arg-Phe-NH(2)--gated Na(+) channels and Na(+)-induced sympathoexcitation and hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20020201

Title: [Regulation of posttetanic increase in choline sensitivity in Helix neurons by Na,K-pump: the role of Na/Ca-exchange and of mobilized calcium].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20020101

Title: Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.

Journal: Journal of the American College of Cardiology 20011101

Title: Pharmacotherapy of the ion transport defect in cystic fibrosis.

Journal: Clinical and experimental pharmacology & physiology 20011101

Title: An endogenous Na+, K+-ATPase inhibitor enhances phosphoinositide hydrolysis in neonatal but not in adult rat brain cortex.

Journal: Neurochemical research 20011101

Title: Modulation of aldosterone-induced stimulation of ENaC synthesis by changing the rate of apical Na+ entry.

Journal: American journal of physiology. Renal physiology 20011001

Title: Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity.

Journal: Journal of neuroscience research 20011001

Title: Role of intracellular calcium in the spermicidal action of 2',4'-dichlorobenzamil, a novel contact spermicide.

Journal: The Journal of pharmacy and pharmacology 20011001

Title: CFTR disruption impairs cAMP-dependent Cl(-) secretion in primary cultures of mouse cortical collecting ducts.

Journal: American journal of physiology. Renal physiology 20010901

Title: Inhibition of mechanical activation of guinea-pig airway afferent neurons by amiloride analogues.

Journal: British journal of pharmacology 20010801

Title: Differential roles of the sodium-calcium exchanger in renin secretion and renal vascular resistance.

Journal: Pflugers Archiv : European journal of physiology 20010801

Title: The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: inhibition by tenidap and benzamil and effect of temperature on transport rate and stoichiometry.

Journal: Pflugers Archiv : European journal of physiology 20010801

Title: Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages.

Journal: Biochimica et biophysica acta 20010620

Title: cAMP-dependent fluid secretion in rat inner medullary collecting ducts.

Journal: American journal of physiology. Renal physiology 20010601

Title: Adrenergic regulation of ion transport across adult alveolar epithelial cells: effects on Cl- channel activation and transport function in cultures with an apical air interface.

Journal: The Journal of membrane biology 20010601

Title: ENaC subunits are molecular components of the arterial baroreceptor complex.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.

Journal: The Journal of biological chemistry 20010518

Title: Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia.

Journal: American journal of physiology. Cell physiology 20010501

Title: Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms.

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Tags:2898-76-2 Molecular Formula|2898-76-2 MDL|2898-76-2 SMILES|2898-76-2 3,5-Diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide