[1]Fauber,BenjaminP.;DeLeonBoenig,Gladys;Burton,Brenda;Eidenschenk,Celine;Everett,Christine;Gobbi,Alberto;Hymowitz,SarahG.;Johnson,AdamR.;Liimatta,Marya;Lockey,Peter;Norman,Maxine;Ouyang,Wenjun;Rene,Olivier;Wong,Harvey[BioorganicandMedicinalChemistryLetters,2013,vol.23,#24,p.6604-6609]
[1]Padala,AnilK.;Wani,Abubakar;Vishwakarma,RamA.;Kumar,Ajay;Bharate,SandipB.[EuropeanJournalofMedicinalChemistry,2016,vol.122,p.744-755]
[2]Fauber,BenjaminP.;DeLeonBoenig,Gladys;Burton,Brenda;Eidenschenk,Celine;Everett,Christine;Gobbi,Alberto;Hymowitz,SarahG.;Johnson,AdamR.;Liimatta,Marya;Lockey,Peter;Norman,Maxine;Ouyang,Wenjun;Rene,Olivier;Wong,Harvey[BioorganicandMedicinalChemistryLetters,2013,vol.23,#24,p.6604-6609]
[1]Fauber,BenjaminP.;DeLeonBoenig,Gladys;Burton,Brenda;Eidenschenk,Celine;Everett,Christine;Gobbi,Alberto;Hymowitz,SarahG.;Johnson,AdamR.;Liimatta,Marya;Lockey,Peter;Norman,Maxine;Ouyang,Wenjun;Rene,Olivier;Wong,Harvey[BioorganicandMedicinalChemistryLetters,2013,vol.23,#24,p.6604-6609]
[2]Padala,AnilK.;Wani,Abubakar;Vishwakarma,RamA.;Kumar,Ajay;Bharate,SandipB.[EuropeanJournalofMedicinalChemistry,2016,vol.122,p.744-755]
[3]Doebelin,Christelle;He,Yuanjun;Campbell,Sean;Nuhant,Philippe;Kumar,Naresh;Koenig,Marcel;Garcia-Ordonez,Ruben;Chang,MiRa;Roush,WilliamR.;Lin,Li;Kahn,Susan;Cameron,MichaelD.;Griffin,PatrickR.;Solt,LauraA.;Kamenecka,TheodoreM.[MedicinalChemistry,2019,vol.15,#6,p.676-684]
[1]Fauber,BenjaminP.;DeLeonBoenig,Gladys;Burton,Brenda;Eidenschenk,Celine;Everett,Christine;Gobbi,Alberto;Hymowitz,SarahG.;Johnson,AdamR.;Liimatta,Marya;Lockey,Peter;Norman,Maxine;Ouyang,Wenjun;Rene,Olivier;Wong,Harvey[BioorganicandMedicinalChemistryLetters,2013,vol.23,#24,p.6604-6609]
[2]Domino,Katrine;Veryser,Cedrick;Wahlqvist,BenjaminA.;Gaardbo,Cecilie;Neumann,KarolineT.;Daasbjerg,Kim;DeBorggraeve,WimM.;Skrydstrup,Troels[AngewandteChemie-InternationalEdition,2018,vol.57,#23,p.6858-6862][Angew.Chem.,2018,vol.130,#23,p.6974-6978,5]
[1]Padala,AnilK.;Wani,Abubakar;Vishwakarma,RamA.;Kumar,Ajay;Bharate,SandipB.[EuropeanJournalofMedicinalChemistry,2016,vol.122,p.744-755]
[2]Doebelin,Christelle;He,Yuanjun;Campbell,Sean;Nuhant,Philippe;Kumar,Naresh;Koenig,Marcel;Garcia-Ordonez,Ruben;Chang,MiRa;Roush,WilliamR.;Lin,Li;Kahn,Susan;Cameron,MichaelD.;Griffin,PatrickR.;Solt,LauraA.;Kamenecka,TheodoreM.[MedicinalChemistry,2019,vol.15,#6,p.676-684]
Title: Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies.
Journal: Archives of toxicology 20180713
Title: Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Journal: Chemico-biological interactions 20180601
Title: Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180401
Title: Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
Journal: Archives of toxicology 20180401
Title: Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells.
Journal: Veterinary immunology and immunopathology 20180301
Title: Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Journal: Frontiers in immunology 20180101
Title: Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170901
Title: B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.
Journal: Toxicology 20170701
Title: Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.
Journal: Archives of toxicology 20170601
Title: Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics.
Journal: Molecular pharmacology 20170401
Title: Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.
Journal: The Journal of biological chemistry 20161125
Title: Activation of the Constitutive Androstane Receptor by Monophthalates.
Journal: Chemical research in toxicology 20161017
Title: Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
Journal: The Journal of biological chemistry 20160520
Title: Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.
Journal: Chemico-biological interactions 20160425
Title: Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.
Journal: Toxicology and applied pharmacology 20160401
Title: Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.
Journal: ACS medicinal chemistry letters 20150813
Title: Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells.
Journal: Toxicology letters 20150805
Title: Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.
Journal: Chemical research in toxicology 20150615
Title: Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.
Journal: Toxicology 20150302
Title: Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux.
Journal: Chemical research in toxicology 20141020
Title: Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140801
Title: Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Journal: Archives of pharmacal research 20140101
Title: Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20131001
Title: Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Journal: Toxicology and applied pharmacology 20130815
Title: Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.
Journal: Biochemical pharmacology 20130801
Title: Resveratrol suppresses T0901317-induced hepatic fat accumulation in mice.
Journal: The AAPS journal 20130701
Title: Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.
Journal: Journal of hepatology 20130501
Title: Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells.
Journal: Toxicology and applied pharmacology 20130415
Title: Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein.
Journal: The Journal of biological chemistry 20130322
Title: A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.
Journal: Biochimie 20130301
Title: Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo.
Journal: Translational research : the journal of laboratory and clinical medicine 20130201
Title: TO901317, a potent LXR agonist, is an inverse agonist of CAR.
Journal: The Journal of toxicological sciences 20130101
Title: Activation of liver X receptor induces macrophage interleukin-5 expression.
Journal: The Journal of biological chemistry 20121221
Title: A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.
Journal: The Journal of biological chemistry 20121102
Title: Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice.
Journal: The Journal of steroid biochemistry and molecular biology 20121101
Title: Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.
Journal: Journal of the American Society of Nephrology : JASN 20121101
Title: Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.
Journal: The Journal of nutritional biochemistry 20121001
Title: Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.
Journal: Molecular pharmacology 20121001
Title: Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.
Journal: Journal of medicinal chemistry 20120913
Title: Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway.
Journal: The Journal of nutritional biochemistry 20120901
Title: Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner.
Journal: Antiviral research 20120901
Title: Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120901
Title: Liver X receptor agonist alleviated high glucose-induced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMP-activated protein kinase.
Journal: Microcirculation (New York, N.Y. : 1994) 20120801
Title: Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ.
Journal: Toxicology letters 20120720
Title: LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.
Journal: Anticancer research 20120701
Title: Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines.
Journal: Diabetologia 20120601
Title: Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol.
Journal: Atherosclerosis 20120601
Title: Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120501
Title: Liver X receptor α is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.
Journal: Diabetes 20120501
Title: Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.
Journal: The Journal of clinical investigation 20120501
Title: ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells.
Journal: Biochemical and biophysical research communications 20120427
Title: HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.
Journal: Journal of lipid research 20120401
Title: Discovery of a new binding mode for a series of liver X receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20120401
Title: Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.
Journal: Toxicology and applied pharmacology 20120315
Title: Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Journal: Brain pathology (Zurich, Switzerland) 20120301
Title: Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.
Journal: Biology of reproduction 20120301
Title: Effect of simvastatin on the expression and regulation mechanism of apolipoprotein M.
Journal: International journal of molecular medicine 20120301
Title: Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.
Journal: American journal of physiology. Renal physiology 20120301
Title: Activation of liver X receptors attenuates endotoxin-induced liver injury in mice with nonalcoholic fatty liver disease.
Journal: Digestive diseases and sciences 20120201
Title: Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line.
Journal: Biochemical pharmacology 20120115
Title: Liver X receptors regulate cholesterol homeostasis in oligodendrocytes.
Journal: Journal of neuroscience research 20120101
Title: Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux.
Journal: Lipids in health and disease 20120101
Title: Myelin-derived lipids modulate macrophage activity by liver X receptor activation.
Journal: PloS one 20120101
Title: Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits.
Journal: Biochimica et biophysica acta 20111201
Title: Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats.
Journal: International immunopharmacology 20111201
Title: Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.
Journal: Lipids 20111101
Title: Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gα i/o inhibition.
Journal: Molecular pharmacology 20111101
Title: T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected].
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20111101
Title: Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.
Journal: Antioxidants & redox signaling 20111015
Title: Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels.
Journal: Neurochemical research 20111001
Title: Modified low density lipoproteins decrease the activity and expression of lysosomal acid lipase in human endothelial and smooth muscle cells.
Journal: Cell biochemistry and biophysics 20110901
Title: n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice.
Journal: Biochimica et biophysica acta 20110901
Title: Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
Journal: Environmental health perspectives 20110801
Title: PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
Journal: The Biochemical journal 20110801
Title: Liver X receptor activation restores memory in aged AD mice without reducing amyloid.
Journal: Neurobiology of aging 20110701
Title: The effect of diet on the response of low-density lipoprotein receptor knockout mice to the liver X receptor agonist T1317.
Journal: Journal of cardiovascular pharmacology 20110701
Title: LXR as a novel antithrombotic target.
Journal: Blood 20110526
Title: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110511
Title: Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110415
Title: Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.
Journal: Shock (Augusta, Ga.) 20110401
Title: Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110401
Title: Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.
Journal: Antioxidants & redox signaling 20110301
Title: Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.
Journal: Gastroenterology 20110301
Title: Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death.
Journal: Endocrinology 20110301
Title: Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Journal: Journal of medicinal chemistry 20110210
Title: Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110201
Title: Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.
Journal: Atherosclerosis 20110201
Title: Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.
Journal: Placenta 20110201
Title: Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs.
Journal: Journal of cellular biochemistry 20110201
Title: Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.
Journal: Atherosclerosis 20110101
Title: The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
Journal: BMC biochemistry 20110101
Title: Human cytochrome P450 1A1 is a novel target gene of liver X receptor α.
Journal: Drug metabolism and pharmacokinetics 20110101
Title: Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.
Journal: International journal of biological sciences 20110101
Title: Palmitic acid-induced apoptosis in pancreatic β-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate.
Journal: In vivo (Athens, Greece) 20110101
Title: LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL.
Journal: Lipids in health and disease 20110101
Title: A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.
Journal: BMC systems biology 20110101
Title: Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.
Journal: PloS one 20110101
Title: TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells.
Journal: Lipids in health and disease 20110101
Title: Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity.
Journal: Journal of lipid research 20101201
Title: hCG-induced down-regulation of PPARγ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells.
Journal: Endocrinology 20101201
Title: Regulation of ABCG1 expression in human keratinocytes and murine epidermis.
Journal: Journal of lipid research 20101101
Title: Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo.
Journal: European journal of heart failure 20101001
Title: The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: a reason for alterations in preeclampsia?
Journal: Placenta 20101001
Title: Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20101001
Title: LXRalpha regulates human CETP expression in vitro and in transgenic mice.
Journal: Atherosclerosis 20100901
Title: Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.
Journal: Anticancer research 20100901
Title: Activation of LXRα induces lipogenesis in HaCaT cells.
Journal: Archives of pharmacal research 20100901
Title: An agonist of liver X receptor slows valvular disease in a hypercholesterolemia mouse model.
Journal: The Journal of heart valve disease 20100901
Title: Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100801
Title: Metabolic switching of human myotubes is improved by n-3 fatty acids.
Journal: Journal of lipid research 20100801
Title: Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1.
Journal: Molecular pharmacology 20100801
Title: Recent progress in liver X receptor-selective modulators.
Journal: Current opinion in drug discovery & development 20100701
Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
Journal: The Journal of biological chemistry 20100625
Title: Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.
Journal: Cardiovascular research 20100601
Title: Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
Journal: Oncogene 20100506
Title: Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20100501
Title: Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Journal: Journal of medicinal chemistry 20100422
Title: Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.
Journal: Journal of medicinal chemistry 20100422
Title: FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Journal: Circulation research 20100305
Title: Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.
Journal: Analytical and bioanalytical chemistry 20100301
Title: Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
Journal: The Journal of biological chemistry 20100219
Title: Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis.
Journal: Free radical biology & medicine 20100215
Title: Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.
Journal: The Journal of endocrinology 20100201
Title: Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma.
Journal: Journal of neurochemistry 20100201
Title: Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury.
Journal: Journal of leukocyte biology 20100201
Title: Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.
Journal: Bioorganic & medicinal chemistry letters 20100115
Title: 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20100115
Title: The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands.
Journal: Molecular pharmacology 20100101
Title: Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein.
Journal: Gynecologic oncology 20100101
Title: 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20100101
Title: Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation.
Journal: Respiratory research 20100101
Title: Liver X receptor agonist methyl-3β-hydroxy-5α,6α-epoxycholanate attenuates atherosclerosis in apolipoprotein E knockout mice without increasing plasma triglyceride.
Journal: Pharmacology 20100101
Title: Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.
Journal: Biochemistry 20091222
Title: Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.
Journal: Neuroscience 20091201
Title: 4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
Journal: Bioorganic & medicinal chemistry 20091201
Title: LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Journal: Atherosclerosis 20091101
Title: Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice.
Journal: American journal of physiology. Endocrinology and metabolism 20091101
Title: Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver.
Journal: Biochimica et biophysica acta 20091101
Title: Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells.
Journal: Free radical research 20091001
Title: An induction in hepatic HDL secretion associated with reduced ATPase expression.
Journal: The American journal of pathology 20091001
Title: Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet.
Journal: Atherosclerosis 20090901
Title: On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Journal: Atherosclerosis 20090801
Title: LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20090801
Title: Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.
Journal: American journal of physiology. Endocrinology and metabolism 20090801
Title: Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.
Journal: The Journal of biological chemistry 20090717
Title: Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice.
Journal: Journal of lipid research 20090701
Title: Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Journal: Endocrinology 20090701
Title: eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice.
Journal: Stroke 20090701
Title: Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells.
Journal: Molecular cancer therapeutics 20090701
Title: Compound reduces viral cholesterol and inhibits HIV-1.
Journal: AIDS patient care and STDs 20090701
Title: Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.
Journal: Endocrinology 20090601
Title: Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.
Journal: Bioorganic & medicinal chemistry 20090515
Title: 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.
Journal: Journal of neurochemistry 20090501
Title: Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists.
Journal: European journal of pharmacology 20090401
Title: Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.
Journal: Bioorganic & medicinal chemistry letters 20090315
Title: LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms.
Journal: Journal of lipid research 20090201
Title: Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c.
Journal: Biochimica et biophysica acta 20090201
Title: Suppression of beta-catenin signaling by liver X receptor ligands.
Journal: Biochemical pharmacology 20090115
Title: Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
Journal: Molecular pharmaceutics 20090101
Title: Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays.
Journal: Methods in molecular biology (Clifton, N.J.) 20090101
Title: Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance.
Journal: Cardiovascular diabetology 20090101
Title: Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome.
Journal: Human molecular genetics 20081201
Title: Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20081201
Title: Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.
Journal: American journal of physiology. Endocrinology and metabolism 20081201
Title: LXR-agonists regulate ApoM expression differentially in liver and intestine.
Journal: Current pharmaceutical biotechnology 20081201
Title: Beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia in apolipoprotein E-deficient mice.
Journal: Canadian journal of physiology and pharmacology 20081201
Title: Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Journal: Journal of medicinal chemistry 20081127
Title: Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.
Journal: Neuroreport 20081119
Title: Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081105
Title: Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.
Journal: The Journal of pharmacology and experimental therapeutics 20081101
Title: Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.
Journal: Endocrinology 20081001
Title: Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Journal: Journal of medicinal chemistry 20080925
Title: Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity.
Journal: American journal of physiology. Endocrinology and metabolism 20080801
Title: PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.
Journal: Biochemical and biophysical research communications 20080711
Title: Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes.
Journal: The Journal of clinical endocrinology and metabolism 20080701
Title: Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitro.
Journal: Biochemical and biophysical research communications 20080620
Title: Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.
Journal: Gastroenterology 20080601
Title: Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus.
Journal: Circulation 20080527
Title: LXRalpha enhances lipid synthesis in SZ95 sebocytes.
Journal: The Journal of investigative dermatology 20080501
Title: The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential.
Journal: Journal of lipid research 20080501
Title: Ligand specificity and evolution of liver X receptors.
Journal: The Journal of steroid biochemistry and molecular biology 20080501
Title: The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- mice.
Journal: Journal of cardiovascular pharmacology 20080501
Title: Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression.
Journal: Science in China. Series C, Life sciences 20080501
Title: Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Journal: Bioorganic & medicinal chemistry 20080415
Title: Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
Journal: The Journal of biological chemistry 20080411
Title: Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators.
Journal: Journal of medicinal chemistry 20080410
Title: Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080401
Title: Effects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats.
Journal: Endocrine 20080401
Title: [Activation of liver X receptor regulates fatty acid synthase expression in diabetic liver].
Journal: Zhonghua yi xue za zhi 20080325
Title: Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080301
Title: Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice.
Journal: Acta biochimica et biophysica Sinica 20080301
Title: LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels.
Journal: Lipids 20080201
Title: OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
Journal: The Journal of biological chemistry 20080104
Title: The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation.
Journal: Atherosclerosis 20080101
Title: Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Journal: Bioorganic & medicinal chemistry letters 20080101
Title: Liver X receptors (LXR) as therapeutic targets in dyslipidemia.
Journal: Cardiovascular therapeutics 20080101
Title: Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.
Journal: Journal of lipid research 20071201
Title: Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.
Journal: Biochemical pharmacology 20071115
Title: Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL.
Journal: Journal of lipid research 20071101
Title: SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
Journal: Molecular cell 20071012
Title: Regulation of 17beta-hydroxysteroid dehydrogenase type 2, type 4 and type 5 by calcitriol, LXR agonist and 5alpha-dihydrotestosterone in human prostate cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology 20071001
Title: Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.
Journal: Bioorganic & medicinal chemistry letters 20071001
Title: N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Journal: Journal of medicinal chemistry 20070823
Title: 2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.
Journal: Bioorganic & medicinal chemistry letters 20070815
Title: Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.
Journal: Molecular and cellular biochemistry 20070801
Title: Effect of T0901317 on hepatic proinflammatory gene expression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Journal: Inflammation 20070801
Title: Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.
Journal: The Journal of biological chemistry 20070720
Title: A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c.
Journal: The Journal of biological chemistry 20070622
Title: Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.
Journal: Bioorganic & medicinal chemistry letters 20070615
Title: Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway.
Journal: Biochemical and biophysical research communications 20070608
Title: The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells.
Journal: Biochemical and biophysical research communications 20070601
Title: Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.
Journal: Molecular human reproduction 20070601
Title: Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.
Journal: Blood 20070515
Title: T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR.
Journal: FEBS letters 20070501
Title: Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.
Journal: Endocrinology 20070401
Title: The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
Journal: Molecular and cellular neurosciences 20070401
Title: Immunomodulatory properties of increased levels of liver X receptor beta in peripheral blood mononuclear cells from multiple sclerosis patients.
Journal: Experimental neurology 20070401
Title: Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
Journal: Bioorganic & medicinal chemistry 20070301
Title: PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Journal: Journal of lipid research 20070201
Title: 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.
Journal: Journal of neurochemistry 20070201
Title: Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.
Journal: Hepatology (Baltimore, Md.) 20070201
Title: Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.
Journal: Oncogene 20070111
Title: The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.
Journal: The Journal of biological chemistry 20070105
Title: Liver X receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells.
Journal: Biochemistry 20061219
Title: 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.
Journal: Biochimica et biophysica acta 20061201
Title: Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.
Journal: Endocrinology 20061101
Title: The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
Journal: Biochemical and biophysical research communications 20061020
Title: Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
Journal: Journal of medicinal chemistry 20061019
Title: Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.
Journal: The Biochemical journal 20061015
Title: Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.
Journal: Bioorganic & medicinal chemistry letters 20061001
Title: Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Journal: Journal of lipid research 20060901
Title: The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism.
Journal: The Journal of biological chemistry 20060825
Title: Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents.
Journal: Bioorganic & medicinal chemistry letters 20060815
Title: Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.
Journal: Endocrinology 20060801
Title: Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801
Title: The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.
Journal: Journal of neurochemistry 20060801
Title: The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.
Journal: Hepatology (Baltimore, Md.) 20060801
Title: Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.
Journal: Shock (Augusta, Ga.) 20060801
Title: Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites.
Journal: The EMBO journal 20060712
Title: Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.
Journal: Cell research 20060701
Title: Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist.
Journal: Cancer research 20060701
Title: [Liver X receptors mediate cholesterol efflux in mouse glomerular mesangial cells].
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060618
Title: ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid-bile acid conjugates (FABACs).
Journal: The Biochemical journal 20060615
Title: Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.
Journal: Journal of lipid research 20060601
Title: Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule.
Journal: American journal of physiology. Renal physiology 20060501
Title: PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.
Journal: Journal of lipid research 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Discovery and optimization of a novel series of liver X receptor-alpha agonists.
Journal: Bioorganic & medicinal chemistry letters 20060315
Title: Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.
Journal: The Journal of biological chemistry 20060310
Title: Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.
Journal: Neuroreport 20060206
Title: Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20060101
Title: Non-steroidal LXR agonists; an emerging therapeutic strategy for the treatment of atherosclerosis.
Journal: Recent patents on cardiovascular drug discovery 20060101
Title: Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line.
Journal: Placenta 20051101
Title: The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver.
Journal: Journal of lipid research 20051001
Title: Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.
Journal: International journal of molecular medicine 20051001
Title: Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Journal: Journal of medicinal chemistry 20050825
Title: Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.
Journal: Cell metabolism 20050501
Title: Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors.
Journal: Atherosclerosis 20050401
Title: Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway.
Journal: Diabetes 20050401
Title: Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20050204
Title: Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20050101
Title: Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Journal: Circulation research 20041210
Title: LXR activation and cholesterol efflux from a lipoprotein depot in vivo.
Journal: Biochimica et biophysica acta 20041108
Title: Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
Journal: The Journal of biological chemistry 20041029
Title: Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Journal: Journal of molecular endocrinology 20041001
Title: Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver.
Journal: The Journal of biological chemistry 20040702
Title: Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20040601
Title: A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
Journal: Journal of neurochemistry 20040201
Title: Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.
Journal: Gastroenterology 20040101
Title: CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040101
Title: T0901317 is a dual LXR/FXR agonist.
Journal: Molecular genetics and metabolism 20040101
Title: Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.
Journal: Journal of molecular biology 20031212
Title: The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse.
Journal: Journal of lipid research 20031101
Title: Molecular determinants of LXRalpha agonism.
Journal: Journal of molecular graphics & modelling 20031101
Title: Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
Journal: The Journal of biological chemistry 20030919
Title: Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.
Journal: The EMBO journal 20030915
Title: X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
Journal: The Journal of biological chemistry 20030718
Title: Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Journal: Molecular endocrinology (Baltimore, Md.) 20030701
Title: Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Journal: Molecular endocrinology (Baltimore, Md.) 20030701
Title: Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.
Journal: The Journal of biological chemistry 20030613
Title: Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.
Journal: Journal of hepatology 20030601
Title: Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.
Journal: The Journal of biological chemistry 20030502
Title: Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.
Journal: Molecular endocrinology (Baltimore, Md.) 20030301
Title: Pharmacological evidence for a role of liver X receptors in atheroprotection.
Journal: FEBS letters 20030211
Title: T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.
Journal: FEBS letters 20030211
Title: On the role of liver X receptors in lipid accumulation in adipocytes.
Journal: Molecular endocrinology (Baltimore, Md.) 20030201
Title: A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
Journal: The Journal of biological chemistry 20030124
Title: Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.
Journal: The Journal of biological chemistry 20030110
Title: Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.
Journal: The Biochemical journal 20021215
Title: Phospholipid transfer protein is regulated by liver X receptors in vivo.
Journal: The Journal of biological chemistry 20021018
Title: Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles.
Journal: The Journal of biological chemistry 20020913
Title: Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.
Journal: The Journal of biological chemistry 20020913
Title: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
Journal: Journal of lipid research 20020701
Title: Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Journal: Journal of medicinal chemistry 20020509
Title: Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
Journal: The Journal of biological chemistry 20020315
Title: Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.
Journal: Molecular endocrinology (Baltimore, Md.) 20020301
Title: Hypolipidemic effects of selective liver X receptor alpha agonists.
Journal: Steroids 20010901
Title: Role of LXRs in control of lipogenesis.
Journal: Genes & development 20001115
Title: Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
Journal: The Journal of biological chemistry 20000519
Title: Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary.
Journal: Molecular endocrinology (Baltimore, Md.)
Title: Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
Journal: Molecular endocrinology (Baltimore, Md.)
